ATE347588T1 - Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten - Google Patents
Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozytenInfo
- Publication number
- ATE347588T1 ATE347588T1 AT97927709T AT97927709T ATE347588T1 AT E347588 T1 ATE347588 T1 AT E347588T1 AT 97927709 T AT97927709 T AT 97927709T AT 97927709 T AT97927709 T AT 97927709T AT E347588 T1 ATE347588 T1 AT E347588T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- lymphocytes
- presentation
- activation
- class
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title abstract 2
- 230000004913 activation Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 210000000447 Th1 cell Anatomy 0.000 abstract 1
- 210000004241 Th2 cell Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000009210 ongoing activation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0601—Invertebrate cells or tissues, e.g. insect cells; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1817596P | 1996-05-23 | 1996-05-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE347588T1 true ATE347588T1 (de) | 2006-12-15 |
Family
ID=21786645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97927709T ATE347588T1 (de) | 1996-05-23 | 1997-05-22 | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US6355479B1 (de) |
| EP (1) | EP0969865B1 (de) |
| JP (2) | JP5006998B2 (de) |
| AT (1) | ATE347588T1 (de) |
| AU (1) | AU723355B2 (de) |
| CA (1) | CA2254975C (de) |
| DE (1) | DE69737070T2 (de) |
| DK (1) | DK0969865T3 (de) |
| ES (1) | ES2278390T3 (de) |
| IL (1) | IL126843A (de) |
| PT (1) | PT969865E (de) |
| WO (1) | WO1997046256A1 (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69737070T2 (de) * | 1996-05-23 | 2007-06-21 | The Scripps Research Institute, La Jolla | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
| US6291430B1 (en) * | 1997-09-12 | 2001-09-18 | Ludwig Institute For Cancer Research | Mage-3 peptides presented by HLA class II molecules |
| ATE437366T1 (de) | 1998-05-11 | 2009-08-15 | Miltenyi Biotec Gmbh | Verfahren zur direkten auswahl von antigen- spezifischen t-zellen |
| US6230662B1 (en) | 1998-06-22 | 2001-05-15 | Theresa Miale | Animal lift and transport apparatus and method for using the same |
| WO2000009665A1 (en) * | 1998-08-10 | 2000-02-24 | Chiron Corporation | Engineered antigen-presenting cells expressing an array of antigens and uses thereof |
| US7807377B2 (en) | 1998-10-20 | 2010-10-05 | Salvatore Albani | Method of isolating antigen-specific T cells employing artificial antigen presenting cells |
| DE69942100D1 (de) * | 1998-10-20 | 2010-04-15 | Androclus Technologies S R L I | Künstliche antigen-spezifischen zellen und zugehörige verfahren |
| US6225443B1 (en) * | 1999-05-19 | 2001-05-01 | Wisconsin Alumni Research Foundation | Cytotoxic T lymphocyte epitopes of the major outer membrane protein of chlamydia trachomatis |
| US7521202B2 (en) | 1999-12-17 | 2009-04-21 | The Board Of Regents Of The University Of Oklahoma | Method and apparatus for the production of soluble MHC antigens and uses thereof |
| US7541429B2 (en) | 2000-10-10 | 2009-06-02 | The Board Of Regents Of The University Of Oklahoma | Comparative ligand mapping from MHC positive cells |
| DE10009341A1 (de) * | 2000-02-22 | 2001-09-06 | Florian Kern | Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) * | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| AU2000243137A1 (en) * | 2000-04-20 | 2001-11-07 | Salvatore Albani | Methods for isolation, quantification, characterization and modulation of antigen-specific t cells |
| US20070026433A1 (en) | 2001-03-09 | 2007-02-01 | Hildebrand William H | Epitope testing using soluble HLA |
| WO2002056908A2 (en) * | 2001-01-16 | 2002-07-25 | Hildebrand William H | Artificial antigen-presenting cells |
| US7579007B2 (en) * | 2001-02-13 | 2009-08-25 | Jdm Technologies, Inc. | Production of “biological carriers” for induction of immune responses and inhibition of viral replication |
| US20040071671A1 (en) * | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
| US20030077248A1 (en) * | 2001-02-20 | 2003-04-24 | Ann Moriarty | Cell therapy method for the treatment of tumors |
| FR2824567B1 (fr) * | 2001-05-11 | 2003-08-08 | Inst Nat Sante Rech Med | Procede d'obtention de lymphocytes tr1 regulateurs specifiques d'antigene |
| US7745140B2 (en) * | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| WO2003057171A2 (en) * | 2002-01-03 | 2003-07-17 | The Trustees Of The University Of Pennsylvania | Activation and expansion of t-cells using an engineered multivalent signaling platform |
| US7638326B2 (en) | 2002-01-03 | 2009-12-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform |
| ES2282355T3 (es) | 2002-10-11 | 2007-10-16 | Sentoclone Ab | Inmunoterapia de cancer. |
| US20040072262A1 (en) * | 2002-10-11 | 2004-04-15 | Montero-Julian Felix A. | Methods and systems for detecting MHC class I binding peptides |
| US7435592B2 (en) | 2003-05-13 | 2008-10-14 | Immunovative Therapies, Ltd. | Compositions for allogeneic cell therapy |
| JP2007511760A (ja) * | 2003-11-03 | 2007-05-10 | ベックマン コールター インコーポレーティッド | Mhc結合ペプチドを検出するための溶液ベースの方法 |
| US7592431B2 (en) | 2004-02-26 | 2009-09-22 | Immunovative Therapies, Ltd. | Biodegradable T-cell Activation device |
| PL2573166T3 (pl) | 2004-02-26 | 2016-11-30 | Sposoby otrzymywania komórek T do terapii komórkowej | |
| EP1766393A4 (de) * | 2004-05-07 | 2008-06-18 | Beckman Coulter Inc | Mhc-brückensystem zum nachweis der ctl-vermittelten lyse antigenpräsentierender zellen |
| EP1765988B1 (de) | 2004-05-27 | 2017-09-20 | The Trustees of The University of Pennsylvania | Neue künstliches antigen präsentierende zellen und verwendungen dafür |
| EP1781313A4 (de) * | 2004-06-17 | 2009-08-26 | Beckman Coulter Inc | Mycobacterium tuberculosis epitope und anwendungsverfahren dafür |
| EP1712615A1 (de) * | 2005-04-15 | 2006-10-18 | Txcell | In vitro Herstellung einer Zellpopulation mittels Nährzellen |
| RU2596491C2 (ru) | 2005-06-08 | 2016-09-10 | Дана-Фарбер Кэнсер Инститьют | Способы и композиции для лечения персистирующих инфекций |
| US20100080792A1 (en) * | 2005-06-16 | 2010-04-01 | Dorothee Herlyn | Method for Identifying a MHC Class II-Dependent Tumor-Associated T Helper Cell Antigen |
| AU2006328945B2 (en) | 2005-12-21 | 2011-06-30 | Sentoclone International Ab | Method for treating malignant melanoma |
| WO2007071389A1 (en) | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Method for treating disseminated cancer |
| WO2007071410A1 (en) | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Method for treating urinary bladder cancer |
| WO2007071388A1 (en) | 2005-12-21 | 2007-06-28 | Sentoclone Ab | Improved method for expansion of tumour-reactive t-lymphocytes for immunotherapy of patients with cancer |
| RU2447900C2 (ru) | 2006-03-01 | 2012-04-20 | Янссен Фармацевтика Н.В. | Лечение рака, комбинирующее лимфоистощающее вещество с цтл и цитокинами |
| BRPI0720342A2 (pt) * | 2006-10-04 | 2018-09-18 | Janssen Pharmaceutica N.V. | preparado de células apresentadoras de antígenos artificiais e seu uso em terapias celulares. |
| JP5623747B2 (ja) * | 2006-12-27 | 2014-11-12 | エモリー ユニバーシティ | 感染症および腫瘍を処置するための組成物および方法 |
| US20110070154A1 (en) * | 2008-08-13 | 2011-03-24 | Hyde Roderick A | Artificial cells |
| WO2010063011A2 (en) | 2008-11-28 | 2010-06-03 | Emory University | Methods for the treatment of infections and tumors |
| US8075895B2 (en) | 2009-09-22 | 2011-12-13 | Janssen Pharmaceutica N.V. | Identification of antigenic peptides from multiple myeloma cells |
| EP2404618A1 (de) | 2010-07-07 | 2012-01-11 | Stichting Katholieke Universiteit meer in het bijzonder Radboud Universiteit Nijmegen | Immunomodulatorische Protein-Konstrukte mit einem helikalen Polymer-Rückgrat |
| WO2012017678A1 (ja) * | 2010-08-06 | 2012-02-09 | 株式会社ケーナインラボ | 免疫機能の強化剤 |
| US9233156B2 (en) | 2011-05-03 | 2016-01-12 | Immunovative Therapies Ltd. | Induction of IL-12 using immunotherapy |
| CA2838041C (en) | 2011-05-03 | 2018-09-25 | Immunovative Therapies, Ltd. | Methods for handling biological drugs containing living cells |
| WO2013163171A1 (en) | 2012-04-24 | 2013-10-31 | Kaufman Dan S | Method for developing natural killer cells from stem cells |
| ES2828982T3 (es) | 2013-05-14 | 2021-05-28 | Univ Texas | Aplicación humana de células t de receptor de antígeno quimérico (car) diseñadas |
| CA2934075C (en) | 2013-12-16 | 2023-10-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cancer immunotherapy by delivering class ii mhc antigens using a vlp-replicon |
| CN113234757B (zh) | 2014-02-14 | 2024-10-29 | 得克萨斯州大学系统董事会 | 嵌合抗原受体及制备方法 |
| WO2015148960A1 (en) | 2014-03-28 | 2015-10-01 | The Board Of Regents Of The University Of Oklahoma | Compositions comprising soluble hla/m. tuberculosis-specific ligand complexes and methods of production and use thereof |
| EP3134437A1 (de) | 2014-04-23 | 2017-03-01 | Board of Regents, The University of Texas System | Chimäre antigenrezeptoren (car) zur verwendung in der therapie und verfahren zur herstellung davon |
| KR20160145186A (ko) | 2014-04-24 | 2016-12-19 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용 |
| CA2964785A1 (en) | 2014-11-05 | 2016-05-12 | Board Of Regents, The University Of Texas System | Gene modified immune effector cells and engineered cells for expansion of immune effector cells |
| US10570186B2 (en) | 2014-11-05 | 2020-02-25 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (CAR) to selectively target protein complexes |
| FR3031519B1 (fr) | 2015-01-14 | 2016-12-30 | Arkema France | Composition a base de terpolymere electroactif |
| DK3271382T3 (da) * | 2015-03-16 | 2020-05-04 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek |
| WO2017075147A1 (en) | 2015-10-27 | 2017-05-04 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor molecules and uses thereof |
| JP7591342B2 (ja) | 2016-06-08 | 2024-11-28 | プレシゲン,インコーポレイテッド | Cd33特異的キメラ抗原受容体 |
| KR20230107408A (ko) | 2016-07-29 | 2023-07-14 | 주노 쎄러퓨티크스 인코퍼레이티드 | 항-cd19 항체에 대한 항-이디오타입 항체 |
| US11883430B2 (en) | 2016-11-09 | 2024-01-30 | Musc Foundation For Research Development | CD38-NAD+ regulated metabolic axis in anti-tumor immunotherapy |
| JP7288401B2 (ja) | 2017-01-10 | 2023-06-07 | プレシゲン,インコーポレイテッド | 新規の遺伝子スイッチ発現系を介したポリペプチドの発現のモジュレーション |
| US11285196B2 (en) | 2017-03-13 | 2022-03-29 | Eslam Abbas Baseuny | Multivalent biologic constructs for inducing a therapeutic modulation of cellular response and uses thereof |
| IL269716B2 (en) | 2017-04-18 | 2025-07-01 | Fujifilm Cellular Dynamics Inc | Antigen-specific immune effector cells |
| JP7262403B2 (ja) | 2017-06-07 | 2023-04-21 | プレシゲン,インコーポレイテッド | 新規の細胞タグの発現 |
| KR102823603B1 (ko) | 2017-10-12 | 2025-06-23 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 면역요법을 위한 t 세포 수용체 |
| CN111918661A (zh) | 2018-02-21 | 2020-11-10 | 得克萨斯大学体系董事会 | 用于活化和扩增自然杀伤细胞的方法及其用途 |
| EA202191463A1 (ru) | 2018-11-28 | 2021-10-13 | Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем | Мультиплексное редактирование генома иммунных клеток для повышения функциональности и устойчивости к подавляющей среде |
| MX2021006393A (es) | 2018-11-29 | 2021-10-13 | Univ Texas | Metodos para expansion ex vivo de celulas exterminadoras naturales y uso de las mismas. |
| JP2023500671A (ja) | 2019-11-06 | 2023-01-10 | ベイラー カレッジ オブ メディスン | がんのt細胞治療のための細胞傷害性エフェクターメモリーt細胞の産生方法 |
