BRPI0414694A - pró-fármaco(s) aciloximetilcarbamato de oxazolidinonas - Google Patents

pró-fármaco(s) aciloximetilcarbamato de oxazolidinonas

Info

Publication number
BRPI0414694A
BRPI0414694A BRPI0414694-8A BRPI0414694A BRPI0414694A BR PI0414694 A BRPI0414694 A BR PI0414694A BR PI0414694 A BRPI0414694 A BR PI0414694A BR PI0414694 A BRPI0414694 A BR PI0414694A
Authority
BR
Brazil
Prior art keywords
acyloxymethylcarbamate
oxazolidinone
prodrug
present
gram
Prior art date
Application number
BRPI0414694-8A
Other languages
English (en)
Inventor
Vara Prasad Venkata Na Josyula
Robert C Gadwood
Lisa Marie Thomasco
Ji-Young Kim
Allison Laura Choy
Frederick Earl Boyer
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0414694A publication Critical patent/BRPI0414694A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"PRó-FáRMACO(S) ACILOXIMETILCARBAMATO DE OXAZOLIDINONAS". A presente invenção refere-se a aciloximetilcarbamato de oxazolidinonas. Os compostos da presente invenção têm atividade potente com biodisponibilidade excelente por via oral, contra bactérias Gram-positivas e Gram-negativas.
BRPI0414694-8A 2003-09-23 2004-09-13 pró-fármaco(s) aciloximetilcarbamato de oxazolidinonas BRPI0414694A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50532903P 2003-09-23 2003-09-23
PCT/IB2004/002983 WO2005028473A1 (en) 2003-09-23 2004-09-13 Acyloxymethylcarbamate prodrugs of oxazolidinones

Publications (1)

Publication Number Publication Date
BRPI0414694A true BRPI0414694A (pt) 2006-11-28

Family

ID=34375571

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414694-8A BRPI0414694A (pt) 2003-09-23 2004-09-13 pró-fármaco(s) aciloximetilcarbamato de oxazolidinonas

Country Status (10)

Country Link
US (1) US7265140B2 (pt)
EP (1) EP1668005B1 (pt)
JP (1) JP2007505890A (pt)
AT (1) ATE353894T1 (pt)
BR (1) BRPI0414694A (pt)
CA (1) CA2539848A1 (pt)
DE (1) DE602004004808T2 (pt)
ES (1) ES2278342T3 (pt)
MX (1) MXPA06003124A (pt)
WO (1) WO2005028473A1 (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2415983B (en) 2003-02-26 2007-09-05 Enventure Global Technology Apparatus for radially expanding and plastically deforming a tubular member
KR101140559B1 (ko) * 2003-08-20 2012-07-05 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
CA2551859C (en) 2003-12-30 2011-10-04 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2005113520A1 (en) * 2004-05-20 2005-12-01 Pharmacia & Upjohn Company Llc Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents
DE102006007146A1 (de) * 2006-02-16 2007-08-23 Bayer Healthcare Ag Aminoacyl-Prodrugs
AU2007223342A1 (en) 2006-03-07 2007-09-13 Bristol-Myers Squibb Company Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
US7776855B2 (en) * 2006-07-27 2010-08-17 Janssen Pharmaceutica N.V. Antimicrobial oxazolidinone prodrugs
DE102006039589A1 (de) * 2006-08-24 2008-03-06 Bayer Healthcare Ag Aminoacyl-Prodrugs II
DE102007028319A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007028407A1 (de) * 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituierte Oxazolidinone und ihre Verwendung
DE102007032347A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
DE102007032345A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Aminoacyl-Prodrugs
DE102007032344A1 (de) 2007-07-11 2009-01-15 Bayer Healthcare Ag Prodrug-Derivate von 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-3-carboxamid
WO2010047737A2 (en) 2008-09-02 2010-04-29 Micurx Pharmaceuticals, Inc. Antimicrobial indoline compounds for treatment of bacterial infections
CN101798302B (zh) 2009-02-06 2014-11-05 上海盟科药业有限公司 抗生素类药物1-(邻-氟苯基)二氢吡啶酮的合成及生产的方法和工艺
DE102010028362A1 (de) 2010-04-29 2011-11-03 Bayer Schering Pharma Aktiengesellschaft Herstellverfahren
WO2012033952A1 (en) 2010-09-10 2012-03-15 Micurx Pharmaceuticals, Inc. 3 - phenyl- 2 -oxo- 1, 3 -oxazolidines for treatment of bacterial infections
WO2013088255A1 (en) 2011-12-15 2013-06-20 Alkermes Pharma Ireland Limited Prodrugs of secondary amine compounds
TW201410657A (zh) 2012-08-02 2014-03-16 Endo Pharmaceuticals Inc 經取代胺基－嘧啶衍生物
EP3107923B1 (en) 2014-02-21 2021-11-03 Shanghai MicuRx Pharmaceutical Co., Ltd. Water-soluble o-carbonyl phosphoramidate prodrugs for therapeutic administration
GB201518950D0 (en) 2015-10-27 2015-12-09 Glaxosmithkline Ip Dev Ltd Compound
WO2019037791A1 (zh) * 2017-08-25 2019-02-28 广州市恒诺康医药科技有限公司 一种长效雷沙吉兰前药及其制备方法和用途
WO2021184339A1 (en) 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent
EP4320094A4 (en) * 2021-04-07 2025-06-25 Cosmas Therapeutics Development Inc. NOVEL MELATONIN RECEPTOR MODULATORS, THEIR PRODUCTION PROCESS AND USES
US11897914B2 (en) * 2021-11-29 2024-02-13 Hongene Biotech Corporation Synthesis of 2′ protected nucleosides
CN119431373B (zh) * 2024-07-24 2025-08-08 科睿迪(南京)医药科技有限公司 一种β-内酰胺酶抑制剂及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1072222C (zh) 1995-09-01 2001-10-03 法玛西雅厄普约翰公司 以c－c键连接于4－8元杂环环的苯基噁唑烷酮
EP1133493A1 (en) * 1998-11-27 2001-09-19 PHARMACIA & UPJOHN COMPANY Oxazolidinone antibacterial agents having a thiocarbonyl functionality
HUP0203869A2 (hu) * 1999-12-21 2003-07-28 Pharmacia & Upjohn Co. Szulfoximin funkcionalitással rendelkező oxazolidinok és alkalmazásuk mikrobaellenes szerként, a vegyületeket tartalmazó gyógyszerkészítmények
GB0108793D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108764D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
WO2003062231A1 (en) * 2002-01-24 2003-07-31 Pharmacia & Upjohn Company Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
TW200403240A (en) * 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents

Also Published As

Publication number Publication date
WO2005028473A1 (en) 2005-03-31
ES2278342T3 (es) 2007-08-01
CA2539848A1 (en) 2005-03-31
DE602004004808D1 (de) 2007-03-29
DE602004004808T2 (de) 2007-12-06
EP1668005A1 (en) 2006-06-14
MXPA06003124A (es) 2006-06-20
ATE353894T1 (de) 2007-03-15
JP2007505890A (ja) 2007-03-15
US20050267104A1 (en) 2005-12-01
EP1668005B1 (en) 2007-02-14
US7265140B2 (en) 2007-09-04

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.