ATE352319T1 - Kombination cyclooxygenase-2 inhibitor/ histone deacetylase inhibitor - Google Patents
Kombination cyclooxygenase-2 inhibitor/ histone deacetylase inhibitorInfo
- Publication number
- ATE352319T1 ATE352319T1 AT02787572T AT02787572T ATE352319T1 AT E352319 T1 ATE352319 T1 AT E352319T1 AT 02787572 T AT02787572 T AT 02787572T AT 02787572 T AT02787572 T AT 02787572T AT E352319 T1 ATE352319 T1 AT E352319T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitor
- combination
- cyclooxygenase
- histone deacetylase
- relates
- Prior art date
Links
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title abstract 3
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title abstract 2
- 229940121372 histone deacetylase inhibitor Drugs 0.000 title abstract 2
- 239000003276 histone deacetylase inhibitor Substances 0.000 title abstract 2
- 206010009944 Colon cancer Diseases 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 210000001072 colon Anatomy 0.000 abstract 2
- 208000029742 colonic neoplasm Diseases 0.000 abstract 2
- 230000003902 lesion Effects 0.000 abstract 2
- 230000036210 malignancy Effects 0.000 abstract 2
- 230000003211 malignant effect Effects 0.000 abstract 2
- 229940111134 coxibs Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33301601P | 2001-11-06 | 2001-11-06 | |
| US41931402P | 2002-10-17 | 2002-10-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE352319T1 true ATE352319T1 (de) | 2007-02-15 |
Family
ID=26988512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02787572T ATE352319T1 (de) | 2001-11-06 | 2002-11-05 | Kombination cyclooxygenase-2 inhibitor/ histone deacetylase inhibitor |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US7402603B2 (de) |
| EP (1) | EP1443967B1 (de) |
| JP (1) | JP4413614B2 (de) |
| KR (1) | KR100937064B1 (de) |
| CN (1) | CN100457183C (de) |
| AT (1) | ATE352319T1 (de) |
| AU (1) | AU2002351844B2 (de) |
| BR (1) | BR0213932A (de) |
| CA (1) | CA2461373A1 (de) |
| CY (1) | CY1106508T1 (de) |
| DE (1) | DE60217895T2 (de) |
| DK (1) | DK1443967T3 (de) |
| ES (1) | ES2280597T3 (de) |
| HU (1) | HUP0402370A3 (de) |
| IL (2) | IL160970A0 (de) |
| MX (1) | MXPA04004312A (de) |
| NO (1) | NO20042148L (de) |
| NZ (1) | NZ544689A (de) |
| PL (1) | PL205853B1 (de) |
| PT (1) | PT1443967E (de) |
| RU (1) | RU2311200C2 (de) |
| WO (1) | WO2003039599A1 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AR043850A1 (es) * | 2003-04-17 | 2005-08-17 | Bayer Pharmaceuticals Corp | Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos |
| CN1791396A (zh) * | 2003-05-21 | 2006-06-21 | 诺瓦提斯公司 | 组蛋白脱乙酰基酶抑制剂与化疗剂的组合 |
| EP1491188A1 (de) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topische Verwendung von Valproinsäure zur Behandlung von Hauterkrankungen |
| WO2005065681A1 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer |
| US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| MX2007001634A (es) * | 2004-08-11 | 2007-04-23 | Kyorin Seiyaku Kk | Nuevo derivado de acido amino benzoico ciclico. |
| JP2008524246A (ja) | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| US7786330B2 (en) | 2005-02-28 | 2010-08-31 | Asahi Glass Company, Limited | Process for producing 1,2-dialkoxy-3-fluorobenzene |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EA200800321A1 (ru) | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| EP1743654A1 (de) * | 2005-07-15 | 2007-01-17 | TopoTarget Germany AG | Verwendung von Histon Deacetylase-Hemmer zusammen mit NSAIDen zur Behandlung von Krebs und/oder Entzündungskrankheiten |
| WO2007016136A2 (en) * | 2005-07-28 | 2007-02-08 | Nitromed, Inc. | Organic nitric oxide enhancing salts of cyclooxygenase-2 selective inhibitors, compositons and methods of use |
| WO2007084390A2 (en) * | 2006-01-13 | 2007-07-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CA2654230C (en) * | 2006-06-12 | 2012-09-11 | Novartis Ag | Process for making a lactate salt of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide |
| EP2086930A2 (de) * | 2006-06-12 | 2009-08-12 | Novartis AG | Polymorphe von n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamid |
| KR101540194B1 (ko) | 2006-06-12 | 2015-07-28 | 노파르티스 아게 | Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법 |
| TR200809829T1 (tr) * | 2006-06-28 | 2009-06-22 | Novartis Ag | HDAC inhibitörlerinin lenfoma tedavisine yönelik olarak kullanımı |
| JPWO2008023438A1 (ja) | 2006-08-25 | 2010-01-07 | 旭硝子株式会社 | １，２−ジアルコキシ−３−フルオロベンゼンの製造方法 |
| BRPI0806365B8 (pt) | 2007-02-06 | 2021-05-25 | Lixte Biotechnology Holdings Inc | composto, uso do composto, composição farmacêutica e uso da composição farmacêutica |
