DK3271382T3 - Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek - Google Patents

Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek Download PDF

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DK3271382T3
DK3271382T3 DK16713750.4T DK16713750T DK3271382T3 DK 3271382 T3 DK3271382 T3 DK 3271382T3 DK 16713750 T DK16713750 T DK 16713750T DK 3271382 T3 DK3271382 T3 DK 3271382T3
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specific
mhc
immunogenic
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Felix Lorenz
Christian Ellinger
Dolores Schendel
Wolfgang Uckert
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Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh
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DK16713750.4T 2015-03-16 2016-03-15 Fremgangsmåde til detektion af nye immunogene T-celleepitoper og isolering af nye antigenspecifikke T-cellereceptorer ved hjælp af et MHC-cellebibliotek DK3271382T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15159212 2015-03-16
PCT/EP2016/055518 WO2016146618A1 (en) 2015-03-16 2016-03-15 Method of detecting new immunogenic t cell epitopes and isolating new antigen-specific t cell receptors by means of an mhc cell library

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US (2) US11001830B2 (da)
EP (1) EP3271382B1 (da)
JP (1) JP6944876B2 (da)
KR (1) KR102668219B1 (da)
CN (1) CN107636152B (da)
AU (1) AU2016232280B2 (da)
DK (1) DK3271382T3 (da)
ES (1) ES2790725T3 (da)
IL (1) IL254511B (da)
SG (1) SG11201707540QA (da)
WO (1) WO2016146618A1 (da)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877206B2 (en) 2007-03-22 2014-11-04 Pds Biotechnology Corporation Stimulation of an immune response by cationic lipids
CA2721366C (en) 2008-04-17 2017-06-06 Elizabeth Ann Vasievich Stimulation of an immune response by enantiomers of cationic lipids
CN105163753B (zh) 2012-06-15 2018-12-21 Pds生物科技公司 阳离子脂质疫苗组合物和使用方法
CN105101991A (zh) 2012-09-21 2015-11-25 Pds生物科技公司 改进的疫苗组合物和使用方法
WO2017083820A1 (en) 2015-11-13 2017-05-18 Pds Biotechnology Corporation Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
CN108884140B (zh) 2015-12-03 2022-10-25 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
US11293021B1 (en) 2016-06-23 2022-04-05 Inscripta, Inc. Automated cell processing methods, modules, instruments, and systems
CN110139873A (zh) 2016-10-03 2019-08-16 朱诺治疗学股份有限公司 Hpv特异性结合分子
SG11201902988UA (en) 2016-10-05 2019-05-30 Pds Biotechnology Corp Novel hpv16 non hla-restricted t-cell vaccines, compositions and methods of use thereof
WO2018071796A2 (en) * 2016-10-13 2018-04-19 The Johns Hopkins University Compositions and methods for identifying functional anti-tumor t cell responses
CN110023497B (zh) 2016-11-07 2021-07-13 杰诺维有限公司 用于t细胞受体合成和向tcr呈递细胞进行稳定的基因组整合的两部分装置
EP3535387B1 (en) 2016-11-07 2022-01-12 Genovie AB An engineered multi-component system for identification and characterisation of t-cell receptors and t-cell antigens
EP3354658A1 (en) * 2017-01-25 2018-08-01 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Novel t cell receptors and immune therapy using the same for the treatment of cancer and infectious diseases
US10011849B1 (en) 2017-06-23 2018-07-03 Inscripta, Inc. Nucleic acid-guided nucleases
US9982279B1 (en) 2017-06-23 2018-05-29 Inscripta, Inc. Nucleic acid-guided nucleases
MX2019015505A (es) 2017-06-30 2020-07-28 Inscripta Inc Metodos, modulos, instrumentos y sistemas de procesamiento de celulas automatizados.
BR112020006643A2 (pt) * 2017-10-03 2020-09-24 Juno Therapeutics Inc moléculas de ligação específica ao hpv
GB201719169D0 (en) 2017-11-20 2018-01-03 Univ College Cardiff Consultants Ltd Novel T-cell receptor and ligand
CA3084957A1 (en) 2017-12-05 2019-06-13 Pds Biotechnology Corporation Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes
WO2019140278A1 (en) * 2018-01-11 2019-07-18 Fred Hutchinson Cancer Research Center Immunotherapy targeting core binding factor antigens
US20210046114A1 (en) * 2018-01-24 2021-02-18 The Council Of The Queensland Institute Of Medical Research Hpv immunotherapy
AU2019249209A1 (en) 2018-04-05 2020-10-15 Juno Therapeutics, Inc. T cell receptors and engineered cells expressing same
US10376889B1 (en) 2018-04-13 2019-08-13 Inscripta, Inc. Automated cell processing instruments comprising reagent cartridges
WO2019196088A1 (en) * 2018-04-13 2019-10-17 Syz Cell Therapy Co. Methods of obtaining tumor-specific t cell receptors
US10526598B2 (en) 2018-04-24 2020-01-07 Inscripta, Inc. Methods for identifying T-cell receptor antigens
US10508273B2 (en) 2018-04-24 2019-12-17 Inscripta, Inc. Methods for identifying selective binding pairs
US10858761B2 (en) 2018-04-24 2020-12-08 Inscripta, Inc. Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells
EP4431943A3 (en) * 2018-05-11 2024-10-23 Memorial Sloan-Kettering Cancer Center Methods for identifying antigen-specific t cell receptors
WO2019217837A1 (en) 2018-05-11 2019-11-14 Memorial Sloan-Kettering Cancer Center T cell receptors targeting pik3ca mutations and uses thereof
AU2019292919A1 (en) 2018-06-30 2021-03-11 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US11142740B2 (en) 2018-08-14 2021-10-12 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US10532324B1 (en) 2018-08-14 2020-01-14 Inscripta, Inc. Instruments, modules, and methods for improved detection of edited sequences in live cells
US20210301324A1 (en) * 2018-08-24 2021-09-30 Repertoire Genesis Incorporation Method for analyzing functional subunit pair gene of t cell receptor and b cell receptor
US11965154B2 (en) 2018-08-30 2024-04-23 Inscripta, Inc. Detection of nuclease edited sequences in automated modules and instruments
US11214781B2 (en) 2018-10-22 2022-01-04 Inscripta, Inc. Engineered enzyme
AU2019368215B2 (en) 2018-10-22 2023-05-18 Inscripta, Inc. Engineered enzymes
KR102251584B1 (ko) * 2018-11-21 2021-05-14 가톨릭대학교 산학협력단 Ｈｌａ 분자에 제한적인 항원 특이 ｔ 세포 반응 측정 및 예측 방법
CN113631713A (zh) 2019-03-25 2021-11-09 因思科瑞普特公司 酵母中的同时多重基因组编辑
US11001831B2 (en) 2019-03-25 2021-05-11 Inscripta, Inc. Simultaneous multiplex genome editing in yeast
CN110128528B (zh) * 2019-04-28 2020-04-03 天津亨佳生物科技发展有限公司 一种针对egfr l858r基因突变的特异性t细胞受体及其应用
AU2020288623A1 (en) 2019-06-06 2022-01-06 Inscripta, Inc. Curing for recursive nucleic acid-guided cell editing
US10920189B2 (en) 2019-06-21 2021-02-16 Inscripta, Inc. Genome-wide rationally-designed mutations leading to enhanced lysine production in E. coli
US10927385B2 (en) 2019-06-25 2021-02-23 Inscripta, Inc. Increased nucleic-acid guided cell editing in yeast
EP3786178A1 (en) 2019-08-30 2021-03-03 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Tcr constructs specific for ebv-derived antigens
US11203762B2 (en) 2019-11-19 2021-12-21 Inscripta, Inc. Methods for increasing observed editing in bacteria
KR102776469B1 (ko) 2019-12-10 2025-03-05 인스크립타 인코포레이티드 신규 mad 뉴클레아제
US10704033B1 (en) 2019-12-13 2020-07-07 Inscripta, Inc. Nucleic acid-guided nucleases
EP4069851A4 (en) 2019-12-18 2023-11-22 Inscripta, Inc. Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells
CN111180071B (zh) * 2019-12-31 2022-02-08 四川大学 高危型hpv型别和宫颈癌前病变阶段关系的计算方法及装置
US10689669B1 (en) 2020-01-11 2020-06-23 Inscripta, Inc. Automated multi-module cell processing methods, instruments, and systems
AU2021213705A1 (en) 2020-01-27 2022-06-16 Inscripta, Inc. Electroporation modules and instrumentation
CN111429965B (zh) * 2020-03-19 2023-04-07 西安交通大学 一种基于多连体特征的t细胞受体对应表位预测方法
EP4125949A4 (en) * 2020-03-23 2024-05-22 The Council of the Queensland Institute of Medical Research COMPOSITIONS AND METHODS FOR TARGETING HPV-INFECTED CELLS
EP4139486A4 (en) 2020-04-24 2024-10-16 The Board of Trustees of the Leland Stanford Junior University Novel t-cell specificities and uses thereof
US20210332388A1 (en) 2020-04-24 2021-10-28 Inscripta, Inc. Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells
US11787841B2 (en) 2020-05-19 2023-10-17 Inscripta, Inc. Rationally-designed mutations to the thrA gene for enhanced lysine production in E. coli
WO2021237932A1 (zh) 2020-05-23 2021-12-02 湖南源品细胞生物科技有限公司 Tcr富集克隆型及其获取方法与应用
CN111574615A (zh) * 2020-05-23 2020-08-25 湖南源品细胞生物科技有限公司 一种tcr富集克隆型及其获取方法与应用
WO2021243695A1 (en) * 2020-06-05 2021-12-09 Guangdong Tcrcure Biopharma Technology Co., Ltd. Tcr-t cell therapy targeting epstein-barr virus
CN111647070B (zh) * 2020-06-17 2022-06-03 深圳豪石生物科技有限公司 T细胞受体或其抗原结合片段及应用
WO2022060749A1 (en) 2020-09-15 2022-03-24 Inscripta, Inc. Crispr editing to embed nucleic acid landing pads into genomes of live cells
WO2022086185A1 (ko) * 2020-10-20 2022-04-28 연세대학교 산학협력단 단일 세포 분석법을 이용한 tcr-항원의 특이성을 확인하는 방법
WO2022087380A1 (en) * 2020-10-23 2022-04-28 Rootpath Genomics, Inc. Compositions and methods for t-cell receptor identification
US11512297B2 (en) 2020-11-09 2022-11-29 Inscripta, Inc. Affinity tag for recombination protein recruitment
CN113999815A (zh) * 2020-12-08 2022-02-01 深圳市人民医院 靶向hpv16相关宫颈癌的tcr-t细胞建立方法
CN112501269B (zh) * 2020-12-15 2022-02-18 清华大学 一种快速鉴定高亲和力tcr抗原交叉反应活性的方法
US20240060042A1 (en) * 2020-12-22 2024-02-22 National University Of Singapore Artificial antigen-presenting cell
AU2021415461A1 (en) 2021-01-04 2023-08-17 Inscripta, Inc. Mad nucleases
US20240376451A1 (en) 2021-01-07 2024-11-14 Inscripta, Inc. Mad nucleases
US11884924B2 (en) 2021-02-16 2024-01-30 Inscripta, Inc. Dual strand nucleic acid-guided nickase editing
EP4091627A1 (en) 2021-05-21 2022-11-23 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Tcr constructs specific for magea4-derived epitopes
CN115995267B (zh) * 2021-10-19 2025-08-15 北京大学 一种基于单细胞多组学测序分析t淋巴细胞tcr特点的方法
CN116262779A (zh) * 2021-12-14 2023-06-16 深圳先进技术研究院 一种单细胞筛选鉴定人乳头瘤病毒特异性tcr的方法
US20250152628A1 (en) * 2022-01-27 2025-05-15 Shanghai General Hospital Tcr targeting cytomegalovirus antigen, t cell expressing tcr, and application
CN116199766B (zh) * 2022-06-22 2024-03-12 清华大学 筛选tcr的方法及其分离的tcr
EP4299734A1 (en) * 2022-07-01 2024-01-03 ETH Zurich Cell line for discovering tcr antigens and uses thereof
EP4328239A1 (en) 2022-08-26 2024-02-28 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Immunotherapeutics based on magea1-derived epitopes
WO2024131372A1 (zh) * 2022-12-23 2024-06-27 上海市第一人民医院 靶向巨细胞病毒pp65的TCR和表达其的T细胞及应用
WO2024139780A1 (zh) * 2022-12-26 2024-07-04 上海市第一人民医院 靶向巨细胞病毒pp65的T细胞受体和表达其的T细胞及应用
EP4397680A1 (en) * 2022-12-29 2024-07-10 Keshihua (Nanjing) Biotechnology Co., Ltd Tcr, polypeptide, expression vector, host cell, pharmaceutical composition and method for obtaining tcr
WO2025006795A1 (en) * 2023-06-30 2025-01-02 Board Of Regents, The University Of Texas System Tsyn-seq: a t cell synapse-based tumor antigen identification platform

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE347588T1 (de) * 1996-05-23 2006-12-15 Scripps Research Inst Systeme zur präsentation von mhc-antigenen der klasse ii und verfahren zur aktivierung von cd4?+-t-lymphozyten
KR100873157B1 (ko) 1999-05-06 2008-12-10 웨이크 포리스트 유니버시티 면역 반응을 유발하는 항원을 동정하기 위한 조성물과 방법
US7026443B1 (en) * 1999-12-10 2006-04-11 Epimmune Inc. Inducing cellular immune responses to human Papillomavirus using peptide and nucleic acid compositions
CA2484941A1 (en) 2002-07-24 2004-02-05 Intercell Ag Antigens encoded by alternative reading frame from pathogenic viruses
EP2402026A3 (en) 2002-09-13 2012-04-18 Intercell AG Method for isolating hepatitis C virus peptides
PL1576967T3 (pl) * 2004-03-18 2008-03-31 Pasteur Institut Rekombinowane białko niosące epitopy ludzkiego wirusa brodawczaka wstawione w białko cyklazy adenylanowej lub jego fragment oraz jego zastosowania terapeutyczne
WO2007017201A1 (en) 2005-08-05 2007-02-15 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt Gmbh Generation of antigen specific t cells
PL1760089T3 (pl) * 2005-09-05 2010-03-31 Immatics Biotechnologies Gmbh Peptydy towarzyszące nowotworom, wiążące się z cząsteczkami klasy I i II antygenów ludzkich leukocytów (HLA) i związana z nimi szczepionka przeciwnowotworowa
EP1762575A1 (en) * 2005-09-12 2007-03-14 Ganymed Pharmaceuticals AG Identification of tumor-associated antigens for diagnosis and therapy
JP5833443B2 (ja) * 2009-08-29 2015-12-16 株式会社バイオメッドコア 抗原特異的ｔ細胞誘導能測定法
ES2635335T3 (es) * 2010-09-20 2017-10-03 Biontech Cell & Gene Therapies Gmbh Receptores de células T específicos de antígeno y epítopos de células T
WO2012044999A2 (en) * 2010-10-01 2012-04-05 Ludwig Institute For Cancer Research Ltd. Reversible protein multimers, methods for their production and use
CA2976580A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing

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US20180073013A1 (en) 2018-03-15
IL254511B (en) 2021-12-01
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CA2979493A1 (en) 2016-09-22
JP6944876B2 (ja) 2021-10-06
KR102668219B1 (ko) 2024-05-28
US12215313B2 (en) 2025-02-04
EP3271382B1 (en) 2020-02-12
AU2016232280A1 (en) 2017-10-12
EP3271382A1 (en) 2018-01-24
US11001830B2 (en) 2021-05-11
HK1248736A1 (en) 2018-10-19
WO2016146618A1 (en) 2016-09-22
SG11201707540QA (en) 2017-10-30
JP2018509911A (ja) 2018-04-12
IL254511A0 (en) 2017-11-30
US20210261947A1 (en) 2021-08-26
CN107636152A (zh) 2018-01-26
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AU2016232280B2 (en) 2018-05-31
ES2790725T3 (es) 2020-10-29

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