ATE290205T1 - Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen - Google Patents

Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen

Info

Publication number
ATE290205T1
ATE290205T1 AT97954785T AT97954785T ATE290205T1 AT E290205 T1 ATE290205 T1 AT E290205T1 AT 97954785 T AT97954785 T AT 97954785T AT 97954785 T AT97954785 T AT 97954785T AT E290205 T1 ATE290205 T1 AT E290205T1
Authority
AT
Austria
Prior art keywords
detecting
active substances
identifying infectious
bioluminescence
infectious active
Prior art date
Application number
AT97954785T
Other languages
English (en)
Inventor
Bruce J Bryan
Stephen Gaalema
Randall B Murphy
Original Assignee
Prolume Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolume Ltd filed Critical Prolume Ltd
Application granted granted Critical
Publication of ATE290205T1 publication Critical patent/ATE290205T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G01N21/763—Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/18—Sulfur containing
    • Y10T436/186—Sulfur dioxide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT97954785T 1996-12-12 1997-12-12 Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen ATE290205T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3374596P 1996-12-12 1996-12-12
US3767597P 1997-02-11 1997-02-11
PCT/US1997/023089 WO1998026277A2 (en) 1996-12-12 1997-12-12 Apparatus and method for detecting and identifying infectious agents

Publications (1)

Publication Number Publication Date
ATE290205T1 true ATE290205T1 (de) 2005-03-15

Family

ID=26710086

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97954785T ATE290205T1 (de) 1996-12-12 1997-12-12 Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen

Country Status (10)

Country Link
US (4) US6458547B1 (de)
EP (1) EP1015872B1 (de)
JP (2) JP3795533B2 (de)
AT (1) ATE290205T1 (de)
AU (1) AU741076B2 (de)
CA (1) CA2271717A1 (de)
DE (1) DE69732667T2 (de)
IL (1) IL129767A0 (de)
NZ (1) NZ335453A (de)
WO (1) WO1998026277A2 (de)

Families Citing this family (273)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2288760T3 (es) 1996-04-25 2008-01-16 Bioarray Solutions Ltd. Ensamblaje electrocinetico controlado por luz de particulas proximas a superficies.
US6117643A (en) 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
US6758961B1 (en) * 1997-12-17 2004-07-06 Ecole Polytechnique Federale De Lausanne Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
US7244349B2 (en) 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
EP1925320A3 (de) 1998-03-27 2008-09-03 Prolume, Ltd. Luciferasen, fluoreszierende Proteine, Nukleinsäuren zur Kodierung der Luciferasen und der fluoreszierenden Proteine sowie deren Verwendung zur Diagnose, zum Screening mit hohem Durchsatz und zur Behandlung neuartiger Probleme
US6518068B1 (en) 1999-07-21 2003-02-11 Tropix, Inc. Luminescence detection workstation
WO2001023082A2 (en) * 1999-09-30 2001-04-05 Nanogen, Inc. Biomolecular attachment sites on microelectronic arrays
US6303082B1 (en) * 1999-12-15 2001-10-16 Nanogen, Inc. Permeation layer attachment chemistry and method
US6620625B2 (en) * 2000-01-06 2003-09-16 Caliper Technologies Corp. Ultra high throughput sampling and analysis systems and methods
CA2403327C (en) * 2000-03-15 2012-05-29 Prolume, Ltd. Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US7109315B2 (en) 2000-03-15 2006-09-19 Bruce J. Bryan Renilla reniformis fluorescent proteins, nucleic acids encoding the fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US6927851B2 (en) * 2000-03-31 2005-08-09 Neogen Corporation Methods and apparatus to improve the sensitivity and reproducibility of bioluminescent analytical methods
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
DE10054487A1 (de) * 2000-11-03 2002-05-23 Eppendorf Ag Verfahren und Vorrichtung zum Temperieren von Proben
GB2368903A (en) * 2000-11-08 2002-05-15 Proimmune Ltd Analysis of biological and biochemical assays
CA2328684A1 (en) * 2000-12-15 2002-06-15 Yahia Gawad Photon-triggered luminescent assay
JPWO2002066969A1 (ja) * 2001-02-19 2004-06-24 協和メデックス株式会社 荷電成分検出装置及びその使用方法並びに検出パネル
JP3729251B2 (ja) * 2001-03-12 2005-12-21 オムロン株式会社 コントローラ及びシステム
US6828545B1 (en) * 2001-05-15 2004-12-07 Raytheon Company Hybrid microelectronic array structure having electrically isolated supported islands, and its fabrication
US7262063B2 (en) * 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
AU2012200643B2 (en) * 2001-06-29 2014-12-04 Meso Scale Technologies, Llc Assay plates reader systems and methods for luminescence test measurements
EP2420824B1 (de) * 2001-06-29 2018-11-28 Meso Scale Technologies LLC Multiwell-Platte mit einer Reihe von Wells und Kit für den Einsatz bei der Durchführung eines ECL-Assays
AU2016201009A1 (en) * 2001-06-29 2016-03-03 Meso Scale Technologies, Llc Assay plates reader systems and methods for luminescence test measurements
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US6710877B2 (en) * 2001-07-23 2004-03-23 Corning Incorporated Apparatus and methods for determining biomolecular interactions
US7063946B2 (en) * 2001-09-10 2006-06-20 Meso Scale Technologies, Llc. Methods, reagents, kits and apparatus for protein function analysis
CA2497740C (en) 2001-10-15 2011-06-21 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by probe elongation-mediated detection
GB0127913D0 (en) 2001-11-21 2002-01-16 Elan Vital Uk Ltd Fluid analyser systems
US6960298B2 (en) * 2001-12-10 2005-11-01 Nanogen, Inc. Mesoporous permeation layers for use on active electronic matrix devices
US7504364B2 (en) * 2002-03-01 2009-03-17 Receptors Llc Methods of making arrays and artificial receptors
US6849910B2 (en) * 2002-04-01 2005-02-01 Bruce J Oberhardt Systems and methods for improving the performance of sensing devices using oscillatory devices
US6946286B2 (en) * 2002-05-09 2005-09-20 Matsushita Electric Industrial Co., Ltd. Method and apparatus for detecting DNA hybridization
US20040005572A1 (en) * 2002-07-05 2004-01-08 Rosner S. Jeffrey Electronically readable microarrays
JP4092990B2 (ja) * 2002-09-06 2008-05-28 株式会社日立製作所 生体および化学試料検査装置
US8524488B2 (en) * 2002-09-10 2013-09-03 The Regents Of The University Of California Methods and devices for determining a cell characteristic, and applications employing the same
US20050037381A1 (en) * 2002-09-16 2005-02-17 Receptors Llc Artificial receptors, building blocks, and methods
US7595883B1 (en) * 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US20060057625A1 (en) * 2002-09-16 2006-03-16 Carlson Robert E Scaffold-based artificial receptors and methods
US7469076B2 (en) * 2003-09-03 2008-12-23 Receptors Llc Sensors employing combinatorial artificial receptors
WO2005003326A2 (en) * 2003-03-28 2005-01-13 Receptors Llc. Artificial receptors including reversibly immobilized building blocks and methods
US20040137481A1 (en) * 2002-09-16 2004-07-15 Receptors Llc Artificial receptor building blocks, components, and kits
US20050136483A1 (en) * 2003-09-03 2005-06-23 Receptors Llc Nanodevices employing combinatorial artificial receptors
US20050037429A1 (en) * 2003-03-28 2005-02-17 Receptors Llc Artificial receptors including reversibly immobilized building blocks and methods
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
JP4497874B2 (ja) * 2002-12-13 2010-07-07 株式会社ルネサステクノロジ 半導体集積回路及びｉｃカード
US20060068030A1 (en) * 2003-01-06 2006-03-30 Nutri-Check Technologies, Llc Individual need-based system for providing supplements
US7927796B2 (en) 2003-09-18 2011-04-19 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
JP4564959B2 (ja) 2003-09-22 2010-10-20 バイオアレイ ソリューションズ リミテッド 生体分子に共有結合できる、複数の官能基を持つ表面固定化高分子電解質
US8883147B2 (en) 2004-10-21 2014-11-11 Xencor, Inc. Immunoglobulins insertions, deletions, and substitutions
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US7563569B2 (en) 2003-10-28 2009-07-21 Michael Seul Optimization of gene expression analysis using immobilized capture probes
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US7981362B2 (en) 2003-11-04 2011-07-19 Meso Scale Technologies, Llc Modular assay plates, reader systems and methods for test measurements
US7687234B2 (en) * 2003-12-15 2010-03-30 Geneohm Sciences, Inc. Carbon electrode surface for attachment of DNA and protein molecules
EP1544602B1 (de) * 2003-12-19 2008-05-07 STMicroelectronics Limited Bio-optische Sensoren
US20050164375A1 (en) * 2004-01-23 2005-07-28 Sysmex Corporation Nucleic acid detection apparatus
US7481997B1 (en) 2004-02-12 2009-01-27 Montana State University Snow mountain virus genome sequence, virus-like particles and methods of use
US20050221279A1 (en) * 2004-04-05 2005-10-06 The Regents Of The University Of California Method for creating chemical sensors using contact-based microdispensing technology
US7501585B2 (en) * 2004-04-29 2009-03-10 Infineon Technologies Ag Semiconductor device support element with fluid-tight boundary
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
US8206651B2 (en) * 2004-07-15 2012-06-26 Lockheed Martin Corporation System for detection of biological agents
EP1774017B1 (de) 2004-07-26 2013-05-15 Pfenex Inc. Verfahren zur verbesserten proteinexpression durch strain-engineering
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
WO2006029234A1 (en) 2004-09-03 2006-03-16 Receptors Llc Combinatorial artificial receptors including tether building blocks
WO2006029383A2 (en) * 2004-09-11 2006-03-16 Receptors Llc Combinatorial artificial receptors including peptide building blocks
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
BRPI0517837A (pt) 2004-11-12 2008-10-21 Xencor Inc variantes fc com ligação alterada a fcrn
US8802820B2 (en) 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
US20060166285A1 (en) * 2005-01-26 2006-07-27 Jainamma Krotz Charged permeation layers for use on active electronic matrix devices
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
EP2004695A2 (de) 2005-07-08 2008-12-24 Xencor, Inc. Optimierte anti-ep-cam-antikörper
US20070053794A1 (en) * 2005-09-08 2007-03-08 Beckman Coulter, Inc. Sample identification system having plural readers
US20070070342A1 (en) * 2005-09-27 2007-03-29 Treado Patrick J Ultrasonic spray deposition of analytes for improved molecular chemical imaging detection
US7226752B1 (en) * 2006-01-19 2007-06-05 Avago Technologies General Ip (Singapore) Pte. Ltd. Methods for detecting an analyte in a sample
CA2657576C (en) 2006-07-14 2023-10-31 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
WO2008010105A2 (en) * 2006-07-19 2008-01-24 Koninklijke Philips Electronics N. V. Device for analyzing samples including a gas evolving means
US7687103B2 (en) * 2006-08-31 2010-03-30 Gamida For Life B.V. Compositions and methods for preserving permeation layers for use on active electronic matrix devices
US8680235B2 (en) * 2006-09-22 2014-03-25 Stowers Institute For Medical Research Branchiostoma derived fluorescent proteins
US7833527B2 (en) 2006-10-02 2010-11-16 Amgen Inc. Methods of treating psoriasis using IL-17 Receptor A antibodies
US20080081332A1 (en) * 2006-10-03 2008-04-03 Jun Amano Methods and devices for conducting diagnostic testing
US7652767B2 (en) * 2006-10-19 2010-01-26 Sporian Microsystems, Inc. Optical sensor with chemically reactive surface
US7602496B2 (en) * 2006-10-19 2009-10-13 Sporian Microsystems, Inc. Optical sensor with biologically reactive surface
FR2908888B1 (fr) * 2006-11-21 2012-08-03 Centre Nat Rech Scient Dispositif pour la detection exaltee de l'emission d'une particule cible
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP2639578B1 (de) 2006-12-14 2016-09-14 Life Technologies Corporation Vorrichtung zur Messung von Analyten mithilfe großer FET-Arrays
US8349167B2 (en) * 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
BRPI0810472A2 (pt) * 2007-04-16 2014-11-11 Momenta Pharmaceuticals Inc Métodos relacionados à glicosilação da superfície celular
US9394571B2 (en) 2007-04-27 2016-07-19 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
KR100801448B1 (ko) * 2007-05-16 2008-02-11 (주)실리콘화일 바이오칩
KR100822672B1 (ko) * 2007-06-27 2008-04-17 (주)실리콘화일 이미지센서를 이용한 진단장치 및 그 제조방법
US20090098594A1 (en) 2007-08-21 2009-04-16 Nodality, Inc. Methods for diagnosis prognosis and methods of treatment
RS56743B1 (sr) 2007-08-21 2018-03-30 Amgen Inc Humani c-fms antigen vezujući proteini
US8431698B2 (en) * 2007-08-29 2013-04-30 Biolume Inc. Bioluminescent endoscopy methods and compounds
TW200918553A (en) 2007-09-18 2009-05-01 Amgen Inc Human GM-CSF antigen binding proteins
US8088593B2 (en) 2007-10-02 2012-01-03 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
AU2008345242B2 (en) 2007-10-31 2014-02-27 Xencor, Inc. Fc variants with altered binding to FcRn
KR100882554B1 (ko) * 2007-11-08 2009-02-12 삼성전자주식회사 생분자 동정 방법
CN102203282B (zh) 2008-06-25 2014-04-30 生命技术公司 使用大规模fet阵列测量分析物的方法和装置
GB2464747B (en) * 2008-10-10 2013-05-15 Hai Kang Life Corp Ltd Method for detection of analyte in microarray of samples and apparatus for performing such method
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
CN102301228A (zh) * 2008-10-22 2011-12-28 生命技术公司 用于生物和化学分析的集成式传感器阵列
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
US8242248B2 (en) 2009-03-23 2012-08-14 Nodality, Inc. Kits for multiparametric phospho analysis
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8574835B2 (en) 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
KR101138472B1 (ko) 2009-12-15 2012-04-25 가천대학교 산학협력단 바이오 칩의 미세환경 내에서 세포를 공배양하는 방법
US8562160B1 (en) * 2010-02-28 2013-10-22 Mario Knapp Chemiluminescent application system
JP2013523184A (ja) 2010-04-15 2013-06-17 アムジエン・インコーポレーテツド ヒトＦＧＦ受容体およびβ−ＫＬＯＴＨＯ結合性タンパク質
WO2011139721A1 (en) 2010-04-27 2011-11-10 The Regents Of The University Of California Cancer biomarkers and methods of use thereof
TW201716791A (zh) 2010-06-30 2017-05-16 生命技術公司 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
EP2598804B1 (de) 2010-06-30 2021-10-20 Life Technologies Corporation Verfahren zur erzeugung eines ausgangssignals in einem isfet-array
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
TWI527245B (zh) 2010-07-03 2016-03-21 生命技術公司 具有微摻雜汲極之化學感測器
WO2012030738A2 (en) 2010-08-30 2012-03-08 Beckman Coulter, Inc. Complex phosphoprotein activation profiles
EP2617061B1 (de) 2010-09-15 2021-06-30 Life Technologies Corporation Verfahren und vorrichtung zur analytmessung
EP2619564B1 (de) 2010-09-24 2016-03-16 Life Technologies Corporation Transistorschaltungen mit zusammengehörigen paaren
US8409866B2 (en) 2010-10-21 2013-04-02 Nokia Corporation Apparatus and associated methods
US20120167392A1 (en) 2010-12-30 2012-07-05 Stmicroelectronics Pte. Ltd. Razor with chemical and biological sensor
CN106323875B (zh) 2011-01-21 2019-07-09 西拉诺斯知识产权有限责任公司 样品使用最大化的系统和方法
CN103562719B (zh) 2011-03-16 2016-01-13 国立大学法人东北大学 生物体组织分析用探针及其使用方法
WO2012155071A1 (en) 2011-05-12 2012-11-15 Gilead Biologics, Inc. Methods of identifying lysyl oxidase - like - 2 (loxl2) binding partners
US9574002B2 (en) 2011-06-06 2017-02-21 Amgen Inc. Human antigen binding proteins that bind to a complex comprising β-Klotho and an FGF receptor
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
US8704610B2 (en) * 2011-08-01 2014-04-22 General Electric Company Apparatus for improving grounding for an electrical component and method of making same