| BRPI0807812A2 (pt) * | 2007-02-15 | 2020-06-23 | Novartis Ag | Combinações de lbh589 com outros agentes terapêuticos para tratar câncer |
| JP5730575B2 (ja) | 2007-10-01 | 2015-06-10 | リクスト・バイオテクノロジー，インコーポレイテッド | Ｈｄａｃ阻害剤 |
| WO2010147612A1 (en) | 2009-06-18 | 2010-12-23 | Lixte Biotechnology, Inc. | Methods of modulating cell regulation by inhibiting p53 |
| WO2010014220A1 (en) | 2008-08-01 | 2010-02-04 | Lixte Biotechnology, Inc. | Neuroprotective agents for the prevention and treatment of neurodegenerative diseases |
| US8227473B2 (en) | 2008-08-01 | 2012-07-24 | Lixte Biotechnology, Inc. | Oxabicycloheptanes and oxabicycloheptenes, their preparation and use |
| US9290440B2 (en) * | 2012-04-16 | 2016-03-22 | Toa Eiyo Ltd. | Bicyclic compound |
| KR20160004299A (ko) | 2013-04-09 | 2016-01-12 | 릭스트 바이오테크놀로지, 인코포레이티드 | 옥사바이시클로헵탄류 및 옥사바이시클로헵텐류의 제형 |
| US9745253B2 (en) | 2015-03-13 | 2017-08-29 | Forma Therapeutics, Inc. | Alpha-cinnamide compounds and compositions as HDAC8 inhibitors |
| EP4324477A3 (de) | 2016-12-08 | 2024-05-22 | Lixte Biotechnology, Inc. | Oxabicycloheptane zur modulation von immunreaktionen |
| CN115108926B (zh) * | 2022-04-02 | 2023-06-20 | 上海工程技术大学 | 一种用于制备厄达替尼的中间体化合物及制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO4960662A1 (es) * | 1997-08-28 | 2000-09-25 | Novartis Ag | Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados |
| PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
-
2002
- 2002-11-05 CA CA002461373A patent/CA2461373A1/en not_active Abandoned
- 2002-11-05 IL IL16097002A patent/IL160970A0/xx unknown
- 2002-11-05 DE DE60217895T patent/DE60217895T2/de not_active Expired - Lifetime
- 2002-11-05 PL PL368539A patent/PL205853B1/pl not_active IP Right Cessation
- 2002-11-05 AU AU2002351844A patent/AU2002351844B2/en not_active Ceased
- 2002-11-05 ES ES02787572T patent/ES2280597T3/es not_active Expired - Lifetime
- 2002-11-05 KR KR1020047006764A patent/KR100937064B1/ko not_active Expired - Fee Related
- 2002-11-05 PT PT02787572T patent/PT1443967E/pt unknown
- 2002-11-05 HU HU0402370A patent/HUP0402370A3/hu unknown
- 2002-11-05 NZ NZ544689A patent/NZ544689A/en not_active IP Right Cessation
- 2002-11-05 MX MXPA04004312A patent/MXPA04004312A/es active IP Right Grant
- 2002-11-05 JP JP2003541889A patent/JP4413614B2/ja not_active Expired - Fee Related
- 2002-11-05 EP EP02787572A patent/EP1443967B1/de not_active Expired - Lifetime
- 2002-11-05 BR BR0213932-4A patent/BR0213932A/pt not_active IP Right Cessation
- 2002-11-05 RU RU2004117170/15A patent/RU2311200C2/ru not_active IP Right Cessation
- 2002-11-05 AT AT02787572T patent/ATE352319T1/de active
- 2002-11-05 WO PCT/EP2002/012343 patent/WO2003039599A1/en not_active Ceased
- 2002-11-05 DK DK02787572T patent/DK1443967T3/da active
- 2002-11-05 CN CNB028214633A patent/CN100457183C/zh not_active Expired - Fee Related
- 2002-11-05 US US10/494,221 patent/US7402603B2/en not_active Expired - Fee Related
-
2004
- 2004-03-18 IL IL160970A patent/IL160970A/en not_active IP Right Cessation
- 2004-05-25 NO NO20042148A patent/NO20042148L/no not_active Application Discontinuation
-
2007
- 2007-04-12 CY CY20071100509T patent/CY1106508T1/el unknown
-
2008
- 2008-05-20 US US12/123,846 patent/US20080227845A1/en not_active Abandoned
-
2009
- 2009-04-07 US US12/419,679 patent/US20090192211A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4413614B2 (ja) | 2010-02-10 |
| HUP0402370A2 (hu) | 2005-02-28 |
| ES2280597T3 (es) | 2007-09-16 |
| US20090192211A1 (en) | 2009-07-30 |
| EP1443967B1 (de) | 2007-01-24 |
| US20080227845A1 (en) | 2008-09-18 |
| IL160970A0 (en) | 2004-08-31 |
| CY1106508T1 (el) | 2012-01-25 |
| NZ544689A (en) | 2007-08-31 |
| PL205853B1 (pl) | 2010-06-30 |
| DK1443967T3 (da) | 2007-04-16 |
| EP1443967A1 (de) | 2004-08-11 |
| DE60217895D1 (en) | 2007-03-15 |
| AU2002351844B2 (en) | 2006-12-21 |
| CN100457183C (zh) | 2009-02-04 |
| US20050032899A1 (en) | 2005-02-10 |
| RU2004117170A (ru) | 2005-04-20 |
| KR100937064B1 (ko) | 2010-01-15 |
| NO20042148L (no) | 2004-08-04 |
| DE60217895T2 (de) | 2007-07-05 |
| US7402603B2 (en) | 2008-07-22 |
| JP2005510517A (ja) | 2005-04-21 |
| PL368539A1 (en) | 2005-04-04 |
| KR20050043744A (ko) | 2005-05-11 |
| PT1443967E (pt) | 2007-04-30 |
| CN1578674A (zh) | 2005-02-09 |
| CA2461373A1 (en) | 2003-05-15 |
| IL160970A (en) | 2010-06-30 |
| MXPA04004312A (es) | 2005-05-16 |
| WO2003039599A1 (en) | 2003-05-15 |
| RU2311200C2 (ru) | 2007-11-27 |
| BR0213932A (pt) | 2004-08-31 |
| HUP0402370A3 (en) | 2008-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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