ATE355304T1 - Radiomarkierte vip-analoge zur diagnose und therapie - Google Patents
Radiomarkierte vip-analoge zur diagnose und therapieInfo
- Publication number
- ATE355304T1 ATE355304T1 AT00950907T AT00950907T ATE355304T1 AT E355304 T1 ATE355304 T1 AT E355304T1 AT 00950907 T AT00950907 T AT 00950907T AT 00950907 T AT00950907 T AT 00950907T AT E355304 T1 ATE355304 T1 AT E355304T1
- Authority
- AT
- Austria
- Prior art keywords
- vip
- radiolabeled
- receptor
- agent
- imaging
- Prior art date
Links
- 238000003745 diagnosis Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 102000012088 Vasoactive Intestinal Peptide Receptors Human genes 0.000 abstract 3
- 108010075974 Vasoactive Intestinal Peptide Receptors Proteins 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 abstract 2
- 102400000015 Vasoactive intestinal peptide Human genes 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000012216 imaging agent Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 238000000163 radioactive labelling Methods 0.000 abstract 2
- 230000003439 radiotherapeutic effect Effects 0.000 abstract 2
- 206010027476 Metastases Diseases 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000012800 visualization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Optics & Photonics (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Radar Systems Or Details Thereof (AREA)
- Transceivers (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN137DE2000 | 2000-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE355304T1 true ATE355304T1 (de) | 2006-03-15 |
Family
ID=11097029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00950907T ATE355304T1 (de) | 2000-02-18 | 2000-07-31 | Radiomarkierte vip-analoge zur diagnose und therapie |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6608174B1 (de) |
| EP (1) | EP1257575B1 (de) |
| AT (1) | ATE355304T1 (de) |
| AU (1) | AU2000263935A1 (de) |
| CA (1) | CA2405714A1 (de) |
| DE (1) | DE60033697D1 (de) |
| WO (1) | WO2001060863A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9029505B2 (en) | 2009-08-14 | 2015-05-12 | Phasebio Pharmaceuticals, Inc. | Modified vasoactive intestinal peptides |
| US9782454B2 (en) | 2010-04-22 | 2017-10-10 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
| CA2873553C (en) | 2011-06-06 | 2020-01-28 | Phasebio Pharmaceuticals, Inc. | Use of modified vasoactive intestinal peptides in the treatment of hypertension |
| KR20150143440A (ko) * | 2013-02-15 | 2015-12-23 | 토마스 제퍼슨 유니버시티 | 떨어져 나가거나 순환 중인 종양세포를 생물학적 유액 내에서 탐지하는 방법 |
| WO2014145718A2 (en) | 2013-03-15 | 2014-09-18 | Longevity Biotech, Inc. | Peptides comprising non-natural amino acids and methods of making and using the same |
| CN114652817B (zh) | 2015-02-09 | 2026-04-17 | 费斯生物制药公司 | 用于治疗肌肉疾病和病症的方法和组合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605641A (en) | 1984-10-09 | 1986-08-12 | Hoffmann-La Roche Inc. | Synthetic vasoactive intestinal peptide analogs |
| US4734400A (en) | 1984-10-09 | 1988-03-29 | Hoffmann-La Roche Inc. | Synthetic vasoactive intestinal peptide analogs |
| GB8525852D0 (en) | 1985-10-19 | 1985-11-20 | Beecham Group Plc | Compounds |
| US4835252A (en) | 1987-02-26 | 1989-05-30 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Vasoactive intestinal peptide analogs |
| US5141924A (en) | 1989-06-30 | 1992-08-25 | Hoffmann-La Roche, Inc. | Synthetic vasoactive intestinal peptide analogs |
| DK0436005T3 (da) | 1989-07-20 | 1995-07-03 | Sandoz Ltd | Mærkede polypeptidderivater |
| DE69101187T2 (de) | 1990-06-26 | 1994-09-29 | Sanwa Kagaku Kenkyusho Co | VIP-Analogen und ihre Verwendung. |
| US5217953A (en) | 1990-11-30 | 1993-06-08 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Vasoactive intestinal peptide antagonist |
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| JPH05238950A (ja) | 1991-04-22 | 1993-09-17 | Sanwa Kagaku Kenkyusho Co Ltd | 易吸収性vip製剤 |
| AU656230B2 (en) | 1991-10-11 | 1995-01-27 | F. Hoffmann-La Roche Ag | Cyclic vasoactive peptides |
| US5565424A (en) | 1994-02-07 | 1996-10-15 | Ramot - University Authority For Applied Research And Industrial Development Ltd. | Superactive VIP antagonists |
| EP0796867B1 (de) * | 1995-06-09 | 2003-11-05 | Itoham Foods Inc. | Peptide, bronchodilator und den blutstrom verbesserndes mittel |
| PL345583A1 (en) | 1998-07-20 | 2001-12-17 | Sod Conseils Rech Applic | Peptide analogues of pacap |
-
2000
- 2000-07-31 WO PCT/US2000/020874 patent/WO2001060863A1/en not_active Ceased
- 2000-07-31 US US09/629,632 patent/US6608174B1/en not_active Expired - Fee Related
- 2000-07-31 AT AT00950907T patent/ATE355304T1/de not_active IP Right Cessation
- 2000-07-31 DE DE60033697T patent/DE60033697D1/de not_active Expired - Lifetime
- 2000-07-31 AU AU2000263935A patent/AU2000263935A1/en not_active Abandoned
- 2000-07-31 CA CA002405714A patent/CA2405714A1/en not_active Abandoned
- 2000-07-31 EP EP00950907A patent/EP1257575B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60033697D1 (de) | 2007-04-12 |
| US6608174B1 (en) | 2003-08-19 |
| EP1257575B1 (de) | 2007-02-28 |
| CA2405714A1 (en) | 2001-08-23 |
| AU2000263935A1 (en) | 2001-08-27 |
| EP1257575A1 (de) | 2002-11-20 |
| WO2001060863A1 (en) | 2001-08-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Gali et al. | Synthesis, characterization, and labeling with 99mTc/188Re of peptide conjugates containing a dithia-bisphosphine chelating agent | |
| Banerjee et al. | 64Cu-labeled inhibitors of prostate-specific membrane antigen for PET imaging of prostate cancer | |
| ES2960729T3 (es) | 177 Lu-dota-hynic-ipsma como un radiofármaco terapéutico dirigido al antígeno prostático específico de membrana | |
| Xu et al. | 99mTc-labeling and evaluation of a HYNIC modified small-molecular inhibitor of prostate-specific membrane antigen | |
| EP3486249B1 (de) | 99mtc-edda/hynic-ipsma als radiopharmazeutikum für den nachweis der überexpression des prostata-spezifischen membranantigens | |
| Marsouvanidis et al. | Gastrin releasing peptide receptor-directed radioligands based on a bombesin antagonist: synthesis, 111In-labeling, and preclinical profile | |
| Hernández-Jiménez et al. | 177Lu-DOTA-HYNIC-Lys (Nal)-Urea-Glu: Synthesis and assessment of the ability to target the prostate specific membrane antigen | |
| Guo et al. | Gallium-67-labeled lactam bridge-cyclized α-melanocyte stimulating hormone peptide for primary and metastatic melanoma imaging | |
| ATE355304T1 (de) | Radiomarkierte vip-analoge zur diagnose und therapie | |
| Liu et al. | Radionuclide-labeled peptides for imaging and treatment of CXCR4-overexpressing malignant tumors | |
| Abouzayed et al. | 177Lu-labeled PSMA targeting therapeutic with optimized linker for treatment of disseminated prostate cancer; evaluation of biodistribution and dosimetry | |
| Ferro-Flores et al. | Radiolabeled protein-inhibitor peptides with rapid clinical translation towards imaging and therapy | |
| M Rey | Radiometal complexes in molecular imaging and therapy | |
| KR20070106731A (ko) | 방사성표지된 갈륨 복합체, 그의 합성방법 및 악성종양에서 egfr 발현의 pet 영상화를 위한 그의 용도 | |
| Luo et al. | An 125I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo | |
| JP3717402B2 (ja) | 映像化する方法および組成物 | |
| MY129008A (en) | Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotheraphy | |
| KR20040055784A (ko) | 종양의 영상 및 치료용 피에이씨에이피 조성물 및 방법 | |
| Liu et al. | Metastatic melanoma imaging using a novel Tc-99m-labeled lactam-cyclized alpha-MSH peptide | |
| JP2002516882A5 (de) | ||
| Ha et al. | Synthesis and evaluation of a radioiodinated bladder cancer specific peptide | |
| CN101597323A (zh) | 一种用于肿瘤显像的放射性同位素标记多肽 | |
| Giblin et al. | In vitro and in vivo evaluation of 111In-labeled E. coli heat-stable enterotoxin analogs for specific targeting of human breast cancers | |
| Liolios et al. | Bispecific PSMA-617/RM2 Heterodimer for Theranostics Applications in Prostate Cancer | |
| Schweinsberg | Novel 99mTc-labeled bombesin analogues with improved pharmacokinetics for targeting of gastrin-releasing-peptide receptor-positive tumors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |