ATE352630T1 - Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie - Google Patents

Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie

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Publication number
ATE352630T1
ATE352630T1 AT04016978T AT04016978T ATE352630T1 AT E352630 T1 ATE352630 T1 AT E352630T1 AT 04016978 T AT04016978 T AT 04016978T AT 04016978 T AT04016978 T AT 04016978T AT E352630 T1 ATE352630 T1 AT E352630T1
Authority
AT
Austria
Prior art keywords
gene therapy
dna molecule
circular dna
production process
replication origin
Prior art date
Application number
AT04016978T
Other languages
English (en)
Inventor
Joel Crouzet
Fabienne Soubrier
Original Assignee
Centelion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9482580&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE352630(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Centelion filed Critical Centelion
Application granted granted Critical
Publication of ATE352630T1 publication Critical patent/ATE352630T1/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
AT04016978T 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie ATE352630T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9510825A FR2738842B1 (fr) 1995-09-15 1995-09-15 Molecule d'adn circulaire a origine de replication conditionnelle, leur procede de preparation et leur utilisation en therapie genique

Publications (1)

Publication Number Publication Date
ATE352630T1 true ATE352630T1 (de) 2007-02-15

Family

ID=9482580

Family Applications (3)

Application Number Title Priority Date Filing Date
AT04016978T ATE352630T1 (de) 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie
AT06017245T ATE492642T1 (de) 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie
AT96931124T ATE284966T1 (de) 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT06017245T ATE492642T1 (de) 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie
AT96931124T ATE284966T1 (de) 1995-09-15 1996-09-13 Zirkuläres dna molekül mit einem abhängigen replikationsursprung, seine herstellungsverfahren und seine verwendung in der gentherapie

Country Status (20)

Country Link
US (3) US6977174B2 (de)
EP (3) EP1508620B1 (de)
JP (3) JP3818665B2 (de)
KR (1) KR100522369B1 (de)
AT (3) ATE352630T1 (de)
BR (1) BRPI9610511B8 (de)
CA (1) CA2229307C (de)
CZ (1) CZ294525B6 (de)
DE (3) DE69634043T2 (de)
DK (3) DK0850310T3 (de)
ES (3) ES2233975T3 (de)
FR (1) FR2738842B1 (de)
HU (1) HU224400B1 (de)
IL (4) IL123641A0 (de)
NO (1) NO323975B1 (de)
PT (3) PT1508620E (de)
SK (1) SK285317B6 (de)
TW (1) TWI231826B (de)
WO (1) WO1997010343A1 (de)
ZA (1) ZA967640B (de)

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EP2643343A1 (de) 2010-11-26 2013-10-02 Institut Pasteur Identifizierung eines menschlichen gyrovirus und anwendungen
EP2788477A2 (de) 2011-12-07 2014-10-15 Institut Pasteur Identifizierung des porcinen parecho-like virus und anwendungen
CA2883227A1 (en) 2012-08-29 2014-03-06 Nature Technology Corporation Dna plasmids with improved expression
WO2014077863A1 (en) 2012-11-19 2014-05-22 Nature Technology Corporation Replicative minicircle vectors with improved expression
HUE067575T2 (hu) * 2013-03-14 2024-10-28 Genvivo Inc Javított timidin-kináz gén
EP3456821B2 (de) 2017-09-19 2024-01-24 Deutsches Krebsforschungszentrum Nicht integrierende dna-vektoren zur genetischen modifikation von zellen
WO2019057774A1 (en) 2017-09-19 2019-03-28 Deutsches Krebsforschungszentrum NON-INTEGRATING DNA VECTORS FOR THE GENETIC MODIFICATION OF CELLS
DK3768846T5 (da) 2018-03-21 2024-08-19 Aldevron L L C Virale og ikke-virale nanoplasmidvektorer med forbedret produktion
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Also Published As

Publication number Publication date
DE69634043D1 (de) 2005-01-20
AU728231B2 (en) 2001-01-04
ATE284966T1 (de) 2005-01-15
IL207348A0 (en) 2010-12-30
DE69638314D1 (de) 2011-02-03
SK34798A3 (en) 1998-11-04
FR2738842A1 (fr) 1997-03-21
EP1724354A3 (de) 2008-10-29
US20090149406A1 (en) 2009-06-11
PT1508620E (pt) 2007-05-31
JP2006136328A (ja) 2006-06-01
US20010014476A1 (en) 2001-08-16
EP1724354A2 (de) 2006-11-22
PT1724354E (pt) 2011-03-09
MX9802005A (es) 1998-08-30
BR9610511A (pt) 1999-01-26
DK1724354T3 (da) 2011-04-04
WO1997010343A1 (fr) 1997-03-20
DK0850310T3 (da) 2005-04-25
EP1508620A1 (de) 2005-02-23
EP1508620B1 (de) 2007-01-24
DK1508620T3 (da) 2007-05-29
ZA967640B (en) 1997-03-25
IL173399A (en) 2010-11-30
AU6992496A (en) 1997-04-01
HU224400B1 (hu) 2005-08-29
JP2000501281A (ja) 2000-02-08
EP1724354B1 (de) 2010-12-22
CZ294525B6 (cs) 2005-01-12
ES2357098T3 (es) 2011-04-18
SK285317B6 (sk) 2006-10-05
ATE492642T1 (de) 2011-01-15
JP4585435B2 (ja) 2010-11-24
KR19990044683A (ko) 1999-06-25
JP4756014B2 (ja) 2011-08-24
CA2229307C (fr) 2013-06-11
CA2229307A1 (fr) 1997-03-20
BRPI9610511B8 (pt) 2016-11-08
HUP9900018A3 (en) 2001-10-29
PT850310E (pt) 2005-05-31
CZ78898A3 (cs) 1998-06-17
JP2007325603A (ja) 2007-12-20
NO323975B1 (no) 2007-07-30
FR2738842B1 (fr) 1997-10-31
EP0850310B1 (de) 2004-12-15
ES2233975T3 (es) 2005-06-16
TWI231826B (en) 2005-05-01
EP0850310A1 (de) 1998-07-01
IL123641A (en) 2006-06-11
BR9610511B1 (pt) 2010-10-19
NO981044D0 (no) 1998-03-10
US6977174B2 (en) 2005-12-20
HUP9900018A1 (hu) 1999-04-28
IL123641A0 (en) 1998-10-30
NO981044L (no) 1998-03-10
DE69636878T2 (de) 2007-11-08
ES2281721T3 (es) 2007-10-01
KR100522369B1 (ko) 2006-10-24
IL173399A0 (en) 2006-06-11
DE69634043T2 (de) 2005-08-18
DE69636878D1 (de) 2007-03-15
JP3818665B2 (ja) 2006-09-06
US20090130674A1 (en) 2009-05-21

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