ATE346855T1 - Immobilisierung von oligonukleotiden an feste träger - Google Patents
Immobilisierung von oligonukleotiden an feste trägerInfo
- Publication number
- ATE346855T1 ATE346855T1 AT02718393T AT02718393T ATE346855T1 AT E346855 T1 ATE346855 T1 AT E346855T1 AT 02718393 T AT02718393 T AT 02718393T AT 02718393 T AT02718393 T AT 02718393T AT E346855 T1 ATE346855 T1 AT E346855T1
- Authority
- AT
- Austria
- Prior art keywords
- polynucleotide
- immobilization
- oligonucleotides
- solid supports
- disclosed
- Prior art date
Links
- 239000007787 solid Substances 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 abstract 5
- 108091033319 polynucleotide Proteins 0.000 abstract 5
- 239000002157 polynucleotide Substances 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28742501P | 2001-04-30 | 2001-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE346855T1 true ATE346855T1 (de) | 2006-12-15 |
Family
ID=23102846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02718393T ATE346855T1 (de) | 2001-04-30 | 2002-04-25 | Immobilisierung von oligonukleotiden an feste träger |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7230095B2 (de) |
| EP (1) | EP1385860B1 (de) |
| JP (1) | JP4054683B2 (de) |
| KR (1) | KR20040015107A (de) |
| AT (1) | ATE346855T1 (de) |
| CA (1) | CA2445838C (de) |
| DE (1) | DE60216440T2 (de) |
| WO (1) | WO2002088160A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101307616B1 (ko) | 2011-02-08 | 2013-09-12 | 경희대학교 산학협력단 | Ｐｎａ 앱타머를 이용하여 금속을 분리하는 방법 |
| US20180057553A1 (en) * | 2015-03-05 | 2018-03-01 | The University Of Tokyo | Conjugate and use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2540122B1 (fr) * | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application |
| GB8822228D0 (en) * | 1988-09-21 | 1988-10-26 | Southern E M | Support-bound oligonucleotides |
| US5352578A (en) * | 1989-02-15 | 1994-10-04 | Worcester Foundation For Experimental Biology | Method of separating oligonucleotides from a mixture |
| KR930702373A (ko) * | 1990-11-08 | 1993-09-08 | 안토니 제이. 페이네 | 합성 올리고누클레오티드에 대한 다중 리포터(Reporter)그룹의 첨합 |
| SE9003743D0 (sv) * | 1990-11-26 | 1990-11-26 | Pharmacia Ab | Method and means for oligonucleotide synthesis |
| EP0511559A1 (de) | 1991-04-30 | 1992-11-04 | F.Hoffmann-La Roche & Co. Aktiengesellschaft | Reagens für eine Oligonukleotidprobe |
| BE1007918A3 (fr) * | 1993-02-19 | 1995-11-21 | Wallone Region | Sondes d'acides nucleiques chimiquement modifiees en 5'(oh) et/ou en 3'(oh) en vue de l'introduction en ces positions d'un ou plusieurs elements de marquage non radioactif et procede de preparation. |
| US5869696A (en) * | 1996-04-22 | 1999-02-09 | Beckman Instruments, Inc. | Universal solid supports and methods for their use |
| US6013789A (en) * | 1998-02-20 | 2000-01-11 | Beckman Coulter, Inc. | Covalent attachment of biomolecules to derivatized polypropylene supports |
| EP0967217B1 (de) * | 1998-06-22 | 2005-12-21 | Affymetrix, Inc. (a California Corporation) | Reagenz und Verfahren zu fester Phase Synthese |
| EP1283881A2 (de) | 2000-05-26 | 2003-02-19 | Noxxon Pharma AG | Immobilisierte nukleinsäuren und verwendungen davon |
-
2002
- 2002-04-25 CA CA2445838A patent/CA2445838C/en not_active Expired - Lifetime
- 2002-04-25 EP EP02718393A patent/EP1385860B1/de not_active Expired - Lifetime
- 2002-04-25 KR KR10-2003-7013716A patent/KR20040015107A/ko not_active Withdrawn
- 2002-04-25 WO PCT/GB2002/001912 patent/WO2002088160A1/en not_active Ceased
- 2002-04-25 JP JP2002585458A patent/JP4054683B2/ja not_active Expired - Lifetime
- 2002-04-25 US US10/475,298 patent/US7230095B2/en not_active Expired - Lifetime
- 2002-04-25 AT AT02718393T patent/ATE346855T1/de not_active IP Right Cessation
- 2002-04-25 DE DE60216440T patent/DE60216440T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7230095B2 (en) | 2007-06-12 |
| CA2445838C (en) | 2011-11-22 |
| US20050048487A1 (en) | 2005-03-03 |
| CA2445838A1 (en) | 2002-11-07 |
| WO2002088160A1 (en) | 2002-11-07 |
| EP1385860B1 (de) | 2006-11-29 |
| EP1385860A1 (de) | 2004-02-04 |
| JP2005503773A (ja) | 2005-02-10 |
| DE60216440D1 (de) | 2007-01-11 |
| KR20040015107A (ko) | 2004-02-18 |
| DE60216440T2 (de) | 2007-09-20 |
| JP4054683B2 (ja) | 2008-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |