ATE349209T1 - Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren - Google Patents

Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren

Info

Publication number
ATE349209T1
ATE349209T1 AT02787554T AT02787554T ATE349209T1 AT E349209 T1 ATE349209 T1 AT E349209T1 AT 02787554 T AT02787554 T AT 02787554T AT 02787554 T AT02787554 T AT 02787554T AT E349209 T1 ATE349209 T1 AT E349209T1
Authority
AT
Austria
Prior art keywords
pde4
inhibitors
production
naphthyridine derivatives
phosphodiesterase isoenzyme
Prior art date
Application number
AT02787554T
Other languages
English (en)
Inventor
Alastair Denholm
Thomas H Keller
Clive Mccarthy
Neil J Press
Roger J Taylor
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126511A external-priority patent/GB0126511D0/en
Priority claimed from GB0209882A external-priority patent/GB0209882D0/en
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE349209T1 publication Critical patent/ATE349209T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/00—Drugs for immunological or allergic disorders
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  • Organic Chemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
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  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
AT02787554T 2001-11-05 2002-11-04 Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren ATE349209T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0126511A GB0126511D0 (en) 2001-11-05 2001-11-05 Organic compounds
GB0209882A GB0209882D0 (en) 2002-04-30 2002-04-30 Organic compounds

Publications (1)

Publication Number Publication Date
ATE349209T1 true ATE349209T1 (de) 2007-01-15

Family

ID=26246741

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02787554T ATE349209T1 (de) 2001-11-05 2002-11-04 Naphthyridine derivate, ihre herstellung und ihre anwendung als phosphodiesterase isoenzyme 4 (pde4) inhibitoren

Country Status (25)

Country Link
US (1) US7273875B2 (de)
EP (1) EP1443925B8 (de)
JP (1) JP4150672B2 (de)
KR (1) KR100623548B1 (de)
CN (1) CN1298324C (de)
AR (1) AR037517A1 (de)
AT (1) ATE349209T1 (de)
BR (1) BR0213877A (de)
CA (1) CA2462211C (de)
CY (1) CY1107532T1 (de)
DE (1) DE60217160T2 (de)
DK (1) DK1443925T3 (de)
ES (1) ES2275935T3 (de)
HU (1) HUP0402311A3 (de)
IL (2) IL161257A0 (de)
MX (1) MXPA04004264A (de)
MY (1) MY130622A (de)
NO (1) NO329093B1 (de)
NZ (1) NZ532586A (de)
PE (1) PE20030535A1 (de)
PL (1) PL368286A1 (de)
PT (1) PT1443925E (de)
RU (1) RU2296764C2 (de)
TW (1) TWI320784B (de)
WO (1) WO2003039544A1 (de)

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US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
MA34373B1 (fr) 2010-07-14 2013-07-03 Novartis Ag Composés hétérocycliques agonistes du récepteur ip
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
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