ATE547708T1 - Verfahren zur handhabung der kinasehemmertherapie - Google Patents

Verfahren zur handhabung der kinasehemmertherapie

Info

Publication number
ATE547708T1
ATE547708T1 AT06077218T AT06077218T ATE547708T1 AT E547708 T1 ATE547708 T1 AT E547708T1 AT 06077218 T AT06077218 T AT 06077218T AT 06077218 T AT06077218 T AT 06077218T AT E547708 T1 ATE547708 T1 AT E547708T1
Authority
AT
Austria
Prior art keywords
tki
methods
therapy
resistance
present
Prior art date
Application number
AT06077218T
Other languages
English (en)
Inventor
David B Agus
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Application granted granted Critical
Publication of ATE547708T1 publication Critical patent/ATE547708T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT06077218T 2002-06-05 2003-06-04 Verfahren zur handhabung der kinasehemmertherapie ATE547708T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38662202P 2002-06-05 2002-06-05

Publications (1)

Publication Number Publication Date
ATE547708T1 true ATE547708T1 (de) 2012-03-15

Family

ID=29736188

Family Applications (2)

Application Number Title Priority Date Filing Date
AT03734386T ATE350039T1 (de) 2002-06-05 2003-06-04 Gefitinib (iressa) zur behandlung von krebs
AT06077218T ATE547708T1 (de) 2002-06-05 2003-06-04 Verfahren zur handhabung der kinasehemmertherapie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT03734386T ATE350039T1 (de) 2002-06-05 2003-06-04 Gefitinib (iressa) zur behandlung von krebs

Country Status (15)

