ATE348147T1 - Serumfreies medium - Google Patents

Serumfreies medium

Info

Publication number: ATE348147T1
Authority: AT; Austria
Prior art keywords: free medium; serum; medium; thrombin; insulin
Prior art date: 1992-08-24

Application number

AT00117026T

Other languages

English (en)

Inventor

Dina Fischer

Moshe Bracha

Original Assignee

Interpharm Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-24

Filing date

1993-08-24

Publication date

2007-01-15

1993-08-24 Application filed by Interpharm Lab Ltd filed Critical Interpharm Lab Ltd

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE348147T1 publication Critical patent/ATE348147T1/de

Links

239000012679 serum free medium Substances 0.000 title abstract 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
239000002609 medium Substances 0.000 abstract 2
102000004877 Insulin Human genes 0.000 abstract 1
108090001061 Insulin Proteins 0.000 abstract 1
108090000190 Thrombin Proteins 0.000 abstract 1
230000003833 cell viability Effects 0.000 abstract 1
229940125396 insulin Drugs 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
239000011814 protection agent Substances 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Toxicology (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Immunology (AREA)
Microbiology (AREA)
General Engineering & Computer Science (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT00117026T 1992-08-24 1993-08-24 Serumfreies medium ATE348147T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL10292992A IL102929A (en)	1992-08-24	1992-08-24	Serum-free medium for mammalian cells

Publications (1)

Publication Number	Publication Date
ATE348147T1 true ATE348147T1 (de)	2007-01-15

Family

ID=11063947

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT93113502T ATE226632T1 (de)	1992-08-24	1993-08-24	Serumfreies medium für säugetierzellen
AT00117026T ATE348147T1 (de)	1992-08-24	1993-08-24	Serumfreies medium

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT93113502T ATE226632T1 (de)	1992-08-24	1993-08-24	Serumfreies medium für säugetierzellen

Country Status (13)

Country	Link
US (1)	US5641647A (de)
EP (2)	EP0584788B1 (de)
JP (1)	JP4124493B2 (de)
AT (2)	ATE226632T1 (de)
AU (1)	AU670957B2 (de)
CA (1)	CA2104643C (de)
CY (1)	CY2572B1 (de)
DE (2)	DE69332430T2 (de)
DK (2)	DK0584788T3 (de)
ES (2)	ES2274756T3 (de)
IL (1)	IL102929A (de)
PT (2)	PT584788E (de)
ZA (1)	ZA936192B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9303601D0 (sv) *	1993-11-01	1993-11-01	Kabi Pharmacia Ab	Improved cell cultivation method and medium
AU4330597A (en) *	1996-08-30	1998-03-19	Life Technologies, Inc.	Serum-free mammalian cell culture medium, and uses thereof
US6692961B1 (en) *	1996-10-11	2004-02-17	Invitrogen Corporation	Defined systems for epithelial cell culture and use thereof
WO1998026084A1 (en) *	1996-12-09	1998-06-18	Wolfgang Andreas Renner	Expression of active interferon beta 1 using recombinant rna replicons
SE9700983D0 (sv) *	1997-03-18	1997-03-18	Ascendia Ab	Stimulering, odling och preservation av pankreas- och andra celler
EP2295540A1 (de) *	1998-11-19	2011-03-16	Organogenesis, Inc.	Biotechnisch konstruiertes Gewebe und Verfahren zu dessen Produktion und Benutzung
UA74557C2 (en)	1999-09-03	2006-01-16	Applied Research Systems	A method for producing a heterologous secreted protein from chinese hamster ovaries cells grown on microcarriers
EP1754784A3 (de) *	1999-09-03	2007-02-28	Applied Research Systems ARS Holding N.V.	Verfahren zur Produktion eines heterologen sezernierten Proteins aus auf Mikroträgern gewachsenen Cho-Zellen
US7445924B2 (en)	2000-11-23	2008-11-04	Bavarian Nordic A/S	Modified Vaccinia Ankara virus variant and cultivation method
US6506576B2 (en)	2001-03-14	2003-01-14	Board Of Trustees Of The University Of Arkansas	Serum-and steroid-free culture media for cerebellar granule neurons
ES2305514T5 (es)	2002-09-05	2019-06-14	Bavarian Nordic As	Método para la amplificación de un poxvirus en condiciones exentas de suero
WO2007103447A2 (en) *	2006-03-06	2007-09-13	Humagene, Inc.	A method for the preparation of recombinant human thrombin
US8415094B2 (en) *	2007-12-21	2013-04-09	Jaffar Ali bin M. Abdullah	Protein-free gamete and embryo handling and culture media products
CN103898123B (zh) *	2012-12-28	2019-03-15	北京韩美药品有限公司	重组人IFN-β-1a及其生产和纯化方法
AU2014225272B2 (en)	2013-03-08	2015-10-22	Neuclone Biologics Pty Ltd	A cell expression system
AU2014225273A1 (en) *	2013-03-08	2015-09-24	Neuclone Biologics Pty Ltd	Cell culture media composition and methods of producing thereof
CN103484426B (zh) *	2013-10-15	2014-11-26	齐鲁制药有限公司	一种无动物源的低蛋白培养基
US9534026B2 (en)	2013-10-31	2017-01-03	China National Research Institute Of Food & Fermentation Industries	Corn active peptide additive for cell culture medium
CN104593318B (zh) *	2013-10-31	2018-05-04	中国食品发酵工业研究院	一种用于细胞培养基的玉米活性肽添加剂
JP7521738B2 (ja) *	2020-05-18	2024-07-24	キヤノン株式会社	目的細胞の生産方法、目的細胞による生産物の生産方法、および無血清培地

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU621972B2 (en) *	1988-12-14	1992-03-26	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Cell culture medium for human liver epithelial cell line
CA2010424A1 (en) *	1989-02-27	1990-08-27	Walter F. Prouty	Tissue culture method
GB9022545D0 (en) *	1990-10-17	1990-11-28	Wellcome Found	Culture medium
US5256766A (en) *	1991-02-19	1993-10-26	The Regents Of The University Of California	Recombinant thrombin receptor and related pharmaceuticals

1992
- 1992-08-24 IL IL10292992A patent/IL102929A/en not_active IP Right Cessation
1993
- 1993-08-23 CA CA 2104643 patent/CA2104643C/en not_active Expired - Lifetime
- 1993-08-23 JP JP20805393A patent/JP4124493B2/ja not_active Expired - Lifetime
- 1993-08-24 PT PT93113502T patent/PT584788E/pt unknown
- 1993-08-24 DK DK93113502T patent/DK0584788T3/da active
- 1993-08-24 AT AT93113502T patent/ATE226632T1/de active
- 1993-08-24 AT AT00117026T patent/ATE348147T1/de active
- 1993-08-24 US US08/111,428 patent/US5641647A/en not_active Expired - Lifetime
- 1993-08-24 ES ES00117026T patent/ES2274756T3/es not_active Expired - Lifetime
- 1993-08-24 DE DE69332430T patent/DE69332430T2/de not_active Expired - Lifetime
- 1993-08-24 AU AU44871/93A patent/AU670957B2/en not_active Expired
- 1993-08-24 ZA ZA936192A patent/ZA936192B/xx unknown
- 1993-08-24 DE DE1993634097 patent/DE69334097T2/de not_active Expired - Lifetime
- 1993-08-24 EP EP19930113502 patent/EP0584788B1/de not_active Expired - Lifetime
- 1993-08-24 EP EP20000117026 patent/EP1045023B1/de not_active Expired - Lifetime
- 1993-08-24 PT PT00117026T patent/PT1045023E/pt unknown
- 1993-08-24 ES ES93113502T patent/ES2185618T3/es not_active Expired - Lifetime
- 1993-08-24 DK DK00117026T patent/DK1045023T3/da active
2007
- 2007-02-09 CY CY0700004A patent/CY2572B1/xx unknown

Also Published As

Publication number	Publication date
JP4124493B2 (ja)	2008-07-23
DE69334097T2 (de)	2007-07-12
CA2104643A1 (en)	1994-02-25
EP0584788A3 (de)	1995-01-18
DK0584788T3 (da)	2003-02-24
JPH06153931A (ja)	1994-06-03
CY2572B1 (en)	2008-07-02
IL102929A (en)	1996-11-14
DE69332430T2 (de)	2003-07-17
PT584788E (pt)	2003-02-28
ZA936192B (en)	1994-03-22
AU4487193A (en)	1994-03-03
EP0584788A2 (de)	1994-03-02
ES2274756T3 (es)	2007-06-01
DE69334097D1 (de)	2007-01-25
DK1045023T3 (da)	2007-03-12
ATE226632T1 (de)	2002-11-15
EP1045023A1 (de)	2000-10-18
AU670957B2 (en)	1996-08-08
EP0584788B1 (de)	2002-10-23
EP1045023B1 (de)	2006-12-13
ES2185618T3 (es)	2003-05-01
US5641647A (en)	1997-06-24
DE69332430D1 (de)	2002-11-28
PT1045023E (pt)	2007-02-28
IL102929A0 (en)	1993-01-31
CA2104643C (en)	2009-07-21

Legal Events

Date

Code

Title

Description

2007-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1045023

Country of ref document: EP

Publication	Publication Date	Title
CY2572B1 (en)	2008-07-02	Serum free medium
ES8802442A1 (es)	1988-06-01	Un procedimiento para preparar un polimero de adn.
MY104021A (en)	1993-10-30	Benzamide protease inhibitors.
DK0590271T3 (da)	1996-12-16	17beta-aryl- og 17beta-heterocyclyl-5alfa, 14beta-androstan-, androsten- og -androstadienderivater med aktivitet på det kardiovaskulære system, fremgangsmåde til fremstilling af disse og farmaceutiske præparater indeholdende disse
AU4215893A (en)	1994-02-10	Liquid thromboplastin reagent
HU9300095D0 (en)	1993-04-28	New benzoic acid derivatives of cardio-vascular effect
AU7090887A (en)	1987-10-08	Plasminogen activators modified in first kringle domain
EP0513738A3 (en)	1993-05-05	Serum-free medium for mammalian cells cultivation
EP0297605A3 (en)	1989-08-23	Cell culture microcarriers
AU8309387A (en)	1988-08-11	Novel plasminogen activators
NZ239900A (en)	1993-09-27	Serum-free mammalian cell culture medium
EP0259943A3 (de)	1988-08-24	Regalboden mit Einteilungen
AU7090687A (en)	1987-10-08	Modified tissue-type plasminogen activators
IT1207518B (it)	1989-05-25	Composizione liquida e polimerizzabile per la produzionedi sostituiti di vetri ottici.
EP0350887A3 (de)	1990-06-13	Serum-freies Medium und Verfahren zur Züchtung von Säugetierzellen
FR2635008B1 (fr)	1990-11-16	Agent activateur de la productivite specifique des cellules animales recombinantes a base de polyvinylpyrrolidone et milieu de culture defini le contenant
FI951667A7 (fi)	1995-04-07	Liuosviljelykasvualusta
AU2196688A (en)	1989-06-08	Modified plasminogen activators
NO933235L (no)	1994-03-14	Anvendelse av en inhibitor for fremstilling av et medikament
SK5095A3 (en)	1995-07-11	Two component fibrin-glue composition for improving in vitro fertilization
DE3887030D1 (de)	1994-02-24	Serumfreier Nährboden.
GB2233666B (en)	1993-08-04	Microbacterium strain 851, culture media for same and production of single cell nutrient solution.
DE3675631D1 (de)	1990-12-20	In-vitro-kulturverfahren.
DK162086D0 (da)	1986-04-10	Laegemiddel indeholdende vaevs-plasminogenaktivator, dets fremstillingog anvendelse
DE69029811D1 (de)	1997-03-06	Rotavirus-typ-b-kulturen und deren verwendung