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
ES2806146T3 (es) 2011-09-22 2021-02-16 Amgen Inc Proteínas de unión al antígeno CD27L
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
TWI679212B (zh) 2011-11-15 2019-12-11 美商安進股份有限公司 針對ｂｃｍａ之e3以及ｃｄ３的結合分子
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US9027400B2 (en) 2011-12-02 2015-05-12 Stmicroelectronics Pte Ltd. Tunable humidity sensor with integrated heater
US9019688B2 (en) 2011-12-02 2015-04-28 Stmicroelectronics Pte Ltd. Capacitance trimming with an integrated heater
CA2858572C (en) 2011-12-08 2023-01-17 Amgen Inc. Human lcat antigen binding proteins and their use in therapy
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US9533302B2 (en) * 2012-03-09 2017-01-03 Lexmark International, Inc. Fluid cartridge and system for dispensing fluid
EP2836828B1 (de) 2012-04-09 2022-12-14 Takulapalli, Bharath Feldeffekttransistor, vorrichtung mit diesem transistor und verfahren zur herstellung und verwendung davon
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
AR091069A1 (es) 2012-05-18 2014-12-30 Amgen Inc Proteinas de union a antigeno dirigidas contra el receptor st2
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
WO2014028939A2 (en) 2012-08-17 2014-02-20 California Institute Of Technology Targeting phosphofructokinase and its glycosylation form for cancer
EP2893327B1 (de) 2012-09-01 2020-11-04 Prolume, Ltd. Coelenterazinverbindungen und verfahren zur verwendung
JP5954872B2 (ja) * 2012-09-20 2016-07-20 ルネサスエレクトロニクス株式会社 半導体集積回路
US9562253B1 (en) 2012-11-09 2017-02-07 Point Of Care Diagnostics, Llc Distinguishing between a bacterial and non-bacterial infection at the point of care
TW201425336A (zh) 2012-12-07 2014-07-01 Amgen Inc Ｂｃｍａ抗原結合蛋白質
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
EP2948478B1 (de) 2013-01-25 2019-04-03 Amgen Inc. Antikörper gegen cdh19 für melanome
JO3519B1 (ar) 2013-01-25 2020-07-05 Amgen Inc تركيبات أجسام مضادة لأجل cdh19 و cd3
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US20150368615A1 (en) 2013-02-01 2015-12-24 Tohoku University Method for separating cell from biological tissue
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US20140271629A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Chrdl-1 antigen binding proteins and methods of treatment
US20140264472A1 (en) 2013-03-15 2014-09-18 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
WO2014140368A1 (en) 2013-03-15 2014-09-18 Amgen Research (Munich) Gmbh Antibody constructs for influenza m2 and cd3
WO2014149778A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensors with consistent sensor surface areas
WO2014144553A1 (en) 2013-03-15 2014-09-18 Amgen Inc. Secreted frizzle-related protein 5 (sfrp5) binding proteins and methods of treatment
TWI636064B (zh) 2013-03-15 2018-09-21 安美基公司 人類ｐａｃ１抗體
EP2970449B1 (de) 2013-03-15 2019-09-25 Amgen Research (Munich) GmbH Einkettige bindemoleküle mit n-terminalen ab
EP2972281B1 (de) 2013-03-15 2023-07-26 Life Technologies Corporation Chemische vorrichtung mit dünnem leitenden element
CN105431889B (zh) * 2013-03-15 2020-08-04 巴拉什·塔库拉帕里 生物标记物传感器阵列和电路及其使用和形成方法
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
SG11201508829QA (en) 2013-05-30 2015-12-30 Biogen Ma Inc Oncostatin m receptor antigen binding proteins
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US10227370B2 (en) 2013-08-02 2019-03-12 California Institute Of Technology Heparan sulfate/heparin mimetics with anti-chemokine and anti-inflammatory activity
US9770461B2 (en) 2013-08-02 2017-09-26 California Institute Of Technology Tailored glycopolymers as anticoagulant heparin mimetics
US9683937B2 (en) * 2013-08-23 2017-06-20 Semiconductor Components Industries, Llc Imaging devices for molecule detection
TW201605896A (zh) 2013-08-30 2016-02-16 安美基股份有限公司 Gitr抗原結合蛋白
TWI688401B (zh) 2013-09-13 2020-03-21 美商安進公司 用於治療骨髓性白血病的表觀遺傳因子與靶向ｃｄ３３及ｃｄ３之雙特異性化合物的組合
CN110411998B (zh) 2013-12-10 2022-06-07 伊鲁米那股份有限公司 用于生物或化学分析的生物传感器及其制造方法
US9196591B2 (en) * 2014-02-17 2015-11-24 International Business Machines Corporation Chip with shelf life
AU2015218903B2 (en) 2014-02-20 2020-10-15 Allergan, Inc. Complement component C5 antibodies
KR20160126054A (ko) 2014-02-27 2016-11-01 알러간, 인코포레이티드 보체 인자 Bb 항체
US9245846B2 (en) 2014-05-06 2016-01-26 International Business Machines Corporation Chip with programmable shelf life
UY36245A (es) 2014-07-31 2016-01-29 Amgen Res Munich Gmbh Constructos de anticuerpos para cdh19 y cd3
WO2016016415A1 (en) 2014-07-31 2016-02-04 Amgen Research (Munich) Gmbh Bispecific single chain antibody construct with enhanced tissue distribution
JP6749312B2 (ja) 2014-07-31 2020-09-02 アムゲン リサーチ （ミュンヘン） ゲーエムベーハーＡＭＧＥＮ Ｒｅｓｅａｒｃｈ（Ｍｕｎｉｃｈ）ＧｍｂＨ 最適化された種間特異的二重特異性単鎖抗体コンストラクト
WO2016040767A2 (en) 2014-09-12 2016-03-17 Amgen Inc. Chrdl-1 epitopes and antibodies
US11543411B2 (en) 2014-12-05 2023-01-03 Prelude Corporation DCIS recurrence and invasive breast cancer
US10379079B2 (en) 2014-12-18 2019-08-13 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
EP3234576B1 (de) 2014-12-18 2023-11-22 Life Technologies Corporation Integrierte schaltung mit hoher datenrate und mit transmitterkonfiguration
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
DK3283524T3 (da) 2015-04-17 2023-05-30 Amgen Res Munich Gmbh BISPECIFIKKE ANTISTOFKONSTRUKTIONER MOD CDH3 og CD3
WO2016189118A1 (en) 2015-05-28 2016-12-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of prognosis and treatment of patients suffering from acute myeloid leukemia
EA039859B1 (ru) 2015-07-31 2022-03-21 Эмджен Рисерч (Мюник) Гмбх Биспецифические конструкты антител, связывающие egfrviii и cd3
TWI744242B (zh) 2015-07-31 2021-11-01 德商安美基研究（慕尼黑）公司 Egfrviii及cd3抗體構築體
TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
TWI717375B (zh) 2015-07-31 2021-02-01 德商安美基研究（慕尼黑）公司 Ｃｄ７０及ｃｄ３抗體構築體
TWI793062B (zh) 2015-07-31 2023-02-21 德商安美基研究（慕尼黑）公司 Ｄｌｌ３及ｃｄ３抗體構築體
TWI796283B (zh) 2015-07-31 2023-03-21 德商安美基研究（慕尼黑）公司 Ｍｓｌｎ及ｃｄ３抗體構築體
CR20180378A (es) 2015-12-23 2018-12-06 Amgen Inc Método para tratar o mejorar trastornos metabólicos con proteínas de unión para el receptor peptídico inhibidor gástrico (gipr) en combinación con agosnistas de glp-1
JOP20170017B1 (ar) 2016-01-25 2021-08-17 Amgen Res Munich Gmbh تركيب صيدلي يتضمن تركيبات جسم مضاد ثنائي الاختصاص
CA3011942A1 (en) 2016-02-03 2017-08-10 Amgen Research (Munich) Gmbh Psma and cd3 bispecific t cell engaging antibody constructs
SG11201805770UA (en) 2016-02-03 2018-08-30 Amgen Res Munich Gmbh BCMA and CD3 Bispecific T Cell Engaging Antibody Constructs
WO2017184790A1 (en) 2016-04-19 2017-10-26 Takulapalli Bharath Nanopore sensor, structure and device including the sensor, and methods of forming and using same
JOP20170091B1 (ar) 2016-04-19 2021-08-17 Amgen Res Munich Gmbh إعطاء تركيبة ثنائية النوعية ترتبط بـ cd33 وcd3 للاستخدام في طريقة لعلاج اللوكيميا النخاعية
CN110312808A (zh) 2016-06-30 2019-10-08 拜欧亿思有限公司 双链核酸信号探针以及利用上述双链核酸信号探针的靶分子检测方法
KR102781241B1 (ko) 2017-01-17 2025-03-14 암젠 인크 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법
AU2018214223B2 (en) 2017-02-02 2025-08-14 Amgen Inc. Low pH pharmaceutical composition comprising T cell engaging antibody constructs
PL3583125T3 (pl) 2017-02-16 2025-07-28 Sonnet BioTherapeutics, Inc. Białka fuzyjne domeny wiążącej albuminę
KR102700015B1 (ko) 2017-05-05 2024-08-29 암젠 인크 개선된 저장 및 투여를 위한 이중특이적 항체 구축물을 포함하는 약제학적 조성물
JOP20190259A1 (ar) 2017-05-31 2019-10-31 Amgen Inc بروتينات ربط مولد ضد مضادة لـ jagged1
AR111842A1 (es) 2017-06-02 2019-08-21 Amgen Inc Antagonistas de péptido pac1
MX2019013919A (es) 2017-06-20 2020-01-21 Amgen Inc Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1.
JP7250706B2 (ja) 2017-06-21 2023-04-03 アムジエン・インコーポレーテツド 胃抑制ペプチド受容体（ｇｉｐｒ）に対するアンタゴニスト結合タンパク質／ｇｌｐ－１受容体アゴニスト融合タンパク質を使用した代謝障害の治療又は寛解方法
FI3661562T3 (fi) 2017-08-04 2024-12-09 Amgen Inc Cys-mab:ien konjugointimenetelmä
TWI827570B (zh) 2017-12-11 2024-01-01 美商安進公司 雙特異性抗體產品之連續製造製程
PH12019502895B1 (en) 2017-12-26 2024-04-24 Illumina Inc Sensor system
UY38041A (es) 2017-12-29 2019-06-28 Amgen Inc Construcción de anticuerpo biespecífico dirigida a muc17 y cd3
CA3107186A1 (en) 2018-07-30 2020-02-06 Amgen Research (Munich) Gmbh Prolonged administration of a bispecific antibody construct binding to cd33 and cd3
WO2020025792A1 (en) 2018-08-03 2020-02-06 Amgen Research (Munich) Gmbh Antibody constructs for cldn18.2 and cd3
WO2020056338A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
AR116548A1 (es) 2018-09-28 2021-05-19 Amgen Inc Anticuerpos contra bcma soluble
AR117650A1 (es) 2018-10-11 2021-08-18 Amgen Inc Procesamiento posterior de constructos de anticuerpos biespecíficos
US20220025058A1 (en) 2018-11-06 2022-01-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of acute myeloid leukemia by eradicating leukemic stem cells
SG11202106478UA (en) 2019-01-03 2021-07-29 Invetx Inc Compositions for increasing half-life of a therapeutic agent in canines and methods of use
KR102240669B1 (ko) * 2019-05-08 2021-04-16 (주)플렉솔루션 유기 전기화학 트랜지스터 소자 및 그 제조방법
AU2020290573B2 (en) 2019-06-13 2026-01-29 Amgen Inc. Automated biomass-based perfusion control in the manufacturing of biologics
US20220306741A1 (en) 2019-09-10 2022-09-29 Amgen Inc. Purification Method for Bispecific antigen-binding Polypeptides with Enhanced Protein L Capture Dynamic Binding Capacity
US11062187B1 (en) * 2019-09-15 2021-07-13 Gideon Samid Shapeless—a new language concept and related technology
CA3156683A1 (en) 2019-11-13 2021-05-20 Amgen Inc. Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules
WO2021150824A1 (en) 2020-01-22 2021-07-29 Amgen Research (Munich) Gmbh Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof
MX2022011632A (es) 2020-03-19 2022-10-13 Amgen Inc Anticuerpos contra mucina 17 y usos de los mismos.
KR20230034954A (ko) 2020-05-11 2023-03-10 인베티엑스 인코포레이티드 개에서 치료제의 반감기를 증가시키기 위한 조성물 및 사용 방법
US12312412B2 (en) 2020-05-19 2025-05-27 Amgen Inc. MAGEB2 binding constructs
AU2021281554A1 (en) 2020-05-29 2022-12-15 Amgen Inc. Adverse effects-mitigating administration of a bispecific antibody construct binding to CD33 and CD3
WO2022008488A1 (en) 2020-07-06 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of slamf1 as a biomarker in colorectal cancer
CN119899259A (zh) 2020-07-10 2025-04-29 因外泰克斯公司 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法
WO2022013256A1 (en) 2020-07-15 2022-01-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of cd160 as a biomarker in acute myeloid leukemia
US20230375558A1 (en) 2020-09-22 2023-11-23 3Helix, Inc. Methods for Using Collagen Hybridizing Peptides to Determine Collagen Content
MX2023005323A (es) 2020-11-06 2023-05-19 Amgen Inc Construcciones polipeptidicas que se unen a cd3.
AU2021374036A1 (en) 2020-11-06 2023-06-08 Amgen Inc. Polypeptide constructs selectively binding to cldn6 and cd3
CA3200317A1 (en) 2020-11-06 2022-05-12 Amgen Inc. Multitargeting bispecific antigen-binding molecules of increased selectivity
KR20230098335A (ko) 2020-11-06 2023-07-03 암젠 인크 클리핑 비율이 감소된 항원 결합 도메인
CN112540034B (zh) * 2020-11-27 2025-04-01 同济大学 一种水下膜渗透传感器的防生物附着装置
US12103961B2 (en) 2020-12-07 2024-10-01 Invetx, Inc. Compositions for increasing half-life of a therapeutic agent in livestock animals and methods of use
US12092642B2 (en) 2021-01-20 2024-09-17 Nautilus Subsidiary, Inc. Systems and methods for biomolecule quantitation
AR125290A1 (es) 2021-04-02 2023-07-05 Amgen Inc Construcciones de unión a mageb2
WO2022234102A1 (en) 2021-05-06 2022-11-10 Amgen Research (Munich) Gmbh Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases
IL316597A (en) 2022-05-12 2024-12-01 Amgen Res Munich Gmbh Multi-chain, multi-purpose, bispecific antigen-binding compounds with enhanced sensitivity
JP2025533434A (ja) 2022-09-14 2025-10-07 アムジエン・インコーポレーテツド 二重特異性分子安定化組成物
WO2024104551A1 (en) 2022-11-14 2024-05-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of the population of slamf4+ ccr5+ effector memory cd4+ t cells as a biomarker in rheumatoid arthritis
KR20250130357A (ko) 2022-12-27 2025-09-01 인베티엑스 인코포레이티드 신생아 fc 수용체 (fcrn)에 대한 결합이 변경된 폴리펩타이드 및 사용 방법
AU2023417626A1 (en) 2022-12-27 2025-07-10 Invetx, Inc. Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use
WO2024155982A2 (en) 2023-01-20 2024-07-25 Invetx, Inc. Bispecific binding agents for use in companion animals
TWI846309B (zh) * 2023-02-03 2024-06-21 旺矽科技股份有限公司 用於半導體測試之電路板及其製造方法
MX2025014635A (es) 2023-06-14 2026-02-03 Amgen Inc Moleculas captadoras de enmascaramiento de celulas t
WO2025181096A1 (en) 2024-02-26 2025-09-04 Institut National de la Santé et de la Recherche Médicale Use of vdac and lamp1 as markers for detecting pocked red blood cells

Family Cites Families (284)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6606802A (de) 1966-05-18 1967-11-20
US3511612A (en) 1967-03-20 1970-05-12 American Cyanamid Co Chemiluminescent systems
US3539794A (en) 1967-09-12 1970-11-10 American Cyanamid Co Self-contained chemiluminescent lighting device
US3597877A (en) 1969-01-23 1971-08-10 Marvin Glass & Associates Multipurpose novelty item used as a decoration or toy
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
US3859125A (en) 1972-10-10 1975-01-07 Gilbreth Co Soluble coated paper
CH594444A5 (de) 1972-12-04 1978-01-13 Gerd Birrenbach
US4006117A (en) 1973-01-24 1977-02-01 Hooker Chemicals & Plastics Corporation Amine phosphite antioxidants
US3843443A (en) 1973-03-30 1974-10-22 J Fishman Polypeptide materials bound to fluorocarbon polymers
CS175047B1 (de) 1974-04-25 1977-04-29
US3939123A (en) 1974-06-18 1976-02-17 Union Carbide Corporation Lightly cross-linked polyurethane hydrogels based on poly(alkylene ether) polyols
FR2289956A1 (fr) 1974-10-29 1976-05-28 Steigerwald Strahltech Dispositif de regulation du courant de faisceau dans un appareil a faisceau de porteurs de charge industriel
FR2292595A1 (fr) 1974-11-28 1976-06-25 Jourdain Jean Fontaine a mousse
DK143689C (da) 1975-03-20 1982-03-15 J Kreuter Fremgangsmaade til fremstilling af en adsorberet vaccine
US4324683A (en) 1975-08-20 1982-04-13 Damon Corporation Encapsulation of labile biological material
NZ187246A (en) 1976-03-04 1980-05-27 New Zealand Dev Finance Hydrophilic hydroxy c2-c4 alkylated crosslinked regenerated cellulose
US4016880A (en) 1976-03-04 1977-04-12 Alza Corporation Osmotically driven active agent dispenser
DE2621974A1 (de) 1976-05-18 1977-11-24 Max Planck Gesellschaft Verfahren zur herstellung eines zur kovalenten bindung mit biologisch aktivem material befaehigten traegermaterials
