ATE355286T1 - Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel - Google Patents

Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel

Info

Publication number: ATE355286T1
Authority: AT; Austria
Prior art keywords: sup; formula; group; residue; general formula
Prior art date: 2001-04-26

Application number

AT02734989T

Other languages

English (en)

Inventor

Ales Halama

Ludmila Hejtmankova

Petr Lustig

Jindrich Richter

Lucie Srsnova

Josef Jirman

Original Assignee

Zentiva As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-04-26

Filing date

2002-04-25

Publication date

2006-03-15

2001-04-26 Priority claimed from CZ20011501A external-priority patent/CZ20011501A3/cs

2001-04-26 Priority claimed from CZ20011502A external-priority patent/CZ20011502A3/cs

2002-04-25 Application filed by Zentiva As filed Critical Zentiva As

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE355286T1 publication Critical patent/ATE355286T1/de

Links

HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 title abstract 4
239000003472 antidiabetic agent Substances 0.000 title abstract 2
229960005095 pioglitazone Drugs 0.000 title abstract 2
229940125708 antidiabetic agent Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
125000003277 amino group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Natural products NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical group 0.000 abstract 1
230000003178 anti-diabetic effect Effects 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
150000002466 imines Chemical class 0.000 abstract 1
125000002560 nitrile group Chemical group 0.000 abstract 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-M phenolate Chemical compound [O-]C1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-M 0.000 abstract 1
229940031826 phenolate Drugs 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyridine Compounds (AREA)
Saccharide Compounds (AREA)

AT02734989T 2001-04-26 2002-04-25 Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel ATE355286T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CZ20011501A CZ20011501A3 (cs)	2001-04-26	2001-04-26	Způsob výroby meziproduktu pro výrobu antidiabetika
CZ20011502A CZ20011502A3 (cs)	2001-04-26	2001-04-26	Způsob výroby antidiabetika

Publications (1)

Publication Number	Publication Date
ATE355286T1 true ATE355286T1 (de)	2006-03-15

Family

ID=25746959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02734989T ATE355286T1 (de)	2001-04-26	2002-04-25	Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel

Country Status (11)

Country	Link
US (1)	US7009057B2 (de)
EP (1)	EP1387843B1 (de)
AT (1)	ATE355286T1 (de)
AU (1)	AU2002311057A1 (de)
DE (1)	DE60218449D1 (de)
EE (1)	EE200300519A (de)
HU (1)	HUP0400091A2 (de)
PL (1)	PL363738A1 (de)
RU (1)	RU2281285C2 (de)
SK (1)	SK14452003A3 (de)
WO (1)	WO2002088120A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2003272072A1 (en)	2002-07-16	2004-02-02	Cadila Healthcare Limited	A process to prepare pioglitazone via several intermediates.
US8993773B2 (en)	2002-07-16	2015-03-31	Cadila Healthcare Limited	Process to prepare pioglitazone via several novel intermediates
WO2004108721A1 (en) *	2003-04-01	2004-12-16	Sun Pharmaceutical Industries Limited	Process for the preparation of 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl] methyl]-2,4-thiazolidinedione
ES2219180B1 (es) *	2003-05-09	2006-03-01	Medichem, S.A.	Compuesto intermedio util para la preparacion de pioglitazona.
US7230016B2 (en)	2003-05-13	2007-06-12	Synthon Ip Inc.	Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same
US20050059708A1 (en) *	2003-05-13	2005-03-17	Karel Pospisilik	Processes for making thiazolidinedione derivatives and compounds thereof
WO2005021542A2 (en) *	2003-08-28	2005-03-10	Ranbaxy Laboratories Limited	Process for the preparation of pioglitazone
CN1319956C (zh) *	2003-09-12	2007-06-06	深圳市海粤门生物科技开发有限公司	一种噻唑烷二酮的衍生物及其药用制剂的制备方法和应用
EP1716144A2 (de)	2004-02-20	2006-11-02	Synthon B.V.	Verfahren zur herstellung von pioglitazon und verbindungen des verfahrens
US7402713B2 (en) *	2006-03-07	2008-07-22	E.I. Du Pont De Nemours And Company	Processes for conversion of tyrosine to p-hydroxystyrene and p-acetoxystyrene
MX356584B (es)	2006-03-16	2018-06-05	Metabolic Solutions Dev Co	Analogos de tiazolidindiona para el tratamiento de enfermedad mediada por inflamacion metabolica.
PL2001469T3 (pl)	2006-03-16	2012-10-31	Metabolic Solutions Dev Co Llc	Analogi tiazolidynodionu
KR100791400B1 (ko)	2006-09-06	2008-01-07	동우신테크 주식회사	티아졸리딘디온 유도체의 제조방법
NZ597381A (en)	2007-09-14	2013-03-28	Metabolic Solutions Dev Co Llc	Thiazolidinedione analogues for the treatment of diabetes and inflammatory diseases
US8304441B2 (en)	2007-09-14	2012-11-06	Metabolic Solutions Development Company, Llc	Thiazolidinedione analogues for the treatment of metabolic diseases
WO2009148195A1 (en) *	2008-06-02	2009-12-10	Daebong Ls, Ltd.	5-(4-hydroxybenzyl)thiazolidine-2,4-dione as intermediate for synthesis of thiazolidinedione based compounds and process for preparing the same
DK2513070T3 (en)	2009-12-15	2018-01-22	Cirius Therapeutics Inc	PPAR-sparing thiazolidinedione salts for the treatment of metabolic disorders
CN108003090A (zh) *	2018-01-05	2018-05-08	白银亿尔精细化工有限公司	一种制备4-[2-(5-乙基-2-吡啶基)乙氧基]硝基苯的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57209274A (en) *	1981-06-16	1982-12-22	Takeda Chem Ind Ltd	Urea derivative, its preparation and its use
WO1986006069A1 (fr) *	1985-04-09	1986-10-23	Takeda Chemical Industries, Ltd.	Derives de thiazolidinedione, leur procede de preparation et composition medicinale les contenant
AR240698A1 (es) *	1985-01-19	1990-09-28	Takeda Chemical Industries Ltd	Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales
JPS62205054A (ja) *	1986-03-05	1987-09-09	Takeda Chem Ind Ltd	尿素誘導体
US5952509A (en) *	1996-06-27	1999-09-14	Takeda Chemical Industries, Ltd.	Production of benzaldehyde compounds
JP4316787B2 (ja)	2000-01-11	2009-08-19	壽製薬株式会社	エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、

