ATE346287T1 - Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix - Google Patents

Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix

Info

Publication number
ATE346287T1
ATE346287T1 AT00975164T AT00975164T ATE346287T1 AT E346287 T1 ATE346287 T1 AT E346287T1 AT 00975164 T AT00975164 T AT 00975164T AT 00975164 T AT00975164 T AT 00975164T AT E346287 T1 ATE346287 T1 AT E346287T1
Authority
AT
Austria
Prior art keywords
chemical sensor
analyte
sensor matrix
supplying samples
cavities
Prior art date
Application number
AT00975164T
Other languages
English (en)
Inventor
John T Mcdevitt
Eric V Anslyn
Jason B Shear
Dean P Neikirk
Damon V Borich
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE346287T1 publication Critical patent/ATE346287T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Fluid Mechanics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Prostheses (AREA)
  • Pyrane Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
AT00975164T 1999-07-16 2000-07-14 Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix ATE346287T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14443599P 1999-07-16 1999-07-16
US14412699P 1999-07-16 1999-07-16
US14443699P 1999-07-16 1999-07-16

Publications (1)

Publication Number Publication Date
ATE346287T1 true ATE346287T1 (de) 2006-12-15

Family

ID=27386038

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00975164T ATE346287T1 (de) 1999-07-16 2000-07-14 Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix

Country Status (7)

Country Link
US (2) US6602702B1 (de)
EP (1) EP1204859B1 (de)
AT (1) ATE346287T1 (de)
AU (3) AU773679B2 (de)
CA (1) CA2379130A1 (de)
DE (1) DE60031988T2 (de)
WO (3) WO2001006244A2 (de)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148354A1 (en) * 1996-10-02 2003-08-07 Saftest, Inc. Devices and methods for isolating and detecting specific substances in complex matrices
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
EP1212599A2 (de) * 1999-08-30 2002-06-12 Illumina, Inc. Verfahren zur verbesserung des signals einer sensorarray
US7316899B2 (en) * 2000-01-31 2008-01-08 The Board Of Regents Of The University Of Texas System Portable sensor array system
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
CA2399908A1 (en) * 2000-02-10 2001-08-16 Todd Dickinson Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
EP1373874A4 (de) * 2001-01-31 2004-03-31 Univ Texas Verfahren und vorrichtung zum eingrenzen von materialien in einem mikrobearbeiteten chemischen sensorarray
US7294478B1 (en) * 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
EP1442027A1 (de) 2001-10-09 2004-08-04 3-Dimensional Pharmaceuticals, Inc. Substituierte diphenyloxazole, deren synthese und deren verwendung als fluoreszenzsonden
US7253003B2 (en) * 2001-10-19 2007-08-07 Wisconsin Alumni Research Foundation Method for monitoring the environment within a microfluidic device
US7304259B2 (en) 2001-11-01 2007-12-04 Siemens Energy & Automation, Inc. Mail processing system with multilevel contaminant detection and sterilization
CA2470724A1 (en) * 2001-12-20 2003-07-03 Safetest, Inc. Devices and methods for isolating and detecting specific substances in complex matrices
WO2003079013A1 (fr) * 2002-03-15 2003-09-25 Sony Corporation Substrat pour essai biologique, appareil d'essai biologique et appareil de lecture
US20060134713A1 (en) 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US20030180814A1 (en) * 2002-03-21 2003-09-25 Alastair Hodges Direct immunosensor assay
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US8257967B2 (en) * 2002-04-26 2012-09-04 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
EP1507145B1 (de) * 2002-05-08 2009-02-18 Panasonic Corporation Biomolekulares substrat und testvorrichtung
