ES8801629A1 - Procedimiento para preparar nuevos derivados de aminoacidos biciclicos - Google Patents

Procedimiento para preparar nuevos derivados de aminoacidos biciclicos

Info

Publication number
ES8801629A1
ES8801629A1 ES557519A ES557519A ES8801629A1 ES 8801629 A1 ES8801629 A1 ES 8801629A1 ES 557519 A ES557519 A ES 557519A ES 557519 A ES557519 A ES 557519A ES 8801629 A1 ES8801629 A1 ES 8801629A1
Authority
ES
Spain
Prior art keywords
alkyl
amino acid
procedure
acid derivatives
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557519A
Other languages
English (en)
Other versions
ES557519A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES8801629A1 publication Critical patent/ES8801629A1/es
Publication of ES557519A0 publication Critical patent/ES557519A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE AMINOACIDOS BICICLICOS, DE FORMULA GENERAL (I), Y SUS SALES FISIOLOGICAMENTE INOCUAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (II)? EN LA QUE R1 SIGNIFICA HIDROGENO O ALQUILO; R2 SIGNIFICA HIDROGENO, ALQUILO O ALQUENILO; Y X AIGNIFICA ALQUILO, ALQUENILO O CICLOALQUILO, CON COMPUESTOS DE FORMULAS GENERALES (III), EN LAS QUE Q1, Q2, P1 Y P2 SIGNIFICAN CONJUNTAMENTE UN DOBLE ENLACE, LLEVANDOSE LA REACCION A EFECTO EN EL SENO DE UN DISOLVENTE ADECUADO A UNA TEMPERATURA INFERIOR AL PUNTO DE EBULLICION DE LA MEZCLA DE REACCION. DE APLICACION EN EL TRATAMIENTO DE LA INSUFICIENCIA CORONARIA DE DIFERENTES ORIGENES.
ES557519A 1985-05-23 1987-04-30 Procedimiento para preparar nuevos derivados de aminoacidos biciclicos Expired ES8801629A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853518514 DE3518514A1 (de) 1985-05-23 1985-05-23 Neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung

Publications (2)

Publication Number Publication Date
ES8801629A1 true ES8801629A1 (es) 1988-02-16
ES557519A0 ES557519A0 (es) 1988-02-16

Family

ID=6271426

Family Applications (3)

Application Number Title Priority Date Filing Date
ES555169A Expired ES8800151A1 (es) 1985-05-23 1986-05-21 Procedimiento para preparar nuevos derivados de aminoacidos biciclicos
ES557519A Expired ES8801629A1 (es) 1985-05-23 1987-04-30 Procedimiento para preparar nuevos derivados de aminoacidos biciclicos
ES557520A Expired ES8802424A1 (es) 1985-05-23 1987-04-30 Procedimiento para preparar acido azabiciclo (3.3.0)-7-octen-3-carboxilico y sus derivados

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES555169A Expired ES8800151A1 (es) 1985-05-23 1986-05-21 Procedimiento para preparar nuevos derivados de aminoacidos biciclicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES557520A Expired ES8802424A1 (es) 1985-05-23 1987-04-30 Procedimiento para preparar acido azabiciclo (3.3.0)-7-octen-3-carboxilico y sus derivados

Country Status (21)

Country Link
US (1) US4920144A (es)
EP (1) EP0203450B1 (es)
JP (2) JPH0819152B2 (es)
KR (1) KR930008630B1 (es)
AR (1) AR246954A1 (es)
AT (1) ATE74366T1 (es)
AU (1) AU592565B2 (es)
CA (1) CA1310794C (es)
DE (2) DE3518514A1 (es)
DK (1) DK171893B1 (es)
ES (3) ES8800151A1 (es)
FI (1) FI83523C (es)
GR (1) GR861316B (es)
HU (1) HU200784B (es)
IE (1) IE59185B1 (es)
IL (1) IL78865A (es)
NO (1) NO172940C (es)
NZ (1) NZ216246A (es)
PH (2) PH24307A (es)
PT (1) PT82631B (es)
ZA (1) ZA863824B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
US5231080A (en) * 1985-10-15 1993-07-27 Hoechst Aktiengesellschaft Method for the treatment of atherosclerosis, thrombosis, and peripheral vessel disease
CN108191969B (zh) * 2018-01-19 2021-01-01 渤海大学 两种来源于大西洋鳟鱼胶原蛋白的ace抑制肽

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3333455A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung n-alkylierter dipeptide und deren estern
JPS61502818A (ja) * 1984-07-30 1986-12-04 シェリング・コ−ポレ−ション シス、エンド−オクタヒドロシクロペンタ〔ｂ〕ピロ−ル−２−カルボキシレ−トの新規製造方法

Also Published As

Publication number Publication date
JPH0848668A (ja) 1996-02-20
KR860008974A (ko) 1986-12-19
EP0203450A2 (de) 1986-12-03
IL78865A (en) 1991-07-18
AU592565B2 (en) 1990-01-18
JP2579744B2 (ja) 1997-02-12
GR861316B (en) 1986-09-19
HUT42506A (en) 1987-07-28
IL78865A0 (en) 1986-09-30
EP0203450A3 (en) 1989-07-26
PH24277A (en) 1990-05-29
FI862136A7 (fi) 1986-11-24
AU5780486A (en) 1986-11-27
DK238786D0 (da) 1986-05-22
NO172940B (no) 1993-06-21
PT82631A (de) 1986-06-01
ZA863824B (en) 1986-12-30
FI862136A0 (fi) 1986-05-21
KR930008630B1 (ko) 1993-09-11
JPS61271299A (ja) 1986-12-01
US4920144A (en) 1990-04-24
ATE74366T1 (de) 1992-04-15
ES8802424A1 (es) 1988-06-01
FI83523B (fi) 1991-04-15
CA1310794C (en) 1992-11-24
IE861361L (en) 1986-11-23
ES557520A0 (es) 1988-06-01
ES557519A0 (es) 1988-02-16
NZ216246A (en) 1989-08-29
DE3684636D1 (de) 1992-05-07
IE59185B1 (en) 1994-01-26
ES8800151A1 (es) 1987-10-16
DE3518514A1 (de) 1986-11-27
JPH0819152B2 (ja) 1996-02-28
EP0203450B1 (de) 1992-04-01
AR246954A1 (es) 1994-10-31
DK171893B1 (da) 1997-08-04
HU200784B (en) 1990-08-28
DK238786A (da) 1986-11-24
NO172940C (no) 1993-09-29
PH24307A (en) 1990-05-29
ES555169A0 (es) 1987-10-16
NO862043L (no) 1986-11-24
FI83523C (fi) 1991-07-25
PT82631B (pt) 1988-08-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20071217