ATE350036T1 - Tetrahydroquinolin-derivate - Google Patents

Tetrahydroquinolin-derivate

Info

Publication number
ATE350036T1
ATE350036T1 AT00964738T AT00964738T ATE350036T1 AT E350036 T1 ATE350036 T1 AT E350036T1 AT 00964738 T AT00964738 T AT 00964738T AT 00964738 T AT00964738 T AT 00964738T AT E350036 T1 ATE350036 T1 AT E350036T1
Authority
AT
Austria
Prior art keywords
tetrahydroquinoline derivatives
derivatives
salts
tetrahydroquinoline
agonism
Prior art date
Application number
AT00964738T
Other languages
English (en)
Inventor
Keigo Hanada
Original Assignee
Kaken Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharma Co Ltd filed Critical Kaken Pharma Co Ltd
Application granted granted Critical
Publication of ATE350036T1 publication Critical patent/ATE350036T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00964738T 1999-10-14 2000-10-06 Tetrahydroquinolin-derivate ATE350036T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29202199 1999-10-14

Publications (1)

Publication Number Publication Date
ATE350036T1 true ATE350036T1 (de) 2007-01-15

Family

ID=17776517

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00964738T ATE350036T1 (de) 1999-10-14 2000-10-06 Tetrahydroquinolin-derivate

Country Status (10)

Country Link
US (1) US7037919B1 (de)
EP (1) EP1221439B1 (de)
KR (2) KR100826485B1 (de)
CN (1) CN1157379C (de)
AT (1) ATE350036T1 (de)
AU (1) AU7558900A (de)
CA (1) CA2387201C (de)
DE (1) DE60032780T2 (de)
ES (1) ES2277853T3 (de)
WO (1) WO2001027086A1 (de)

