ATE353214T1 - Nitrooxyderivate von fluvastatin, pravastatin, cerivastatin, atorvastatin und rosuvastatin als cholesterinsenkende mittel mit verbesserter antiphlogistischer, antithrombotischer und thrombozytenaggregationshemmender wirkung - Google Patents

Nitrooxyderivate von fluvastatin, pravastatin, cerivastatin, atorvastatin und rosuvastatin als cholesterinsenkende mittel mit verbesserter antiphlogistischer, antithrombotischer und thrombozytenaggregationshemmender wirkung

Info

Publication number: ATE353214T1
Authority: AT; Austria
Prior art keywords: antithrbotic; antiphlogistic; cerivastatin; rosuvastatin; fluvastatin
Prior art date: 2003-05-27

Application number

AT04741636T

Other languages

English (en)

Inventor

Francesca Benedini

Ennio Ongini

Soldato Piero Del

Original Assignee

Nicox Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-05-27

Filing date

2004-05-24

Publication date

2007-02-15

2004-05-24 Application filed by Nicox Sa filed Critical Nicox Sa

2007-02-15 Application granted granted Critical

2007-02-15 Publication of ATE353214T1 publication Critical patent/ATE353214T1/de

Links

XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title 1
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title 1
-1 NITROOXY DERIVATIVES OF FLUVASTATIN Chemical class 0.000 title 1
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 title 1
230000002776 aggregation Effects 0.000 title 1
238000004220 aggregation Methods 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
230000001741 anti-phlogistic effect Effects 0.000 title 1
239000003529 anticholesteremic agent Substances 0.000 title 1
229940127226 anticholesterol agent Drugs 0.000 title 1
229960005370 atorvastatin Drugs 0.000 title 1
229960005110 cerivastatin Drugs 0.000 title 1
SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 title 1
230000000694 effects Effects 0.000 title 1
230000001976 improved effect Effects 0.000 title 1
229960002965 pravastatin Drugs 0.000 title 1
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title 1
229960000672 rosuvastatin Drugs 0.000 title 1
BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT04741636T 2003-05-27 2004-05-24 Nitrooxyderivate von fluvastatin, pravastatin, cerivastatin, atorvastatin und rosuvastatin als cholesterinsenkende mittel mit verbesserter antiphlogistischer, antithrombotischer und thrombozytenaggregationshemmender wirkung ATE353214T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP03101530		2003-05-27

Publications (1)

Publication Number	Publication Date
ATE353214T1 true ATE353214T1 (de)	2007-02-15

Family

ID=33483985

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04741636T ATE353214T1 (de)	2003-05-27	2004-05-24	Nitrooxyderivate von fluvastatin, pravastatin, cerivastatin, atorvastatin und rosuvastatin als cholesterinsenkende mittel mit verbesserter antiphlogistischer, antithrombotischer und thrombozytenaggregationshemmender wirkung

Country Status (22)

Country	Link
US (4)	US7166638B2 (de)
EP (1)	EP1626716B1 (de)
KR (1)	KR101136434B1 (de)
CN (1)	CN1794987B (de)
AR (1)	AR044561A1 (de)
AT (1)	ATE353214T1 (de)
AU (1)	AU2004243443B2 (de)
BR (1)	BRPI0410049A (de)
CA (1)	CA2527168C (de)
CY (1)	CY1107614T1 (de)
DE (1)	DE602004004652T2 (de)
DK (1)	DK1626716T3 (de)
ES (1)	ES2280978T3 (de)
MX (1)	MXPA05012755A (de)
NO (1)	NO20056152L (de)
NZ (1)	NZ543086A (de)
PL (1)	PL379019A1 (de)
PT (1)	PT1626716E (de)
RU (1)	RU2362770C2 (de)
SI (1)	SI1626716T1 (de)
WO (1)	WO2004105754A1 (de)
ZA (1)	ZA200509460B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200616604A (en)	2004-08-26	2006-06-01	Nicholas Piramal India Ltd	Nitric oxide releasing prodrugs containing bio-cleavable linker
KR20070053214A (ko)	2004-08-26	2007-05-23	니콜라스 피라말 인디아 리미티드	신규 생분해성 링커를 함유하는 프로드럭
NZ569396A (en)	2006-02-03	2011-06-30	Nicox Sa	Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
EP1889617A1 (de) *	2006-07-11	2008-02-20	Freie Universität Berlin	Triphenylsubstituierte fünfgliedrige Heterocyclen und deren Verwendung als Antikreb- und entzündungshemmende Mittel
MX2009011009A (es) *	2007-04-13	2009-10-30	Nicox Sa	Formas cristalinas de atorvastatin 4-(nitrooxi)butil ester.
EP2164484A1 (de) *	2007-06-25	2010-03-24	Nicox S.A.	Verwendung von stickoxid freisetzenden statinen bei der behandlung von pulmonaler arterieller hypertonie
US20090226515A1 (en) *	2008-03-04	2009-09-10	Pharma Pass Ii Llc	Statin compositions
WO2009147009A2 (en) *	2008-06-06	2009-12-10	Nicox S.A.	Compositions comprising atorvastatin 4-(nitrooxy) butyl ester and a hypolipidemic drug
US7807716B2 (en) *	2008-09-24	2010-10-05	Oral Delivery Technology Ltd.	Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
CN101613284B (zh) *	2009-06-26	2013-05-08	四川抗菌素工业研究所有限公司	洛伐他汀、辛伐他汀和辛伐他汀-6-氧化物的硝基氧基衍生物及其制备方法
EP2371404A3 (de)	2010-03-30	2014-08-20	Biotronik AG	Medizinisches Implantat mit einer Beschichtung bestehend aus oder enthaltend mindestens einen Nitro-Statin-Wirkstoff
WO2011160974A2 (en)	2010-06-21	2011-12-29	Nicox S.A.	Statin derivatives
CA2897571C (en)	2013-01-21	2018-12-18	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
US9499621B2 (en)	2013-04-08	2016-11-22	Cytodyn, Inc.	Felinized antibodies and methods of treating retroviral infections in felines
EP2949324A1 (de)	2014-05-27	2015-12-02	Consorci Institut Catala de Ciencies Cardiovasculars	Prävention und/oder Behandlung von Ischämie-/Reperfusionsschäden
CN104327057B (zh) *	2014-10-17	2017-01-18	上海应用技术学院	多取代吲哚类他汀内酯脱水化合物及其用途
JP2018526448A (ja) *	2015-09-07	2018-09-13	浙江華海薬業股▲フン▼有限公司	一酸化窒素を放出可能なプロドラッグ分子
CN108114282B (zh) *	2016-11-28	2021-03-02	北京大学第三医院	他汀类化合物治疗缺血性疾病的用途
BR112019020353A2 (pt)	2017-03-31	2020-04-28	Fundació Institut De Recerca De L'hospital De La Santa Creu I Sant Pau	estatina para prevenção/redução de dano relacionado à isquemia
EP3381452A1 (de)	2017-03-31	2018-10-03	Instituto Catalán de Ciencias Cardiovasculares (ICCC), Hospital de la Santa Creu i Sant Pau, Avda.	Statin zur verhinderung/verringerung von beschädigung im zusammenhang mit ischämie
CN107043373B (zh) *	2017-03-31	2020-04-28	中国医药集团总公司四川抗菌素工业研究所	一种噁三唑类no供体型他汀衍生物及其制备方法和应用
CN107098843B (zh) *	2017-03-31	2020-04-28	中国医药集团总公司四川抗菌素工业研究所	一种fk409类no供体型他汀降血脂药物衍生物及其制备方法
CN106938979B (zh) *	2017-03-31	2019-08-02	中国医药集团总公司四川抗菌素工业研究所	一种no供体型他汀衍生物、制备方法和应用
CN110183329B (zh) *	2019-06-19	2022-09-13	中国医药集团总公司四川抗菌素工业研究所	硝酸酯类no供体型他汀衍生物及其制备方法
CN113929609B (zh) *	2021-10-13	2024-08-23	深圳弘汇生物医药有限公司	一种调血脂的阿托伐他汀衍生物及其组合物、制备方法和医药用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8927981D0 (en) *	1989-12-11	1990-02-14	Ici Plc	Carbamoyl derivative
IE904261A1 (en) *	1990-11-26	1992-06-03	Sanofi Sa	Use of a statin derivative in the treatment of eye¹complaints
JP2648897B2 (ja) *	1991-07-01	1997-09-03	塩野義製薬株式会社	ピリミジン誘導体
HU9203780D0 (en) *	1991-12-12	1993-03-29	Sandoz Ag	Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
WO1997013405A1 (en) *	1995-10-13	1997-04-17	The United States Of America, Represented By The Secretary Of Agriculture	In ovo yeast treatment to diminish salmonellae populations in poultry
IT1276071B1 (it)	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
IT1295694B1 (it)	1996-11-14	1999-05-27	Nicox Sa	Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1311924B1 (it)	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1311923B1 (it) *	1999-04-13	2002-03-20	Nicox Sa	Composti farmaceutici.
IT1314184B1 (it)	1999-08-12	2002-12-06	Nicox Sa	Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
US6573385B1 (en) *	1999-11-11	2003-06-03	Biocon India Limited	Process for manufacturing simvastatin and novel intermediates thereof
US6476235B2 (en) *	2001-01-09	2002-11-05	Warner-Lambert Company	Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
US20030100493A1 (en)	2001-07-19	2003-05-29	Sol Weiss	Sublingual use of inhibitors in the biosynthesis of cholesterol

2004
- 2004-05-20 US US10/849,561 patent/US7166638B2/en not_active Expired - Fee Related
- 2004-05-24 BR BRPI0410049-2A patent/BRPI0410049A/pt not_active IP Right Cessation
- 2004-05-24 EP EP04741636A patent/EP1626716B1/de not_active Expired - Lifetime
- 2004-05-24 MX MXPA05012755A patent/MXPA05012755A/es active IP Right Grant
- 2004-05-24 DE DE602004004652T patent/DE602004004652T2/de not_active Expired - Lifetime
- 2004-05-24 NZ NZ543086A patent/NZ543086A/en not_active IP Right Cessation
- 2004-05-24 PT PT04741636T patent/PT1626716E/pt unknown
- 2004-05-24 CA CA2527168A patent/CA2527168C/en not_active Expired - Fee Related
- 2004-05-24 AT AT04741636T patent/ATE353214T1/de active
- 2004-05-24 DK DK04741636T patent/DK1626716T3/da active
- 2004-05-24 PL PL379019A patent/PL379019A1/pl not_active Application Discontinuation
- 2004-05-24 AU AU2004243443A patent/AU2004243443B2/en not_active Ceased
- 2004-05-24 WO PCT/EP2004/050897 patent/WO2004105754A1/en not_active Ceased
- 2004-05-24 CN CN2004800144981A patent/CN1794987B/zh not_active Expired - Fee Related
- 2004-05-24 SI SI200430242T patent/SI1626716T1/sl unknown
- 2004-05-24 KR KR1020057022246A patent/KR101136434B1/ko not_active Expired - Fee Related
- 2004-05-24 ES ES04741636T patent/ES2280978T3/es not_active Expired - Lifetime
- 2004-05-24 RU RU2005138139/04A patent/RU2362770C2/ru not_active IP Right Cessation
- 2004-05-26 AR ARP040101813A patent/AR044561A1/es not_active Application Discontinuation
2005
- 2005-11-22 ZA ZA200509460A patent/ZA200509460B/en unknown
- 2005-12-23 NO NO20056152A patent/NO20056152L/no not_active Application Discontinuation
2006
- 2006-11-01 US US11/590,770 patent/US7297808B2/en not_active Expired - Fee Related
2007
- 2007-04-13 CY CY20071100515T patent/CY1107614T1/el unknown
- 2007-10-05 US US11/905,910 patent/US7563909B2/en not_active Expired - Fee Related
- 2007-10-05 US US11/905,893 patent/US7462716B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN1794987A (zh)	2006-06-28
PT1626716E (pt)	2007-04-30
DE602004004652D1 (de)	2007-03-22
RU2362770C2 (ru)	2009-07-27
SI1626716T1 (sl)	2007-06-30
US20050165084A1 (en)	2005-07-28
US20080090857A1 (en)	2008-04-17
RU2005138139A (ru)	2006-05-10
ES2280978T3 (es)	2007-09-16
NZ543086A (en)	2009-11-27
US20080096908A1 (en)	2008-04-24
CA2527168A1 (en)	2004-12-09
US7166638B2 (en)	2007-01-23
US20070072942A1 (en)	2007-03-29
US7297808B2 (en)	2007-11-20
AU2004243443B2 (en)	2009-09-10
CN1794987B (zh)	2010-09-29
US7462716B2 (en)	2008-12-09
EP1626716A1 (de)	2006-02-22
AU2004243443A1 (en)	2004-12-09
AR044561A1 (es)	2005-09-21
BRPI0410049A (pt)	2006-04-25
WO2004105754A1 (en)	2004-12-09
DK1626716T3 (da)	2007-05-14
ZA200509460B (en)	2007-04-25
DE602004004652T2 (de)	2007-11-08
US7563909B2 (en)	2009-07-21
NO20056152L (no)	2005-12-23
CY1107614T1 (el)	2013-03-13
KR20060013551A (ko)	2006-02-10
KR101136434B1 (ko)	2012-04-19
PL379019A1 (pl)	2006-06-26
CA2527168C (en)	2014-08-12
EP1626716B1 (de)	2007-02-07
HK1090295A1 (en)	2006-12-22
MXPA05012755A (es)	2006-02-13

Legal Events

Date

Code

Title

Description

2007-08-15

UEP

Publication of translation of european patent specification

Ref document number: 1626716

Country of ref document: EP

Publication	Publication Date	Title
ATE353214T1 (de)	2007-02-15	Nitrooxyderivate von fluvastatin, pravastatin, cerivastatin, atorvastatin und rosuvastatin als cholesterinsenkende mittel mit verbesserter antiphlogistischer, antithrombotischer und thrombozytenaggregationshemmender wirkung
ATE319686T1 (de)	2006-03-15	Mutilin-derivate und ihre anwendung als antibakterielle mittel
DE60308998D1 (de)	2006-11-23	N-aryl-2-oxazolidinon-5-carbonsäureamide und deren derivate und deren verwendung als antibakterielle mittel
DE602005013491D1 (de)	2009-05-07	Benzamidderivate und deren verwendung als glucokinaseaktivierende mittel
DE60327341D1 (de)	2009-06-04	Hybridmoleküle von makroliden mit steroidalen/nicht-steroidalen antientzündlich aktiven molekülen
DE50306327D1 (de)	2007-03-08	Als aerosol versprühbare w/o-emulsionen
DE602004017108D1 (de)	2008-11-27	Stickstoff enthaltende kondensierte ringverbindung und deren verwendung als hiv-integrasehemmer
ATE543825T1 (de)	2012-02-15	Spiro-oxindolverbindungen und ihre verwendungen als therapeutische mittel
DE60332798D1 (de)	2010-07-15	Verringerung des Verhältnisses von Spitzen- zu Durchschnittsleistung
ATE438639T1 (de)	2009-08-15	2-cyanopyrrolidin-derivate und ihre verwendung als arzneimittel
DE60025147D1 (de)	2006-02-02	Kosmetische Zusammensetzung und Verwendungen
ATE345108T1 (de)	2006-12-15	Kosmetische zusammensetzungen enthaltend resveratrol und retinoide
EP1357809A4 (de)	2005-01-26	Hygienisierung von nahrungsmitteln
ATE370958T1 (de)	2007-09-15	Phosphonooxy-chinazolin derivate und ihre pharmazeutische verwendung
ATE395339T1 (de)	2008-05-15	Biphenylderivate und deren verwendung als fungizide
DE60133831D1 (de)	2008-06-12	Verwendung von cci-779 als antineoplastisches mittel
DE60303951D1 (de)	2006-05-04	Kombinationen von cyclohexandionoxim-herbiziden und safeners
ATE420084T1 (de)	2009-01-15	Neue imidazolderivate und deren verwendung als pharmazeutische mittel
DE60311694D1 (de)	2007-03-29	Kosmetische Zusammensetzung
DE602004010708D1 (de)	2008-01-24	Imidazopyridinsubstituierte tropanderivate mit ccr5-rezeptorantagonistischer wirkung zur behandlung von hiv und entzündungen
ATE401908T1 (de)	2008-08-15	Pharmazeutische zusammensetzungen von erythropoietin
ATE326213T1 (de)	2006-06-15	Kosmetische mittel enthaltend kickererbsen- extrakt und retinoide
ATE437860T1 (de)	2009-08-15	2-hydroxy-mutilin-carbamat derivate und ihre anwendung als antibakterielle mittel
ATE527983T1 (de)	2011-10-15	Kosmetische und dermatologische lichtschutzformulierungen mit einem gehalt an partikulären uv-filtersubstanzen und alkylnaphthalaten
DE60302152D1 (de)	2005-12-08	Diaminothiazole und ihre anwendung als cdk4 inhibitoren