Country Link
US (3) US7384940B2 (de)
EP (3) EP1837025A3 (de)
JP (1) JP2005529162A (de)
KR (1) KR20050037510A (de)
AT (2) ATE350039T1 (de)
AU (1) AU2003238871B2 (de)
BR (1) BR0311814A (de)
CA (2) CA2590618A1 (de)
DE (1) DE60310922T2 (de)
DK (1) DK1509230T3 (de)
ES (1) ES2279120T3 (de)
MX (1) MXPA04012129A (de)
PT (1) PT1509230E (de)
SI (1) SI1509230T1 (de)
WO (1) WO2003103676A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070014801A1 (en) * 2001-01-24 2007-01-18 Gish Kurt C Methods of diagnosis of prostate cancer, compositions and methods of screening for modulators of prostate cancer
EP1837025A3 (de) * 2002-06-05 2007-12-19 Cedars-Sinai Medical Center Verfahren zur Krebsbehandlung mit Kinaseinhibitoren
US20050059012A1 (en) * 2002-07-31 2005-03-17 Daniel Afar Diagnosis of ZD1839 resistant tumors
TW200501960A (en) * 2002-10-02 2005-01-16 Bristol Myers Squibb Co Synergistic kits and compositions for treating cancer
EP1493445A1 (de) * 2003-07-04 2005-01-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibierung von Stress-induzierter Liganden-abhängiger EGFR Aktivierung
US20080286771A1 (en) * 2004-07-23 2008-11-20 Kevin Hudson Method of Predicting the Responsiveness of a Tumour to Erbb Receptor Drugs
CN108421044A (zh) * 2005-02-03 2018-08-21 综合医院公司 治疗吉非替尼耐药性癌症的方法
US9662325B2 (en) * 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
CN101171010B (zh) 2005-03-07 2014-09-17 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
ATE477495T1 (de) 2005-03-16 2010-08-15 Osi Pharm Inc Biologische marker prediktiv für das ansprechen von krebs auf inhibitoren der kinase des rezeptors für epidermalen wachstumsfaktor
BRPI0618042A2 (pt) 2005-11-04 2011-08-16 Wyeth Corp usos de uma rapamicina e de uma herceptina, produto, pacote farmacêutico, e, composição farmacêutica
US7820159B2 (en) * 2006-10-31 2010-10-26 Instiute of Virology of the Slovak Academy of Sciences MN/CA IX and EGFR pathway inhibition
EP2518508A1 (de) * 2006-11-28 2012-10-31 U3 Pharma GmbH Aktiviertes HER3 als Marker zur Vorhersage der Therapieeffizienz
US20080206777A1 (en) * 2007-02-27 2008-08-28 Nuclea Biomarkers, Llc Gene and protein expression profiles associated with the therapeutic efficacy of EGFR-TK inhibitors
JP5240739B2 (ja) * 2007-04-13 2013-07-17 オーエスアイ・フアーマシユーテイカルズ・エル・エル・シー キナーゼ阻害剤に対する抗癌応答を予測する生物学的マーカー
CA2694154A1 (en) * 2007-10-03 2009-04-09 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
EP2208066A2 (de) * 2007-10-03 2010-07-21 OSI Pharmaceuticals, Inc. Biologische marker zur vorhersage der antikrebs-antwort auf insulinähnlicher-wachstumsfaktor-1-rezeptorkinase-inhibitoren
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
CN102641270A (zh) 2008-06-17 2012-08-22 惠氏有限责任公司 含有hki-272和长春瑞滨的抗肿瘤组合
US8669273B2 (en) 2008-08-04 2014-03-11 Wyeth Llc Antineoplastic combinations of 4-anilino-3-cyanoquinolines and capecitabine
WO2010099137A2 (en) * 2009-02-26 2010-09-02 Osi Pharmaceuticals, Inc. In situ methods for monitoring the emt status of tumor cells in vivo
IL264349B2 (en) 2009-04-06 2024-01-01 Wyeth Llc Regimen comprising neratinib for the treatment of cancer
EP2542893A2 (de) * 2010-03-03 2013-01-09 OSI Pharmaceuticals, LLC Biologische marker als prädiktoren der antikrebsreaktion auf insulinähnlichen wachstumsfaktor-1-rezeptor-kinaseinhibitoren
EP2545187B1 (de) * 2010-03-09 2018-09-05 Dana-Farber Cancer Institute, Inc. Verfahren zur diagnose und behandlung von krebs bei patienten mit resistenz bzw. entwicklung einer resistenz gegenüber einer ersten krebstherapie
WO2011113942A2 (en) * 2010-03-18 2011-09-22 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for predicting the responsiveness to chemotherapy
CL2011000273A1 (es) 2011-02-08 2011-06-17 Univ Pontificia Catolica Chile Uso de un inhibidor de la enzima fosfohidrolasa de acido fosfatidico (pap) o combinacion de inhibidores, en que el inhibidor es d(+) propranolol, y la combinacion es mezcla racemica de propranolol o d(+) propranolol junto con desipramina, para preparar un medicamento util en el tratamiento del cancer.
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ，エルエルシー 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
CN105891496A (zh) * 2014-12-09 2016-08-24 上海华盈生物医药科技有限公司 酪氨酸激酶抑制剂类靶向用药指导抗体芯片和检测方法
US9890187B2 (en) 2015-06-26 2018-02-13 Epos-Iasis Research And Development, Ltd. Prototype systems of theranostic biomarkers for in vivo molecular management of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020039764A1 (en) * 1999-03-12 2002-04-04 Rosen Craig A. Nucleic, acids, proteins, and antibodies
US20020110563A1 (en) * 2000-11-01 2002-08-15 Reed Steven G. Compositions and methods for the therapy and diagnosis of lung cancer
JP4579471B2 (ja) * 1999-06-25 2010-11-10 ジェネンテック， インコーポレイテッド 抗ＥｒｂＢ２抗体を用いる前立腺癌の処置
GB9925958D0 (en) * 1999-11-02 1999-12-29 Bundred Nigel J Therapeutic use
GB0008368D0 (en) * 2000-04-06 2000-05-24 Astrazeneca Ab Combination product
US20040029151A1 (en) * 2002-04-09 2004-02-12 Affymetrix, Inc. Molecular genetic profiling of gleason grades 3 and 4/5 prostate cancer
EP1837025A3 (de) * 2002-06-05 2007-12-19 Cedars-Sinai Medical Center Verfahren zur Krebsbehandlung mit Kinaseinhibitoren
US20050059012A1 (en) * 2002-07-31 2005-03-17 Daniel Afar Diagnosis of ZD1839 resistant tumors
US20050244419A1 (en) * 2003-07-25 2005-11-03 Pierre-Francois Tosi Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers

Also Published As

Publication number Publication date
CA2590618A1 (en) 2003-12-18
DE60310922D1 (de) 2007-02-15
US20060134115A1 (en) 2006-06-22
WO2003103676A2 (en) 2003-12-18
US20070141621A1 (en) 2007-06-21
ATE350039T1 (de) 2007-01-15
AU2003238871B2 (en) 2009-04-23
WO2003103676A3 (en) 2004-03-25
ES2279120T3 (es) 2007-08-16
EP1509230B1 (de) 2007-01-03
DK1509230T3 (da) 2007-05-14
PT1509230E (pt) 2007-03-30
US7803546B2 (en) 2010-09-28
EP1803821B1 (de) 2012-02-29
AU2003238871A1 (en) 2003-12-22
EP1837025A2 (de) 2007-09-26
DE60310922T2 (de) 2007-10-11
US7384940B2 (en) 2008-06-10
US20040001833A1 (en) 2004-01-01
EP1803821A2 (de) 2007-07-04
JP2005529162A (ja) 2005-09-29
KR20050037510A (ko) 2005-04-22
CA2487983A1 (en) 2003-12-18
EP1509230A2 (de) 2005-03-02
BR0311814A (pt) 2005-03-15
EP1803821A3 (de) 2007-12-26
MXPA04012129A (es) 2005-04-19
EP1837025A3 (de) 2007-12-19
SI1509230T1 (sl) 2007-06-30

Similar Documents

Publication Publication Date Title
DE60310922D1 (de) Gefitinib (iressa) zur behandlung von krebs
Gotay et al. Quality of life in patients who survive a dire prognosis compared to control cancer survivors
Zeng Temporal pitch in electric hearing
Griffiths The neural processing of complex sounds
Patterson Late effects of organ preservation treatment on swallowing and voice; presentation, assessment, and screening
Rick et al. Magnetic field therapy in patients with cytostatics‐induced polyneuropathy: a prospective randomized placebo‐controlled phase‐III study
ATE440536T1 (de) Verfahren zur diagnose, behandlung und prävention von knochenverlust
EP1466174A4 (de) Mutationen in der mit der resistenz gegenüber sti-571 assoziierten bcr-abl-tyrosinkinase
DE602004026767D1 (de) Immunsorbens-bluttests zur beurteilung von paroxysmalen zerebralentladungen
ATE339957T1 (de) Verwendung von egfr tyrosine kinase hemmern zur behandlung von brustkrebs
Sikora et al. The changing demographics of head and neck squamous cell carcinoma in the United States
EP1190669A3 (de) Bürstenförmige Schreibinstrumente für die Gesundheit und Therapie
ATE496635T1 (de) Verfahren und zusammensetzungen zur hemmung, prävention oder verringerung des tumorzellwachstums bei patienten, die gegen die antineoplastischen wirkungen einer antiöstrogen- therapie resistent sind
ATE356995T1 (de) Verfahren zur identifizierung von mitteln zur behandlung von diabetes
Wu et al. Multisensory activation of ventral cochlear nucleus D‐stellate cells modulates dorsal cochlear nucleus principal cell spatial coding
DE60329020D1 (de) Assays zur überwachung von krebspatienten auf grundlage der spiegel des analyten für die extrazelluläre domäne (ecd) des epidermalen wachstumsfaktor-rezeptors (egfr), allein oder in kombination mit anderen analyten, in proben von körperflüssigkeiten
Ranieri et al. Cortical excitability as a prognostic and phenotypic stratification biomarker in amyotrophic lateral sclerosis
Zatorre Brain imaging studies of musical perception and musical imagery
Todd et al. Encoding a melody using only temporal information for cochlear-implant and normal-hearing listeners
Kikuta et al. Anatomical study of the supraorbital and supratrochlear nerves: A new classification and application to understanding some migraine headaches
McCloskey et al. Providing an escape option reduces retaliatory aggression
Ammanuel et al. Correlation of natural language assessment results with health-related quality of life in adult glioma patients
DE60232734D1 (de) Verwendung von polarisiertem 129Xe zur Herstellung eines Medikaments zur Verwendung in einem in-vivo-NMR-Verfahren
Hill et al. Quality of life issues in recurrent respiratory papillomatosis
WO2004072242A3 (en) Screening of compounds for hematological disorder treatment