US4162355A (en) 1976-06-30 1979-07-24 Board Of Regents, For And On Behalf Of The University Of Florida Copolymers of (a) aminimides and (b) vinyl pendant primary halomethy monomers useful for affinity chromatography
US4175183A (en) 1977-03-01 1979-11-20 Development Finance Corporation Of New Zealand Hydroxyalkylated cross-linked regenerated cellulose and method of preparation thereof
US4281645A (en) 1977-06-28 1981-08-04 Duke University, Inc. Method and apparatus for monitoring metabolism in body organs
SE7811630L (sv) 1977-11-17 1979-05-18 Welsh Nat School Med Metod for uppteckt eller mengdbestemning av substanser med anvendning av merkningsteknik
US4180524A (en) 1978-02-16 1979-12-25 Phillips Petroleum Company Disproportionation/double-bond isomerization of olefins
US4179402A (en) 1978-05-15 1979-12-18 Shell Oil Company Resin-metal-ligand composition
US4329332A (en) 1978-07-19 1982-05-11 Patrick Couvreur Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them
US4322311A (en) 1978-08-04 1982-03-30 Damon Corporation Process for producing controlled porosity microcapsules
US4244721A (en) 1979-01-31 1981-01-13 Pedro Buarque De Macedo Method of making composite borosilicate glass articles
US4241537A (en) 1979-05-10 1980-12-30 W. R. Grace & Co. Plant growth media utilizing polyurethane hydrogel
EP0025350A3 (de) 1979-09-05 1981-06-10 Dynatech Ag Apparat zum Feststellen von Lumineszenz-Reaktionen
US4282287A (en) 1980-01-24 1981-08-04 Giese Roger W Biochemical avidin-biotin multiple-layer system
DE3011059A1 (de) 1980-03-21 1981-10-01 Siemens AG, 1000 Berlin und 8000 München Optischer stern-koppler mit planarem mischerelement
DE3026067A1 (de) 1980-07-10 1982-02-04 Henkel KGaA, 4000 Düsseldorf Dosiervorrichtung mit kugelventil und verfahren zum betrieb
DE3027198A1 (de) 1980-07-18 1982-02-11 Bayer Ag, 5090 Leverkusen Feste, in wasser dispergierbare, isocyanatgruppen aufweisende kunststoffvorlaeufer, ein verfahren zur herstellung von waessrigen kunststoffdispersionen unter verwendung dieser kunststoffvorlaeufer, sowie die verwendung der kunststoffvorlaeufer als vernetzungsmittel fuer waessrige kunststoffdispersionen
US4439585A (en) 1980-11-12 1984-03-27 Tyndale Plains-Hunter, Ltd. Polyurethane diacrylate compositions as carrier for pharmacological agents
GB2098719B (en) 1981-05-20 1984-11-21 Rolls Royce Gas turbine engine combustion apparatus
AU552068B2 (en) 1981-09-21 1986-05-22 Asama Chemical Co. Ltd. Preservation of edible oils
US4882165A (en) 1981-11-09 1989-11-21 The Regents Of The University Of California Light sensitive liposomes
US4565647B1 (en) 1982-04-26 1994-04-05 Procter & Gamble Foaming surfactant compositions
US4507230A (en) 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4512762A (en) 1982-11-23 1985-04-23 The Beth Israel Hospital Association Method of treatment of atherosclerosis and a balloon catheter for same
US4581335A (en) 1982-12-01 1986-04-08 Texas A&M University System Process for producing a cloned luciferase-synthesizing microorganism
US4523224A (en) 1982-12-27 1985-06-11 Welch Allyn Inc. Color filter wheel synchronizer
US4614712A (en) 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
US4528180A (en) 1983-03-01 1985-07-09 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
US4687663B1 (en) 1983-03-01 1997-10-07 Chesebrough Ponds Usa Co Dental preparation article and method for storage and delivery thereof
US4849213A (en) 1983-03-01 1989-07-18 Schaeffer Hans A Dental preparation, article and method for storage and delivery therof
GB8314523D0 (en) 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4485227A (en) 1983-06-16 1984-11-27 Howmedica, Inc. Biocompatible poly-(ether-urethane-urea) and process for its preparation
US4542102A (en) 1983-07-05 1985-09-17 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
SE454391B (sv) 1983-07-07 1988-04-25 Simrad Optronics As Elektronisk nattkikare med spegelobjektiv och elektronisk bildforsterkare
DE8335529U1 (de) 1983-12-10 1984-03-08 Upat Gmbh & Co, 7830 Emmendingen Spritz-kartusche
US4665022A (en) 1984-02-17 1987-05-12 The Regents Of The University Of California Bioluminescent assay reagent and method
US5283122A (en) 1984-04-19 1994-02-01 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US4789633A (en) 1984-04-19 1988-12-06 University Of Tennessee Research Corporation Fused liposome and acid induced method for liposome fusion
US4927916A (en) 1984-04-23 1990-05-22 The General Hospital Corporation Method of producing fibrin-specific monoclonal antibodies lacking fibrinogen-cross-reactivity using fibrin-specific peptides
GB8412587D0 (en) 1984-05-17 1986-12-17 Secr Defence Aircrew headgear
US4534317A (en) 1984-08-30 1985-08-13 Cape Cod Research Procedures for monitoring fish food consumption
US4657853A (en) 1984-09-14 1987-04-14 E. I. Du Pont De Nemours And Company Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody
FR2571506B1 (fr) 1984-10-05 1987-01-23 Trt Telecom Radio Electr Systeme d'observation nocturne semi-actif a intensification de lumiere
IL77144A (en) * 1984-11-27 1991-04-15 Orgenics Ltd Method and apparatus for performing solid phase immuno-assay on test card in a plurality of samples
US4774189A (en) 1984-12-24 1988-09-27 Flow Cytometry Standards Corp. Fluorescent calibration microbeads simulating stained cells
US4767206A (en) 1984-12-24 1988-08-30 Flow Cytometry Standards Corporation Calibration method for flow cytometry using fluorescent microbeads and synthesis thereof
US5422266A (en) 1984-12-31 1995-06-06 University Of Georgia Research Foundation, Inc. Recombinant DNA vectors capable of expressing apoaequorin
NZ214563A (en) 1984-12-31 1991-05-28 Univ Georgia Production of apoaeqorin using recombinant dna
DE3500180A1 (de) 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US4681870A (en) 1985-01-11 1987-07-21 Imre Corporation Protein A-silica immunoadsorbent and process for its production
US4772453A (en) 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4921757A (en) 1985-04-26 1990-05-01 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
US4853327A (en) 1985-07-10 1989-08-01 Molecular Diagnostics, Inc. Enhanced phthalazinedione chemiluminescence
US4950588A (en) 1985-07-10 1990-08-21 Molecular Diagnostics, Inc. Prolonged enhanced chemiluminescence
DE3537877A1 (de) 1985-10-24 1987-04-30 Geiger Reinhard Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate
US4714682A (en) 1985-12-11 1987-12-22 Flow Cytometry Standards Corporation Fluorescent calibration microbeads simulating stained cells
JPS62171695A (ja) 1985-12-14 1987-07-28 Chisso Corp 発光蛋白アクアリン遺伝子を用いるアクアリン活性を有する蛋白質の製造法
GB2185360B (en) 1986-01-11 1989-10-25 Pilkington Perkin Elmer Ltd Display system
FR2597725B1 (fr) 1986-04-29 1990-06-15 Noirot Extraits Procede pour l'obtention d'un effet de phosphorescence et produits obtenus selon ce procede.
JPS62261942A (ja) 1986-05-08 1987-11-14 Chisso Corp 金属の検出方法
CA1340806C (en) 1986-07-02 1999-11-02 James Merrill Prober Method, system and reagents for dna sequencing
US5284646A (en) 1986-07-03 1994-02-08 Advanced Magnetics Inc. Hepatocyte specific receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5352432A (en) 1986-07-03 1994-10-04 Advanced Magnetics, Inc. Hepatocyte specific composition and their use as diagnostic imaging agents
US5342607A (en) 1986-07-03 1994-08-30 Advanced Magnetics, Inc. Receptor mediated endocytosis type magnetic resonance imaging contrast agents
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5221623A (en) 1986-07-22 1993-06-22 Boyce Thompson Institute For Plant Research, Inc. Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms
US4711659A (en) 1986-08-18 1987-12-08 Moore William P Attrition resistant controlled release fertilizers
US4804403A (en) 1986-08-18 1989-02-14 Melamine Chemicals, Inc. Attrition-resistant, controlled release fertilizers
US4867908A (en) 1986-08-29 1989-09-19 Becton, Dickinson And Company Method and materials for calibrating flow cytometers and other analysis instruments
US5093240A (en) 1986-10-15 1992-03-03 Chisso Corporation Variant aequorin genes and process for producing variant aequorin proteins
US4861876A (en) 1986-11-26 1989-08-29 Wayne State University Hematoporphyrin derivative and method of preparation and purification
US4762881A (en) 1987-01-09 1988-08-09 E. I. Du Pont De Nemours And Company Photoreactive benzoylphenylalanines and related peptides
US4885250A (en) 1987-03-02 1989-12-05 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US4954444A (en) 1987-03-02 1990-09-04 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US5292814A (en) 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
US4891043A (en) 1987-05-28 1990-01-02 Board Of Trustees Of The University Of Illinois System for selective release of liposome encapsulated material via laser radiation
US4968613A (en) 1987-07-29 1990-11-06 Kikkoman Corporation Luciferase gene and novel recombinant DNA as well as a method of producing luciferase
DE3725291A1 (de) 1987-07-30 1989-02-09 Hilti Ag Kartuschenmagazin fuer fliessfaehige massen
JPS6447379A (en) 1987-08-19 1989-02-21 Chisso Corp Preparation of calcium-dependent oxygenation enzyme
US4822994A (en) 1987-09-23 1989-04-18 Itt Electro Optical Products A Division Of Itt Corporation Small arms sight for use during daylight and nighttime conditions
JP2592623B2 (ja) 1987-11-18 1997-03-19 チッソ株式会社 アポエクオリンの製造法
US5182202A (en) 1987-11-30 1993-01-26 Kikkoman Corporation Purified luciferase from luciola cruciata
US4895721A (en) 1988-01-22 1990-01-23 Carter-Wallace Inc. Peroxide gel dentifrice compositions
US4931498A (en) 1988-02-25 1990-06-05 Purdue Research Foundation Immobilized artificial membranes
US4927879A (en) 1988-02-25 1990-05-22 Purdue Research Foundation Method for solid phase membrane mimetics
US5688657A (en) 1988-03-31 1997-11-18 International Bio-Immune Systems, Inc. Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor
JPH088864B2 (ja) 1988-04-12 1996-01-31 キッコーマン株式会社 ルシフェラーゼ
US4963368A (en) 1988-04-18 1990-10-16 Nabisco Brands, Inc. Oxidoreductase enzyme stabilized highly unsaturated fatty acids and derivatives of such acids
US4948210A (en) 1988-06-20 1990-08-14 Murasa International Infrared zoom illuminator
US5190762A (en) 1988-07-06 1993-03-02 Applied Genetics, Inc. Method of administering proteins to living skin cells
US5077211A (en) 1988-07-06 1991-12-31 Applied Genetics, Inc. Purification and administration of dna repair enzymes
US5272079A (en) 1988-07-06 1993-12-21 Applied Genetics, Inc. Purification and administration of DNA repair enzymes
DE68928914T2 (de) 1988-08-04 1999-09-09 Amrad Corp. Ltd. (in vitro)-vermehrung von embryonalen stammzellen unter verwendung von leukämie-inhibitionsfaktor (lif)
DE68927437T2 (de) 1988-08-09 1997-03-06 Toray Industries Verfahren zur herstellung von luciferase durch rekombinante expression eines luciferase-kodierenden gens
US5604123A (en) 1988-08-09 1997-02-18 Toray Industries, Inc. Luciferase, gene encoding the same and production process of the same
US4924358A (en) 1988-09-12 1990-05-08 Inventech Licensing Co. Safety-sparkler wand w/chemiluminescent or electric-light illumination
US4919140A (en) 1988-10-14 1990-04-24 Purdue Research Foundation Method and apparatus for regenerating nerves
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
WO1990005539A1 (en) 1988-11-14 1990-05-31 Brigham And Women's Hospital Antibodies specific for elam-1 and the use thereof
US4961920A (en) 1988-12-08 1990-10-09 Luminis Pty, Ltd. Phototherapeutic monovinyl and divinyl ether-linked dimers
US5196524A (en) 1989-01-06 1993-03-23 Eli Lilly And Company Fusion reporter gene for bacterial luciferase
US5148022A (en) 1989-02-15 1992-09-15 Hitachi, Ltd. Method for optically inspecting human body and apparatus for the same
JPH02234698A (ja) 1989-03-08 1990-09-17 Toyobo Co Ltd 細菌ルシフェラーゼ系によるｄｎａプローブの検出法
US5020694A (en) 1989-03-16 1991-06-04 Chesebrough-Pond's, Inc. Multi-cavity dispensing container
US5067019A (en) 1989-03-31 1991-11-19 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Programmable remapper for image processing
US5116868A (en) 1989-05-03 1992-05-26 The Johns Hopkins University Effective ophthalmic irrigation solution
US5068830A (en) 1989-05-09 1991-11-26 Advanced Micro Devices High speed static ram sensing system
US5092992A (en) 1989-06-07 1992-03-03 J. T. Baker Inc. Polyethyleneimine matrixes for affinity chromatography
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US4999208A (en) 1989-06-07 1991-03-12 Nabisco Brands, Inc. Extrusion baking of cookies having liposome encapsulated ingredients
US5346455A (en) 1989-07-17 1994-09-13 Papermasters, Inc. Methods of making pop-up promotional items
US4953963A (en) 1989-08-17 1990-09-04 Miller Alan K Aviator's night vision system
JPH0378373A (ja) 1989-08-22 1991-04-03 Fuji Photo Optical Co Ltd テレビカメラ操作装置
US5023745A (en) 1989-09-06 1991-06-11 Erico International Corporation Surge arrestor apparatus and method
US5084780A (en) 1989-09-12 1992-01-28 Itt Corporation Telescopic sight for day/night viewing
US5360726A (en) 1989-09-12 1994-11-01 Board Of Trustees Operating Michigan State University Polypeptides enabling sorting of proteins to vacuoles in plants
JPH03122588A (ja) 1989-10-05 1991-05-24 Hitachi Medical Corp 放射線検出器，データ収集装置およびこれを用いる放射線ｃｔ装置
US5225212A (en) 1989-10-20 1993-07-06 Liposome Technology, Inc. Microreservoir liposome composition and method
US5288623A (en) 1989-10-26 1994-02-22 Chisso Corporation Process for secretory production of a calcium-binding protein
US5215899A (en) 1989-11-09 1993-06-01 Miles Inc. Nucleic acid amplification employing ligatable hairpin probe and transcription
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5188837A (en) 1989-11-13 1993-02-23 Nova Pharmaceutical Corporation Lipsopheres for controlled delivery of substances
US5002392A (en) 1989-12-01 1991-03-26 Akzo N.V. Multichannel optical monitoring system
GB8927365D0 (en) 1989-12-04 1990-01-31 Ici Plc Reagent
US5292658A (en) 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5057296A (en) 1990-12-10 1991-10-15 Mobil Oil Corp. Method for synthesizing mesoporous crystalline material
US5108725A (en) 1990-01-25 1992-04-28 Mobil Oil Corp. Synthesis of mesoporous crystalline material
US5029963A (en) 1990-02-15 1991-07-09 Itt Corporation Replacement device for a driver's viewer
JP2626738B2 (ja) * 1990-03-13 1997-07-02 三共株式会社 化学発光検出装置
US5328603A (en) 1990-03-20 1994-07-12 The Center For Innovative Technology Lignocellulosic and cellulosic beads for use in affinity and immunoaffinity chromatography of high molecular weight proteins
US5219737A (en) 1990-03-27 1993-06-15 Kikkoman Corporation Mutant luciferase of a firefly, mutant luciferase genes, recombinant dnas containing the genes and a method of producing mutant luciferase
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5446157A (en) 1990-04-23 1995-08-29 Morgan; Lee R. Boron difluoride compounds useful in photodynamic therapy and production of laser light
US5189029A (en) 1990-04-23 1993-02-23 Bo-Dekk Ventures, Ltd. Indacene compounds and methods for using the same
US5016643A (en) 1990-05-02 1991-05-21 Board Of Regents, The University Of Texas System Vascular entoptoscope
US5192679A (en) 1990-05-03 1993-03-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Growing ehrlichia species in a continuous cell line
US5132101A (en) 1990-05-04 1992-07-21 Cytopharm, Inc. Acetylene-cumulene porphycene compounds for photodynamic therapy
US5416017A (en) 1990-05-18 1995-05-16 The Scripps Research Institute Cholera toxin gene regulated by tissue-specific promoters
US5117553A (en) 1990-06-25 1992-06-02 General Electric Company Method of assembling rotor magnets
US5059417A (en) 1990-06-26 1991-10-22 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Peroxide gel dentifrice
US5196318A (en) 1990-06-26 1993-03-23 The Texas A&M University System Precisely regulated expression of deleterious genes
DK0537270T3 (da) 1990-07-02 1999-06-07 Univ California Påvisning af analytter ved overføring af fluorescensenergi
US5405206A (en) 1990-07-13 1995-04-11 Bedol; Mark A. Finger-mounted writing apparatus
US5374534A (en) 1990-07-19 1994-12-20 Charm Sciences, Inc. Method of preparing D-luciferin derivatives
BE1005073A7 (fr) 1990-08-30 1993-04-13 Collet Marcel Georges Procede d'illumination des liquides et dispositifs appropries a un tel procede.
