ATE346951T1 - Test zum nachweis von inhibitoren des enzyms myeloperokidase - Google Patents
Test zum nachweis von inhibitoren des enzyms myeloperokidaseInfo
- Publication number
- ATE346951T1 ATE346951T1 AT02728295T AT02728295T ATE346951T1 AT E346951 T1 ATE346951 T1 AT E346951T1 AT 02728295 T AT02728295 T AT 02728295T AT 02728295 T AT02728295 T AT 02728295T AT E346951 T1 ATE346951 T1 AT E346951T1
- Authority
- AT
- Austria
- Prior art keywords
- myeloperoxidase
- detector molecule
- reacting
- oxidised
- enzyme
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 102000003896 Myeloperoxidases Human genes 0.000 abstract 5
- 108090000235 Myeloperoxidases Proteins 0.000 abstract 5
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 4
- QDHHCQZDFGDHMP-UHFFFAOYSA-N Chloramine Chemical compound ClN QDHHCQZDFGDHMP-UHFFFAOYSA-N 0.000 abstract 2
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 238000002835 absorbance Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SE2001/001014 WO2001085146A1 (en) | 2000-05-12 | 2001-05-08 | Pharmaceutical compounds for treating copd |
| SE0103766A SE0103766D0 (sv) | 2001-11-09 | 2001-11-09 | Novel assay |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE346951T1 true ATE346951T1 (de) | 2006-12-15 |
Family
ID=26655416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02728295T ATE346951T1 (de) | 2001-05-08 | 2002-05-06 | Test zum nachweis von inhibitoren des enzyms myeloperokidase |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1387893B1 (de) |
| JP (1) | JP4095446B2 (de) |
| CN (1) | CN1228452C (de) |
| AT (1) | ATE346951T1 (de) |
| AU (1) | AU2002258327B2 (de) |
| CA (1) | CA2446039A1 (de) |
| DE (1) | DE60216442T2 (de) |
| DK (1) | DK1387893T3 (de) |
| ES (1) | ES2275865T3 (de) |
| IL (1) | IL158462A0 (de) |
| NZ (1) | NZ528999A (de) |
| WO (1) | WO2002090575A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039385A1 (es) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | Derivados de tioxantina como inhibidores de la mieloperoxidasa |
| US7195891B2 (en) * | 2004-08-11 | 2007-03-27 | General Atomics | Methods and compositions of enzymatic cycling based assays for myeloperoxidase |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| CN103917529B (zh) | 2011-11-11 | 2016-08-17 | 辉瑞大药厂 | 2-硫代嘧啶酮类 |
| AU2016257179A1 (en) | 2015-05-05 | 2017-11-02 | Pfizer Inc. | 2-thiopyrimidinones |
| CN105891182B (zh) * | 2016-06-17 | 2018-05-29 | 云南圣清环境监测科技有限公司 | 一种对过氧化氢酶定量的方法 |
| CN106908601B (zh) * | 2017-03-06 | 2019-02-12 | 海格德生物科技（深圳）有限公司 | 人髓过氧化物酶活性及总量检测试剂盒及检测方法和制备方法 |
| CN109975282A (zh) * | 2019-04-04 | 2019-07-05 | 华侨大学 | 一种基于酶催化碘化钾氧化显色检测过氧化氢含量的分光光度法 |
| CN114509429A (zh) * | 2021-12-20 | 2022-05-17 | 苏州百源基因技术有限公司 | 一种尿碘检测试剂盒及其使用方法 |
| WO2025190901A1 (en) | 2024-03-13 | 2025-09-18 | Institut National de la Santé et de la Recherche Médicale | Use of myeloperoxidase (mpo) inhibitors for promoting cd8+ t cell responses |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976823A (en) * | 1997-03-19 | 1999-11-02 | Integrated Biomedical Technology, Inc. | Low range total available chlorine test strip |
-
2002
- 2002-05-06 IL IL15846202A patent/IL158462A0/xx unknown
- 2002-05-06 CN CN02809553.7A patent/CN1228452C/zh not_active Expired - Fee Related
- 2002-05-06 DK DK02728295T patent/DK1387893T3/da active
- 2002-05-06 CA CA002446039A patent/CA2446039A1/en not_active Abandoned
- 2002-05-06 AU AU2002258327A patent/AU2002258327B2/en not_active Ceased
- 2002-05-06 EP EP02728295A patent/EP1387893B1/de not_active Expired - Lifetime
- 2002-05-06 NZ NZ528999A patent/NZ528999A/en unknown
- 2002-05-06 AT AT02728295T patent/ATE346951T1/de not_active IP Right Cessation
- 2002-05-06 DE DE60216442T patent/DE60216442T2/de not_active Expired - Fee Related
- 2002-05-06 ES ES02728295T patent/ES2275865T3/es not_active Expired - Lifetime
- 2002-05-06 WO PCT/SE2002/000877 patent/WO2002090575A1/en not_active Ceased
- 2002-05-06 JP JP2002587634A patent/JP4095446B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60216442D1 (de) | 2007-01-11 |
| JP2004525646A (ja) | 2004-08-26 |
| JP4095446B2 (ja) | 2008-06-04 |
| CA2446039A1 (en) | 2002-11-14 |
| EP1387893B1 (de) | 2006-11-29 |
| DK1387893T3 (da) | 2007-02-19 |
| AU2002258327B2 (en) | 2007-03-01 |
| EP1387893A1 (de) | 2004-02-11 |
| WO2002090575A1 (en) | 2002-11-14 |
| ES2275865T3 (es) | 2007-06-16 |
| IL158462A0 (en) | 2004-05-12 |
| CN1507495A (zh) | 2004-06-23 |
| CN1228452C (zh) | 2005-11-23 |
| DE60216442T2 (de) | 2007-09-27 |
| NZ528999A (en) | 2005-04-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1387893 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |