ATE224889T1 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents

Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Info

Publication number: ATE224889T1
Authority: AT; Austria
Prior art keywords: bisindolylmaleimide; substituted; cell proliferation; inhibit cell; inhibit
Prior art date: 1996-07-29

Application number

AT97918934T

Other languages

English (en)

Inventor

Urvashi Hooda Dhingra

Donna Mary Huryn

Dennis Dalton Keith

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-29

Filing date

1997-07-19

Publication date

2002-10-15

1997-07-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2002-10-15 Application granted granted Critical

2002-10-15 Publication of ATE224889T1 publication Critical patent/ATE224889T1/de

Links

DQYBRTASHMYDJG-UHFFFAOYSA-N Bisindolylmaleimide IV Natural products C1=CC=C2C(C=3C(=O)NC(C=3C=3C4=CC=CC=C4NC=3)=O)=CNC2=C1 DQYBRTASHMYDJG-UHFFFAOYSA-N 0.000 title 1
150000003924 bisindolylmaleimides Chemical class 0.000 title 1
230000004663 cell proliferation Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

AT97918934T 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation ATE224889T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2207896P	1996-07-29	1996-07-29
US4849697P	1997-06-03	1997-06-03
PCT/EP1997/003888 WO1998004551A1 (en)	1996-07-29	1997-07-19	Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (1)

Publication Number	Publication Date
ATE224889T1 true ATE224889T1 (de)	2002-10-15

Family

ID=26695475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97918934T ATE224889T1 (de)	1996-07-29	1997-07-19	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Country Status (20)

Country	Link
US (1)	US6228877B1 (de)
EP (1)	EP0915870B1 (de)
JP (1)	JP2000516588A (de)
KR (1)	KR20000029640A (de)
CN (1)	CN1077571C (de)
AR (1)	AR007969A1 (de)
AT (1)	ATE224889T1 (de)
AU (1)	AU740011B2 (de)
BR (1)	BR9711607A (de)
CA (1)	CA2262089A1 (de)
CO (1)	CO4900054A1 (de)
DE (1)	DE69715870T2 (de)
DK (1)	DK0915870T3 (de)
ES (1)	ES2183163T3 (de)
HR (1)	HRP970415A2 (de)
MA (1)	MA24354A1 (de)
PE (1)	PE91598A1 (de)
PT (1)	PT915870E (de)
TR (1)	TR199900186T2 (de)
WO (1)	WO1998004551A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20000585B1 (en) *	1998-03-17	2009-02-28	F. Hoffmann - La Roche Ag	Substituted bisindolymaleimides for the inhibition of cell proliferation
US6350786B1 (en) *	1998-09-22	2002-02-26	Hoffmann-La Roche Inc.	Stable complexes of poorly soluble compounds in ionic polymers
CA2385071A1 (en) *	1999-10-12	2001-04-19	Norman Kong	Substituted pyrroles as antiproliferative agents for the treatment of cancer
US6559164B1 (en)	1999-10-12	2003-05-06	Hoffmann-La Roche Inc.	Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) *	1999-12-16	2001-11-06	Hoffmann-La Roche Inc.	Substituted pyrroles
US6281356B1 (en) *	1999-12-22	2001-08-28	Hoffmann-La Roche Inc.	Substituted pyrroles
US6326501B1 (en) *	2000-04-19	2001-12-04	Hoffmann-La Roche Inc.	Methylation of indole compounds using dimethyl carbonate
CA2308994A1 (en) *	2000-05-19	2001-11-19	Aegera Therapeutics Inc.	Neuroprotective compounds
US7129250B2 (en)	2000-05-19	2006-10-31	Aegera Therapeutics Inc.	Neuroprotective and anti-proliferative compounds
TWI335221B (en)	2001-09-27	2011-01-01	Alcon Inc	Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
JP2005508365A (ja) *	2001-10-29	2005-03-31	ネクターセラピューティックスエイエル，コーポレイション	プロテインキナーゼｃインヒビターのポリマー結合体
CA2393720C (en)	2002-07-12	2010-09-14	Eli Lilly And Company	Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
DK1846406T5 (da)	2005-02-09	2011-10-31	Arqule Inc	Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer
MX2009006533A (es) *	2006-12-19	2009-06-26	Novartis Ag	Derivados de indolil-maleimida como inhibidores de cinasa.
JP5490688B2 (ja)	2007-06-22	2014-05-14	アークルインコーポレイテッド	癌の治療のためのインドリルピロリジン
CA2690799C (en) *	2007-06-22	2015-06-16	Arqule, Inc.	Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
CN101801937A (zh)	2007-06-22	2010-08-11	艾科尔公司	喹唑啉酮化合物及其使用方法
GB201111427D0 (en) *	2011-07-05	2011-08-17	Amakem Nv	Novel bisindolylmaleimides, pan-pkc inhibitors
EP3741375A1 (de)	2014-07-17	2020-11-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	Verfahren zur behandlung von erkrankungen in zusammenhang mit neuromuskulären verbindungen
WO2016207366A1 (en)	2015-06-26	2016-12-29	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of viral infections
CN109535158B (zh) *	2016-04-26	2021-04-23	浙江工业大学	一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
CN107973785B (zh) *	2017-11-27	2019-12-31	浙江工业大学上虞研究院有限公司	一种用于检测银离子的荧光探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK75289A3 (en)	1988-02-10	1998-05-06	Hoffmann La Roche	Substituted pyrroles, their use for producing a drug, and the drug on their base
IL94274A0 (en) *	1989-05-05	1991-03-10	Goedecke Ag	Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5380746A (en)	1989-05-05	1995-01-10	Goedecke Aktiengesellschaft	Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
JPH0539289A (ja)	1991-02-15	1993-02-19	Masahiro Irie	無水マレイン酸誘導体およびその製造方法
AU3761393A (en)	1992-03-20	1993-10-21	Wellcome Foundation Limited, The	Indole derivatives with antiviral activity
DE4217964A1 (de)	1992-05-30	1993-12-02	Goedecke Ag	Indolocarbazol-Imide und deren Verwendung

1997
- 1997-07-15 PE PE1997000629A patent/PE91598A1/es not_active Application Discontinuation
- 1997-07-19 BR BR9711607A patent/BR9711607A/pt not_active IP Right Cessation
- 1997-07-19 TR TR1999/00186T patent/TR199900186T2/xx unknown
- 1997-07-19 WO PCT/EP1997/003888 patent/WO1998004551A1/en not_active Ceased
- 1997-07-19 DE DE69715870T patent/DE69715870T2/de not_active Expired - Fee Related
- 1997-07-19 AU AU42963/97A patent/AU740011B2/en not_active Ceased
- 1997-07-19 CA CA002262089A patent/CA2262089A1/en not_active Abandoned
- 1997-07-19 PT PT97918934T patent/PT915870E/pt unknown
- 1997-07-19 CN CN97196783A patent/CN1077571C/zh not_active Expired - Fee Related
- 1997-07-19 JP JP10508452A patent/JP2000516588A/ja not_active Ceased
- 1997-07-19 EP EP97918934A patent/EP0915870B1/de not_active Expired - Lifetime
- 1997-07-19 AT AT97918934T patent/ATE224889T1/de not_active IP Right Cessation
- 1997-07-19 ES ES97918934T patent/ES2183163T3/es not_active Expired - Lifetime
- 1997-07-19 KR KR1019997000711A patent/KR20000029640A/ko not_active Abandoned
- 1997-07-19 DK DK97918934T patent/DK0915870T3/da active
- 1997-07-22 AR ARP970103308A patent/AR007969A1/es unknown
- 1997-07-25 CO CO97042636A patent/CO4900054A1/es unknown
- 1997-07-25 HR HR60/048,496A patent/HRP970415A2/hr not_active Application Discontinuation
- 1997-07-29 MA MA24743A patent/MA24354A1/fr unknown
1998
- 1998-12-22 US US09/218,404 patent/US6228877B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU4296397A (en)	1998-02-20
CN1077571C (zh)	2002-01-09
US6228877B1 (en)	2001-05-08
ES2183163T3 (es)	2003-03-16
WO1998004551A1 (en)	1998-02-05
EP0915870B1 (de)	2002-09-25
KR20000029640A (ko)	2000-05-25
DE69715870D1 (de)	2002-10-31
CN1226248A (zh)	1999-08-18
PT915870E (pt)	2003-01-31
EP0915870A1 (de)	1999-05-19
AR007969A1 (es)	1999-11-24
JP2000516588A (ja)	2000-12-12
DK0915870T3 (da)	2003-02-03
TR199900186T2 (xx)	1999-03-22
PE91598A1 (es)	1998-12-24
HRP970415A2 (en)	1998-08-31
CA2262089A1 (en)	1998-02-05
BR9711607A (pt)	1999-08-24
DE69715870T2 (de)	2003-06-18
MA24354A1 (fr)	1998-07-01
CO4900054A1 (es)	2000-03-27
AU740011B2 (en)	2001-10-25

Legal Events

Date

Code

Title

Description

2003-04-15

UEP

Publication of translation of european patent specification

Ref document number: 0915870

Country of ref document: EP

2007-04-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE240318T1 (de)	2003-05-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
DE69715870D1 (de)	2002-10-31	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ID19875A (id)	1998-08-13	Poliolefin yang dimodifikasi menurut reologi
NO984316D0 (no)	1998-09-17	Skjµreverkt°y
DE69727942D1 (de)	2004-04-08	Transplantat-gewebekonstruktion zum ersatz der knorpelstruktur
NO983462D0 (no)	1998-07-28	Isoleringsverkt°y
ID24314A (id)	2000-07-13	Tempat umpan bersekat-sekat
DE69718481D1 (de)	2003-02-20	Elektrolyt
ATE243693T1 (de)	2003-07-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
NO990552D0 (no)	1999-02-05	Innrettingsverkt°y
EP1039897A4 (de)	2002-10-02	Inadon und tetralon verbindungen zur hemmung der zellproliferation
ATE347551T1 (de)	2006-12-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
ID17786A (id)	1998-01-29	Sel fotoelektrokima
DK0906279T3 (da)	2003-02-03	Pyrrolderivater
ATE306484T1 (de)	2005-10-15	Substituierte bisindolylmaleimide zur inhibierung der zellproliferation
FI961983A0 (fi)	1996-05-09	Multivibratorkrets
FI961658L (fi)	1997-10-17	Laitteisto sähköenergian kulutuksen mittaamiseksi
DE69722799D1 (de)	2003-07-17	Zellzusammenstellungen
ATA196697A (de)	2000-08-15	Panzerungsplatte
FI961981A0 (fi)	1996-05-09	Multivibratorkrets
ID16641A (id)	1997-10-23	Peralatan elektromagnit untuk mengukur tenaga listrik
FR2743284B1 (fr)	1998-03-27	Assiette papillote
FI961982A0 (fi)	1996-05-09	Multivibratorkrets
ID18647A (id)	1998-04-30	Gurdi bor bebatuan
ID18947A (id)	1998-05-28	Pesawat untuk menjepit piringan