ATE224889T1 - Substituierte bisindolylmaleimide zur inhibierung der zellproliferation - Google Patents

Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Info

Publication number
ATE224889T1
ATE224889T1 AT97918934T AT97918934T ATE224889T1 AT E224889 T1 ATE224889 T1 AT E224889T1 AT 97918934 T AT97918934 T AT 97918934T AT 97918934 T AT97918934 T AT 97918934T AT E224889 T1 ATE224889 T1 AT E224889T1
Authority
AT
Austria
Prior art keywords
bisindolylmaleimide
substituted
cell proliferation
inhibit cell
inhibit
Prior art date
Application number
AT97918934T
Other languages
English (en)
Inventor
Urvashi Hooda Dhingra
Donna Mary Huryn
Dennis Dalton Keith
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE224889T1 publication Critical patent/ATE224889T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97918934T 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation ATE224889T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2207896P 1996-07-29 1996-07-29
US4849697P 1997-06-03 1997-06-03
PCT/EP1997/003888 WO1998004551A1 (en) 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (1)

Publication Number Publication Date
ATE224889T1 true ATE224889T1 (de) 2002-10-15

Family

ID=26695475

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97918934T ATE224889T1 (de) 1996-07-29 1997-07-19 Substituierte bisindolylmaleimide zur inhibierung der zellproliferation

Country Status (20)

Country Link
US (1) US6228877B1 (de)
EP (1) EP0915870B1 (de)
JP (1) JP2000516588A (de)
KR (1) KR20000029640A (de)
CN (1) CN1077571C (de)
AR (1) AR007969A1 (de)
AT (1) ATE224889T1 (de)
AU (1) AU740011B2 (de)
BR (1) BR9711607A (de)
CA (1) CA2262089A1 (de)
CO (1) CO4900054A1 (de)
DE (1) DE69715870T2 (de)
DK (1) DK0915870T3 (de)
ES (1) ES2183163T3 (de)
HR (1) HRP970415A2 (de)
MA (1) MA24354A1 (de)
PE (1) PE91598A1 (de)
PT (1) PT915870E (de)
TR (1) TR199900186T2 (de)
WO (1) WO1998004551A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999047518A1 (en) * 1998-03-17 1999-09-23 F. Hoffmann-La Roche Ag Substituted bisindolymaleimides for the inhibition of cell proliferation
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers
RU2002110111A (ru) * 1999-10-12 2003-12-20 Ф.Хоффманн-Ля Рош Аг (Ch) Замещенные пирролы в качестве антипролиферативных средств для лечения рака
US6559164B1 (en) 1999-10-12 2003-05-06 Hoffmann-La Roche Inc. Substituted pyrroles suitable for continuous infusion
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
US6326501B1 (en) * 2000-04-19 2001-12-04 Hoffmann-La Roche Inc. Methylation of indole compounds using dimethyl carbonate
US7129250B2 (en) * 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
WO2003037384A2 (en) * 2001-10-29 2003-05-08 Nektar Therapeutics Al, Corporation Polymer conjugates of protein kinase c inhibitors
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
DE602006017965D1 (de) 2005-02-09 2010-12-16 Arqule Inc Maleimid-derivate, pharmazeutische zusammensetzungen und verfahren zur behandlung von krebs
KR20090100363A (ko) 2006-12-19 2009-09-23 노파르티스 아게 키나제 억제제로서의 인돌릴말레이미드 유도체
KR20100024494A (ko) 2007-06-22 2010-03-05 아르퀼 인코포레이티드 퀴나졸리논 화합물 및 이의 사용 방법
US8304425B2 (en) * 2007-06-22 2012-11-06 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
CA2690782C (en) 2007-06-22 2016-02-02 Arqule, Inc. Compositions and methods for treatment of cancer
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
WO2016008966A1 (en) 2014-07-17 2016-01-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN109535158B (zh) * 2016-04-26 2021-04-23 浙江工业大学 一种双芳基马来酰亚胺类化合物及其药学上可接受的盐及其制备方法和应用
CN107973785B (zh) * 2017-11-27 2019-12-31 浙江工业大学上虞研究院有限公司 一种用于检测银离子的荧光探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK75289A3 (en) 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
JPH0539289A (ja) 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
JPH07504673A (ja) 1992-03-20 1995-05-25 ザ・ウエルカム・ファウンデーション・リミテッド 抗ウイルス活性を有するインドール誘導体
DE4217964A1 (de) 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
ES2183163T3 (es) 2003-03-16
EP0915870B1 (de) 2002-09-25
WO1998004551A1 (en) 1998-02-05
DK0915870T3 (da) 2003-02-03
AU740011B2 (en) 2001-10-25
TR199900186T2 (xx) 1999-03-22
AR007969A1 (es) 1999-11-24
JP2000516588A (ja) 2000-12-12
US6228877B1 (en) 2001-05-08
CO4900054A1 (es) 2000-03-27
MA24354A1 (fr) 1998-07-01
PE91598A1 (es) 1998-12-24
CN1077571C (zh) 2002-01-09
DE69715870T2 (de) 2003-06-18
EP0915870A1 (de) 1999-05-19
KR20000029640A (ko) 2000-05-25
PT915870E (pt) 2003-01-31
AU4296397A (en) 1998-02-20
CA2262089A1 (en) 1998-02-05
HRP970415A2 (en) 1998-08-31
CN1226248A (zh) 1999-08-18
BR9711607A (pt) 1999-08-24
DE69715870D1 (de) 2002-10-31

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