ATE352784T1 - Verfahren zum screenen für gpr40-liganden - Google Patents

Verfahren zum screenen für gpr40-liganden

Info

Publication number
ATE352784T1
ATE352784T1 AT01994292T AT01994292T ATE352784T1 AT E352784 T1 ATE352784 T1 AT E352784T1 AT 01994292 T AT01994292 T AT 01994292T AT 01994292 T AT01994292 T AT 01994292T AT E352784 T1 ATE352784 T1 AT E352784T1
Authority
AT
Austria
Prior art keywords
screening
ligands
gpr40
gpr40 ligands
methods
Prior art date
Application number
AT01994292T
Other languages
English (en)
Inventor
John Leon Andrews
Celia Patricia Briscoe
Diane Michelle Ignar
Alison Isobel Muir
Howard Ray Sauls Jr
Mohammad Tadayyon
Original Assignee
Glaxo Group Ltd
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Smithkline Beecham Plc filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE352784T1 publication Critical patent/ATE352784T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/10Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT01994292T 2000-12-22 2001-12-18 Verfahren zum screenen für gpr40-liganden ATE352784T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0031527.5A GB0031527D0 (en) 2000-12-22 2000-12-22 New use

Publications (1)

Publication Number Publication Date
ATE352784T1 true ATE352784T1 (de) 2007-02-15

Family

ID=9905799

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01994292T ATE352784T1 (de) 2000-12-22 2001-12-18 Verfahren zum screenen für gpr40-liganden

Country Status (7)

Country Link
EP (1) EP1354200B1 (de)
AT (1) ATE352784T1 (de)
AU (1) AU2002246702A1 (de)
DE (1) DE60126337T2 (de)
ES (1) ES2280427T3 (de)
GB (1) GB0031527D0 (de)
WO (1) WO2002057783A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60332320D1 (de) 2002-02-14 2010-06-10 Takeda Pharmaceutical Neues screening-verfahren
WO2004022551A1 (ja) * 2002-09-06 2004-03-18 Takeda Pharmaceutical Company Limited フランまたはチオフェン誘導体およびその医薬用途
US7056685B1 (en) 2002-11-05 2006-06-06 Amgen Inc. Receptor ligands and methods of modulating receptors
AU2003277576A1 (en) 2002-11-08 2004-06-07 Takeda Pharmaceutical Company Limited Receptor function controlling agent
AU2003297644A1 (en) * 2002-12-04 2004-06-23 Synaptic Pharmaceutical Corporation Uses of the snorf55 receptor
JP4574177B2 (ja) * 2003-01-17 2010-11-04 武田薬品工業株式会社 新規スクリーニング方法
EP1584925B1 (de) * 2003-01-17 2011-06-01 Takeda Pharmaceutical Company Limited Neues screening-verfahren
US20060160088A1 (en) * 2003-02-17 2006-07-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 40 (gpr40)
EP1630152A4 (de) 2003-05-30 2009-09-23 Takeda Pharmaceutical Verbindung mit kondensiertem ring
WO2005015990A1 (en) * 2003-08-18 2005-02-24 Betagenon Ab New diabetes type 2 animal model
WO2005051890A1 (en) * 2003-11-19 2005-06-09 Smithkline Beecham Corporation Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40
EA011010B1 (ru) 2004-02-27 2008-12-30 Эмджен, Инк. Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина
EP1731505B1 (de) 2004-03-30 2015-01-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropansäurederivate
US20060003344A1 (en) * 2004-06-30 2006-01-05 Pfizer Inc. Methods related to a single nucleotide polymorphism of the G protein coupled receptor, GPR40
JP2007284350A (ja) 2004-07-27 2007-11-01 Takeda Chem Ind Ltd 糖尿病治療剤
US7465804B2 (en) 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
WO2007033002A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
JP4990789B2 (ja) * 2005-11-04 2012-08-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 Gpr40とホスホリパーゼとを用いる疾患に有用な物質のスクリーニング方法
CA2662305C (en) 2006-09-07 2012-04-17 Amgen Inc. Heterocyclic gpr40 modulators
WO2008030618A1 (en) 2006-09-07 2008-03-13 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
US7572934B2 (en) 2007-04-16 2009-08-11 Amgen Inc. Substituted biphenyl GPR40 modulators
BRPI0818253A2 (pt) 2007-10-10 2015-04-07 Amgen Inc Moduladores de gpr40 bifenil substituídos
WO2009111056A1 (en) 2008-03-06 2009-09-11 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
JP5551707B2 (ja) 2008-10-15 2014-07-16 アムジエン・インコーポレーテツド スピロ環gpr40調節因子
PL233938B1 (pl) * 2018-01-08 2019-12-31 CELON PHARMA Spólka Akcyjna Pochodne kwasu 3-fenylo-4-heksynowego jako agoniści GPR40

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309854B1 (en) * 1996-12-17 2001-10-30 Smithkline Beecham Corporation Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72
US6555339B1 (en) * 1997-04-14 2003-04-29 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human protein-coupled receptors
DE60125227T2 (de) * 2000-12-01 2007-09-20 Astellas Pharma Inc. Verfahren zum screening von diabetes-heilverfahren

Also Published As

Publication number Publication date
ES2280427T3 (es) 2007-09-16
WO2002057783A3 (en) 2003-08-07
EP1354200A2 (de) 2003-10-22
DE60126337D1 (de) 2007-03-15
EP1354200B1 (de) 2007-01-24
WO2002057783A2 (en) 2002-07-25
AU2002246702A1 (en) 2002-07-30
GB0031527D0 (en) 2001-02-07
DE60126337T2 (de) 2007-11-15

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