ATE353331T1 - Verfahren zur herstellung substituierter 5-amino- pyrazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidin - Google Patents
Verfahren zur herstellung substituierter 5-amino- pyrazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidinInfo
- Publication number
- ATE353331T1 ATE353331T1 AT04796445T AT04796445T ATE353331T1 AT E353331 T1 ATE353331 T1 AT E353331T1 AT 04796445 T AT04796445 T AT 04796445T AT 04796445 T AT04796445 T AT 04796445T AT E353331 T1 ATE353331 T1 AT E353331T1
- Authority
- AT
- Austria
- Prior art keywords
- triazolo
- pyrazolo
- pyrimidine
- amino
- producing substituted
- Prior art date
Links
- IXECJBAWCMPTMB-UHFFFAOYSA-N NC1=NC2=NN=CC2=C2N=CNN12 Chemical class NC1=NC2=NN=CC2=C2N=CNN12 IXECJBAWCMPTMB-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51505103P | 2003-10-28 | 2003-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353331T1 true ATE353331T1 (de) | 2007-02-15 |
Family
ID=34572798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04796445T ATE353331T1 (de) | 2003-10-28 | 2004-10-26 | Verfahren zur herstellung substituierter 5-amino- pyrazolo-(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidin |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7223861B2 (de) |
| EP (1) | EP1678182B1 (de) |
| JP (2) | JP4782693B2 (de) |
| CN (2) | CN101899050A (de) |
| AR (1) | AR046560A1 (de) |
| AT (1) | ATE353331T1 (de) |
| CA (1) | CA2543431A1 (de) |
| CY (1) | CY1106393T1 (de) |
| DE (1) | DE602004004677T2 (de) |
| DK (1) | DK1678182T3 (de) |
| ES (1) | ES2278353T3 (de) |
| HR (1) | HRP20070063T3 (de) |
| MX (1) | MXPA06004722A (de) |
| PL (1) | PL1678182T3 (de) |
| PT (1) | PT1678182E (de) |
| SI (1) | SI1678182T1 (de) |
| WO (1) | WO2005044819A1 (de) |
| ZA (1) | ZA200603307B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1283839E (pt) * | 2000-05-26 | 2005-08-31 | Schering Corp | Antagonistas do receptor a2a da adenosina |
| DK1678182T3 (da) * | 2003-10-28 | 2007-06-04 | Schering Corp | Fremgangsmåde til fremstilling af substituerede 5-amino-pyrazolo[4,3-E]-1,2,4-triazolo-[1,5-C]pyrimidiner |
| JPWO2006132275A1 (ja) * | 2005-06-07 | 2009-01-08 | 協和醗酵工業株式会社 | 運動障害の予防および／または治療剤 |
| EP2462144B1 (de) * | 2009-08-07 | 2017-09-20 | Merck Sharp & Dohme Corp. | Verfahren zur herstellung eines 2-alkinyl substituierten 5-amino-pyrazolo-[4, 3-e]-1,2,4-triazolo [1,5-c] pyrimidins |
| US20110144049A1 (en) * | 2009-10-21 | 2011-06-16 | Serebruany Victor L | Treating Cardiac Arrhythmias, Heart Failure, Peripheral Artery Disease and Stroke with Cyclopentyl-Triazolo-Pyrimidine or Derivative Thereof |
| WO2013024474A1 (en) * | 2011-08-18 | 2013-02-21 | Mapi Phrarma Ltd. | Polymorphs of preladenant |
| US9529039B2 (en) | 2012-05-10 | 2016-12-27 | Unitechno, Inc. | Semiconductor transporting and testing fixture |
| PL3197875T3 (pl) * | 2014-09-26 | 2020-03-31 | F. Hoffmann-La Roche Ag | Sposoby wytwarzania związków (cyklopentylo[d]pirymidyn-4-ylo)piperazynowych |
| JP2022507734A (ja) | 2018-11-20 | 2022-01-18 | メルク・シャープ・アンド・ドーム・コーポレーション | 置換アミノトリアゾロピリミジン及びアミノトリアゾロピラジンアデノシン受容体アンタゴニスト、医薬組成物及びそれらの使用 |
| US12414952B2 (en) | 2018-11-20 | 2025-09-16 | Merck Sharp & Dohme Llc | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| AR117164A1 (es) | 2018-11-30 | 2021-07-14 | Merck Sharp & Dohme | Derivados de amino-triazoloquinazolina 9-sustituidos como antagonistas del receptor de adenosina, composiciones farmacéuticas y su uso para el tratamiento de diversos tipos de cáncer |
| JP2022511778A (ja) | 2018-11-30 | 2022-02-01 | メルク・シャープ・アンド・ドーム・コーポレーション | アデノシン受容体拮抗薬としての７－、８－及び１０－置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4039733A1 (de) * | 1990-12-13 | 1992-06-17 | Basf Ag | Substituierte 5-aminopyrazole |
| IT1264901B1 (it) * | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| US6448253B1 (en) * | 1998-09-16 | 2002-09-10 | King Pharmaceuticals Research And Development, Inc. | Adenosine A3 receptor modulators |
| PT1283839E (pt) | 2000-05-26 | 2005-08-31 | Schering Corp | Antagonistas do receptor a2a da adenosina |
| WO2002062801A1 (en) * | 2001-02-05 | 2002-08-15 | Otsuka Pharmaceutical Factory, Inc. | Triazoloquinazoline and pyrazolotriazolopyrimidine derivatives, medicinal compositions, adenosine a3 receptor affinity agents, ocular tension lowering agents, preparations for preventing and treating glaucoma and method of lowering ocular tension |
| CA2446099A1 (en) * | 2001-05-01 | 2002-11-14 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| AU2002346503A1 (en) * | 2001-11-30 | 2003-06-17 | Schering Corporation | Adenosine A2a receptor antagonists |
| DK1678182T3 (da) * | 2003-10-28 | 2007-06-04 | Schering Corp | Fremgangsmåde til fremstilling af substituerede 5-amino-pyrazolo[4,3-E]-1,2,4-triazolo-[1,5-C]pyrimidiner |
| ATE377599T1 (de) * | 2003-12-01 | 2007-11-15 | Schering Corp | Verfahren zur herstellung von substituierten 5- aminopyrazolo(4,3-e)-1,2,4-triazolo(1,5- c)pyrimidinen |
-
2004
- 2004-10-26 DK DK04796445T patent/DK1678182T3/da active
- 2004-10-26 CN CN2010101611983A patent/CN101899050A/zh active Pending
- 2004-10-26 ES ES04796445T patent/ES2278353T3/es not_active Expired - Lifetime
- 2004-10-26 PL PL04796445T patent/PL1678182T3/pl unknown
- 2004-10-26 CN CN200480039044XA patent/CN1898246B/zh not_active Expired - Fee Related
- 2004-10-26 EP EP04796445A patent/EP1678182B1/de not_active Expired - Lifetime
- 2004-10-26 HR HR20070063T patent/HRP20070063T3/xx unknown
- 2004-10-26 DE DE602004004677T patent/DE602004004677T2/de not_active Expired - Lifetime
- 2004-10-26 JP JP2006538174A patent/JP4782693B2/ja not_active Expired - Fee Related
- 2004-10-26 WO PCT/US2004/035472 patent/WO2005044819A1/en not_active Ceased
- 2004-10-26 US US10/973,631 patent/US7223861B2/en not_active Expired - Lifetime
- 2004-10-26 CA CA002543431A patent/CA2543431A1/en not_active Abandoned
- 2004-10-26 PT PT04796445T patent/PT1678182E/pt unknown
- 2004-10-26 AT AT04796445T patent/ATE353331T1/de active
- 2004-10-26 SI SI200430198T patent/SI1678182T1/sl unknown
- 2004-10-26 MX MXPA06004722A patent/MXPA06004722A/es active IP Right Grant
- 2004-10-27 AR ARP040103912A patent/AR046560A1/es not_active Application Discontinuation
-
2006
- 2006-04-25 ZA ZA200603307A patent/ZA200603307B/en unknown
-
2007
- 2007-03-16 CY CY20071100375T patent/CY1106393T1/el unknown
- 2007-04-20 US US11/788,682 patent/US7439361B2/en not_active Expired - Lifetime
-
2008
- 2008-09-11 US US12/208,717 patent/US7601833B2/en not_active Expired - Lifetime
-
2009
- 2009-09-02 US US12/552,765 patent/US20090326241A1/en not_active Abandoned
-
2011
- 2011-03-22 JP JP2011063381A patent/JP2011116795A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20050090492A1 (en) | 2005-04-28 |
| PL1678182T3 (pl) | 2007-05-31 |
| CA2543431A1 (en) | 2005-05-19 |
| JP2007509948A (ja) | 2007-04-19 |
| HRP20070063T3 (hr) | 2007-04-30 |
| AR046560A1 (es) | 2005-12-14 |
| PT1678182E (pt) | 2007-04-30 |
| WO2005044819A1 (en) | 2005-05-19 |
| US20090326241A1 (en) | 2009-12-31 |
| CN1898246B (zh) | 2010-10-27 |
| CN101899050A (zh) | 2010-12-01 |
| SI1678182T1 (sl) | 2007-06-30 |
| MXPA06004722A (es) | 2006-07-05 |
| ES2278353T3 (es) | 2007-08-01 |
| EP1678182B1 (de) | 2007-02-07 |
| DE602004004677T2 (de) | 2007-11-15 |
| US7439361B2 (en) | 2008-10-21 |
| US20090005559A1 (en) | 2009-01-01 |
| US7601833B2 (en) | 2009-10-13 |
| US7223861B2 (en) | 2007-05-29 |
| JP4782693B2 (ja) | 2011-09-28 |
| CN1898246A (zh) | 2007-01-17 |
| US20070203340A1 (en) | 2007-08-30 |
| ZA200603307B (en) | 2008-07-30 |
| EP1678182A1 (de) | 2006-07-12 |
| DK1678182T3 (da) | 2007-06-04 |
| HK1086008A1 (en) | 2006-09-08 |
| DE602004004677D1 (de) | 2007-03-22 |
| CY1106393T1 (el) | 2011-10-12 |
| JP2011116795A (ja) | 2011-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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