ATE347616T1 - Ribonukleinsäurederivate - Google Patents

Ribonukleinsäurederivate

Info

Publication number
ATE347616T1
ATE347616T1 AT00929665T AT00929665T ATE347616T1 AT E347616 T1 ATE347616 T1 AT E347616T1 AT 00929665 T AT00929665 T AT 00929665T AT 00929665 T AT00929665 T AT 00929665T AT E347616 T1 ATE347616 T1 AT E347616T1
Authority
AT
Austria
Prior art keywords
substituent
sample
ribonuclic
acid derivatives
rna
Prior art date
Application number
AT00929665T
Other languages
English (en)
Inventor
Andrew Simon Goldsborough
Original Assignee
Cyclops Genome Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9910156.0A external-priority patent/GB9910156D0/en
Priority claimed from GBGB9910158.6A external-priority patent/GB9910158D0/en
Priority claimed from GBGB9910157.8A external-priority patent/GB9910157D0/en
Priority claimed from GBGB9910154.5A external-priority patent/GB9910154D0/en
Application filed by Cyclops Genome Sciences Ltd filed Critical Cyclops Genome Sciences Ltd
Application granted granted Critical
Publication of ATE347616T1 publication Critical patent/ATE347616T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Turbine Rotor Nozzle Sealing (AREA)
  • Window Of Vehicle (AREA)
  • Materials For Medical Uses (AREA)
AT00929665T 1999-04-30 2000-05-02 Ribonukleinsäurederivate ATE347616T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9910156.0A GB9910156D0 (en) 1999-04-30 1999-04-30 Polynucleotides
GBGB9910158.6A GB9910158D0 (en) 1999-04-30 1999-04-30 Isolation of nucleic acid
GBGB9910157.8A GB9910157D0 (en) 1999-04-30 1999-04-30 Polynucleotides
GBGB9910154.5A GB9910154D0 (en) 1999-04-30 1999-04-30 Polynucleotides

Publications (1)

Publication Number Publication Date
ATE347616T1 true ATE347616T1 (de) 2006-12-15

Family

ID=27451902

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00929665T ATE347616T1 (de) 1999-04-30 2000-05-02 Ribonukleinsäurederivate
AT00929666T ATE421583T1 (de) 1999-04-30 2000-05-02 Isolierung von nukleinsäuren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00929666T ATE421583T1 (de) 1999-04-30 2000-05-02 Isolierung von nukleinsäuren

Country Status (6)

Country Link
US (4) US6794140B1 (de)
EP (2) EP1177281B1 (de)
AT (2) ATE347616T1 (de)
AU (4) AU4589000A (de)
DE (2) DE60032235T2 (de)
WO (4) WO2000075306A2 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569342B2 (en) 1997-12-10 2009-08-04 Sierra Molecular Corp. Removal of molecular assay interferences
EP1177281B1 (de) 1999-04-30 2009-01-21 Cyclops Genome Sciences Limited Isolierung von nukleinsäuren
US6677120B2 (en) * 2001-03-30 2004-01-13 Isis Pharmaceuticals, Inc. Building blocks for the solution phase synthesis of oligonucleotides
US20060009409A1 (en) * 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
ATE556714T1 (de) 2002-02-01 2012-05-15 Life Technologies Corp Doppelsträngige oligonukleotide
US20040005568A1 (en) * 2002-07-03 2004-01-08 Stojanovic Milan N. Movement of multi-enzymatic nanoassemblies on recognition landscapes
US20040072226A1 (en) * 2002-07-03 2004-04-15 Stojanovic Milan N. Movement of multi-enzymatic nanoassemblies on recognition landscapes
GB0217963D0 (en) * 2002-08-02 2002-09-11 Cyclops Genome Sciences Ltd Purification of nucleic acids
DE10315581B4 (de) * 2003-04-05 2007-06-28 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Verfahren zur Qualitätsbestimmung von RNA-Proben
GB0317199D0 (en) 2003-07-23 2003-08-27 Cyclops Genome Sciences Ltd Clean-up beads
JP2006527993A (ja) * 2003-07-23 2006-12-14 シクロプス ゲノム サイエンス リミテッド クリーンアップビーズ
DE10344819B4 (de) * 2003-09-26 2017-06-29 Sartorius Stedim Biotech Gmbh Adsorptionsmembranen, Verfahren zur Herstellung derselben und Vorrichtungen, welche die Adsorptionsmembranen umfassen
US20060105372A1 (en) 2004-11-05 2006-05-18 Bair Robert J Compositions and methods for purifying nucleic acids from stabilization reagents
US20090075342A1 (en) * 2005-04-26 2009-03-19 Sharon Cload Metabolic profile directed aptamer medicinal chemistry
WO2006138145A1 (en) 2005-06-14 2006-12-28 Northwestern University Nucleic acid functionalized nanoparticles for therapeutic applications
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
WO2007145940A2 (en) * 2006-06-05 2007-12-21 The University Of North Carolina At Chapel Hill High-throughput rna structure analysis
EP2121987B1 (de) 2007-02-09 2012-06-13 Northwestern University Partikel zur erkennung intrazellulärer ziele
JP2010523078A (ja) * 2007-03-30 2010-07-15 キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング リボース環を含む修飾ポリヌクレオチド
EP2160464B1 (de) 2007-05-30 2014-05-21 Northwestern University Nukleinsäure-funktionalisierte nanopartikel für therapeutische anwendungen
US9551033B2 (en) 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
CN102014919B (zh) 2008-03-03 2015-02-25 托斯克公司 减少毒性的甲氨蝶呤佐剂及其使用方法
US20110053226A1 (en) * 2008-06-13 2011-03-03 Riboxx Gmbh Method for enzymatic synthesis of chemically modified rna
EP2365803B1 (de) 2008-11-24 2017-11-01 Northwestern University Polyvalente rna-nanoteilchen-zusammensetzungen
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
EP2272976A1 (de) * 2009-07-06 2011-01-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur Differenzierung von Polynucleotid-Strängen
WO2011041485A1 (en) 2009-09-30 2011-04-07 Gene Security Network, Inc. Methods for non-invasive prenatal ploidy calling
CA2779099C (en) 2009-10-30 2021-08-10 Northwestern University Templated nanoconjugates
EP2333102A1 (de) * 2009-12-14 2011-06-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur Identifizierung von RNA-Liganden
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
WO2011146632A1 (en) 2010-05-18 2011-11-24 Gene Security Network Inc. Methods for non-invasive prenatal ploidy calling
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
EP2388324A1 (de) 2010-05-20 2011-11-23 Siemens Healthcare Diagnostics Inc. Kontrollmaterial für Nukleinsäureteste
FR2968302B1 (fr) 2010-12-06 2012-11-30 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
CN103608466B (zh) 2010-12-22 2020-09-18 纳特拉公司 非侵入性产前亲子鉴定方法
RU2671980C2 (ru) 2011-02-09 2018-11-08 Натера, Инк. Способы неинвазивного пренатального установления плоидности
IN2014CN02574A (de) * 2011-09-07 2015-06-26 Chem Inc X
AU2012308302A1 (en) 2011-09-14 2014-03-20 Northwestern University Nanoconjugates able to cross the blood-brain barrier
US9040679B2 (en) 2012-04-30 2015-05-26 General Electric Company Methods and compositions for extraction and storage of nucleic acids
US9480966B2 (en) 2012-04-30 2016-11-01 General Electric Company Substrates and methods for collection, stabilization and elution of biomolecules
US9044738B2 (en) 2012-04-30 2015-06-02 General Electric Company Methods and compositions for extraction and storage of nucleic acids
US9040675B2 (en) 2012-04-30 2015-05-26 General Electric Company Formulations for nucleic acid stabilization on solid substrates
SG10201907347YA (en) 2012-07-13 2019-09-27 X Chem Inc Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
FR2994184B1 (fr) 2012-08-02 2017-12-08 Biomerieux Sa Procedes de fonctionalisation et reactifs utilises dans de tels procedes utilisant un anhydride aza-isatoique ou un de ses derives, molecules biologiques ainsi traitees et kits
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
WO2014093688A1 (en) * 2012-12-12 2014-06-19 1Massachusetts Institute Of Technology Compositions and methods for functional nucleic acid delivery
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
JP6612220B2 (ja) 2013-10-07 2019-11-27 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 核酸における化学修飾の検出
CA2945962C (en) 2014-04-21 2023-08-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
US9850269B2 (en) 2014-04-25 2017-12-26 Translate Bio, Inc. Methods for purification of messenger RNA
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
CA2965500A1 (en) * 2014-10-24 2016-04-28 Abbott Molecular Inc. Enrichment of small nucleic acids
US11213593B2 (en) 2014-11-21 2022-01-04 Northwestern University Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
WO2016180430A1 (en) 2015-05-08 2016-11-17 Curevac Ag Method for producing rna
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
EP4660315A3 (de) 2015-05-29 2026-03-18 CureVac Manufacturing GmbH Verfahren zur herstellung und reinigung von rna mit mindestens einem schritt der tangentialen strömungsfiltration
KR102566292B1 (ko) 2015-06-05 2023-08-10 더블유.알. 그레이스 앤드 캄파니-콘. 흡착성 바이오프로세싱 정화제와 이의 제조 및 사용 방법
ES2818569T3 (es) 2015-09-09 2021-04-13 Drawbridge Health Inc Métodos para la recopilación, estabilización y conservación de muestras
US10214739B2 (en) * 2015-10-30 2019-02-26 Axagarius Gmbh & Co. Kg RNA binding solution
RU2760913C2 (ru) 2016-04-15 2021-12-01 Натера, Инк. Способы выявления рака легкого
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
EP3535274A4 (de) * 2016-11-07 2020-07-29 Nanosur LLC Post-transkriptionell chemisch modifizierte doppelsträngige rna
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
GB2590814B (en) 2017-01-10 2021-11-03 Drawbridge Health Inc Devices, systems, and methods for sample collection
WO2018156418A1 (en) * 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
WO2018231090A1 (ru) * 2017-06-16 2018-12-20 Борис Славинович ФАРБЕР Комбинаторные производные олигонуклеотидов рнк
WO2019109046A1 (en) 2017-11-30 2019-06-06 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
US12084720B2 (en) 2017-12-14 2024-09-10 Natera, Inc. Assessing graft suitability for transplantation
US12398389B2 (en) 2018-02-15 2025-08-26 Natera, Inc. Methods for isolating nucleic acids with size selection
FR3078977B1 (fr) * 2018-03-16 2023-03-17 Biomerieux Sa Procede d'extraction d'acides nucleiques
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
US12305235B2 (en) 2019-06-06 2025-05-20 Natera, Inc. Methods for detecting immune cell DNA and monitoring immune system
US11446303B2 (en) 2019-06-21 2022-09-20 Tosk, Inc. Uridine phosphorylase (UPase) inhibitors for treatment of liver conditions
EP4396348A2 (de) * 2021-08-31 2024-07-10 Nanosur LLC Modifizierte dsrna-zusammensetzungen mit hohem molekulargewicht
WO2023101963A2 (en) * 2021-11-30 2023-06-08 Northwestern University Compositions for inhibiting dipeptide repeat protein-ribosomal rna interaction and uses thereof
WO2024167836A1 (en) * 2023-02-06 2024-08-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and modifications for reducing innate immune responses to rna
US20250270299A1 (en) * 2024-01-31 2025-08-28 Helix Nanotechnologies Inc Methods of using compositions comprising sbi domains

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4588718A (en) * 1984-03-28 1986-05-13 The Upjohn Company Carboxy containing ester prodrugs of corticosteroids
US5681726A (en) * 1988-09-19 1997-10-28 Stratagene Method of double stranded DNA synthesis
US5859221A (en) * 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
WO1992003568A1 (en) * 1990-08-13 1992-03-05 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5707796A (en) 1990-06-11 1998-01-13 Nexstar Pharmaceuticals, Inc. Method for selecting nucleic acids on the basis of structure
US5660985A (en) * 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5426180A (en) * 1991-03-27 1995-06-20 Research Corporation Technologies, Inc. Methods of making single-stranded circular oligonucleotides
US6235887B1 (en) * 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
US5496546A (en) 1993-02-24 1996-03-05 Jui H. Wang Compositions and methods of application of reactive antiviral polyadenylic acid derivatives
ATE174600T1 (de) * 1993-10-27 1999-01-15 Ribozyme Pharm Inc 2'-amido-und 2'-peptido-modifizierte oligonukleotide
US5700642A (en) * 1995-05-22 1997-12-23 Sri International Oligonucleotide sizing using immobilized cleavable primers
AU3891097A (en) * 1996-07-24 1998-02-10 Michelle M. Hanna Base-protected nucleotide analogs with protected thiol groups
US5849902A (en) * 1996-09-26 1998-12-15 Oligos Etc. Inc. Three component chimeric antisense oligonucleotides
US20030083272A1 (en) * 1997-09-19 2003-05-01 Lahive & Cockfield, Llp Sense mrna therapy
DE19801153A1 (de) 1998-01-14 1999-07-15 Jenne Andreas Verfahren zur Selektion von Ribozymen, die Ribonucleinsäuren in trans an 2'-OH-Gruppen kovalent modifizieren können und durch dieses Verfahren erhältliche Ribozyme
CA2330574A1 (en) * 1998-04-29 1999-11-04 Ribozyme Pharmaceuticals, Inc. Nucleoside triphosphates and their incorporation into ribozymes
AU5728999A (en) 1998-07-28 2000-02-21 Micromet Ag Heterominibodies
EP1177281B1 (de) 1999-04-30 2009-01-21 Cyclops Genome Sciences Limited Isolierung von nukleinsäuren
US6720144B1 (en) * 2001-06-21 2004-04-13 Quest Diagnostics Detection of clonal T-cell receptor-γ gene rearrangement by PCR/temporal temperature gradient gel electrophoresis (TTGE)
GB0217963D0 (en) 2002-08-02 2002-09-11 Cyclops Genome Sciences Ltd Purification of nucleic acids
JP2006527993A (ja) 2003-07-23 2006-12-14 シクロプス ゲノム サイエンス リミテッド クリーンアップビーズ

Also Published As

Publication number Publication date
WO2000066605A3 (en) 2001-04-26
US20050272679A1 (en) 2005-12-08
EP1196631B1 (de) 2006-12-06
WO2000066605A2 (en) 2000-11-09
DE60032235T2 (de) 2007-11-15
US20050074753A1 (en) 2005-04-07
EP1196631A1 (de) 2002-04-17
US7244568B2 (en) 2007-07-17
AU4767300A (en) 2001-12-17
US6867290B2 (en) 2005-03-15
US20030039985A1 (en) 2003-02-27
US6794140B1 (en) 2004-09-21
ATE421583T1 (de) 2009-02-15
DE60032235D1 (de) 2007-01-18
AU4588000A (en) 2000-12-28
AU4589000A (en) 2000-11-17
WO2001094626A1 (en) 2001-12-13
WO2000075306A3 (en) 2001-05-17
DE60041442D1 (de) 2009-03-12
EP1177281A2 (de) 2002-02-06
AU4767400A (en) 2000-12-28
WO2000075302A3 (en) 2001-04-26
WO2000075306A2 (en) 2000-12-14
EP1177281B1 (de) 2009-01-21
WO2000075302A2 (en) 2000-12-14

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