| US20230079539A1 (en) | 2020-02-10 | 2023-03-16 | Board Of Regents, The University Of Texas System | Methods for rapid cloning and expression of hla class i cells |
| BR112022024027A2 (pt) | 2020-05-27 | 2023-02-07 | Antion Biosciences Sa | Moléculas adaptadoras para redirecionar células t car para um antígeno de interesse |
| WO2022140759A2 (en) | 2020-12-23 | 2022-06-30 | Janssen Biotech, Inc. | Neoantigen peptide mimics |
| WO2023211972A1 (en) | 2022-04-28 | 2023-11-02 | Medical University Of South Carolina | Chimeric antigen receptor modified regulatory t cells for treating cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5242687A (en) | 1989-03-15 | 1993-09-07 | Tkb Associates Limited Partnership | Method of reducing cellular immune response involving T-cells using CD8-bearing antigen presenting cells |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| JP2683461B2 (ja) * | 1991-07-05 | 1997-11-26 | 住友電気工業株式会社 | 光ファイバケーブルの製造方法 |
| US5583031A (en) * | 1992-02-06 | 1996-12-10 | President And Fellows Of Harvard College | Empty major histocompatibility class II heterodimers |
| US5314813A (en) * | 1992-02-19 | 1994-05-24 | Scripps Research Institute | Drosophila cell lines expressing genes encoding MHC class I antigens and B2-microglobulin and capable of assembling empty complexes and methods of making said cell lines |
| WO1996012009A2 (en) * | 1994-10-14 | 1996-04-25 | Tykocinski Mark L | Methods for engineering antigen-presenting cells |
| DE69737070T2 (de) * | 1996-05-23 | 2007-06-21 | The Scripps Research Institute, La Jolla | Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten |
-
1997
- 1997-05-22 DE DE69737070T patent/DE69737070T2/de not_active Expired - Lifetime
- 1997-05-22 ES ES97927709T patent/ES2278390T3/es not_active Expired - Lifetime
- 1997-05-22 AT AT97927709T patent/ATE347588T1/de active
- 1997-05-22 WO PCT/US1997/008697 patent/WO1997046256A1/en not_active Ceased
- 1997-05-22 CA CA002254975A patent/CA2254975C/en not_active Expired - Lifetime
- 1997-05-22 AU AU32103/97A patent/AU723355B2/en not_active Expired
- 1997-05-22 US US09/194,285 patent/US6355479B1/en not_active Expired - Lifetime
- 1997-05-22 EP EP97927709A patent/EP0969865B1/de not_active Expired - Lifetime
- 1997-05-22 JP JP50061698A patent/JP5006998B2/ja not_active Expired - Lifetime
- 1997-05-22 IL IL126843A patent/IL126843A/en not_active IP Right Cessation
- 1997-05-22 PT PT97927709T patent/PT969865E/pt unknown
- 1997-05-22 DK DK97927709T patent/DK0969865T3/da active
-
2000
- 2000-11-17 US US09/715,891 patent/US7074617B1/en not_active Expired - Fee Related
-
2004
- 2004-04-08 US US10/822,173 patent/US7439335B2/en not_active Expired - Fee Related
- 2004-07-29 US US10/903,213 patent/US7402430B2/en not_active Expired - Fee Related
-
2012
- 2012-03-29 JP JP2012077703A patent/JP2012143245A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012143245A (ja) | 2012-08-02 |
| DE69737070T2 (de) | 2007-06-21 |
| AU3210397A (en) | 1998-01-05 |
| ES2278390T3 (es) | 2007-08-01 |
| EP0969865B1 (de) | 2006-12-06 |
| EP0969865A4 (de) | 2001-07-11 |
| CA2254975A1 (en) | 1997-12-11 |
| JP5006998B2 (ja) | 2012-08-22 |
| IL126843A (en) | 2007-06-17 |
| DK0969865T3 (da) | 2007-03-19 |
| US20050054090A1 (en) | 2005-03-10 |
| EP0969865A1 (de) | 2000-01-12 |
| US7439335B2 (en) | 2008-10-21 |
| JP2000511898A (ja) | 2000-09-12 |
| CA2254975C (en) | 2008-12-16 |
| US20050059144A1 (en) | 2005-03-17 |
| US7074617B1 (en) | 2006-07-11 |
| PT969865E (pt) | 2007-02-28 |
| US7402430B2 (en) | 2008-07-22 |
| WO1997046256A1 (en) | 1997-12-11 |
| US6355479B1 (en) | 2002-03-12 |
| DE69737070D1 (de) | 2007-01-18 |
| AU723355B2 (en) | 2000-08-24 |
| IL126843A0 (en) | 1999-09-22 |
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