EP1549954B1 (de) * 2002-05-14 2008-11-26 Arryx, Inc. Optisch adressierter sensor mit breitem spektrum
US7332273B2 (en) 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
US20070275411A1 (en) 2006-05-25 2007-11-29 Mcgall Glenn H Silane mixtures
US20030003587A1 (en) * 2002-06-28 2003-01-02 Murray George M Molecularly imprinted polymer based sensors for the detection of narcotics
US7183455B2 (en) * 2002-08-27 2007-02-27 Drdc Limited Adhesive dressing
US6900133B2 (en) 2002-09-18 2005-05-31 Applied Materials, Inc Method of etching variable depth features in a crystalline substrate
GB0225791D0 (en) * 2002-11-05 2002-12-11 Kratos Analytical Ltd Charged particle spectrometer and detector therefor
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
FR2846957B1 (fr) * 2002-11-13 2005-09-30 Commissariat Energie Atomique Micro-systeme a remplissage de micro-billes et procede d'obtention
AU2003302264A1 (en) 2002-12-20 2004-09-09 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
EP1590669B1 (de) * 2003-02-05 2009-11-25 The General Hospital Corporation System auf mikrochipbasis zur hiv-diagnostik
US20040241880A1 (en) * 2003-05-30 2004-12-02 Leproust Eric M. Ligand array assays having reduced fluorescent dye degradation and compositions for practicing the same
US7298478B2 (en) 2003-08-14 2007-11-20 Cytonome, Inc. Optical detector for a particle sorting system
EP1695082A2 (de) * 2003-12-11 2006-08-30 Board of Regents, The University of Texas System Verfahren und vorrichtung für die analyse von speichel unter verwendung eines sensorarrays
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
CN1934445A (zh) * 2004-03-18 2007-03-21 富士胶片株式会社 在样品检验方法中使用的分析元件
US7776531B1 (en) 2004-03-25 2010-08-17 Illumina, Inc. Compositions and methods for stabilizing surface bound probes
US7442339B2 (en) * 2004-03-31 2008-10-28 Intel Corporation Microfluidic apparatus, Raman spectroscopy systems, and methods for performing molecular reactions
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
US7763454B2 (en) 2004-07-09 2010-07-27 Church & Dwight Co., Inc. Electronic analyte assaying device
US7308164B1 (en) 2004-09-16 2007-12-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for texturing surfaces of optical fiber sensors used for blood glucose monitoring
US7608042B2 (en) * 2004-09-29 2009-10-27 Intellidx, Inc. Blood monitoring system
US20060229531A1 (en) * 2005-02-01 2006-10-12 Daniel Goldberger Blood monitoring system
WO2006043899A1 (en) * 2004-10-18 2006-04-27 Nanyang Technological University A transducer
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
CA2588753C (en) 2004-12-03 2014-02-18 Cytonome, Inc. Unitary cartridge for particle processing
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7405831B2 (en) 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
DE102005013198B4 (de) * 2005-03-16 2007-07-19 BAM Bundesanstalt für Materialforschung und -prüfung Optochemische Sensormembran und Verfahren zur Herstellung
US20060228734A1 (en) * 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
US8377398B2 (en) 2005-05-31 2013-02-19 The Board Of Regents Of The University Of Texas System Methods and compositions related to determination and use of white blood cell counts
CA2610875A1 (en) 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
EP1922419A4 (de) * 2005-06-10 2010-11-17 Life Technologies Corp Verfahren und system zur genetischen multiplex-analyse
EP2508867A1 (de) 2005-06-24 2012-10-10 Board Of Regents, The University Of Texas System Systeme und Verfahren einschliesslich in sich geschlossener Kassetten mit Nachweissystemen und Flüssigkeitszufuhrsystemen
US7791728B2 (en) * 2005-08-11 2010-09-07 Hewlett-Packard Development Company, L.P. System for optically analyzing a substance with a selected single-wavelength
