ATE353335T1 - Einkettige antikörper gegen eine p53 mutante - Google Patents

Einkettige antikörper gegen eine p53 mutante

Info

Publication number
ATE353335T1
ATE353335T1 AT01914142T AT01914142T ATE353335T1 AT E353335 T1 ATE353335 T1 AT E353335T1 AT 01914142 T AT01914142 T AT 01914142T AT 01914142 T AT01914142 T AT 01914142T AT E353335 T1 ATE353335 T1 AT E353335T1
Authority
AT
Austria
Prior art keywords
mutant
single chain
antibodies against
chain antibodies
scfv
Prior art date
Application number
AT01914142T
Other languages
English (en)
Inventor
Beka Solomon
Gerald Cohen
Dimitri Govorko
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Application granted granted Critical
Publication of ATE353335T1 publication Critical patent/ATE353335T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01914142T 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante ATE353335T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/526,738 US6630584B1 (en) 2000-03-16 2000-03-16 Single chain antibody against mutant p53

Publications (1)

Publication Number Publication Date
ATE353335T1 true ATE353335T1 (de) 2007-02-15

Family

ID=24098588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914142T ATE353335T1 (de) 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante

Country Status (6)

Country Link
US (2) US6630584B1 (de)
EP (1) EP1272609B1 (de)
AT (1) ATE353335T1 (de)
AU (1) AU2001239517A1 (de)
DE (1) DE60126482T2 (de)
WO (1) WO2001068801A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630584B1 (en) * 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53
US7799556B2 (en) * 2004-06-17 2010-09-21 George Dacai Liu System and method for antigen structure-independent detection of antigens captured on antibody arrays
US20060263837A1 (en) * 2004-06-17 2006-11-23 Liu George D Immunoassay system and method for detection of antigens
EP1781315B1 (de) 2004-08-23 2015-01-07 Yeda Research And Development Co., Ltd. Peptidhemmer zur vermittlung von stressreaktionen
ATE437185T1 (de) * 2005-03-25 2009-08-15 Univ Ramot Gegen das gemeinsame epitop von mutierten p53 gerichtete humane synthetische einzelkettenantikörper und anwendungen davon
EP1945261A4 (de) 2005-11-07 2010-05-12 Scripps Research Inst Zusammensetzungen und verfahren zur steuerung der spezifität von gewebefaktor-signalisierungen
US8187601B2 (en) * 2008-07-01 2012-05-29 Aveo Pharmaceuticals, Inc. Fibroblast growth factor receptor 3 (FGFR3) binding proteins
GB2482536B (en) 2010-08-05 2013-07-24 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
US20140088017A1 (en) 2011-05-23 2014-03-27 Yeda Research And Development Co., Ltd. Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
WO2014093417A1 (en) 2012-12-12 2014-06-19 University Of Virginia Patent Foundation Compositions and methods for regulating erythropoiesis
WO2014128701A1 (en) * 2013-02-20 2014-08-28 Yeda Research And Development Co. Ltd. Interferon treatment targeting mutant p53 expressing cells
US10053498B2 (en) 2014-11-21 2018-08-21 University of the Sciences of Philadelphia Compositions comprising serum albumin and p53 peptides fusion proteins
CA2980292A1 (en) * 2015-03-23 2016-09-29 The Johns Hopkins University Hla-restricted epitopes encoded by somatically mutated genes
GB201617564D0 (en) 2016-10-17 2016-11-30 Agency For Science Technology And Research And National University Of Singapore And Singapore Health Anti-p53 antibodies
WO2018213467A1 (en) 2017-05-16 2018-11-22 The Johns Hopkins University Manabodies and methods of using
US20210355199A1 (en) 2018-06-28 2021-11-18 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling
CN113528467B (zh) * 2021-06-24 2023-12-01 新乡学院 一种靶向性双展示噬菌体及其制备方法和应用
EP4413023A1 (de) * 2021-10-08 2024-08-14 SOLA Biosciences LLC Zusammensetzungen und verfahren zur behandlung von p53-vermitteltem krebs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5258498A (en) * 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
JPH09505735A (ja) * 1993-11-22 1997-06-10 オニックス ファーマシューティカルズ，インコーポレイティド ｐ５３−結合性ポリペプチド及びそれをコードするポリヌクレオチド
FR2755144B1 (fr) * 1996-10-29 1998-11-27 Rhone Poulenc Rorer Sa Fragments d'anticorps a chaine unique anti-p53 et utilisation
US20020155114A1 (en) * 1998-08-31 2002-10-24 James D. Marks Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US6630584B1 (en) 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53

Also Published As

Publication number Publication date
US6630584B1 (en) 2003-10-07
US20030022244A1 (en) 2003-01-30
AU2001239517A1 (en) 2001-09-24
EP1272609A2 (de) 2003-01-08
WO2001068801A2 (en) 2001-09-20
WO2001068801A3 (en) 2002-02-07
EP1272609B1 (de) 2007-02-07
DE60126482T2 (de) 2007-11-29
EP1272609A4 (de) 2004-12-22
DE60126482D1 (de) 2007-03-22
US7288637B2 (en) 2007-10-30

Similar Documents

Publication Publication Date Title
ATE353335T1 (de) Einkettige antikörper gegen eine p53 mutante
DE60142614D1 (de) Inität
CY1122505T1 (el) Anti-il-12 αντισωματα, συνθεσεις, μεθοδοι και χρησεις για την θεραπευτικη αγωγη της παθολογιας του crohn
UA87093C2 (ru) ГУМАНИЗИРОВАННЫЙ ИММУНОГЛОБУЛИН, КОТОРЫЙ СПЕЦИФИЧЕСКИ СВЯЗЫВАЕТСЯ С БЕТА-АМИЛОИДНЫМ ПЕПТИДОМ (Аβ)
CY2019029I1 (el) Anti-tnf αντισωματα, συνθεσεις, μεθοδοi και χρησεις
DK0862633T3 (da) VP-antigen af JC-virus
CY2014038I1 (el) Αντι-il-6 αντισωματα, συνθεσεις, μεθοδοι και χρησεις
ATE366746T1 (de) Gegen das semp1-protein gerichtete antikörper, verfahren zu deren herstellung, und deren anwendungen
CY1118462T1 (el) Μονοκλωνικο αντισωμα κατα της πρωτεϊνης συνδεσης οστεοπροτεγερινης
AT500379B1 (de) Tau-proteine
CY1108545T1 (el) Πρωτεϊνες υπομοναδας υποδοχεα κυτοκινης θηλαστικου, σχετικα αντιδραστηρια και μεθοδοι
CA2469833A1 (en) Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them
EA200501286A1 (ru) МОЛЕКУЛЫ АНТИТЕЛ СО СПЕЦИФИЧНОСТЬЮ К ЧЕЛОВЕЧЕСКОМУ IL-1β
NO20025450D0 (no) Ny farmasöytisk sammensetning
EA200700083A1 (ru) Антитела, направленные против бета-амилоидного пептида, и способы их применения
NO983284L (no) Anvendelse av et anti-faktor 1X monoklonalt antistoff og en nukleinsyre som koder for et monoklonalt antistoff for fremstilling av et medikament for behandling av trombose- og emboli-assosierte lidelser.
CY1111237T1 (el) Χρηση πραμιπεξολης για αντιμετωπιση αμυοτροφικης πλευρικης σκληρυνσης
DE60237778D1 (de) Antikörper gegen kdr, deren herstellung und verwendungen
DK0807125T3 (da) Monoklonale antistoffer mod CD6 til behandling og diagnosticering af psoriasis
EP1411962A4 (de) Behandlung von bauchspeicheldrüsenkrebs mit einem monoklonalen antikörper
JP2004510683A5 (de)
ATE362490T1 (de) Monoklonale antikörper gegen den menschlichen ldl-rezeptor, deren herstellung und verwendung
ATE393170T1 (de) Humanisierter antikörper gegen fibroblastenwachstumsfaktor 8 und fragment des antikörpers
ATE482980T1 (de) Antikörper variable region eines monoklonalen antikörpers gegen den humanen tumor nekrose faktor-alpha und dafür kodierendes gen
AU2002350406A1 (en) Identification of ses-3 (spr-5) in c. elegans and the uses of the same

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties