ATE350666T1 - Verfahren zur analyse von proteinproben - Google Patents

Verfahren zur analyse von proteinproben

Info

Publication number
ATE350666T1
ATE350666T1 AT02769368T AT02769368T ATE350666T1 AT E350666 T1 ATE350666 T1 AT E350666T1 AT 02769368 T AT02769368 T AT 02769368T AT 02769368 T AT02769368 T AT 02769368T AT E350666 T1 ATE350666 T1 AT E350666T1
Authority
AT
Austria
Prior art keywords
proteins
isotopically
labeled
samples
quantitative analysis
Prior art date
Application number
AT02769368T
Other languages
English (en)
Inventor
Kenneth C Parker
Timothy K Nadler
George J Vella
Yulin Huang
Rudolf H Aeberesold
Marcus B Smolka
Original Assignee
Perseptive Biosystems Inc
Inst Systems Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perseptive Biosystems Inc, Inst Systems Biology filed Critical Perseptive Biosystems Inc
Application granted granted Critical
Publication of ATE350666T1 publication Critical patent/ATE350666T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/964—Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
AT02769368T 2001-05-08 2002-05-07 Verfahren zur analyse von proteinproben ATE350666T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/851,058 US7045296B2 (en) 2001-05-08 2001-05-08 Process for analyzing protein samples

Publications (1)

Publication Number Publication Date
ATE350666T1 true ATE350666T1 (de) 2007-01-15

Family

ID=25309855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02769368T ATE350666T1 (de) 2001-05-08 2002-05-07 Verfahren zur analyse von proteinproben

Country Status (7)

Country Link
US (1) US7045296B2 (de)
EP (1) EP1392848B1 (de)
JP (1) JP4188701B2 (de)
AT (1) ATE350666T1 (de)
AU (1) AU2002340828A1 (de)
DE (1) DE60217328T2 (de)
WO (1) WO2002090929A2 (de)

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US7846748B2 (en) * 2002-12-02 2010-12-07 The University Of North Carolina At Chapel Hill Methods of quantitation and identification of peptides and proteins
CA2658334C (en) 2003-01-16 2012-07-10 Caprotec Bioanalytics Gmbh Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
US7195751B2 (en) * 2003-01-30 2007-03-27 Applera Corporation Compositions and kits pertaining to analyte determination
WO2004086281A1 (en) * 2003-03-25 2004-10-07 Institut Suisse De Bioinformatique Method for comparing proteomes
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US20050147985A1 (en) * 2004-01-05 2005-07-07 Applera Corporation Mixtures of isobarically labeled analytes and fragments ions derived therefrom
US7307169B2 (en) * 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
US20050148087A1 (en) 2004-01-05 2005-07-07 Applera Corporation Isobarically labeled analytes and fragment ions derived therefrom
US7355045B2 (en) * 2004-01-05 2008-04-08 Applera Corporation Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof
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JP5009784B2 (ja) * 2004-04-30 2012-08-22 マイクロマス ユーケー リミテッド 質量分析計
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US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
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JP2006078192A (ja) * 2004-09-07 2006-03-23 Shimadzu Corp 生体高分子の質量分析法
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
JP4563764B2 (ja) * 2004-10-01 2010-10-13 丸善製薬株式会社 ペプチドの定量方法
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US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
US20060183238A1 (en) * 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
WO2006129401A1 (ja) * 2005-05-31 2006-12-07 Jcl Bioassay Corporation プロテオーム網羅的解析における特異的蛋白質のスクリーニング方法
EP1886135B1 (de) * 2005-06-03 2019-11-06 Waters Technologies Corporation Erstellung und verwendung eines katalogs von informationen über polypeptide für chemische analysen
JP5199101B2 (ja) * 2005-10-13 2013-05-15 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー 生体分子の検定を開発するための方法
CA2628708C (en) 2005-11-08 2011-11-29 Tohoku University Method of quantifying membrane protein by using mass spectrometer
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KR100805777B1 (ko) 2007-02-22 2008-02-21 한국기초과학지원연구원 질량 스펙트럼 데이터 및 １차원 젤에서의 밴드 위치분석을 포함하는 단백질 수식화 분석 시스템 및 이를이용한 단백질 수식화 분석 방법
US7880140B2 (en) * 2007-05-02 2011-02-01 Dh Technologies Development Pte. Ltd Multipole mass filter having improved mass resolution
US7820963B2 (en) * 2007-08-06 2010-10-26 Metabolic Alayses, Inc. Method for generation and use of isotopic patterns in mass spectral data of simple organisms
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US8969251B2 (en) * 2007-10-02 2015-03-03 Methabolic Analyses, Inc. Generation and use of isotopic patterns in mass spectral phenotypic comparison of organisms
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JP5299956B2 (ja) 2008-09-29 2013-09-25 国立大学法人東北大学 質量分析装置を用いた代謝酵素群の一斉タンパク質定量に用いるペプチド
JP5317336B2 (ja) 2009-02-23 2013-10-16 国立大学法人東北大学 質量分析装置を用いたタンパク質定量のための評価用ペプチド、人工標準タンパク質、及びタンパク質の定量方法
CN102510903B (zh) * 2009-04-14 2015-07-01 系统生物学研究所 蛋白质和多肽的质谱鉴定和定量检测的方法学革新
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CA3214092A1 (en) * 2011-03-15 2012-09-20 Massachusetts Institute Of Technology Multiplexed detection with isotope-coded reporters
EP2735871B1 (de) 2011-07-22 2017-12-06 Tohoku University Verfahren zur herstellung von mit stabilen isotopen gekennzeichneten zielpeptidfragmenten in der massenspektrometrie
CN105452481A (zh) 2013-06-07 2016-03-30 麻省理工学院 基于亲和力检测配体编码的合成性生物标记物
EP3607085A1 (de) 2017-04-07 2020-02-12 Massachusetts Institute Of Technology Verfahren zur räumlichen profilierung der proteaseaktivität in gewebe und gewebeschnitten
CA3094088A1 (en) * 2018-03-16 2019-09-19 Quest Diagnostics Investments Llc Mass spectrometric determination of testosterone in multiplexed patient samples
EP3856921A2 (de) 2018-09-25 2021-08-04 Massachusetts Institute Of Technology Lungenproteasenanosensoren und verwendungen davon
CN109444279A (zh) * 2018-11-06 2019-03-08 北京蛋白世界生物科技有限公司 一种15n代谢标记蛋白质结合质谱平行反应监测定量的方法
CN109438551B (zh) * 2018-11-06 2024-05-28 北京蛋白世界生物科技有限公司 一种微量蛋白质样品浓缩的方法
WO2020150560A1 (en) 2019-01-17 2020-07-23 Massachusetts Institute Of Technology Sensors for detecting and imaging of cancer metastasis
CN110044988B (zh) * 2019-04-26 2021-01-29 常州大学 一种弯曲毛细管电泳检测多酶的方法

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Also Published As

Publication number Publication date
US20020192720A1 (en) 2002-12-19
JP4188701B2 (ja) 2008-11-26
EP1392848B1 (de) 2007-01-03
DE60217328T2 (de) 2007-07-19
WO2002090929A2 (en) 2002-11-14
US7045296B2 (en) 2006-05-16
EP1392848A4 (de) 2005-06-22
DE60217328D1 (de) 2007-02-15
WO2002090929A3 (en) 2003-09-25
JP2004533610A (ja) 2004-11-04
EP1392848A2 (de) 2004-03-03
AU2002340828A1 (en) 2002-11-18

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