US20070123801A1 (en) * 2005-11-28 2007-05-31 Daniel Goldberger Wearable, programmable automated blood testing system
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP2021491A4 (de) 2006-05-10 2010-02-24 Univ Texas Nachweis von tumorbiomarkern bei mundkrebs
US8092385B2 (en) 2006-05-23 2012-01-10 Intellidx, Inc. Fluid access interface
US7382944B1 (en) 2006-07-14 2008-06-03 The United States Of America As Represented By The Administration Of The National Aeronautics And Space Administration Protective coating and hyperthermal atomic oxygen texturing of optical fibers used for blood glucose monitoring
US20080153096A1 (en) * 2006-11-02 2008-06-26 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
US7522282B2 (en) 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
CA2671872A1 (en) * 2006-12-07 2008-06-12 University Of Florida Research Foundation, Inc. Materials and methods for efficient and accurate detection of analytes
EP2639578B1 (de) 2006-12-14 2016-09-14 Life Technologies Corporation Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008089495A2 (en) 2007-01-19 2008-07-24 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
US8838195B2 (en) 2007-02-06 2014-09-16 Medtronic Minimed, Inc. Optical systems and methods for ratiometric measurement of blood glucose concentration
US7787126B2 (en) 2007-03-26 2010-08-31 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US20080268442A1 (en) * 2007-04-24 2008-10-30 Igd Intel, Llc Method and system for preparing a blood sample for a disease association gene transcript test
EP2162057A1 (de) 2007-05-10 2010-03-17 Glumetrics, Inc. Verschleissbeständiger gleichgewichtsfluoreszenzsensor für intravaskuläre echtzeit-glukosemessung
US20080309923A1 (en) * 2007-06-14 2008-12-18 Falk R Aaron Compact chemical sensor
US20110059040A1 (en) * 2007-06-27 2011-03-10 Kiser Patrick F Compositions and methods for inhibiting viral and bacterial activity
US8580845B2 (en) * 2007-06-29 2013-11-12 Board Of Regents, The University Of Texas System Functionalized expanded porphyrins
ES2556627T3 (es) 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
EP2217316A4 (de) 2007-11-21 2013-01-16 Glumetrics Inc Verwendung eines intravaskulären equilibrium-sensors für enge glykämische kontrolle
US8180421B2 (en) * 2007-12-12 2012-05-15 Kimberly-Clark Worldwide, Inc. Resonance energy transfer based detection of nosocomial infection
EP2265677B1 (de) * 2008-04-09 2019-05-15 Battelle Memorial Institute Korrosionsdetektionsprodukt und verfahren
WO2009129186A2 (en) 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
EP2982437B1 (de) 2008-06-25 2017-12-06 Life Technologies Corporation Verfahren und vorrichtung zur messung von analyten mithilfe grossskaliger fet-arrays
US9880137B2 (en) * 2008-09-04 2018-01-30 The Board Of Trustees Of The University Of Illinois Colorimetric sensor arrays based on nanoporous pigments
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8385998B2 (en) * 2008-10-24 2013-02-26 Jin Zhang Contact lens integrated with a biosensor for the detection of glucose and other components in tears
US8802074B2 (en) * 2008-11-26 2014-08-12 Board Of Regents, The University Of Texas System Polymers functionalized with ion-specific recognition elements
US8753290B2 (en) 2009-03-27 2014-06-17 Intellectual Inspiration, Llc Fluid transfer system and method
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
EP2438152A4 (de) * 2009-06-05 2012-12-12 Glumetrics Inc Algorithmen zur kalibrierung eines analytsensors
CA2766597A1 (en) * 2009-07-01 2011-01-06 Board Of Regents, The University Of Texas System Methods of determining the presence and/or concentration of an analyte in a sample
GB0913258D0 (en) * 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
EP2483679A4 (de) 2009-09-30 2013-04-24 Glumetrics Inc Sensoren mit thrombenresistenter beschichtung
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
EP2542890B1 (de) * 2010-03-01 2015-05-06 Quanterix Corporation Verfahren zur erweiterung des dynamischen bereichs bei tests für den nachweis von molekülen oder partikeln
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8473222B2 (en) * 2010-03-11 2013-06-25 Glumetrics, Inc. Measurement devices and methods for measuring analyte concentration incorporating temperature and pH correction
JP5632529B2 (ja) * 2010-04-07 2014-11-26 エンパイア テクノロジー ディベロップメント エルエルシー 化学化合物用の検出器
EP2388592A1 (de) * 2010-05-19 2011-11-23 Stichting Dutch Polymer Institute Kügelchen und Verfahren zu deren Herstellung und Sensorvorrichtung
WO2012054104A1 (en) * 2010-06-29 2012-04-26 Life Technologies Corporation Immobilized buffer particles and uses thereof
US20110318820A1 (en) 2010-06-29 2011-12-29 Life Technologies Corporation Immobilized Buffer Particles and Uses Thereof
CN106932456B (zh) 2010-06-30 2020-02-21 生命科技公司 用于测试isfet阵列的方法和装置
CN119165030A (zh) 2010-06-30 2024-12-20 生命科技公司 阵列列积分器
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
US8653567B2 (en) 2010-07-03 2014-02-18 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
EP2617061B1 (de) 2010-09-15 2021-06-30 Life Technologies Corporation Verfahren und vorrichtung zur analytmessung
CN103299182A (zh) 2010-09-24 2013-09-11 生命科技公司 匹配的晶体管对电路
US9671413B2 (en) 2010-11-12 2017-06-06 William Marsh Rice University Prostate cancer point of care diagnostics
WO2012065117A2 (en) 2010-11-12 2012-05-18 William Marsh Rice University Oral cancer point of care diagnostics
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US8735175B2 (en) * 2011-03-18 2014-05-27 Chris D. Geddes Multicolor microwave-accelerated metal-enhanced fluorescence (M-MAMEF)
KR20140029404A (ko) * 2011-03-23 2014-03-10 캘리포니아 인스티튜트 오브 테크놀로지 폴리메라아제 연쇄 반응 핵산 증폭을 수행하기 위한 시스템
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
SG194892A1 (en) 2011-05-12 2013-12-30 Univ Rice William M Bio-nano-chips for on-site drug screening
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
KR101772452B1 (ko) 2011-12-19 2017-08-30 야마하하쓰도키 가부시키가이샤 대상물 선별 장치 및 대상물 선별 방법
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US9533308B2 (en) 2012-02-10 2017-01-03 California Institute Of Technology PC board-based polymerase chain reaction systems, methods and materials
US8860579B1 (en) * 2012-03-06 2014-10-14 Ali T. Alouani Illegal drug detector and method of its use
EP2856177B1 (de) 2012-05-25 2020-11-18 The University of North Carolina At Chapel Hill Mikrofluidische vorrichtungen, feste träger für reagenzien und zugehörige verfahren
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
EP2908140B1 (de) * 2012-10-15 2019-08-14 National University Corporation Nagoya University Mikrokanalchip zur mikropartikeltrennung, mikropartikeltrennverfahren und system zur mikropartikeltrennung mithilfe des chips
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US20140264471A1 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Chemical device with thin conductive element
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
WO2014149778A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensors with consistent sensor surface areas
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
EP2972280B1 (de) 2013-03-15 2021-09-29 Life Technologies Corporation Chemischer sensor mit stetigen sensoroberflächen
CN105051270B (zh) * 2013-03-15 2019-05-07 代表亚利桑那大学的亚利桑那校董会 生物传感器微阵列构成和方法
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9028772B2 (en) * 2013-06-28 2015-05-12 Google Inc. Methods for forming a channel through a polymer layer using one or more photoresist layers
US8816278B1 (en) * 2013-09-05 2014-08-26 Globalfoundries Singapore Pte. Ltd. Imaging methods
US20150111778A1 (en) * 2013-10-21 2015-04-23 William Marsh Rice University Bio-nano-chip for anticonvulsant drug salivary assay
SG11201607817YA (en) * 2014-03-20 2016-10-28 Agency Science Tech & Res Film sensor for indicating food quality
GB2524541A (en) * 2014-03-26 2015-09-30 Ibm Microfluidic chip with conic bead trapping cavities and fabrication thereof
KR102593647B1 (ko) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 트랜스미터 구성을 갖춘 높은 데이터율 집적 회로
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
TW202024628A (zh) 2014-12-18 2020-07-01 美商生命技術公司 用於使用大規模fet陣列量測分析物之方法及設備
GB201501012D0 (en) * 2015-01-21 2015-03-04 Base4 Innovation Ltd Improved droplet sequencing apparatus and method
EP3313573A2 (de) * 2015-07-22 2018-05-02 The University of North Carolina at Chapel Hill Fluidische vorrichtungen mit kügelchenvertiefungsgeometrien mit räumlich getrennten kügelchenrückhalte- und -signaldetektionssegmenten sowie zugehörige verfahren
WO2017132727A1 (en) * 2016-02-02 2017-08-10 The University Of Adelaide Apparatus, method and system for detecting a chemical driving property using a fluorophore
DE102016117919B4 (de) 2016-09-22 2025-01-30 Endress+Hauser (Deutschland) Gmbh+Co. Kg Dosiervorrichtung einer Prozessanlage
US11243192B2 (en) * 2016-09-27 2022-02-08 Vaon, Llc 3-D glass printable hand-held gas chromatograph for biomedical and environmental applications
JP7025141B2 (ja) * 2017-06-21 2022-02-24 シンロイヒ株式会社 蛍光検出方法、インク組成物、塗装体、及び対象物の識別方法
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor
US11383236B2 (en) 2017-11-10 2022-07-12 Christopher Walker Polymerase chain reaction using a microfluidic chip fabricated with printed circuit board techniques
EP3794080B1 (de) 2018-05-18 2024-04-10 The University of North Carolina at Chapel Hill Zusammensetzungen, vorrichtungen und verfahren zur verbesserung einer oberflächeneigenschaft eines substrats
CA3115966C (en) * 2018-10-25 2023-03-14 Tl Genomics Inc. Pretreatment of blood for classifying blood cells using microchannel
WO2020176577A1 (en) * 2019-02-27 2020-09-03 Gentex Corporation Tactical chemical detector
US12140542B2 (en) 2019-03-28 2024-11-12 National University Corporation Ehime University Optical analysis chip
US20230134948A1 (en) * 2020-04-02 2023-05-04 Public University Corporation Nagoya City University Staining method, microscopic observation method, staining agent and staining kit
DE102020216542A1 (de) 2020-12-23 2022-06-23 Robert Bosch Gesellschaft mit beschränkter Haftung Membran für eine mikrofluidische Kartusche mit Ausnehmungen für einen Mikrokanal oder ein Sensorelement und Verfahren zur Herstellung einer Membran und einer Kartusche mit Membran

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3696932A (en) 1970-09-30 1972-10-10 Pall Corp Disposable filter assembly
US3701433A (en) 1970-11-10 1972-10-31 Pall Corp Filter for use in the filtration of blood
US3709868A (en) 1971-03-08 1973-01-09 Hoffmann La Roche Opium alkaloid antigens and antibodies specific therefor
US3843696A (en) 1972-09-05 1974-10-22 Syva Co Methadone analog compounds
CS164231B2 (de) 1972-09-28 1975-11-07
US3856469A (en) 1973-01-02 1974-12-24 Syva Corp Interferant removal from amphetamine immunoassay
US3954623A (en) 1974-05-28 1976-05-04 Johnson & Johnson Blood filtration unit
US3876504A (en) 1974-06-10 1975-04-08 Early Warning Co Procedure for determination of antigens and antibodies and articles for use therewith
US4189382A (en) 1974-11-07 1980-02-19 Sherwood Medical Industries Inc. Blood coagulation and separation
US4036946A (en) 1975-10-20 1977-07-19 Marcos Kleinerman Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances
US4050898A (en) 1976-04-26 1977-09-27 Eastman Kodak Company Integral analytical element
US4069017A (en) 1977-01-14 1978-01-17 Eastman Kodak Company Colorimetric assay for bilirubin
US4200613A (en) 1977-06-03 1980-04-29 Ramco Laboratories Inc. Radioimmunoassay apparatus
US4115277A (en) 1977-06-17 1978-09-19 Pioneer Filters, Inc. Blood filtering apparatus of graduated fiber density
US4294817A (en) 1977-11-25 1981-10-13 International Diagnostic Technology, Inc. Method of fluoro immunoassay
US4245041A (en) 1977-12-07 1981-01-13 American Monitor Corporation Triglycerides assay and reagents therefor
US4246107A (en) 1978-03-06 1981-01-20 Asahi Kasei Kogyo Kabushiki Kaisha Separation of lymphocytes from lymphocyte-containing suspension by filtration
US4378429A (en) 1979-08-23 1983-03-29 Modrovich Ivan Endre Enzymatic method and stabilized solutions for determining total cholesterol in human serum
US4344743A (en) 1979-12-04 1982-08-17 Bessman Samuel P Piezoelectric driven diaphragm micro-pump
DE3029579C2 (de) 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US4596657A (en) 1982-06-04 1986-06-24 Miles Laboratories, Inc. Blood bag system with integral filtering means
US4567149A (en) 1983-03-17 1986-01-28 Mast Immunosystems, Ltd. Binding assay system and method of making and using same
US4922591A (en) * 1984-03-20 1990-05-08 Carboloy Inc. Tool storage and changing system
US4672028A (en) 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
JPH0823558B2 (ja) 1984-11-27 1996-03-06 オ−ジエニクス リミテツド 検定装置
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5354825A (en) 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
US4661445A (en) 1985-05-24 1987-04-28 Saxinger W Carl Competitive ELISA for the detection of HTLV-III antibodies
US4623461A (en) 1985-05-31 1986-11-18 Murex Corporation Transverse flow diagnostic device
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4810378A (en) 1986-04-21 1989-03-07 Miles Laboratories, Inc. Red blood cell filtering system
US4777021A (en) * 1986-04-25 1988-10-11 Richard K. Wertz Manifold vacuum device for biochemical and immunological uses
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US4812293A (en) * 1986-06-30 1989-03-14 Becton, Dickinson And Company Vacuum actuated assay device and method of using same
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4753776A (en) 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4925800A (en) 1986-12-04 1990-05-15 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibody against human pneumocystis carinii
US4813277A (en) 1987-03-30 1989-03-21 Amoco Corporation Method for collecting magnetizable particles in an above ground storage tank
US4828386A (en) 1987-06-19 1989-05-09 Pall Corporation Multiwell plates containing membrane inserts
US5209904A (en) 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
US4938742A (en) 1988-02-04 1990-07-03 Smits Johannes G Piezoelectric micropump with microvalves
US5162863A (en) 1988-02-15 1992-11-10 Canon Kabushiki Kaisha Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
EP0339623B1 (de) * 1988-04-26 1993-12-15 Nippon Telegraph And Telephone Corporation Lasermagnetisches Immuntestverfahren und Gerät dazu
US4874499A (en) 1988-05-23 1989-10-17 Massachusetts Institute Of Technology Electrochemical microsensors and method of making such sensors
US5252294A (en) 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
DE68926504T2 (de) 1988-07-20 1996-09-12 David Segev Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen
IT1226712B (it) 1988-08-05 1991-02-05 Eniricerche Spa Metodo immunoenzimatico elisa monopiastra con inibizione competitiva per la rivelazione di anticorpi antisporozoitari di plasmodium falciparum.
US5108933A (en) 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
FR2638848B1 (fr) 1988-11-04 1993-01-22 Chemunex Sa Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
IE67038B1 (en) 1988-12-22 1996-02-21 Patrick Joseph Joyce Immunodiagnostic assays for use in the detection and determination of mastitis
US6008031A (en) 1989-05-12 1999-12-28 Duke University Method of analysis and manipulation of DNA utilizing mismatch repair systems
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5053197A (en) 1989-07-19 1991-10-01 Pb Diagnostic Systems, Inc. Diagnostic assay module
JP3127449B2 (ja) 1989-07-28 2001-01-22 三菱化学株式会社 抗体の測定法
CA2024548C (en) 1989-09-05 2002-05-28 David Issachar Analyte specific chemical sensor
US5137833A (en) 1989-09-21 1992-08-11 Russell Anthony P Method for detecting polyhydroxyl compounds
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US4997577A (en) 1989-12-20 1991-03-05 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
ATE137269T1 (de) 1990-01-26 1996-05-15 Abbott Lab Verbessertes verfahren zur amplifikation von nuklein säurezielsequenz, einsetzbar für die polymerase und ligasekettenreaktion
US5183740A (en) 1990-02-23 1993-02-02 The United States Of America As Represented By The Secretary Of The Navy Flow immunosensor method and apparatus
US5182366A (en) 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
US5965695A (en) 1990-05-15 1999-10-12 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
US5223393A (en) 1990-06-12 1993-06-29 Microgenics Corporation Detection of analytes having binding sites for at least two binding moieties
WO1992000880A1 (en) 1990-07-09 1992-01-23 S.C.I. Operations Pty Limited Trading As Smorgon Plastics An improved container
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5071076A (en) 1990-08-10 1991-12-10 Omni Quest Corporation Method for producing magnetic microparticles from metallocenes
US5235028A (en) 1990-08-31 1993-08-10 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5235039A (en) 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
US5578444A (en) 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
WO1993002360A1 (en) 1991-07-16 1993-02-04 Transmed Biotech Incorporated Methods and compositions for simultaneous analysis of multiple analytes
US5211850A (en) 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
US5288214A (en) 1991-09-30 1994-02-22 Toshio Fukuda Micropump
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
JPH05157684A (ja) 1991-12-02 1993-06-25 Seikagaku Kogyo Co Ltd 吸光光度計
US6063581A (en) 1992-01-22 2000-05-16 Axis-Shield Asa Immunoassay for homocysteine
US5262127A (en) 1992-02-12 1993-11-16 The Regents Of The University Of Michigan Solid state chemical micro-reservoirs
US5654497A (en) 1992-03-03 1997-08-05 Lockheed Martin Energy Systems, Inc. Motor vehicle fuel analyzer
US5391272A (en) 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
US5518887A (en) 1992-03-30 1996-05-21 Abbott Laboratories Immunoassays empolying generic anti-hapten antibodies and materials for use therein
US5248742A (en) 1992-04-27 1993-09-28 Gencorp Inc. Unsaturated polyester-epoxy resin network composition
US5278303A (en) 1992-06-12 1994-01-11 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
GB9311988D0 (en) 1993-06-10 1993-07-28 Pall Corp Device and method for separating plasma from a blood product
US5382512A (en) 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
FR2710410B1 (fr) 1993-09-20 1995-10-20 Bio Merieux Procédé et dispositif pour la détermination d'un analyte dans un échantillon .
