ATE356130T1 - Inhibitoren von cruzipain und anderen cysteinproteasen - Google Patents
Inhibitoren von cruzipain und anderen cysteinproteasenInfo
- Publication number
- ATE356130T1 ATE356130T1 AT02732145T AT02732145T ATE356130T1 AT E356130 T1 ATE356130 T1 AT E356130T1 AT 02732145 T AT02732145 T AT 02732145T AT 02732145 T AT02732145 T AT 02732145T AT E356130 T1 ATE356130 T1 AT E356130T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- cruzipain
- cysteine proteases
- general formula
- compounds
- Prior art date
Links
- 108090000711 cruzipain Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108010005843 Cysteine Proteases Proteins 0.000 title 1
- 102000005927 Cysteine Proteases Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010001935 American trypanosomiasis Diseases 0.000 abstract 1
- 208000024699 Chagas disease Diseases 0.000 abstract 1
- 239000002852 cysteine proteinase inhibitor Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0101179A GB0101179D0 (en) | 2001-01-17 | 2001-01-17 | Biologically active compounds |
| US27535901P | 2001-03-13 | 2001-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356130T1 true ATE356130T1 (de) | 2007-03-15 |
Family
ID=26245571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02732145T ATE356130T1 (de) | 2001-01-17 | 2002-01-17 | Inhibitoren von cruzipain und anderen cysteinproteasen |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7425562B2 (de) |
| EP (1) | EP1362052B1 (de) |
| JP (1) | JP4608183B2 (de) |
| KR (1) | KR100860067B1 (de) |
| CN (1) | CN1269822C (de) |
| AT (1) | ATE356130T1 (de) |
| AU (1) | AU2002219397B2 (de) |
| BR (1) | BR0206501A (de) |
| CA (1) | CA2436462C (de) |
| CY (1) | CY1106640T1 (de) |
| DE (1) | DE60218633T2 (de) |
| DK (1) | DK1362052T3 (de) |
| ES (1) | ES2281516T3 (de) |
| IL (2) | IL156774A0 (de) |
| MX (1) | MXPA03006224A (de) |
| NO (1) | NO328208B1 (de) |
| NZ (1) | NZ526913A (de) |
| PT (1) | PT1362052E (de) |
| RU (1) | RU2329266C2 (de) |
| WO (1) | WO2002057270A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03005601A (es) | 2000-12-22 | 2004-12-02 | Axys Pharm Inc | Nuevos compuestos y composiciones como inhibidores de catepsina. |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| JP2005504078A (ja) | 2001-09-14 | 2005-02-10 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | カテプシン阻害剤としての新規化合物および組成物 |
| MXPA04004450A (es) | 2001-11-14 | 2004-08-11 | Aventis Pharma Inc | Nuevos compuestos y composiciones como inhibidores de catepsina s. |
| WO2004007501A1 (en) * | 2002-07-16 | 2004-01-22 | Amura Therapeutics Limited | Biologically active compounds |
| US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| SE0400022D0 (sv) * | 2004-01-08 | 2004-01-08 | Medivir Ab | New compounds |
| AU2005203972B2 (en) * | 2004-01-08 | 2010-11-18 | Medivir Ab | Cysteine protease inhibitors |
| JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
| US7488848B2 (en) * | 2005-03-21 | 2009-02-10 | Virobay, Inc. | Alpha ketoamide compounds as cysteine protease inhibitors |
| GB0513840D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
| GB0513839D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
| GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614052D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614073D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614046D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614037D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614053D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614044D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| WO2008114054A1 (en) * | 2007-03-19 | 2008-09-25 | Medivir Ab | Protease inhibitors |
| US7893067B2 (en) | 2007-06-27 | 2011-02-22 | Medivir Ab | Cysteine protease inhibitors |
| EP2240491B1 (de) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ON DERIVATE ALS INHIBITOREN VON CYSTEIN PROTEINASEN |
| GB0804701D0 (en) | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
| GB0804702D0 (en) * | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
| US9409880B2 (en) | 2011-01-20 | 2016-08-09 | The Regents Of The University Of Colorado, A Body Corporate | Modulators of TLR3/dsRNA complex and uses thereof |
| EP2891492B1 (de) * | 2012-08-30 | 2022-11-09 | The University of Tokyo | Endoparasitenbekämpfungsmittel |
| CN106279188A (zh) * | 2016-07-21 | 2017-01-04 | 青岛科技大学 | 一种多取代呋喃并[2,3‑b]吡咯衍生物的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652574A (en) | 1970-04-01 | 1972-03-28 | Abbott Lab | Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof |
| DE3601226A1 (de) * | 1986-01-17 | 1987-07-23 | Bayer Ag | Dihydropyridinlactole, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| RU2137768C1 (ru) * | 1993-12-15 | 1999-09-20 | Мерк энд Ко, Инк. | Ингибиторы hiv протеазы |
| DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
| JP2000517319A (ja) | 1996-08-28 | 2000-12-26 | スミスクライン・ビーチャム・コーポレイション | システインプロテアーゼのインヒビター |
| HUP0001232A3 (en) | 1996-12-23 | 2001-02-28 | Elan Pharmaceuticals Inc San F | Cycloalkyl, lactam, lactone derivatives and their thio analogues inhibiting betha-amyloid peptide release and/or its synthesis and pharmaceutical compositions containing the compounds |
| AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
| MA26618A1 (fr) | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
| CO5150165A1 (es) | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| WO2002040462A2 (en) | 2000-11-17 | 2002-05-23 | Medivir Uk Limited | Cysteine protease inhibitors |
| MXPA03005601A (es) | 2000-12-22 | 2004-12-02 | Axys Pharm Inc | Nuevos compuestos y composiciones como inhibidores de catepsina. |
-
2002
- 2002-01-17 WO PCT/GB2002/000184 patent/WO2002057270A1/en not_active Ceased
- 2002-01-17 MX MXPA03006224A patent/MXPA03006224A/es active IP Right Grant
- 2002-01-17 BR BR0206501-0A patent/BR0206501A/pt not_active IP Right Cessation
- 2002-01-17 DE DE60218633T patent/DE60218633T2/de not_active Expired - Lifetime
- 2002-01-17 AU AU2002219397A patent/AU2002219397B2/en not_active Ceased
- 2002-01-17 ES ES02732145T patent/ES2281516T3/es not_active Expired - Lifetime
- 2002-01-17 PT PT02732145T patent/PT1362052E/pt unknown
- 2002-01-17 JP JP2002557947A patent/JP4608183B2/ja not_active Expired - Fee Related
- 2002-01-17 CA CA2436462A patent/CA2436462C/en not_active Expired - Fee Related
- 2002-01-17 DK DK02732145T patent/DK1362052T3/da active
- 2002-01-17 KR KR1020037009524A patent/KR100860067B1/ko not_active Expired - Fee Related
- 2002-01-17 RU RU2003125270/04A patent/RU2329266C2/ru not_active IP Right Cessation
- 2002-01-17 EP EP02732145A patent/EP1362052B1/de not_active Expired - Lifetime
- 2002-01-17 IL IL15677402A patent/IL156774A0/xx active IP Right Grant
- 2002-01-17 AT AT02732145T patent/ATE356130T1/de active
- 2002-01-17 CN CNB028038142A patent/CN1269822C/zh not_active Expired - Fee Related
- 2002-01-17 US US10/466,384 patent/US7425562B2/en not_active Expired - Fee Related
- 2002-01-17 NZ NZ526913A patent/NZ526913A/xx not_active IP Right Cessation
-
2003
- 2003-07-03 IL IL156774A patent/IL156774A/en not_active IP Right Cessation
- 2003-07-16 NO NO20033220A patent/NO328208B1/no not_active IP Right Cessation
-
2007
- 2007-06-04 CY CY20071100742T patent/CY1106640T1/el unknown
-
2008
- 2008-09-15 US US12/211,069 patent/US20090247471A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20030075161A (ko) | 2003-09-22 |
| NO20033220D0 (no) | 2003-07-16 |
| US7425562B2 (en) | 2008-09-16 |
| US20040138250A1 (en) | 2004-07-15 |
| CN1269822C (zh) | 2006-08-16 |
| PT1362052E (pt) | 2007-04-30 |
| DE60218633T2 (de) | 2008-02-21 |
| CA2436462C (en) | 2011-07-05 |
| CN1486320A (zh) | 2004-03-31 |
| EP1362052B1 (de) | 2007-03-07 |
| BR0206501A (pt) | 2004-01-13 |
| ES2281516T3 (es) | 2007-10-01 |
| CY1106640T1 (el) | 2012-01-25 |
| DE60218633D1 (de) | 2007-04-19 |
| JP2004518674A (ja) | 2004-06-24 |
| HK1060729A1 (en) | 2004-08-20 |
| JP4608183B2 (ja) | 2011-01-05 |
| MXPA03006224A (es) | 2004-10-15 |
| EP1362052A1 (de) | 2003-11-19 |
| NZ526913A (en) | 2004-12-24 |
| NO328208B1 (no) | 2010-01-11 |
| KR100860067B1 (ko) | 2008-09-24 |
| CA2436462A1 (en) | 2002-07-25 |
| AU2002219397B2 (en) | 2008-02-14 |
| DK1362052T3 (da) | 2007-07-09 |
| IL156774A0 (en) | 2004-02-08 |
| RU2003125270A (ru) | 2005-02-20 |
| IL156774A (en) | 2008-08-07 |
| WO2002057270A1 (en) | 2002-07-25 |
| NO20033220L (no) | 2003-09-17 |
| US20090247471A1 (en) | 2009-10-01 |
| RU2329266C2 (ru) | 2008-07-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60218633D1 (de) | Inhibitoren von cruzipain und anderen cysteinproteasen | |
| TR199901191T2 (xx) | Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�. | |
| BR0215405A (pt) | Composições e processos de uso de collajolie | |
| BR0111451A (pt) | Inibidores de serina protease | |
| SE0201976D0 (sv) | Novel compounds | |
| BRPI0418251A (pt) | fosfonatos, monofosfonamidatos, bisfosfonamidatos para o tratamento de doenças virais | |
| SE0102315D0 (sv) | Compounds | |
| ATE454378T1 (de) | Verbindungen, die sich als inhibitoren vonjak und anderen proteinkinasen eignen | |
| PT1465864E (pt) | Inibidores de factor xa e outras serina proteases envolvidos na cascata da coagulacao | |
| DE60235083D1 (de) | Substituierte tetracyclin-verbindungen zur behandlung von malaria | |
| ATE443043T1 (de) | Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer | |
| BR0317715A (pt) | Composições e processos de uso de collajolie | |
| DE60237725D1 (de) | Vervendung von dexrazoxane in der prävention und behandlung der alzeheimer-krankheit | |
| EA200301100A1 (ru) | Новые фталазиноны | |
| DE60230127D1 (de) | Inhibitoren von integrin alpha-v-beta-6 | |
| CY1108446T1 (el) | Μη νευροτοξικοι παραγοντες ενεργοποιησης πλασμινογονου για την αντιμετωπιση αποπληξιας | |
| DE60105418D1 (de) | Serinprotease-inhibitoren | |
| ATE303384T1 (de) | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren | |
| BR0116166A (pt) | Inibidores da serina protease | |
| SE0101932D0 (sv) | Pharmaceutical combinations | |
| DE60306934D1 (de) | Verwendung von Nitrilenverbindungen als Arztneimittel | |
| DE60211132D1 (de) | 2-alkylierte cyclodextrinderivate : umkehrungsmittel von medikament-induzierter neuromuskulärer blockierung | |
| SE0101038D0 (sv) | Novel compounds | |
| SE0003476D0 (sv) | Compounds | |
| EP1441761A4 (de) | Verfahren zur prävention und behandlung von infektionen mit dem flavivirus bei tieren |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1362052 Country of ref document: EP |