ATE353894T1 - Acyloxymethylcarbamat-prodrugs von oxazolidinonen - Google Patents
Acyloxymethylcarbamat-prodrugs von oxazolidinonenInfo
- Publication number
- ATE353894T1 ATE353894T1 AT04769372T AT04769372T ATE353894T1 AT E353894 T1 ATE353894 T1 AT E353894T1 AT 04769372 T AT04769372 T AT 04769372T AT 04769372 T AT04769372 T AT 04769372T AT E353894 T1 ATE353894 T1 AT E353894T1
- Authority
- AT
- Austria
- Prior art keywords
- oxazolidinones
- carbamat
- acyloxymethyl
- prodrugs
- present
- Prior art date
Links
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50532903P | 2003-09-23 | 2003-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353894T1 true ATE353894T1 (de) | 2007-03-15 |
Family
ID=34375571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04769372T ATE353894T1 (de) | 2003-09-23 | 2004-09-13 | Acyloxymethylcarbamat-prodrugs von oxazolidinonen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7265140B2 (de) |
| EP (1) | EP1668005B1 (de) |
| JP (1) | JP2007505890A (de) |
| AT (1) | ATE353894T1 (de) |
| BR (1) | BRPI0414694A (de) |
| CA (1) | CA2539848A1 (de) |
| DE (1) | DE602004004808T2 (de) |
| ES (1) | ES2278342T3 (de) |
| MX (1) | MXPA06003124A (de) |
| WO (1) | WO2005028473A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004076798A2 (en) | 2003-02-26 | 2004-09-10 | Enventure Global Technology | Apparatus for radially expanding and plastically deforming a tubular member |
| KR20110097942A (ko) * | 2003-08-20 | 2011-08-31 | 제노포트 인코포레이티드 | 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법 |
| ES2405329T3 (es) * | 2003-12-30 | 2013-05-30 | Xenoport, Inc. | Síntesis de profármacos de carbarnato de aciloxialquilo y productos intermedios de los mismos |
| WO2005113520A1 (en) * | 2004-05-20 | 2005-12-01 | Pharmacia & Upjohn Company Llc | Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents |
| DE102006007146A1 (de) | 2006-02-16 | 2007-08-23 | Bayer Healthcare Ag | Aminoacyl-Prodrugs |
| CA2645031A1 (en) | 2006-03-07 | 2007-09-13 | Bristol-Myers Squibb Company | Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors |
| US7776855B2 (en) * | 2006-07-27 | 2010-08-17 | Janssen Pharmaceutica N.V. | Antimicrobial oxazolidinone prodrugs |
| DE102006039589A1 (de) | 2006-08-24 | 2008-03-06 | Bayer Healthcare Ag | Aminoacyl-Prodrugs II |
| DE102007028407A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007028319A1 (de) * | 2007-06-20 | 2008-12-24 | Bayer Healthcare Ag | Substituierte Oxazolidinone und ihre Verwendung |
| DE102007032345A1 (de) * | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Aminoacyl-Prodrugs |
| DE102007032344A1 (de) | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Prodrug-Derivate von 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-carboxamid |
| DE102007032347A1 (de) | 2007-07-11 | 2009-01-15 | Bayer Healthcare Ag | Aminoacyl-Prodrugs |
| US20100069441A1 (en) | 2008-09-02 | 2010-03-18 | Mikhail Fedorovich Gordeev | Antimicrobial indoline compounds for treatment of bacterial infections |
| CN101798302B (zh) | 2009-02-06 | 2014-11-05 | 上海盟科药业有限公司 | 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺 |
| DE102010028362A1 (de) | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | Herstellverfahren |
| US20120065170A1 (en) | 2010-09-10 | 2012-03-15 | Micurx Pharmaceuticals, Inc. | Antimicrobial Cyclocarbonyl Heterocyclic Compounds For Treatment Of Bacterial Infections |
| WO2013088255A1 (en) * | 2011-12-15 | 2013-06-20 | Alkermes Pharma Ireland Limited | Prodrugs of secondary amine compounds |
| US9145411B2 (en) | 2012-08-02 | 2015-09-29 | Asana Biosciences, Llc | Substituted amino-pyrimidine derivatives |
| CN105612166B (zh) | 2014-02-21 | 2019-02-19 | 上海盟科药业有限公司 | 治疗用水溶性(o-羰基)氨基磷酸酯前药 |
| GB201518950D0 (en) * | 2015-10-27 | 2015-12-09 | Glaxosmithkline Ip Dev Ltd | Compound |
| WO2019037791A1 (zh) * | 2017-08-25 | 2019-02-28 | 广州市恒诺康医药科技有限公司 | 一种长效雷沙吉兰前药及其制备方法和用途 |
| WO2021184339A1 (en) | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
| JP2024516114A (ja) * | 2021-04-07 | 2024-04-12 | コスマス セラピューティックス ディベロップメント インコーポレイテッド | メラトニン受容体の新規調節因子、ならびにその製造方法および使用 |
| EP4441066A1 (de) * | 2021-11-29 | 2024-10-09 | Hongene Biotech Corporation | Synthese von 2' acetylester-geschützten nukleosiden |
| CN119431373B (zh) * | 2024-07-24 | 2025-08-08 | 科睿迪(南京)医药科技有限公司 | 一种β-内酰胺酶抑制剂及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2228647A1 (en) | 1995-09-01 | 1997-03-13 | Pharmacia & Upjohn Company | Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings |
| EP1133493A1 (de) * | 1998-11-27 | 2001-09-19 | PHARMACIA & UPJOHN COMPANY | Thiocarbonylgruppe enthaltende oxazolidinone als antibakterielle mittel |
| EA005567B1 (ru) * | 1999-12-21 | 2005-04-28 | Фармация Энд Апджон Компани | Оксазолидиноны, обладающие сульфоксиминовой функциональностью |
| GB0108793D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| GB0108764D0 (en) * | 2001-04-07 | 2001-05-30 | Astrazeneca Ab | Chemical compounds |
| JP4208243B2 (ja) * | 2002-01-24 | 2009-01-14 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 抗微生物性ジヒドロチアジンおよびジヒドロチオピランオキサゾリジノン |
| TW200403240A (en) * | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
-
2004
- 2004-09-09 US US10/937,187 patent/US7265140B2/en not_active Expired - Fee Related
- 2004-09-13 AT AT04769372T patent/ATE353894T1/de not_active IP Right Cessation
- 2004-09-13 CA CA002539848A patent/CA2539848A1/en not_active Abandoned
- 2004-09-13 ES ES04769372T patent/ES2278342T3/es not_active Expired - Lifetime
- 2004-09-13 MX MXPA06003124A patent/MXPA06003124A/es not_active Application Discontinuation
- 2004-09-13 JP JP2006526723A patent/JP2007505890A/ja not_active Withdrawn
- 2004-09-13 BR BRPI0414694-8A patent/BRPI0414694A/pt not_active IP Right Cessation
- 2004-09-13 EP EP04769372A patent/EP1668005B1/de not_active Expired - Lifetime
- 2004-09-13 DE DE602004004808T patent/DE602004004808T2/de not_active Expired - Fee Related
- 2004-09-13 WO PCT/IB2004/002983 patent/WO2005028473A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1668005A1 (de) | 2006-06-14 |
| DE602004004808T2 (de) | 2007-12-06 |
| US20050267104A1 (en) | 2005-12-01 |
| EP1668005B1 (de) | 2007-02-14 |
| MXPA06003124A (es) | 2006-06-20 |
| CA2539848A1 (en) | 2005-03-31 |
| BRPI0414694A (pt) | 2006-11-28 |
| ES2278342T3 (es) | 2007-08-01 |
| JP2007505890A (ja) | 2007-03-15 |
| US7265140B2 (en) | 2007-09-04 |
| WO2005028473A1 (en) | 2005-03-31 |
| DE602004004808D1 (de) | 2007-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |