ATE347551T1 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents
Substituierte bisindolylmaleimide zur inhibierung der zellproliferationInfo
- Publication number
- ATE347551T1 ATE347551T1 AT97918935T AT97918935T ATE347551T1 AT E347551 T1 ATE347551 T1 AT E347551T1 AT 97918935 T AT97918935 T AT 97918935T AT 97918935 T AT97918935 T AT 97918935T AT E347551 T1 ATE347551 T1 AT E347551T1
- Authority
- AT
- Austria
- Prior art keywords
- bisindolylmaleimide
- substituted
- cell proliferation
- inhibit cell
- inhibit
- Prior art date
Links
- DQYBRTASHMYDJG-UHFFFAOYSA-N Bisindolylmaleimide IV Natural products C1=CC=C2C(C=3C(=O)NC(C=3C=3C4=CC=CC=C4NC=3)=O)=CNC2=C1 DQYBRTASHMYDJG-UHFFFAOYSA-N 0.000 title 1
- 150000003924 bisindolylmaleimides Chemical class 0.000 title 1
- 230000004663 cell proliferation Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2208096P | 1996-07-29 | 1996-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE347551T1 true ATE347551T1 (de) | 2006-12-15 |
Family
ID=21807715
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97918935T ATE347551T1 (de) | 1996-07-29 | 1997-07-19 | Substituierte bisindolylmaleimide zur inhibierung der zellproliferation |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5891901A (de) |
| EP (1) | EP0915871B1 (de) |
| JP (1) | JP2000516590A (de) |
| KR (1) | KR20000029627A (de) |
| CN (1) | CN1077572C (de) |
| AR (1) | AR007970A1 (de) |
| AT (1) | ATE347551T1 (de) |
| AU (1) | AU739704B2 (de) |
| BR (1) | BR9710902A (de) |
| CA (1) | CA2262088A1 (de) |
| CO (1) | CO4890846A1 (de) |
| DE (1) | DE69737060D1 (de) |
| HR (1) | HRP970417A2 (de) |
| MA (1) | MA24288A1 (de) |
| PE (1) | PE91498A1 (de) |
| TR (1) | TR199900153T2 (de) |
| WO (1) | WO1998004553A1 (de) |
| ZA (1) | ZA976487B (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1064279E (pt) * | 1998-03-17 | 2003-10-31 | Hoffmann La Roche | Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular |
| US6521658B1 (en) * | 1999-05-28 | 2003-02-18 | Abbott Laboratories | Cell proliferation inhibitors |
| US6313143B1 (en) * | 1999-12-16 | 2001-11-06 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6281356B1 (en) * | 1999-12-22 | 2001-08-28 | Hoffmann-La Roche Inc. | Substituted pyrroles |
| US6326501B1 (en) * | 2000-04-19 | 2001-12-04 | Hoffmann-La Roche Inc. | Methylation of indole compounds using dimethyl carbonate |
| TW201041580A (en) | 2001-09-27 | 2010-12-01 | Alcon Inc | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma |
| US20050123975A1 (en) * | 2003-11-19 | 2005-06-09 | Applera Corporation | Methods for determining the degradation state or concentration of nucleic acids |
| EP3741375A1 (de) | 2014-07-17 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Verfahren zur behandlung von erkrankungen in zusammenhang mit neuromuskulären verbindungen |
| WO2016207366A1 (en) | 2015-06-26 | 2016-12-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of viral infections |
| WO2019000224A1 (zh) * | 2017-06-27 | 2019-01-03 | 中国海洋大学 | 双吲哚马来酰亚胺衍生物及其制备方法和用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227850A (en) * | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
| US5380746A (en) * | 1989-05-05 | 1995-01-10 | Goedecke Aktiengesellschaft | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
| CA2015996C (en) * | 1989-05-05 | 2001-08-28 | Hartmut Osswald | Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals |
| JPH0539289A (ja) * | 1991-02-15 | 1993-02-19 | Masahiro Irie | 無水マレイン酸誘導体およびその製造方法 |
| AU3761393A (en) * | 1992-03-20 | 1993-10-21 | Wellcome Foundation Limited, The | Indole derivatives with antiviral activity |
| DE4217964A1 (de) * | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
-
1997
- 1997-07-15 PE PE1997000627A patent/PE91498A1/es not_active Application Discontinuation
- 1997-07-19 EP EP97918935A patent/EP0915871B1/de not_active Expired - Lifetime
- 1997-07-19 AU AU42964/97A patent/AU739704B2/en not_active Ceased
- 1997-07-19 WO PCT/EP1997/003890 patent/WO1998004553A1/en not_active Ceased
- 1997-07-19 TR TR1999/00153T patent/TR199900153T2/xx unknown
- 1997-07-19 BR BR9710902A patent/BR9710902A/pt not_active Application Discontinuation
- 1997-07-19 CN CN97196784A patent/CN1077572C/zh not_active Expired - Fee Related
- 1997-07-19 KR KR1019997000696A patent/KR20000029627A/ko not_active Ceased
- 1997-07-19 CA CA002262088A patent/CA2262088A1/en not_active Abandoned
- 1997-07-19 DE DE69737060T patent/DE69737060D1/de not_active Expired - Lifetime
- 1997-07-19 AT AT97918935T patent/ATE347551T1/de not_active IP Right Cessation
- 1997-07-19 JP JP10508454A patent/JP2000516590A/ja not_active Ceased
- 1997-07-22 ZA ZA9706487A patent/ZA976487B/xx unknown
- 1997-07-22 AR ARP970103310A patent/AR007970A1/es not_active Application Discontinuation
- 1997-07-24 US US08/899,913 patent/US5891901A/en not_active Expired - Fee Related
- 1997-07-25 CO CO97042577A patent/CO4890846A1/es unknown
- 1997-07-25 HR HR60/022,080A patent/HRP970417A2/hr not_active Application Discontinuation
- 1997-07-29 MA MA24745A patent/MA24288A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000516590A (ja) | 2000-12-12 |
| EP0915871A1 (de) | 1999-05-19 |
| AR007970A1 (es) | 1999-11-24 |
| CN1226249A (zh) | 1999-08-18 |
| EP0915871B1 (de) | 2006-12-06 |
| AU4296497A (en) | 1998-02-20 |
| ZA976487B (en) | 1998-01-29 |
| AU739704B2 (en) | 2001-10-18 |
| US5891901A (en) | 1999-04-06 |
| DE69737060D1 (de) | 2007-01-18 |
| KR20000029627A (ko) | 2000-05-25 |
| CA2262088A1 (en) | 1998-02-05 |
| CO4890846A1 (es) | 2000-02-28 |
| TR199900153T2 (xx) | 1999-04-21 |
| PE91498A1 (es) | 1998-12-22 |
| HRP970417A2 (en) | 1998-08-31 |
| WO1998004553A1 (en) | 1998-02-05 |
| BR9710902A (pt) | 1999-08-17 |
| CN1077572C (zh) | 2002-01-09 |
| MA24288A1 (fr) | 1998-04-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |