NO20042097L - Naftyridinderivater, deres fremstilling og deres anvendelse som fosfodiesterase-isoenzym 4-(PDE4) inhibitorer. - Google Patents

Naftyridinderivater, deres fremstilling og deres anvendelse som fosfodiesterase-isoenzym 4-(PDE4) inhibitorer.

Info

Publication number
NO20042097L
NO20042097L NO20042097A NO20042097A NO20042097L NO 20042097 L NO20042097 L NO 20042097L NO 20042097 A NO20042097 A NO 20042097A NO 20042097 A NO20042097 A NO 20042097A NO 20042097 L NO20042097 L NO 20042097L
Authority
NO
Norway
Prior art keywords
pde4
inhibitors
preparation
naphthyridine derivatives
phosphodiesterase isoenzyme
Prior art date
Application number
NO20042097A
Other languages
English (en)
Other versions
NO329093B1 (no
Inventor
Alastair Denholm
Thomas Hugo Keller
Clive Mccarthy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0126511A external-priority patent/GB0126511D0/en
Priority claimed from GB0209882A external-priority patent/GB0209882D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20042097L publication Critical patent/NO20042097L/no
Publication of NO329093B1 publication Critical patent/NO329093B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/12—Antidiarrhoeals
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
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  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
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  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
NO20042097A 2001-11-05 2004-05-21 Naftyridinderivater, deres fremstilling og deres anvendelse samt farmasoytisk sammensetning omfattende en slik forbindelse NO329093B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0126511A GB0126511D0 (en) 2001-11-05 2001-11-05 Organic compounds
GB0209882A GB0209882D0 (en) 2002-04-30 2002-04-30 Organic compounds
PCT/EP2002/012300 WO2003039544A1 (en) 2001-11-05 2002-11-04 Naphtyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors

Publications (2)

Publication Number Publication Date
NO20042097L true NO20042097L (no) 2004-05-21
NO329093B1 NO329093B1 (no) 2010-08-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042097A NO329093B1 (no) 2001-11-05 2004-05-21 Naftyridinderivater, deres fremstilling og deres anvendelse samt farmasoytisk sammensetning omfattende en slik forbindelse

Country Status (25)

Country Link
US (1) US7273875B2 (no)
EP (1) EP1443925B8 (no)
JP (1) JP4150672B2 (no)
KR (1) KR100623548B1 (no)
CN (1) CN1298324C (no)
AR (1) AR037517A1 (no)
AT (1) ATE349209T1 (no)
BR (1) BR0213877A (no)
CA (1) CA2462211C (no)
CY (1) CY1107532T1 (no)
DE (1) DE60217160T2 (no)
DK (1) DK1443925T3 (no)
ES (1) ES2275935T3 (no)
HU (1) HUP0402311A3 (no)
IL (2) IL161257A0 (no)
MX (1) MXPA04004264A (no)
MY (1) MY130622A (no)
NO (1) NO329093B1 (no)
NZ (1) NZ532586A (no)
PE (1) PE20030535A1 (no)
PL (1) PL368286A1 (no)
PT (1) PT1443925E (no)
RU (1) RU2296764C2 (no)
TW (1) TWI320784B (no)
WO (1) WO2003039544A1 (no)

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GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
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US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
CA2770873A1 (en) 2009-08-12 2011-02-17 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
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CA2771432A1 (en) 2009-08-20 2011-02-24 Novartis Ag Heterocyclic oxime compounds
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EP2813227A1 (en) 2009-10-22 2014-12-17 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
MA34373B1 (fr) 2010-07-14 2013-07-03 Novartis Ag Composés hétérocycliques agonistes du récepteur ip
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
JP2014505088A (ja) 2011-02-10 2014-02-27 ノバルティス アーゲー Ｃ−ＭＥＴチロシンキナーゼ阻害剤としての［１，２，４］トリアゾロ［４，３−ｂ］ピリダジン化合物
JP5808826B2 (ja) 2011-02-23 2015-11-10 インテリカイン， エルエルシー 複素環化合物およびその使用
KR20140014184A (ko) 2011-02-25 2014-02-05 아이알엠 엘엘씨 Trk 억제제로서의 화합물 및 조성물
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CN108299400B (zh) 2013-03-14 2021-02-19 达特神经科学(开曼)有限公司 作为pde4抑制剂的取代的吡啶和取代的吡嗪化合物
WO2014151147A1 (en) 2013-03-15 2014-09-25 Intellikine, Llc Combination of kinase inhibitors and uses thereof
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