ATE349201T1 - Vorrichtung und verfahren zur herstellung von mikropartikeln - Google Patents

Vorrichtung und verfahren zur herstellung von mikropartikeln

Info

Publication number
ATE349201T1
ATE349201T1 AT00991722T AT00991722T ATE349201T1 AT E349201 T1 ATE349201 T1 AT E349201T1 AT 00991722 T AT00991722 T AT 00991722T AT 00991722 T AT00991722 T AT 00991722T AT E349201 T1 ATE349201 T1 AT E349201T1
Authority
AT
Austria
Prior art keywords
emulsion
mixing assembly
static mixing
microparticles
static
Prior art date
Application number
AT00991722T
Other languages
English (en)
Inventor
Shawn L Lyons
Steven G Wright
Original Assignee
Alkermes Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkermes Inc filed Critical Alkermes Inc
Application granted granted Critical
Publication of ATE349201T1 publication Critical patent/ATE349201T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00991722T 1999-11-12 2000-11-03 Vorrichtung und verfahren zur herstellung von mikropartikeln ATE349201T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/438,659 US6331317B1 (en) 1999-11-12 1999-11-12 Apparatus and method for preparing microparticles

Publications (1)

Publication Number Publication Date
ATE349201T1 true ATE349201T1 (de) 2007-01-15

Family

ID=23741495

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00991722T ATE349201T1 (de) 1999-11-12 2000-11-03 Vorrichtung und verfahren zur herstellung von mikropartikeln

Country Status (12)

Country Link
US (7) US6331317B1 (de)
EP (1) EP1231898B1 (de)
JP (1) JP4146639B2 (de)
AT (1) ATE349201T1 (de)
AU (1) AU771497B2 (de)
CA (1) CA2390284C (de)
CY (1) CY1106372T1 (de)
DE (1) DE60032631T2 (de)
DK (1) DK1231898T3 (de)
ES (1) ES2277867T3 (de)
PT (1) PT1231898E (de)
WO (1) WO2001034113A2 (de)

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Also Published As

Publication number Publication date
US6395304B2 (en) 2002-05-28
AU3437901A (en) 2001-06-06
US20010031801A1 (en) 2001-10-18
DE60032631T2 (de) 2007-10-04
CA2390284C (en) 2008-10-21
ES2277867T3 (es) 2007-08-01
US6713090B2 (en) 2004-03-30
CA2390284A1 (en) 2001-05-17
US20040197469A1 (en) 2004-10-07
WO2001034113A2 (en) 2001-05-17
DE60032631D1 (de) 2007-02-08
PT1231898E (pt) 2007-03-30
EP1231898A2 (de) 2002-08-21
EP1231898B1 (de) 2006-12-27
CY1106372T1 (el) 2011-10-12
DK1231898T3 (da) 2007-04-10
US6861016B2 (en) 2005-03-01
US20030147967A1 (en) 2003-08-07
US20050196457A1 (en) 2005-09-08
JP4146639B2 (ja) 2008-09-10
WO2001034113A3 (en) 2002-03-14
US20020146461A1 (en) 2002-10-10
US6331317B1 (en) 2001-12-18
JP2003513710A (ja) 2003-04-15
US6540393B1 (en) 2003-04-01
AU771497B2 (en) 2004-03-25
US6537586B2 (en) 2003-03-25

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