JP3488465B2 (ja) 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US5499909A (en) 1993-11-17 1996-03-19 Aisin Seiki Kabushiki Kaisha Of Kariya Pneumatically driven micro-pump
AU681470B2 (en) 1993-12-28 1997-08-28 Westonbridge International Limited Micropump
US5616698A (en) 1994-01-10 1997-04-01 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
US5631130A (en) 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
US5583162A (en) 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
JPH0842457A (ja) 1994-07-27 1996-02-13 Aisin Seiki Co Ltd マイクロポンプ
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5965590A (en) 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
WO1998053300A2 (en) * 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparaus for sequential processing of analytes
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
KR100314996B1 (ko) 1994-11-10 2002-01-15 윌리암 제이. 버크 액체분배시스템
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5616790A (en) 1994-11-18 1997-04-01 California Institute Of Technology Lipid-based metal sensor
US5550373A (en) 1994-12-30 1996-08-27 Honeywell Inc. Fabry-Perot micro filter-detector
US5571401A (en) 1995-03-27 1996-11-05 California Institute Of Technology Sensor arrays for detecting analytes in fluids
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5690807A (en) 1995-08-03 1997-11-25 Massachusetts Institute Of Technology Method for producing semiconductor particles
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5714122A (en) 1995-11-22 1998-02-03 Minnesota Mining And Manufacturing Company Emulsion for robust sensing
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
WO1997025437A1 (en) * 1996-01-04 1997-07-17 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Method for assaying proteolytic enzymes using fluorescence-quenched substrates
JP3664328B2 (ja) 1996-01-19 2005-06-22 富士写真フイルム株式会社 血漿または血清試料の調製方法
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
AU706862B2 (en) * 1996-04-03 1999-06-24 Applied Biosystems, Llc Device and method for multiple analyte detection
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5840256A (en) 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
JP3950493B2 (ja) 1996-04-26 2007-08-01 東レ・ダウコーニング株式会社 導電性シリコーンゴム組成物、半導体装置の製造方法およびその半導体装置
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5866430A (en) 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
US5770370A (en) * 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
GB2315131B (en) * 1996-07-10 2000-11-29 Cambridge Imaging Ltd Improvements in and relating to imaging
US5707502A (en) 1996-07-12 1998-01-13 Chiron Diagnostics Corporation Sensors for measuring analyte concentrations and methods of making same
US5854684A (en) * 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US5872623A (en) 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US5861658A (en) 1996-10-03 1999-01-19 International Business Machines Corporation Inorganic seal for encapsulation of an organic layer and method for making the same
US5748091A (en) 1996-10-04 1998-05-05 Mcdonnell Douglas Corporation Fiber optic ice detector
US6048732A (en) 1996-10-16 2000-04-11 Board Of Regents, The University Of Texas System Receptor and method for citrate determination
JP2001504389A (ja) 1996-10-21 2001-04-03 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ビーズを分配する装置と方法
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
CA2389358C (en) 1996-12-31 2008-07-15 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US5827748A (en) 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
US5981297A (en) 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US6037137A (en) 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6045579A (en) 1997-05-01 2000-04-04 Spinal Concepts, Inc. Adjustable height fusion device
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
US7115884B1 (en) * 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US5922617A (en) 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US5992820A (en) 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
JP3944996B2 (ja) 1998-03-05 2007-07-18 株式会社日立製作所 Ｄｎａプローブアレー
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6151973A (en) 1999-01-29 2000-11-28 Glaxo Wellcome Inc. Bead picking apparatus and method

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DE60031988D1 (de) 2007-01-04
WO2001006244A8 (en) 2007-10-11
WO2001006253A8 (en) 2001-06-21
US6589779B1 (en) 2003-07-08
AU1325501A (en) 2001-02-05
US6602702B1 (en) 2003-08-05
AU1325201A (en) 2001-02-05
CA2379130A1 (en) 2001-01-25
WO2001006239A2 (en) 2001-01-25
AU1429701A (en) 2001-02-05
EP1204859B1 (de) 2006-11-22
EP1204859A2 (de) 2002-05-15
AU773679B2 (en) 2004-06-03
WO2001006244A2 (en) 2001-01-25
WO2001006239A8 (en) 2001-06-21
DE60031988T2 (de) 2007-06-14
WO2001006253A2 (en) 2001-01-25

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