ATE355291T1 - A2a adenosinrezeptorantagonisten - Google Patents
A2a adenosinrezeptorantagonistenInfo
- Publication number
- ATE355291T1 ATE355291T1 AT02805189T AT02805189T ATE355291T1 AT E355291 T1 ATE355291 T1 AT E355291T1 AT 02805189 T AT02805189 T AT 02805189T AT 02805189 T AT02805189 T AT 02805189T AT E355291 T1 ATE355291 T1 AT E355291T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- sup
- receptor antagonists
- adenosine receptor
- sub
- Prior art date
Links
- 229940121359 adenosine receptor antagonist Drugs 0.000 title abstract 2
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title abstract 2
- 101150051188 Adora2a gene Proteins 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 208000028867 ischemia Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34245501P | 2001-12-18 | 2001-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE355291T1 true ATE355291T1 (de) | 2006-03-15 |
Family
ID=23341901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02805189T ATE355291T1 (de) | 2001-12-18 | 2002-12-18 | A2a adenosinrezeptorantagonisten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7189730B2 (de) |
| EP (1) | EP1456209B1 (de) |
| AT (1) | ATE355291T1 (de) |
| AU (1) | AU2002357295A1 (de) |
| DE (1) | DE60218525T2 (de) |
| ES (1) | ES2279903T3 (de) |
| WO (1) | WO2003051882A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE404561T1 (de) * | 2001-04-17 | 2008-08-15 | Dainippon Sumitomo Pharma Co | Neue adeninderivate |
| DK1401837T3 (da) * | 2001-06-29 | 2005-11-07 | Cv Therapeutics Inc | Purinderivater som A2B-adenosinreceptorantagonister |
| NL1023355C2 (nl) * | 2003-05-07 | 2004-11-09 | Oce Tech Bv | Hot melt inkt omvattend een mengsel van kleurstoffen. |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| WO2009034386A1 (en) * | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
| CA2721851A1 (en) * | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
| CN102459269B (zh) * | 2009-04-28 | 2014-10-15 | 全药工业株式会社 | 嘌呤衍生物以及使用所述嘌呤衍生物的抗肿瘤剂 |
| US8263762B2 (en) | 2009-06-30 | 2012-09-11 | Dogwood Pharmaceuticals, Inc. | Alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thereof as A2AR agonists |
| CA3021947A1 (en) * | 2016-04-26 | 2017-11-02 | Sumitomo Dainippon Pharma Co., Ltd. | Substituted purine derivative |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9125001D0 (en) | 1991-11-25 | 1992-01-22 | Ici Plc | Heterocyclic compounds |
| US5866702A (en) * | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| US6329381B1 (en) | 1997-11-28 | 2001-12-11 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds |
| WO2000044750A1 (en) * | 1999-02-01 | 2000-08-03 | Cv Therapeutics, Inc. | PURINE INHIBITORS OF CYCLIN DEPENDENT KINASE 2 AND Iλ-A$g(a) |
| NZ516260A (en) * | 1999-07-02 | 2004-08-27 | Eisai Co Ltd | Fused imidazole compounds and remedies for diabetes mellitus |
| US20030187261A1 (en) | 2000-01-07 | 2003-10-02 | Libor Havlicek | Purine derivatives, process for their preparation and use thereof |
| ATE404561T1 (de) * | 2001-04-17 | 2008-08-15 | Dainippon Sumitomo Pharma Co | Neue adeninderivate |
| DK1401837T3 (da) | 2001-06-29 | 2005-11-07 | Cv Therapeutics Inc | Purinderivater som A2B-adenosinreceptorantagonister |
| ITRM20010465A1 (it) * | 2001-07-31 | 2003-01-31 | Sigma Tau Ind Farmaceuti | Derivati della triazolil-imidazopiridina e delle triazolilpurine utili come ligandi del recettore a2a dell'adenosina e loro uso come medicam |
-
2002
- 2002-12-18 US US10/322,985 patent/US7189730B2/en not_active Expired - Fee Related
- 2002-12-18 DE DE60218525T patent/DE60218525T2/de not_active Expired - Lifetime
- 2002-12-18 ES ES02805189T patent/ES2279903T3/es not_active Expired - Lifetime
- 2002-12-18 AU AU2002357295A patent/AU2002357295A1/en not_active Abandoned
- 2002-12-18 AT AT02805189T patent/ATE355291T1/de not_active IP Right Cessation
- 2002-12-18 EP EP02805189A patent/EP1456209B1/de not_active Expired - Lifetime
- 2002-12-18 WO PCT/US2002/040361 patent/WO2003051882A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003051882A1 (en) | 2003-06-26 |
| US7189730B2 (en) | 2007-03-13 |
| EP1456209B1 (de) | 2007-02-28 |
| EP1456209A1 (de) | 2004-09-15 |
| DE60218525D1 (de) | 2007-04-12 |
| AU2002357295A1 (en) | 2003-06-30 |
| DE60218525T2 (de) | 2007-11-22 |
| US20030149060A1 (en) | 2003-08-07 |
| ES2279903T3 (es) | 2007-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200601160A1 (ru) | 2,6-бисгетероарил-4-аминопиримидины в качестве антагонистов аденозиновых рецепторов | |
| DK1401837T3 (da) | Purinderivater som A2B-adenosinreceptorantagonister | |
| NO20020823L (no) | Heteropolysykliske forbindelser og deres anvendelse som metabotropiske glutamatreseptorantagonister | |
| JO2294B1 (en) | 4 - Phenylpyridine derivatives | |
| MXPA06000716A (es) | Derivados de quinolina y quinazolina que tienen afinidad hacia receptores del tipo 5ht1. | |
| DE60236719D1 (de) | Purinderivate als antagonisten an purinergen rezeptoren | |
| PT1159279E (pt) | 4-oxo-4,7-di-hidrotieno¬2,3-b|piridino-5-carboxamidas como agentes antivirais | |
| ES2092639T3 (es) | Mejoras en o relativas a antagonistas de receptores de aminoacidos excitatorios. | |
| YU30902A (sh) | Novi ciklopropani kao cgrp antagonisti, lekovi koji sadrže navedena jedinjenja i postupak za njihovu proizvodnju | |
| ATE355291T1 (de) | A2a adenosinrezeptorantagonisten | |
| DE69838662D1 (de) | Morphinanderivate und ihre medizinische Anwendung | |
| NZ528997A (en) | Sulfonamides | |
| EA200000336A1 (ru) | Антагонисты рецептора витронектина | |
| DE60112574D1 (de) | Bicyclische cyclohexylamine und ihre verwendung als nmda-rezeptor antagonisten | |
| ATE284871T1 (de) | Bicyclische vasopressin-agoniste | |
| WO2002042280A3 (en) | Pyrimidine derivatives | |
| WO2005061475A3 (en) | Ornithine derivatives as prostaglandin e2 agonists or antagonists | |
| MXPA02011464A (es) | Derivados 1,4-diazepan-2,5-diona y su uso como antagonistas del receptor de la nk-1. | |
| DE69812010D1 (de) | 4-Aminopyrrole (3,2-d) Pyrimidinen als Antagonisten des Neuropeptide Y Receptors | |
| DE69717969D1 (de) | Substituierte n-methyl-n-(4-(piperidin-1-yl)-2-arylbutyl)-benzamide zur behandlung von allergischen erkrankungen | |
| NO20033049D0 (no) | Fremgangsmåte for fremstilling av (+/-) trans-4-p-fluorfenyl- 3-hydroksymetyl-1 | |
| DE69925160D1 (de) | Arylpiperidin- und aryl-1,2,5,6-tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität | |
| ATE238300T1 (de) | (3,4-dihydro-2h-benzo(1,4)oxazinyl-methyl)-3-(1 - indol-3-yl)-alkylamine | |
| NO993372L (no) | Substituerte 4-(6-fluor-(1H)-indol-3-yl)-1,2,3,6-tetrahydropyridin for behandling av CNS-forstyrrelser | |
| CA2247105A1 (en) | Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl-amino)piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic di seases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |