ATE352784T1 - Verfahren zum screenen für gpr40-liganden - Google Patents
Verfahren zum screenen für gpr40-ligandenInfo
- Publication number
- ATE352784T1 ATE352784T1 AT01994292T AT01994292T ATE352784T1 AT E352784 T1 ATE352784 T1 AT E352784T1 AT 01994292 T AT01994292 T AT 01994292T AT 01994292 T AT01994292 T AT 01994292T AT E352784 T1 ATE352784 T1 AT E352784T1
- Authority
- AT
- Austria
- Prior art keywords
- screening
- ligands
- gpr40
- gpr40 ligands
- methods
- Prior art date
Links
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 title abstract 3
- 101000912510 Homo sapiens Free fatty acid receptor 1 Proteins 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000012216 screening Methods 0.000 title abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Endocrinology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0031527.5A GB0031527D0 (en) | 2000-12-22 | 2000-12-22 | New use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE352784T1 true ATE352784T1 (de) | 2007-02-15 |
Family
ID=9905799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01994292T ATE352784T1 (de) | 2000-12-22 | 2001-12-18 | Verfahren zum screenen für gpr40-liganden |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1354200B1 (de) |
| AT (1) | ATE352784T1 (de) |
| AU (1) | AU2002246702A1 (de) |
| DE (1) | DE60126337T2 (de) |
| ES (1) | ES2280427T3 (de) |
| GB (1) | GB0031527D0 (de) |
| WO (1) | WO2002057783A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60332320D1 (de) | 2002-02-14 | 2010-06-10 | Takeda Pharmaceutical | Neues screening-verfahren |
| WO2004022551A1 (ja) * | 2002-09-06 | 2004-03-18 | Takeda Pharmaceutical Company Limited | フランまたはチオフェン誘導体およびその医薬用途 |
| US7056685B1 (en) | 2002-11-05 | 2006-06-06 | Amgen Inc. | Receptor ligands and methods of modulating receptors |
| AU2003277576A1 (en) | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| AU2003297644A1 (en) * | 2002-12-04 | 2004-06-23 | Synaptic Pharmaceutical Corporation | Uses of the snorf55 receptor |
| JP4574177B2 (ja) * | 2003-01-17 | 2010-11-04 | 武田薬品工業株式会社 | 新規スクリーニング方法 |
| EP1584925B1 (de) * | 2003-01-17 | 2011-06-01 | Takeda Pharmaceutical Company Limited | Neues screening-verfahren |
| US20060160088A1 (en) * | 2003-02-17 | 2006-07-20 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 40 (gpr40) |
| EP1630152A4 (de) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | Verbindung mit kondensiertem ring |
| WO2005015990A1 (en) * | 2003-08-18 | 2005-02-24 | Betagenon Ab | New diabetes type 2 animal model |
| WO2005051890A1 (en) * | 2003-11-19 | 2005-06-09 | Smithkline Beecham Corporation | Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to gpr40 |
| EA011010B1 (ru) | 2004-02-27 | 2008-12-30 | Эмджен, Инк. | Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина |
| EP1731505B1 (de) | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropansäurederivate |
| US20060003344A1 (en) * | 2004-06-30 | 2006-01-05 | Pfizer Inc. | Methods related to a single nucleotide polymorphism of the G protein coupled receptor, GPR40 |
| JP2007284350A (ja) | 2004-07-27 | 2007-11-01 | Takeda Chem Ind Ltd | 糖尿病治療剤 |
| US7465804B2 (en) | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| WO2007033002A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| JP4990789B2 (ja) * | 2005-11-04 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Gpr40とホスホリパーゼとを用いる疾患に有用な物質のスクリーニング方法 |
| CA2662305C (en) | 2006-09-07 | 2012-04-17 | Amgen Inc. | Heterocyclic gpr40 modulators |
| WO2008030618A1 (en) | 2006-09-07 | 2008-03-13 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| US7572934B2 (en) | 2007-04-16 | 2009-08-11 | Amgen Inc. | Substituted biphenyl GPR40 modulators |
| BRPI0818253A2 (pt) | 2007-10-10 | 2015-04-07 | Amgen Inc | Moduladores de gpr40 bifenil substituídos |
| WO2009111056A1 (en) | 2008-03-06 | 2009-09-11 | Amgen Inc. | Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders |
| JP5551707B2 (ja) | 2008-10-15 | 2014-07-16 | アムジエン・インコーポレーテツド | スピロ環gpr40調節因子 |
| PL233938B1 (pl) * | 2018-01-08 | 2019-12-31 | CELON PHARMA Spólka Akcyjna | Pochodne kwasu 3-fenylo-4-heksynowego jako agoniści GPR40 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309854B1 (en) * | 1996-12-17 | 2001-10-30 | Smithkline Beecham Corporation | Polynucleotides encoding ligands of the neuropeptide receptor HFGAN72 |
| US6555339B1 (en) * | 1997-04-14 | 2003-04-29 | Arena Pharmaceuticals, Inc. | Non-endogenous, constitutively activated human protein-coupled receptors |
| DE60125227T2 (de) * | 2000-12-01 | 2007-09-20 | Astellas Pharma Inc. | Verfahren zum screening von diabetes-heilverfahren |
-
2000
- 2000-12-22 GB GBGB0031527.5A patent/GB0031527D0/en not_active Ceased
-
2001
- 2001-12-18 AU AU2002246702A patent/AU2002246702A1/en not_active Abandoned
- 2001-12-18 AT AT01994292T patent/ATE352784T1/de not_active IP Right Cessation
- 2001-12-18 WO PCT/US2001/048985 patent/WO2002057783A2/en not_active Ceased
- 2001-12-18 DE DE60126337T patent/DE60126337T2/de not_active Expired - Lifetime
- 2001-12-18 ES ES01994292T patent/ES2280427T3/es not_active Expired - Lifetime
- 2001-12-18 EP EP01994292A patent/EP1354200B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2280427T3 (es) | 2007-09-16 |
| WO2002057783A3 (en) | 2003-08-07 |
| EP1354200A2 (de) | 2003-10-22 |
| DE60126337D1 (de) | 2007-03-15 |
| EP1354200B1 (de) | 2007-01-24 |
| WO2002057783A2 (en) | 2002-07-25 |
| AU2002246702A1 (en) | 2002-07-30 |
| GB0031527D0 (en) | 2001-02-07 |
| DE60126337T2 (de) | 2007-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |