ATE353335T1 - Einkettige antikörper gegen eine p53 mutante - Google Patents

Einkettige antikörper gegen eine p53 mutante

Info

Publication number
ATE353335T1
ATE353335T1 AT01914142T AT01914142T ATE353335T1 AT E353335 T1 ATE353335 T1 AT E353335T1 AT 01914142 T AT01914142 T AT 01914142T AT 01914142 T AT01914142 T AT 01914142T AT E353335 T1 ATE353335 T1 AT E353335T1
Authority
AT
Austria
Prior art keywords
mutant
single chain
antibodies against
chain antibodies
scfv
Prior art date
Application number
AT01914142T
Other languages
English (en)
Inventor
Beka Solomon
Gerald Cohen
Dimitri Govorko
Original Assignee
Univ Ramot
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ramot filed Critical Univ Ramot
Application granted granted Critical
Publication of ATE353335T1 publication Critical patent/ATE353335T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT01914142T 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante ATE353335T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/526,738 US6630584B1 (en) 2000-03-16 2000-03-16 Single chain antibody against mutant p53

Publications (1)

Publication Number Publication Date
ATE353335T1 true ATE353335T1 (de) 2007-02-15

Family

ID=24098588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01914142T ATE353335T1 (de) 2000-03-16 2001-03-09 Einkettige antikörper gegen eine p53 mutante

Country Status (6)

Country Link
US (2) US6630584B1 (de)
EP (1) EP1272609B1 (de)
AT (1) ATE353335T1 (de)
AU (1) AU2001239517A1 (de)
DE (1) DE60126482T2 (de)
WO (1) WO2001068801A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6630584B1 (en) * 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53
US7799556B2 (en) * 2004-06-17 2010-09-21 George Dacai Liu System and method for antigen structure-independent detection of antigens captured on antibody arrays
US20060263837A1 (en) * 2004-06-17 2006-11-23 Liu George D Immunoassay system and method for detection of antigens
AU2005276117C1 (en) 2004-08-23 2013-04-18 Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science Peptide inhibitors for mediating stress responses
WO2006100681A2 (en) * 2005-03-25 2006-09-28 Ramot At Tel Aviv University Ltd. Human synthetic single-chain antibodies directed against the common epitope of mutant p53 and their uses
US20100028358A1 (en) 2005-11-07 2010-02-04 Wolfram Ruf Compositions and Methods for Controlling Tissue Factor Signaling Specificity
WO2010002862A2 (en) * 2008-07-01 2010-01-07 Aveo Pharmaceuticals, Inc. Fibroblast growth factor receptor 3 (fgfr3) binding proteins
GB2482536B (en) * 2010-08-05 2013-07-24 Hera Pharmaceuticals Inc Expression of antibody or a fragment thereof in lactobacillus
EP3263127B1 (de) 2011-05-23 2019-08-21 Yeda Research and Development Co. Ltd Verwendung einer akt-phosphorylierung als biomarker zur prognose neurodegenerativer erkrankungen und zur behandlung davon
WO2014093417A1 (en) 2012-12-12 2014-06-19 University Of Virginia Patent Foundation Compositions and methods for regulating erythropoiesis
EP2958584A1 (de) * 2013-02-20 2015-12-30 Yeda Research and Development Co., Ltd. Gegen mutante p53-exprimierende zellen gerichtete interferonbehandlung
WO2016081897A1 (en) 2014-11-21 2016-05-26 University of the Sciences of Philadelphia COMPOSITIONS AND METHODS OF USING THERAPEUTIC p53 PEPTIDES AND ANALOGUES
EP3286222A4 (de) * 2015-03-23 2018-08-08 The Johns Hopkins University Durch somatisch mutierte gene codierte hla-beschränkte epitope
GB201617564D0 (en) 2016-10-17 2016-11-30 Agency For Science Technology And Research And National University Of Singapore And Singapore Health Anti-p53 antibodies
US11807662B2 (en) 2017-05-16 2023-11-07 The Johns Hopkins University MANAbodies and methods of using
US20210355199A1 (en) 2018-06-28 2021-11-18 University Of Virginia Patent Foundation Compositions and methods for detecting and regulating fibronectin-integrin interaction and signaling
WO2021127184A1 (en) 2019-12-17 2021-06-24 The Johns Hopkins University MANAbodies TARGETING TUMOR ANTIGENS AND METHODS OF USING
CN113528467B (zh) * 2021-06-24 2023-12-01 新乡学院 一种靶向性双展示噬菌体及其制备方法和应用
WO2023060248A1 (en) * 2021-10-08 2023-04-13 Sola Biosciences Llc Compositions and methods for the treatment of p53-mediated cancers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5258498A (en) * 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
EP0734439A4 (de) * 1993-11-22 2000-07-12 Onyx Pharma Inc p53-bindende Polypeptide und Polynucleotide die für diese kodieren
FR2755144B1 (fr) * 1996-10-29 1998-11-27 Rhone Poulenc Rorer Sa Fragments d'anticorps a chaine unique anti-p53 et utilisation
US20020155114A1 (en) * 1998-08-31 2002-10-24 James D. Marks Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins
US6630584B1 (en) * 2000-03-16 2003-10-07 Ramot At Tel-Aviv University Ltd. Single chain antibody against mutant p53

Also Published As

Publication number Publication date
US7288637B2 (en) 2007-10-30
EP1272609A2 (de) 2003-01-08
WO2001068801A2 (en) 2001-09-20
AU2001239517A1 (en) 2001-09-24
DE60126482T2 (de) 2007-11-29
EP1272609B1 (de) 2007-02-07
DE60126482D1 (de) 2007-03-22
EP1272609A4 (de) 2004-12-22
WO2001068801A3 (en) 2002-02-07
US6630584B1 (en) 2003-10-07
US20030022244A1 (en) 2003-01-30

Similar Documents

Publication Publication Date Title
DE60126482D1 (de) Einkettige antikörper gegen eine p53 mutante
CY1122505T1 (el) Anti-il-12 αντισωματα, συνθεσεις, μεθοδοι και χρησεις για την θεραπευτικη αγωγη της παθολογιας του crohn
CY2019029I2 (el) Anti-tnf αντισωματα, συνθεσεις, μεθοδοi και χρησεις
ATE366746T1 (de) Gegen das semp1-protein gerichtete antikörper, verfahren zu deren herstellung, und deren anwendungen
DK0862633T3 (da) VP-antigen af JC-virus
CY2014038I1 (el) Αντι-il-6 αντισωματα, συνθεσεις, μεθοδοι και χρησεις
DK1265928T3 (da) RSV-neutraliserende antistoffer med ultra høj affinitet
CY1118462T1 (el) Μονοκλωνικο αντισωμα κατα της πρωτεϊνης συνδεσης οστεοπροτεγερινης
AT500379B1 (de) Tau-proteine
WO2004032868A3 (en) Methods of treating alzheimer's disease using antibodies directed against amyloid beta peptide and compositions thereof
CY1108545T1 (el) Πρωτεϊνες υπομοναδας υποδοχεα κυτοκινης θηλαστικου, σχετικα αντιδραστηρια και μεθοδοι
CA2469833A1 (en) Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them
MXPA02011656A (es) Moleculas de acido nucleico nrg-2, polipeptidos, y metodos de diagnostico y terapeuticos.
EA200501286A1 (ru) МОЛЕКУЛЫ АНТИТЕЛ СО СПЕЦИФИЧНОСТЬЮ К ЧЕЛОВЕЧЕСКОМУ IL-1β
EA200700083A1 (ru) Антитела, направленные против бета-амилоидного пептида, и способы их применения
DE122012000001I1 (de) Humane antikorper gegen CTLA-4 und deren verwendungen.
DE60142342D1 (de) Antikörper gegen doppelintegrinen, zusammensetzungen, verfahren und verwendungen
WO2004016286A3 (en) Pharmaceutical anti-tnf-alpha antibody formulation
DK0807125T3 (da) Monoklonale antistoffer mod CD6 til behandling og diagnosticering af psoriasis
DK1383785T3 (da) Rekombinant tumorspecifikt antistof og anvendelse deraf
WO2007124133A3 (en) Methods and compositions based on shiga toxin type 1 protein
JP2004510683A5 (de)
DE60238987D1 (de) Behandlung von bauchspeicheldrüsenkrebs mit einem monoklonalen antikörper
ATE362490T1 (de) Monoklonale antikörper gegen den menschlichen ldl-rezeptor, deren herstellung und verwendung
WO2001057219A3 (en) Mammalian interleukin-1-delta and -epsilon. their use in therapeutic and diagnostic methods

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties