ATE353877T1 - Verfahren zur herstellung von monoifluorierten pyridinyl- und pyrimidinyl-beta-ketoestern - Google Patents
Verfahren zur herstellung von monoifluorierten pyridinyl- und pyrimidinyl-beta-ketoesternInfo
- Publication number
- ATE353877T1 ATE353877T1 AT04717645T AT04717645T ATE353877T1 AT E353877 T1 ATE353877 T1 AT E353877T1 AT 04717645 T AT04717645 T AT 04717645T AT 04717645 T AT04717645 T AT 04717645T AT E353877 T1 ATE353877 T1 AT E353877T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridinyl
- keto esters
- pyrimidinyl
- monoifluorinated
- beta
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 PYRIMIDINYL Chemical class 0.000 title 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 title 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03290568A EP1454900A1 (de) | 2003-03-07 | 2003-03-07 | Verfahren zur herstellung von pyridinyl und pyrimidinyl mono-fluorierten beta-keto Estern |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353877T1 true ATE353877T1 (de) | 2007-03-15 |
Family
ID=32799102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04717645T ATE353877T1 (de) | 2003-03-07 | 2004-03-05 | Verfahren zur herstellung von monoifluorierten pyridinyl- und pyrimidinyl-beta-ketoestern |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7135569B2 (de) |
| EP (2) | EP1454900A1 (de) |
| JP (1) | JP4805809B2 (de) |
| CN (1) | CN100398518C (de) |
| AT (1) | ATE353877T1 (de) |
| DE (1) | DE602004004767T2 (de) |
| ES (1) | ES2281786T3 (de) |
| RU (1) | RU2330844C2 (de) |
| WO (1) | WO2004078725A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU556140A1 (ru) * | 1975-01-06 | 1977-04-30 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср | (1-Оксоинданил-2)-пиридины в качестве промежуточных продуктов дл синтеза биологически активных соединений с способ их получени |
| DE69803186T2 (de) * | 1997-07-18 | 2002-07-18 | F2 Chemicals Ltd., Preston | Katalysierte fluorierung von carbonylverbindungen |
| US6455728B1 (en) * | 1999-11-01 | 2002-09-24 | Air Products And Chemicals, Inc. | Direct fluorination process for preparing high purity 2-fluoro-1,3-dicarbonyl compounds using oxygen as a radical scavenger |
| NZ547205A (en) * | 2001-09-21 | 2007-11-30 | Sanofi Aventis | Intermediates of substituted 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)one derivatives |
| EP1295885A1 (de) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | Substituierte 2-pyridinyl-6,7,8,9-tetrahydropyrimido(1,2-a)pyrimidin-4-on- und 7-pyridinyl-2,3-dihydroimidazo(1,2-a)pyrimidin-5(1H)onderivate |
| EP1295884A1 (de) * | 2001-09-21 | 2003-03-26 | Sanofi-Synthelabo | 2-Pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-on and 7-Pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)on Derivate |
-
2003
- 2003-03-07 EP EP03290568A patent/EP1454900A1/de not_active Withdrawn
-
2004
- 2004-03-05 EP EP04717645A patent/EP1603876B1/de not_active Expired - Lifetime
- 2004-03-05 ES ES04717645T patent/ES2281786T3/es not_active Expired - Lifetime
- 2004-03-05 DE DE602004004767T patent/DE602004004767T2/de not_active Expired - Lifetime
- 2004-03-05 WO PCT/EP2004/003052 patent/WO2004078725A1/en not_active Ceased
- 2004-03-05 RU RU2005131007/04A patent/RU2330844C2/ru not_active IP Right Cessation
- 2004-03-05 CN CNB200480009687XA patent/CN100398518C/zh not_active Expired - Fee Related
- 2004-03-05 JP JP2006504814A patent/JP4805809B2/ja not_active Expired - Fee Related
- 2004-03-05 AT AT04717645T patent/ATE353877T1/de not_active IP Right Cessation
-
2005
- 2005-09-07 US US11/221,023 patent/US7135569B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20060058526A1 (en) | 2006-03-16 |
| ES2281786T3 (es) | 2007-10-01 |
| DE602004004767T2 (de) | 2007-12-06 |
| EP1454900A1 (de) | 2004-09-08 |
| US7135569B2 (en) | 2006-11-14 |
| CN100398518C (zh) | 2008-07-02 |
| RU2330844C2 (ru) | 2008-08-10 |
| JP2006519815A (ja) | 2006-08-31 |
| RU2005131007A (ru) | 2006-06-27 |
| CN1771229A (zh) | 2006-05-10 |
| WO2004078725A1 (en) | 2004-09-16 |
| DE602004004767D1 (de) | 2007-03-29 |
| JP4805809B2 (ja) | 2011-11-02 |
| EP1603876B1 (de) | 2007-02-14 |
| EP1603876A1 (de) | 2005-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |