ATE350039T1 - Gefitinib (iressa) zur behandlung von krebs - Google Patents

Gefitinib (iressa) zur behandlung von krebs

Info

Publication number
ATE350039T1
ATE350039T1 AT03734386T AT03734386T ATE350039T1 AT E350039 T1 ATE350039 T1 AT E350039T1 AT 03734386 T AT03734386 T AT 03734386T AT 03734386 T AT03734386 T AT 03734386T AT E350039 T1 ATE350039 T1 AT E350039T1
Authority
AT
Austria
Prior art keywords
tki
methods
resistance
therapy
present
Prior art date
Application number
AT03734386T
Other languages
English (en)
Inventor
David B Agus
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Application granted granted Critical
Publication of ATE350039T1 publication Critical patent/ATE350039T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03734386T 2002-06-05 2003-06-04 Gefitinib (iressa) zur behandlung von krebs ATE350039T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38662202P 2002-06-05 2002-06-05

Publications (1)

Publication Number Publication Date
ATE350039T1 true ATE350039T1 (de) 2007-01-15

Family

ID=29736188

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06077218T ATE547708T1 (de) 2002-06-05 2003-06-04 Verfahren zur handhabung der kinasehemmertherapie
AT03734386T ATE350039T1 (de) 2002-06-05 2003-06-04 Gefitinib (iressa) zur behandlung von krebs

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06077218T ATE547708T1 (de) 2002-06-05 2003-06-04 Verfahren zur handhabung der kinasehemmertherapie

Country Status (15)

Country Link
US (3) US7384940B2 (de)
EP (3) EP1837025A3 (de)
JP (1) JP2005529162A (de)
KR (1) KR20050037510A (de)
AT (2) ATE547708T1 (de)
AU (1) AU2003238871B2 (de)
BR (1) BR0311814A (de)
CA (2) CA2590618A1 (de)
DE (1) DE60310922T2 (de)
DK (1) DK1509230T3 (de)
ES (1) ES2279120T3 (de)
MX (1) MXPA04012129A (de)
PT (1) PT1509230E (de)
SI (1) SI1509230T1 (de)
WO (1) WO2003103676A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014801A1 (en) * 2001-01-24 2007-01-18 Gish Kurt C Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer
CA2590618A1 (en) 2002-06-05 2003-12-18 Cedars-Sinai Medical Center Method of treating cancer using kinase inhibitors
US20050059012A1 (en) * 2002-07-31 2005-03-17 Daniel Afar Diagnosis of ZD1839 resistant tumors
TW200501960A (en) * 2002-10-02 2005-01-16 Bristol Myers Squibb Co Synergistic kits and compositions for treating cancer
EP1493445A1 (de) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibierung von Stress-induzierter Liganden-abhängiger EGFR Aktivierung
MX2007000944A (es) * 2004-07-23 2007-04-13 Astrazeneca Ab Metodo para pronosticar la sensibilidad de un tumor a farmacos del receptor erbb.
CN120022370A (zh) * 2005-02-03 2025-05-23 综合医院公司 治疗吉非替尼耐药性癌症的方法
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US9662325B2 (en) * 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
BRPI0608818A2 (pt) 2005-03-07 2010-01-26 Univ Chicago uso de antagonista opióides para atenuação de proliferação e migração de células endoteliais
ATE477495T1 (de) 2005-03-16 2010-08-15 Osi Pharm Inc Biologische marker prediktiv für das ansprechen von krebs auf inhibitoren der kinase des rezeptors für epidermalen wachstumsfaktor
US20070104721A1 (en) 2005-11-04 2007-05-10 Wyeth Antineoplastic combinations with mTOR inhibitor,herceptin, and/or hki-272
US7820159B2 (en) * 2006-10-31 2010-10-26 Instiute of Virology of the Slovak Academy of Sciences MN/CA IX and EGFR pathway inhibition
AU2007324868B2 (en) * 2006-11-28 2014-03-20 Daiichi Sankyo Europe Gmbh Activated HER3 as a marker for predicting therapeutic efficacy
ES2376978T3 (es) * 2007-02-27 2012-03-21 Nuclea Biomarkers Llc Método para predecir la respuesta de pacientes de NSCLC al tratamiento por parte de un inhibidor de EGFR-TK
US8377636B2 (en) * 2007-04-13 2013-02-19 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to kinase inhibitors
EP2208066A2 (de) * 2007-10-03 2010-07-21 OSI Pharmaceuticals, Inc. Biologische marker zur vorhersage der antikrebs-antwort auf insulinähnlicher-wachstumsfaktor-1-rezeptorkinase-inhibitoren
JP2010540960A (ja) * 2007-10-03 2010-12-24 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド インスリン様成長因子−１受容体キナーゼ阻害剤に対する抗癌反応を予測する生物学的マーカー
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
ES2431355T3 (es) 2008-06-17 2013-11-26 Wyeth Llc Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
DK2326329T3 (en) 2008-08-04 2017-02-20 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
US20110171124A1 (en) * 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
EP4218760A3 (de) 2009-04-06 2023-08-16 Wyeth LLC Behandlungsschema mit neratinib für brustkrebs
EP2542893A2 (de) * 2010-03-03 2013-01-09 OSI Pharmaceuticals, LLC Biologische marker als prädiktoren der antikrebsreaktion auf insulinähnlichen wachstumsfaktor-1-rezeptor-kinaseinhibitoren
US20130059851A1 (en) * 2010-03-09 2013-03-07 Dana-Farber Cancer Institute, Inc. Methods of Diagnosing and Treating Cancer in Patients Having or Developing Resistance to a First Cancer Therapy
EP2548027A2 (de) * 2010-03-18 2013-01-23 Institut National de la Santé et de la Recherche Médicale Verfahren zur vorhersage der ansprechbarkeit auf eine chemotherapie
CL2011000273A1 (es) 2011-02-08 2011-06-17 Univ Pontificia Catolica Chile Uso de un inhibidor de la enzima fosfohidrolasa de acido fosfatidico (pap) o combinacion de inhibidores, en que el inhibidor es d(+) propranolol, y la combinacion es mezcla racemica de propranolol o d(+) propranolol junto con desipramina, para preparar un medicamento util en el tratamiento del cancer.
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ，エルエルシー 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
CN105891496A (zh) * 2014-12-09 2016-08-24 上海华盈生物医药科技有限公司 酪氨酸激酶抑制剂类靶向用药指导抗体芯片和检测方法
US9890187B2 (en) 2015-06-26 2018-02-13 Epos-Iasis Research And Development, Ltd. Prototype systems of theranostic biomarkers for in vivo molecular management of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039764A1 (en) * 1999-03-12 2002-04-04 Rosen Craig A. Nucleic, acids, proteins, and antibodies
US20020110563A1 (en) * 2000-11-01 2002-08-15 Reed Steven G. Compositions and methods for the therapy and diagnosis of lung cancer
KR100754049B1 (ko) * 1999-06-25 2007-08-31 제넨테크, 인크. 전립선암을 치료하기 위한 약제 제조에 사용되는 항-ErbB2 항체 및 조성물
GB9925958D0 (en) * 1999-11-02 1999-12-29 Bundred Nigel J Therapeutic use
GB0008368D0 (en) * 2000-04-06 2000-05-24 Astrazeneca Ab Combination product
US20040029151A1 (en) * 2002-04-09 2004-02-12 Affymetrix, Inc. Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer
CA2590618A1 (en) * 2002-06-05 2003-12-18 Cedars-Sinai Medical Center Method of treating cancer using kinase inhibitors
US20050059012A1 (en) * 2002-07-31 2005-03-17 Daniel Afar Diagnosis of ZD1839 resistant tumors
US20050244419A1 (en) * 2003-07-25 2005-11-03 Pierre-Francois Tosi Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers

Also Published As

Publication number Publication date
US20040001833A1 (en) 2004-01-01
BR0311814A (pt) 2005-03-15
EP1509230A2 (de) 2005-03-02
EP1803821A2 (de) 2007-07-04
DE60310922T2 (de) 2007-10-11
US20060134115A1 (en) 2006-06-22
EP1837025A3 (de) 2007-12-19
EP1803821B1 (de) 2012-02-29
KR20050037510A (ko) 2005-04-22
EP1509230B1 (de) 2007-01-03
ES2279120T3 (es) 2007-08-16
SI1509230T1 (sl) 2007-06-30
DE60310922D1 (de) 2007-02-15
EP1803821A3 (de) 2007-12-26
EP1837025A2 (de) 2007-09-26
DK1509230T3 (da) 2007-05-14
US20070141621A1 (en) 2007-06-21
CA2590618A1 (en) 2003-12-18
AU2003238871A1 (en) 2003-12-22
US7803546B2 (en) 2010-09-28
US7384940B2 (en) 2008-06-10
CA2487983A1 (en) 2003-12-18
JP2005529162A (ja) 2005-09-29
ATE547708T1 (de) 2012-03-15
WO2003103676A3 (en) 2004-03-25
WO2003103676A2 (en) 2003-12-18
PT1509230E (pt) 2007-03-30
MXPA04012129A (es) 2005-04-19
AU2003238871B2 (en) 2009-04-23

Similar Documents

Publication Publication Date Title
ATE350039T1 (de) Gefitinib (iressa) zur behandlung von krebs
Gotay et al. Quality of life in patients who survive a dire prognosis compared to control cancer survivors
Umino et al. Speech intelligibility following maxillectomy with and without a prosthesis: an analysis of 54 cases
Griffiths The neural processing of complex sounds
Rick et al. Magnetic field therapy in patients with cytostatics‐induced polyneuropathy: a prospective randomized placebo‐controlled phase‐III study
DE602004026767D1 (de) Immunsorbens-bluttests zur beurteilung von paroxysmalen zerebralentladungen
WO2003065006A3 (en) Methods and compositions for treating cancer
ATE403750T1 (de) Methoden und kompositionen zur bewertung von antikörper behandlungen
ATE496635T1 (de) Verfahren und zusammensetzungen zur hemmung, prävention oder verringerung des tumorzellwachstums bei patienten, die gegen die antineoplastischen wirkungen einer antiöstrogen- therapie resistent sind
EP1190669A3 (de) Bürstenförmige Schreibinstrumente für die Gesundheit und Therapie
Sikora et al. The changing demographics of head and neck squamous cell carcinoma in the United States
ATE430935T1 (de) Nachweis und behandlung von prostatakrebs
Wu et al. Multisensory activation of ventral cochlear nucleus D‐stellate cells modulates dorsal cochlear nucleus principal cell spatial coding
BRPI0412110A (pt) genes regulados no cáncer ovariano como alvos prognósticos e terapêuticos
DE60329020D1 (de) Assays zur überwachung von krebspatienten auf grundlage der spiegel des analyten für die extrazelluläre domäne (ecd) des epidermalen wachstumsfaktor-rezeptors (egfr), allein oder in kombination mit anderen analyten, in proben von körperflüssigkeiten
DE60122673D1 (de) Methoden zur diagnose und behandlung von herzkrankheiten
Todd et al. Encoding a melody using only temporal information for cochlear-implant and normal-hearing listeners
DE60224299D1 (de) Kombinationsmedikationen mit einem selektiven cyclooxygenase-2-inhibitor
Walker et al. Psychosocial aspects of cancer in the elderly
WO2004047727A3 (en) Compositions and methods for diagnosing and treating mood disorders
ATE85707T1 (de) Entwicklungsverfahren fuer arzneimittel zur behandlung von stoerungen.
WO2004072242A3 (en) Screening of compounds for hematological disorder treatment
Hill et al. Quality of life issues in recurrent respiratory papillomatosis
WO2003061573A3 (en) Methods and compositions for treating urological disorders using 1435, 559, 34021, 44099, 25278, 641, 260, 55089, 21407, 42032, 46656, 62553, 302, 323, 12303, 985, 13237, 13601, 18926, 318, 2058 or 6351 mo
DE60225845D1 (de) Zusammensetzungen und verfahren zur diagnose und behandlung von diabetes, insulinresistenz und dyslipidämie

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1509230

Country of ref document: EP

REN Ceased due to non-payment of the annual fee