ATE353335T1 - Einkettige antikörper gegen eine p53 mutante - Google Patents

Einkettige antikörper gegen eine p53 mutante

Info

Publication number
ATE353335T1
ATE353335T1 AT01914142T AT01914142T ATE353335T1 AT E353335 T1 ATE353335 T1 AT E353335T1 AT 01914142 T AT01914142 T AT 01914142T AT 01914142 T AT01914142 T AT 01914142T AT E353335 T1 ATE353335 T1 AT E353335T1
Authority
AT
Austria
Prior art keywords
mutant
single chain
antibodies against
chain antibodies
scfv
Prior art date
Application number
AT01914142T
Other languages
English (en)
Inventor
Beka Solomon
Gerald Cohen
Dimitri Govorko
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Application granted granted Critical
Publication of ATE353335T1 publication Critical patent/ATE353335T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01914142T 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante ATE353335T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/526,738 US6630584B1 (en) 2000-03-16 2000-03-16 Single chain antibody against mutant p53

Publications (1)

Publication Number Publication Date
ATE353335T1 true ATE353335T1 (de) 2007-02-15

Family

ID=24098588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914142T ATE353335T1 (de) 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante

Country Status (6)

Country Link
US (2) US6630584B1 (de)
EP (1) EP1272609B1 (de)
AT (1) ATE353335T1 (de)
AU (1) AU2001239517A1 (de)
DE (1) DE60126482T2 (de)
WO (1) WO2001068801A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630584B1 (en) * 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53
US20060263837A1 (en) * 2004-06-17 2006-11-23 Liu George D Immunoassay system and method for detection of antigens
US7799556B2 (en) * 2004-06-17 2010-09-21 George Dacai Liu System and method for antigen structure-independent detection of antigens captured on antibody arrays
AU2005276117C1 (en) 2004-08-23 2013-04-18 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Peptide inhibitors for mediating stress responses
WO2006100681A2 (en) * 2005-03-25 2006-09-28 Ramot At Tel Aviv University Ltd. Human synthetic single-chain antibodies directed against the common epitope of mutant p53 and their uses
NZ568762A (en) 2005-11-07 2011-11-25 Scripps Research Inst Use of an inhibitor of tissue factor signaling in the manufacture of a medcament for inhibiting or suppressing tissue factor/tissue factor VIIa signaling involving protease activated receptor 2 in a mammal
EP2313435A4 (de) * 2008-07-01 2012-08-08 Aveo Pharmaceuticals Inc An den fibroblastenwachstumsfaktorrezeptor 3 (fgfr3) bindende proteine
GB2482536B (en) 2010-08-05 2013-07-24 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
CA2836503C (en) 2011-05-23 2020-09-22 Yeda Research And Development Co. Ltd. Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same
WO2014093417A1 (en) 2012-12-12 2014-06-19 University Of Virginia Patent Foundation Compositions and methods for regulating erythropoiesis
US20150366944A1 (en) * 2013-02-20 2015-12-24 Yeda Research And Development Co. Ltd. Interferon treatment targeting mutant p53 expressing cells
EP3220953B1 (de) 2014-11-21 2020-04-01 University of the Sciences in Philadelphia Zusammensetzungen und verfahren zur verwendung therapeutischer p53-peptide und analoge
WO2016154246A1 (en) * 2015-03-23 2016-09-29 The Johns Hopkins University Hla-restricted epitopes encoded by somatically mutated genes
GB201617564D0 (en) 2016-10-17 2016-11-30 Agency For Science Technology And Research And National University Of Singapore And Singapore Health Anti-p53 antibodies
AU2018269370B2 (en) 2017-05-16 2025-06-05 The Johns Hopkins University Manabodies and methods of using
US20210355199A1 (en) 2018-06-28 2021-11-18 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling
CN113528467B (zh) * 2021-06-24 2023-12-01 新乡学院 一种靶向性双展示噬菌体及其制备方法和应用
CA3234720A1 (en) * 2021-10-08 2023-04-13 Sola Biosciences Llc Compositions and methods for the treatment of p53-mediated cancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5258498A (en) * 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
CA2177074A1 (en) * 1993-11-22 1995-06-01 James R. Bischoff P53-binding polypeptides and polynucleotides encoding same
FR2755144B1 (fr) * 1996-10-29 1998-11-27 Rhone Poulenc Rorer Sa Fragments d'anticorps a chaine unique anti-p53 et utilisation
US20020155114A1 (en) * 1998-08-31 2002-10-24 James D. Marks Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US6630584B1 (en) 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53

Also Published As

Publication number Publication date
AU2001239517A1 (en) 2001-09-24
WO2001068801A2 (en) 2001-09-20
US20030022244A1 (en) 2003-01-30
WO2001068801A3 (en) 2002-02-07
DE60126482T2 (de) 2007-11-29
EP1272609B1 (de) 2007-02-07
US6630584B1 (en) 2003-10-07
EP1272609A2 (de) 2003-01-08
US7288637B2 (en) 2007-10-30
DE60126482D1 (de) 2007-03-22
EP1272609A4 (de) 2004-12-22

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