2002
- 2002-04-25 HU HU0400091A patent/HUP0400091A2/hu unknown
- 2002-04-25 EP EP02734989A patent/EP1387843B1/de not_active Expired - Lifetime
- 2002-04-25 SK SK1445-2003A patent/SK14452003A3/sk unknown
- 2002-04-25 AT AT02734989T patent/ATE355286T1/de not_active IP Right Cessation
- 2002-04-25 RU RU2003134542/04A patent/RU2281285C2/ru not_active IP Right Cessation
- 2002-04-25 WO PCT/CZ2002/000024 patent/WO2002088120A1/en not_active Ceased
- 2002-04-25 PL PL02363738A patent/PL363738A1/xx not_active Application Discontinuation
- 2002-04-25 AU AU2002311057A patent/AU2002311057A1/en not_active Abandoned
- 2002-04-25 US US10/475,099 patent/US7009057B2/en not_active Expired - Fee Related
- 2002-04-25 EE EEP200300519A patent/EE200300519A/xx unknown
- 2002-04-25 DE DE60218449T patent/DE60218449D1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EE200300519A (et)	2004-02-16
RU2281285C2 (ru)	2006-08-10
US7009057B2 (en)	2006-03-07
HUP0400091A2 (hu)	2004-06-28
WO2002088120B1 (en)	2004-02-26
WO2002088120A1 (en)	2002-11-07
AU2002311057A1 (en)	2002-11-11
RU2003134542A (ru)	2005-06-10
DE60218449D1 (de)	2007-04-12
EP1387843B1 (de)	2007-02-28
SK14452003A3 (sk)	2004-04-06
PL363738A1 (en)	2004-11-29
EP1387843A1 (de)	2004-02-11
US20050043360A1 (en)	2005-02-24

Legal Events

Date	Code	Title	Description
2007-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE355286T1 (de)	2006-03-15	Verfahren zur herstellung von pioglitazone als antidiabetisches mitttel
HRP20020438B1 (en)	2011-01-31	Process for preparing 4-trifluoromethylsulphinylpyrazole derivative
ATE348814T1 (de)	2007-01-15	Verfahren zur herstellung von chinolinderivaten
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ATE442363T1 (de)	2009-09-15	Verfahren zur herstellung von pyridinverbindungen
DE59808710D1 (de)	2003-07-17	Verfahren zur herstellung von 2-(3-pyrazolyl-oxymethylen)nitrobenzolen
DE602004008863D1 (de)	2007-10-25	Zusammensetzung und Verfahren zur Behandlung von Halbleitersubstraten
DE60104704D1 (de)	2004-09-09	Verfahren zur herstellung einer substituierten imidazopyridinverbindung
DE50100698D1 (de)	2003-11-06	Verfahren zur Herstellung von 1,3,6-Hexantricarbonitril
ATE419230T1 (de)	2009-01-15	Verfahren zur herstellung von 2,6-dihalo-para- trifluoromethylanilin
BR0015163A (pt)	2002-07-09	Substrato enzimático, processo de sìntese de um substrato enzimático, composição e processo para a detecção e/ou a identificação e/ou a quantificação de pelo menos um microorganismo, kit de diagnóstico e utilização de um substrato enzimático
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ATE528358T1 (de)	2011-10-15	Verfahren zur herstellung einer azoverbindung
DE60308204D1 (de)	2006-10-19	Verfahren zur herstellung von aminopyrrolidinderivaten
DE69821925D1 (de)	2004-04-01	Verfahren zur herstellung eines aminoalkohol
ATE240945T1 (de)	2003-06-15	Verfahren zur herstellung von 4-((2',5'-diamino- 6'-halogenpyrimidin-4'-yl)amino)-cyclopent-2- enylmethanolen
DE60125386D1 (de)	2007-02-01	Verfahren zur Prävention einer durch Gefrieren induzierten Abnahme der Aktivität eines Proteins
ATE195115T1 (de)	2000-08-15	Verfahren zur herstellung von 5,6-dihydroxy-2- amino-1,2,3,4-tetrahydronaphthalin-derivaten
ATE251616T1 (de)	2003-10-15	Verfahren zur herstellung von 5- hydroxymethylthiazole
EP1650195A4 (de)	2008-09-17	Verfahren zur inhibierung der produktion von osteopontin
ATE286881T1 (de)	2005-01-15	Verfahren zur zyklisierung von optisch aktiven 4- amino-2-halogenbuttersäuren
WO2002100804A3 (en)	2003-05-08	Novel use of sulfamic acids as resolving agent.
DE60222475D1 (de)	2007-10-25	Poly-beta-carbonsäureacrylamid polymer, seine verwendung und verfahren zu seiner herstellung
DE60028998D1 (de)	2006-08-03	Verfahren zur herstellung einer benzylamin-verbindung
EP1035125A3 (de)	2002-07-10	2-Pyridylsilan, Verfahren zur deren Herstellung und Verwendung