ATE35414T1 - Salze von dimeren indol-dihydroindol-alkaloiden. - Google Patents

Salze von dimeren indol-dihydroindol-alkaloiden.

Info

Publication number: ATE35414T1
Authority: AT; Austria
Prior art keywords: salts; dimeric indole; alkaloids; dihydroindole alkaloids; indole dihydroindole
Prior art date: 1983-12-21

Application number

AT84308817T

Other languages

English (en)

Inventor

Stanislaw Rolski

Ralph Robert Pfeiffer

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-12-21

Filing date

1984-12-17

Publication date

1988-07-15

1984-12-17 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1988-07-15 Application granted granted Critical

1988-07-15 Publication of ATE35414T1 publication Critical patent/ATE35414T1/de

Links

UKTNDLHXQNQKBH-UHFFFAOYSA-N 2,3-dihydro-1h-indole;1h-indole Chemical class C1=CC=C2NCCC2=C1.C1=CC=C2NC=CC2=C1 UKTNDLHXQNQKBH-UHFFFAOYSA-N 0.000 title 1
229940122803 Vinca alkaloid Drugs 0.000 abstract 1
XTEGVFVZDVNBPF-UHFFFAOYSA-N naphthalene-1,5-disulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicinal Preparation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT84308817T 1983-12-21 1984-12-17 Salze von dimeren indol-dihydroindol-alkaloiden. ATE35414T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/564,119 US4558053A (en)	1983-12-21	1983-12-21	Naphthalene-1,5-disulfonate salts of dimeric indole-dihydroindole alkaloids
EP84308817A EP0147152B1 (de)	1983-12-21	1984-12-17	Salze von dimeren Indol-dihydroindol-Alkaloiden

Publications (1)

Publication Number	Publication Date
ATE35414T1 true ATE35414T1 (de)	1988-07-15

Family

ID=24253222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT84308817T ATE35414T1 (de)	1983-12-21	1984-12-17	Salze von dimeren indol-dihydroindol-alkaloiden.

Country Status (6)

Country	Link
US (1)	US4558053A (de)
EP (1)	EP0147152B1 (de)
JP (1)	JPS60169488A (de)
AT (1)	ATE35414T1 (de)
DE (1)	DE3472405D1 (de)
GB (1)	GB2151621B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5095109A (en) *	1989-06-08	1992-03-10	University Of Vermont	Novel alkaloids
FR2918566B1 (fr)	2007-07-11	2009-10-09	Pierre Fabre Medicament Sa	Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
US20130178618A1 (en)	2012-01-10	2013-07-11	William Allen Boulanger	Novel pharmaceutical intermediates and methods for preparing the same
US12116372B1 (en)	2023-12-14	2024-10-15	William Allen Boulanger	Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US30560A (en) *		1860-11-06		Improvement in lightning-rods
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine
US3205220A (en) *	1961-10-26	1965-09-07	Lilly Co Eli	Leurosidine and leurocristine and their production
US4012390A (en) *	1974-10-16	1977-03-15	Eli Lilly And Company	Vinblastinoic acid
USRE30560E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
US4143041A (en) *	1977-01-19	1979-03-06	Eli Lilly And Company	4'-Deoxyvincristine and related compounds
US4191688A (en) *	1977-08-08	1980-03-04	Eli Lilly And Company	Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4203898A (en) *	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
AR225153A1 (es) *	1978-10-10	1982-02-26	Lilly Co Eli	Un procedimiento para la preparacion de sulfato de vindesina
US4259242A (en) *	1978-10-10	1981-03-31	Eli Lilly And Company	Method of preparing vindesine sulfate

1983
- 1983-12-21 US US06/564,119 patent/US4558053A/en not_active Expired - Fee Related
1984
- 1984-12-17 DE DE8484308817T patent/DE3472405D1/de not_active Expired
- 1984-12-17 EP EP84308817A patent/EP0147152B1/de not_active Expired
- 1984-12-17 GB GB08431804A patent/GB2151621B/en not_active Expired
- 1984-12-17 AT AT84308817T patent/ATE35414T1/de not_active IP Right Cessation
- 1984-12-19 JP JP59269585A patent/JPS60169488A/ja active Pending

Also Published As

Publication number	Publication date
EP0147152A3 (en)	1985-08-14
GB2151621B (en)	1987-07-08
US4558053A (en)	1985-12-10
GB2151621A (en)	1985-07-24
EP0147152A2 (de)	1985-07-03
DE3472405D1 (en)	1988-08-04
EP0147152B1 (de)	1988-06-29
JPS60169488A (ja)	1985-09-02
GB8431804D0 (en)	1985-01-30

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Legal Events

Date	Code	Title	Description
1988-10-15	UEP	Publication of translation of european patent specification
1991-09-15	REN	Ceased due to non-payment of the annual fee