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US7855229B2 (en) 2000-08-24 2010-12-21 University Of Tennessee Research Foundation Treating wasting disorders with selective androgen receptor modulators
US7622503B2 (en) 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US7919647B2 (en) 2000-08-24 2011-04-05 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
US8853266B2 (en) 2001-12-06 2014-10-07 University Of Tennessee Research Foundation Selective androgen receptor modulators for treating diabetes
US7772433B2 (en) 2002-02-28 2010-08-10 University Of Tennessee Research Foundation SARMS and method of use thereof
EP1520856A4 (de) * 2002-06-19 2010-01-13 Kaken Pharma Co Ltd Androgenrezeptorantagonist
US20050277660A1 (en) * 2002-08-01 2005-12-15 Motonori Miyakawa Novel tetrahydroquinoline derivatives
MXPA05003456A (es) 2002-10-04 2005-07-05 Millennium Pharm Inc Antagonistas del receptor de pgd2 para el tratamiento de enfermedades inflamatorias.
US7504508B2 (en) 2002-10-04 2009-03-17 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
US8309603B2 (en) 2004-06-07 2012-11-13 University Of Tennessee Research Foundation SARMs and method of use thereof
US7011600B2 (en) 2003-02-28 2006-03-14 Fallbrook Technologies Inc. Continuously variable transmission
AU2004266160A1 (en) 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
EP1761515B1 (de) * 2003-12-20 2008-11-05 MERCK PATENT GmbH 2-(hetero-)aryl substituierte tetrahydrochinolinderivate
SE0400285D0 (sv) * 2004-02-10 2004-02-10 Astrazeneca Ab Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof
WO2005090282A1 (en) 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
EP1734963A4 (de) 2004-04-02 2008-06-18 Merck & Co Inc Verfahren zur behandlung von menschen mit metabolischen und anthropometrischen störungen
US9889110B2 (en) 2004-06-07 2018-02-13 University Of Tennessee Research Foundation Selective androgen receptor modulator for treating hormone-related conditions
US9884038B2 (en) 2004-06-07 2018-02-06 University Of Tennessee Research Foundation Selective androgen receptor modulator and methods of use thereof
AU2006216713A1 (en) 2005-02-24 2006-08-31 Millennium Pharmaceuticals, Inc. PGD2 receptor antagonists for the treatment of inflammatory diseases
EP1891067B1 (de) 2005-06-17 2016-01-13 Ligand Pharmaceuticals Incorporated Androgenrezeptormodulatorverbindungen und verfahren
KR101641317B1 (ko) 2005-10-28 2016-07-20 폴브룩 인텔렉츄얼 프로퍼티 컴퍼니 엘엘씨 전동 드라이브
EP1954959B1 (de) 2005-11-22 2013-05-15 Fallbrook Intellectual Property Company LLC Stufenlos verstellbares getriebe
CN100376582C (zh) * 2006-04-26 2008-03-26 浙江大学 一种六氢呋喃[3,2-c]喹啉衍生物的制备方法
US9730908B2 (en) 2006-08-24 2017-08-15 University Of Tennessee Research Foundation SARMs and method of use thereof
US9844528B2 (en) 2006-08-24 2017-12-19 University Of Tennessee Research Foundation SARMs and method of use thereof
UA98777C2 (en) * 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
EP2125469A2 (de) 2007-02-01 2009-12-02 Fallbrook Technologies Inc. System und verfahren zur getriebe- und/oder antriebsmotorsteuerung
CN101688609B (zh) 2007-02-16 2013-09-04 福博科技术公司 无限变速式无级变速器、无级变速器及其方法、组件、子组件和部件
US8393989B2 (en) 2007-04-24 2013-03-12 Fallbrook Intellectual Property Company Llc Electric traction drives
US7968603B2 (en) 2007-09-11 2011-06-28 University Of Tennessee Research Foundation Solid forms of selective androgen receptor modulators
JP5783723B2 (ja) 2007-12-21 2015-09-24 フォールブルック インテレクチュアル プロパティー カンパニー エルエルシー 自動変速機及びその方法
WO2009111328A1 (en) 2008-02-29 2009-09-11 Fallbrook Technologies Inc. Continuously and/or infinitely variable transmissions and methods therefor
EP2276345A4 (de) * 2008-04-24 2012-06-06 Univ California Kleinmolekulare hemmer des androgenrezeptors
US8398518B2 (en) 2008-06-23 2013-03-19 Fallbrook Intellectual Property Company Llc Continuously variable transmission
CA2732668C (en) 2008-08-05 2017-11-14 Fallbrook Technologies Inc. Methods for control of transmission and prime mover
US8167759B2 (en) 2008-10-14 2012-05-01 Fallbrook Technologies Inc. Continuously variable transmission
KR101911672B1 (ko) 2009-04-16 2018-10-24 폴브룩 인텔렉츄얼 프로퍼티 컴퍼니 엘엘씨 무단 변속기를 위한 고정자 조립체 및 시프팅 장치
US8512195B2 (en) 2010-03-03 2013-08-20 Fallbrook Intellectual Property Company Llc Infinitely variable transmissions, continuously variable transmissions, methods, assemblies, subassemblies, and components therefor
US8888643B2 (en) 2010-11-10 2014-11-18 Fallbrook Intellectual Property Company Llc Continuously variable transmission
WO2012174176A1 (en) * 2011-06-17 2012-12-20 Merck Sharp & Dohme Corp. Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulators
US9744149B2 (en) 2012-07-13 2017-08-29 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US9969683B2 (en) 2012-07-13 2018-05-15 Gtx, Inc. Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
MX375256B (es) 2012-07-13 2025-03-06 Gtx Inc Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms).
US10987334B2 (en) 2012-07-13 2021-04-27 University Of Tennessee Research Foundation Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
US10314807B2 (en) 2012-07-13 2019-06-11 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
US9622992B2 (en) 2012-07-13 2017-04-18 Gtx, Inc. Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
US10258596B2 (en) 2012-07-13 2019-04-16 Gtx, Inc. Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
CN105017266B (zh) * 2015-07-17 2017-07-18 安徽农业大学 手性2‑芳基‑1,2,3,4‑四氢喹啉类化合物及其合成方法
CN112566666A (zh) 2018-05-14 2021-03-26 努瓦申生物公司 靶向抗癌核激素受体的化合物
MX2021012690A (es) 2019-04-19 2022-01-31 Ligand Pharm Inc Formas cristalinas y metodos para producir formas cristalinas de un compuesto.
JP2022532342A (ja) 2019-05-14 2022-07-14 ニューベイション・バイオ・インコーポレイテッド 抗がん核内ホルモン受容体標的化化合物
TW202131930A (zh) 2019-11-13 2021-09-01 美商諾維雪碧歐公司 抗癌核荷爾蒙受體標靶化合物
US20230212126A1 (en) * 2020-06-08 2023-07-06 Universität Zürich Small-molecule inhibitors of the frs2-fgfr interaction and their use in medicine, in the prevention and treatment of cancer
TW202304928A (zh) 2021-03-23 2023-02-01 美商諾維雪碧歐公司 抗癌核荷爾蒙受體標靶化合物
US12006314B2 (en) 2021-05-03 2024-06-11 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
CN116969959B (zh) * 2023-08-03 2025-10-31 浙江大学 取代四氢喹啉类衍生物及其应用

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FR2500441A1 (fr) 1981-02-23 1982-08-27 Roussel Uclaf Nouveaux medicaments derives de la 3-hydroxy dodecahydro benz (e) inden-7-one, produits derives de la 3-hydroxy dodecahydro benz (e) inden-7-one et leur procede de preparation
US5288725A (en) * 1992-10-15 1994-02-22 Merck & Co., Inc. Pyrroloquinoline Bradykinin antagonist
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US5925527A (en) 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries

Also Published As

Publication number Publication date
KR100731566B1 (ko) 2007-06-22
CA2387201A1 (en) 2001-04-19
CN1157379C (zh) 2004-07-14
DE60032780T2 (de) 2007-11-08
EP1221439A1 (de) 2002-07-10
KR20070036192A (ko) 2007-04-02
KR20020056901A (ko) 2002-07-10
CN1378535A (zh) 2002-11-06
EP1221439A4 (de) 2003-01-15
DE60032780D1 (de) 2007-02-15
ES2277853T3 (es) 2007-08-01
EP1221439B1 (de) 2007-01-03
WO2001027086A1 (en) 2001-04-19
US7037919B1 (en) 2006-05-02
CA2387201C (en) 2009-05-26
KR100826485B1 (ko) 2008-05-02
AU7558900A (en) 2001-04-23

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Legal Events

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