US5387526A (en) 1990-09-11 1995-02-07 General Atomics Coated capillary tube for the controlled release of reagent
AU654323B2 (en) 1991-01-04 1994-11-03 Perseptive Biosystems, Inc. Sulfonamide bonded hydrophilic coating
US5206161A (en) 1991-02-01 1993-04-27 Genentech, Inc. Human plasma carboxypeptidase B
GB9102325D0 (en) 1991-02-02 1991-03-20 Dextro North Limited Novelty device
US5403750A (en) 1991-03-06 1995-04-04 W. R. Grace & Co.-Conn. Biocompatible, low protein adsorption affinity matrix
US5348392A (en) 1991-03-13 1994-09-20 Dow Corning France S.A. Apparatus for mixing and dispensing a multicomponent composition
FR2674223B1 (fr) 1991-03-13 1993-06-25 Dow Corning Sa Dispositifs pour melanger et distribuer une composition de silicone a plusieurs composants.
FR2673948B1 (fr) 1991-03-13 1995-03-10 Dow Corning Sa Compositions de silicone expansibles utiles a la realisation de pansements medicaux.
US5146077A (en) 1991-03-19 1992-09-08 Itt Corporation Gated voltage apparatus for high light resolution and bright source protection of image intensifier tube
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
US5422982A (en) 1991-05-02 1995-06-06 Dow Corning Corporation Neural networks containing variable resistors as synapses
US5313306A (en) 1991-05-13 1994-05-17 Telerobotics International, Inc. Omniview motionless camera endoscopy system
US5410962A (en) 1991-05-16 1995-05-02 Collier; Harry B. Special effects rotating rubber stamp
US5085853A (en) 1991-06-24 1992-02-04 Chesebrough-Pond's U.S.A., Division Of Conopco, Inc. Flavor for peroxide-bicarbonate oral compositions
US5229285A (en) 1991-06-27 1993-07-20 Kikkoman Corporation Thermostable luciferase of firefly, thermostable luciferase gene of firefly, novel recombinant dna, and process for the preparation of thermostable luciferase of firefly
US5179120A (en) 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
US5262401A (en) 1991-06-28 1993-11-16 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
US5158349A (en) 1991-07-03 1992-10-27 Lexington & Associates, Inc. Multi-color chemical lighting device
US5215898A (en) 1991-07-22 1993-06-01 The United States Of America As Represented By The Secretary Of Agriculture Cytotoxic protein from the yeast Pichia inositovora
US5383100A (en) 1991-08-02 1995-01-17 Kikos; J. Peter Multi-channel tubular display package
US5277913A (en) 1991-09-09 1994-01-11 Thompson David H Liposomal delivery system with photoactivatable triggered release
US5331950A (en) 1991-10-22 1994-07-26 Welch Allyn, Inc. Video laparoscope with high-illuminance low-wattage light source
US5222797A (en) 1991-10-31 1993-06-29 Lexington & Associates Multi-chamber chemiluminescent optical display device
US5390086A (en) 1991-10-31 1995-02-14 Lexington & Associates, Inc. Multi-chamber chemiluminescent optical display device
US5632957A (en) * 1993-11-01 1997-05-27 Nanogen Molecular biological diagnostic systems including electrodes
US5605662A (en) * 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5849486A (en) * 1993-11-01 1998-12-15 Nanogen, Inc. Methods for hybridization analysis utilizing electrically controlled hybridization
US5619995A (en) 1991-11-12 1997-04-15 Lobodzinski; Suave M. Motion video transformation system and method
US5846708A (en) * 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5327666A (en) 1991-12-13 1994-07-12 Difranco Domenico Method for making a novelty item and the novelty item therefrom
US5413098A (en) 1991-12-24 1995-05-09 Sextant Medical Corporation Path constrained spectrophotometer and method for determination of spatial distribution of light or other radiation scattering and absorbing substances in a radiation scattering medium
DE4210759A1 (de) 1992-04-01 1993-10-07 Boehringer Mannheim Gmbh Substituierte Thiazolin-Dioxetan-Substrate, Verfahren zur Herstellung und Verwendung
DE4202302C2 (de) 1992-01-28 1999-06-10 Dietrich H W Prof Groenemeyer Computer-Tomograph
US5368518A (en) 1992-02-14 1994-11-29 Hitchcock; Elise G. Puppet head
US5400698A (en) 1992-03-05 1995-03-28 Scoope, Inc. Apparatus for molding and baking dough and batter
US5337745A (en) 1992-03-10 1994-08-16 Benaron David A Device and method for in vivo qualitative or quantative measurement of blood chromophore concentration using blood pulse spectrophotometry
US5334640A (en) 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5484589A (en) 1992-04-20 1996-01-16 Rufeld, Inc. Anti-viral methods using RNAse and DNAse
CA2095743A1 (en) 1992-05-07 1993-11-08 Thomas R. Russo Shampoos containing polyglyceryl esters
DE4223430C1 (de) 1992-06-24 1993-11-11 Siemens Ag Computertomograph mit Mitteln zur Darstellung von Schattenbildern
US5352448A (en) 1992-07-20 1994-10-04 Purdue Research Foundatioin Oral administration of antigens
US5511564A (en) 1992-07-29 1996-04-30 Valleylab Inc. Laparoscopic stretching instrument and associated method
US5323492A (en) 1992-08-10 1994-06-28 Demars Robert A Illuminated article of wearing apparel with afterglow
US5177812A (en) 1992-08-10 1993-01-12 Demars Robert A Illuminated article of wearing apparel
US5486161A (en) 1993-02-02 1996-01-23 Zomed International Medical probe device and method
US5419558A (en) 1992-09-04 1995-05-30 Jones; Timothy M. Puzzle box with hand tool
US5311859A (en) 1992-09-11 1994-05-17 Welch Allyn, Inc. Add-on video camera arrangement for optical laparoscope
US5407691A (en) 1992-09-16 1995-04-18 The Planning Factory, Inc. Chocolate candy imprinting process
US5482719A (en) 1992-10-30 1996-01-09 Guillet; James E. Drug delivery systems
US5360728A (en) 1992-12-01 1994-11-01 Woods Hole Oceanographic Institution (W.H.O.I.) Modified apoaequorin having increased bioluminescent activity
US5405958A (en) 1992-12-21 1995-04-11 Transitions Optical, Inc. Photochromic spiro(indoline)naphthoxazine compounds
US5292556A (en) 1992-12-22 1994-03-08 E. I. Du Pont De Nemours And Company Method for preparing negative-working wash-off relief images
US5399122A (en) 1993-01-07 1995-03-21 Aerobal Corp. Balloon with accompanying helium supplying cartridge
US5374292A (en) 1993-02-08 1994-12-20 Pursell Industries Machine system and process for producing attrition resistant slow release fertilizers
WO1994018342A1 (en) 1993-02-12 1994-08-18 Sealite Sciences, Inc. Preparation of photoprotein conjugates and methods of use thereof
US5366881A (en) 1993-02-23 1994-11-22 The United States Of America As Represented By The Secretary Of The Navy Polymerizable lipids for preparing vesicles that controllably release an encapsulant
US5341538A (en) 1993-03-05 1994-08-30 Sun Stix Incorporated Sun lotion applicator
US5397609A (en) 1993-03-11 1995-03-14 Chapman; Jeffrey A. Carvable novelty articles and methods
US5351931A (en) 1993-03-23 1994-10-04 Teresa Houben Paper-making kit with improved basin and web supporting screen
US5353378A (en) 1993-04-16 1994-10-04 Hilco Corporation Sound and light emitting face apparel
FI931858A0 (fi) * 1993-04-23 1993-04-23 Colin Gerald Potter Foerfarande foer uppmaetning av kemiluminescens i prov pao matris
US5411427A (en) 1993-04-26 1995-05-02 Premium Balloon Accessories Balloon weight and latch assembly
US5416193A (en) 1993-04-30 1995-05-16 Pfizer Inc. Coupling reagent and method
US5625049A (en) 1993-05-12 1997-04-29 Us Health Nucleic acids encoding human astrovirus serotype 2
US5407391A (en) 1993-05-14 1995-04-18 The Walt Disney Company Negative bust illusion and related method
US5364797A (en) 1993-05-20 1994-11-15 Mobil Oil Corp. Sensor device containing mesoporous crystalline material
US5465724A (en) 1993-05-28 1995-11-14 Acuson Corporation Compact rotationally steerable ultrasound transducer
JPH0779783A (ja) 1993-06-28 1995-03-28 Chisso Corp ビブリオ フィシエリ由来のフラビン還元酵素遺伝子
US5396069A (en) 1993-07-01 1995-03-07 The United States Of America As Represented By The Secretary Of The Air Force Portable monocular night vision apparatus
US5413454A (en) 1993-07-09 1995-05-09 Movsesian; Peter Mobile robotic arm
US5411730A (en) 1993-07-20 1995-05-02 Research Corporation Technologies, Inc. Magnetic microparticles
US5363984A (en) 1993-07-23 1994-11-15 Gldrj Company Display device having an article dispenser therein
US5389033A (en) 1993-07-23 1995-02-14 Rauch; Blair D. Toy sword made of foam material
US5460022A (en) 1993-08-20 1995-10-24 Armament Systems And Procedures, Inc. Concealed handcuff key
US5381956A (en) 1993-08-26 1995-01-17 Wet Design Self activating falling water display
US5362865A (en) 1993-09-02 1994-11-08 Monsanto Company Enhanced expression in plants using non-translated leader sequences
US5458931A (en) 1993-09-07 1995-10-17 Leeman Designs Inc. Decorative medallions providing enhanced display of graphic matter
US5470881A (en) 1993-09-09 1995-11-28 West Virginia University Research Corporation Urea ophthalmic ointment and solution
US5491084A (en) 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US5432623A (en) 1993-09-27 1995-07-11 Egan; Michael S. Optical lens incorporating an integral hologram
US5540649A (en) 1993-10-08 1996-07-30 Leonard Medical, Inc. Positioner for medical instruments
US5412118A (en) 1993-10-12 1995-05-02 Lever Brothers Company, Division Of Conopco, Inc. Thickened foam stable compositions comprising alkyl(alkyl glycosid)uronamides
US5435010A (en) 1993-10-18 1995-07-25 May; Robert E. Moisture sensitive article of clothing and method of manufacturing the same
US5417431A (en) 1993-11-03 1995-05-23 Laservison Productions, Inc. Trading card with three-dimensional effect
US5405905A (en) 1993-11-26 1995-04-11 Hy-Tec Enterprises Artificial soil and soil-forming composition
US5397014A (en) 1993-12-22 1995-03-14 Aydt; Robert Dual aperture retained tab
US5396408A (en) 1994-01-03 1995-03-07 Szczech, Iii; John J. Detachable window decoration
FI95484C (fi) 1994-01-17 1996-02-12 Marko Virta Menetelmä näytteessä olevan metallin määrittämiseksi
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US5398972A (en) 1994-03-14 1995-03-21 Todaro; Frank S. Fortune telling card
US5383684A (en) 1994-03-28 1995-01-24 Smath; Jerome R. Book
US5405056A (en) 1994-04-01 1995-04-11 Mills; Gregory B. Stereo dispensing container and system
GB2288232A (en) 1994-04-06 1995-10-11 Brf International Photosensitive derivatives of ATP as assay control standards
US5478501A (en) 1994-04-07 1995-12-26 The Andrew Jergens Company Bathing composition containing coated cationic polymer
US5653539A (en) 1994-05-02 1997-08-05 Rosengaus; Eliezer Method and apparatus for remotely measuring the temperature of a surface
US5536382A (en) 1994-05-23 1996-07-16 Advanced Molecular Systems, Inc. Capillary electrophoresis assay method useful for the determination of constituents of a clinical sample
US5413332A (en) 1994-05-26 1995-05-09 Amber Forrest, Inc. Eggball
JP3030678B2 (ja) 1994-06-17 2000-04-10 崇 近藤 自動車ドアの補助開閉機構
US5679773A (en) 1995-01-17 1997-10-21 Affymax Technologies N.V Reagants and methods for immobilized polymer synthesis and display
US5650135A (en) 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5792456A (en) 1994-08-04 1998-08-11 Bristol-Myers Squibb Company Mutant BR96 antibodies reactive with human carcinomas
US5686578A (en) 1994-08-05 1997-11-11 Immunomedics, Inc. Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype
US5535053A (en) 1994-08-15 1996-07-09 Itt Corporation Night vision goggle assembly with independant monocular devices
US5795737A (en) 1994-09-19 1998-08-18 The General Hospital Corporation High level expression of proteins
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
JPH08136546A (ja) * 1994-11-15 1996-05-31 Bio Sensor Kenkyusho:Kk 物質分析法
US5630426A (en) 1995-03-03 1997-05-20 Neovision Corporation Apparatus and method for characterization and treatment of tumors
US5624711A (en) 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
US5637463A (en) 1995-05-04 1997-06-10 Hoffmann-La Roche Inc. Method to detect protein-protein interactions
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US5553853A (en) 1995-08-28 1996-09-10 Sackitey; Solomon K. Game apparatus and method of play for teaching dna related technologies
US5622172A (en) 1995-09-29 1997-04-22 Siemens Medical Systems, Inc. Acoustic display system and method for ultrasonic imaging
US5619999A (en) 1995-12-28 1997-04-15 Siemens Medical Systems, Inc. Body surface position locator for ultrasound transducer
US5804387A (en) 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US5876995A (en) 1996-02-06 1999-03-02 Bryan; Bruce Bioluminescent novelty items
US5770371A (en) 1996-06-27 1998-06-23 Novo Nordisk Biotech, Inc. Modification of cryptic splice sites in heterologous genes expressed in fungi
US5747338A (en) 1996-08-15 1998-05-05 Chiron Corporation Method and construct for screening for inhibitors of transcriptional activation

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US20030113741A1 (en) 2003-06-19
US20030013103A1 (en) 2003-01-16
US6649357B2 (en) 2003-11-18
EP1015872A2 (de) 2000-07-05
JP2001511887A (ja) 2001-08-14
IL129767A0 (en) 2000-02-29
WO1998026277A3 (en) 1999-06-24
JP2006145545A (ja) 2006-06-08
AU6012898A (en) 1998-07-03
DE69732667D1 (de) 2005-04-07
DE69732667T2 (de) 2006-01-19
EP1015872B1 (de) 2005-03-02
JP4287853B2 (ja) 2009-07-01
US6649356B2 (en) 2003-11-18
NZ335453A (en) 2001-07-27
AU741076B2 (en) 2001-11-22
WO1998026277A2 (en) 1998-06-18
JP3795533B2 (ja) 2006-07-12
US20030059798A1 (en) 2003-03-27
US6458547B1 (en) 2002-10-01
US6682899B2 (en) 2004-01-27
CA2271717A1 (en) 1998-06-18

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