ATE356880T1 - Rapamycin analoge - Google Patents
Rapamycin analogeInfo
- Publication number
- ATE356880T1 ATE356880T1 AT00990461T AT00990461T ATE356880T1 AT E356880 T1 ATE356880 T1 AT E356880T1 AT 00990461 T AT00990461 T AT 00990461T AT 00990461 T AT00990461 T AT 00990461T AT E356880 T1 ATE356880 T1 AT E356880T1
- Authority
- AT
- Austria
- Prior art keywords
- rapamycin
- rapamycin analogue
- anticancers
- neurotrophins
- antifungals
- Prior art date
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 3
- 108010025020 Nerve Growth Factor Proteins 0.000 abstract 1
- 102000007072 Nerve Growth Factors Human genes 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 230000001851 biosynthetic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 108091008053 gene clusters Proteins 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 abstract 1
- 229960002930 sirolimus Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16222999P | 1999-10-29 | 1999-10-29 | |
| US19857800P | 2000-04-20 | 2000-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356880T1 true ATE356880T1 (de) | 2007-04-15 |
Family
ID=26858557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00990461T ATE356880T1 (de) | 1999-10-29 | 2000-10-30 | Rapamycin analoge |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6670168B1 (de) |
| EP (1) | EP1244800B1 (de) |
| AT (1) | ATE356880T1 (de) |
| AU (1) | AU2748701A (de) |
| DE (1) | DE60033965T2 (de) |
| ES (1) | ES2283344T3 (de) |
| WO (1) | WO2001034816A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE356880T1 (de) * | 1999-10-29 | 2007-04-15 | Kosan Biosciences Inc | Rapamycin analoge |
| ES2296063T3 (es) | 2002-07-16 | 2008-04-16 | Biotica Technology Limited | Produccion de poliquetidos y otros productos naturales. |
| AU2003254168A1 (en) | 2002-07-30 | 2004-02-16 | Wyeth | Parenteral formulations containing a rapamycin hydroxyester |
| WO2004060283A2 (en) | 2002-12-16 | 2004-07-22 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
| US7375088B2 (en) | 2003-01-21 | 2008-05-20 | Thallion Pharmaceuticals Inc. | Polyene polyketides, processes for their production and their use as a pharmaceutical |
| WO2004087045A2 (en) * | 2003-03-28 | 2004-10-14 | Kosan Biosciences, Inc. | Devices, methods, and compositions to prevent restenosis |
| WO2005024025A1 (en) | 2003-09-11 | 2005-03-17 | Ecopia Biosciences Inc. | Polyene polyketides and methods of production |
| JP2007505932A (ja) | 2003-09-18 | 2007-03-15 | マクサイト， インコーポレイテッド | 経強膜送達 |
| JP2007534337A (ja) * | 2004-04-27 | 2007-11-29 | ワイス | ラパマイシン特異的メチラーゼを用いるラパマイシンの標識 |
| GB0417852D0 (en) * | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| RU2007119585A (ru) * | 2004-12-20 | 2009-01-27 | Вайет (Us) | Производные рапамицина и их применение при лечении неврологических заболеваний |
| SG158143A1 (en) | 2004-12-20 | 2010-01-29 | Wyeth Corp | Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders |
| WO2006086750A1 (en) | 2005-02-09 | 2006-08-17 | Macusight, Inc. | Liquid formulations for treatment of diseases or conditions |
| US8663639B2 (en) | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
| EP2468881A3 (de) * | 2005-07-21 | 2012-08-15 | Abbott Laboratories | Mehrfache Genexpression mit sORF-Konstrukten und Verfahren mit Polyproteinen, Pro-Proteinen und Proteolyse |
| BRPI0614338B1 (pt) | 2005-08-08 | 2018-01-02 | Bayer Cropscience Nv | Processos para a identificação de um evento elite em amostras biológicas, para a confirmação da pureza das sementes, para a seleção de sementes em relação à presença do dito evento elite, para a determinação do status de zigosidade de uma planta, material de planta ou semente que compreende o dito evento elite, para detecção da presença do dito evento elite, e para a produção de uma planta ou de uma semente de algodão que compreende o dito evento elite, bem como kits para a identificação do dito evento elite, par de iniciadores adequado para uso na detecção específica do mesmo, e sonda específica para a identificação do dito evento elite |
| EP1962819A1 (de) * | 2005-12-20 | 2008-09-03 | Wyeth | Steuerung der formstabilität einer cci-779-dosierung durch steuerung der unreinheiten von wirkstoffen |
| US8492400B2 (en) | 2006-02-09 | 2013-07-23 | Santen Pharmaceutical Co., Ltd. | Stable formulations, and methods of their preparation and use |
| CN101443004B (zh) | 2006-03-23 | 2013-03-06 | 参天制药株式会社 | 用于与血管通透性有关的疾病或病症的制剂 |
| US7883855B2 (en) | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
| US20080051691A1 (en) * | 2006-08-28 | 2008-02-28 | Wyeth | Implantable shunt or catheter enabling gradual delivery of therapeutic agents |
| JP4968611B2 (ja) | 2006-12-29 | 2012-07-04 | アボット・ラボラトリーズ | 免疫抑制剤の改善された測定法 |
| US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
| ES2405364T3 (es) | 2006-12-29 | 2013-05-30 | Abbott Laboratories | Ensayo diagnóstico para la detección de una molécula o fármaco en sangre entera |
| WO2008082984A2 (en) | 2006-12-29 | 2008-07-10 | Abbott Laboratories | Non-denaturing lysis reagent for use with capture-in-solution immunoassay |
| CA2676613A1 (en) * | 2007-01-29 | 2008-08-07 | Wyeth | Immunophilin ligands and methods for modulating immunophilin and calcium channel activity |
| TW200845960A (en) * | 2007-04-05 | 2008-12-01 | Wyeth Corp | Wortmannin-rapalog conjugate and uses thereof |
| WO2009105510A1 (en) * | 2008-02-19 | 2009-08-27 | Wyeth | Methods for using rapamycin analogues in the treatment of neurological disorders |
| US8447409B2 (en) * | 2008-10-15 | 2013-05-21 | Cochlear Limited | Electroneural interface for a medical implant |
| WO2011053699A1 (en) * | 2009-10-30 | 2011-05-05 | Abbott Laboratories | Sorf constructs and multiple gene expression |
| KR101331491B1 (ko) | 2012-03-21 | 2013-11-20 | 이화여자대학교 산학협력단 | 증가된 라파마이신 생성능을 갖는 신규 미생물 균주 |
| GB201312318D0 (en) * | 2013-07-09 | 2013-08-21 | Isomerase Therapeutics Ltd | Novel methods and compounds |
| CN104195201A (zh) * | 2014-09-28 | 2014-12-10 | 河北圣雪大成制药有限责任公司 | 一种发酵法生产新霉素所使用的发酵培养基 |
| CN107286227B (zh) * | 2016-03-31 | 2021-01-05 | 南京诺云生物科技有限公司 | Streptomyces hirsutus ATCC 19091蛋白的新用途 |
| WO2018201160A1 (en) | 2017-04-28 | 2018-11-01 | Agrospheres, Inc. | Compositions and methods for enzyme immobilization |
| CN107365811B (zh) * | 2017-09-15 | 2025-05-06 | 常州兰陵制药有限公司 | 利用游动放线菌发酵生产雷帕霉素的工艺 |
| BR112020005803A2 (pt) | 2017-09-25 | 2020-12-01 | Agrospheres, Inc. | composições e métodos para produção e administração moduláveis de produtos biológicos |
| CN107557403A (zh) * | 2017-10-31 | 2018-01-09 | 无锡福祈制药有限公司 | 一种提高西罗莫司发酵产量的方法 |
| CN113164557A (zh) | 2018-07-23 | 2021-07-23 | 因柯利尔疗法公司 | 治疗神经性病症的方法 |
| CA3107349A1 (en) | 2018-07-23 | 2020-01-30 | Enclear Therapies, Inc. | Methods of treating neurological disorders |
| WO2020210634A1 (en) | 2019-04-11 | 2020-10-15 | Enclear Therapies, Inc. | Methods of amelioration of cerebrospinal fluid and devices and systems therefor |
| IL301751A (en) | 2020-09-29 | 2023-05-01 | Enclear Therapies Inc | Subarachnoid fluid management method and system |
| US20240350463A1 (en) * | 2021-06-25 | 2024-10-24 | Apertor Pharmaceuticals, Inc. | Small molecule compounds |
| EP4359417A2 (de) * | 2021-06-25 | 2024-05-01 | Apertor Pharmaceuticals, Inc. | Kleinmolekülige verbindungen |
| GB202415232D0 (en) | 2024-10-16 | 2024-11-27 | Nacamed As | Composition |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
| US6060234A (en) * | 1991-01-17 | 2000-05-09 | Abbott Laboratories | Polyketide derivatives and recombinant methods for making same |
| US5093338A (en) | 1991-04-23 | 1992-03-03 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| JP3140228B2 (ja) * | 1992-02-17 | 2001-03-05 | ファイザー製薬株式会社 | 新規な大環状ラクトンおよびその生産菌 |
| US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
| US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| US6066721A (en) | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
| US5362735A (en) * | 1994-02-23 | 1994-11-08 | Smithkline Beecham Corporation | Rapamycin derivatives |
| JP3633629B2 (ja) | 1995-07-06 | 2005-03-30 | ザ レランド スタンフォード ジュニア ユニバーシティ | ポリケチドの無細胞合成 |
| GB9710962D0 (en) | 1997-05-28 | 1997-07-23 | Univ Cambridge Tech | Polyketides and their synthesis |
| DK0910633T3 (da) * | 1996-07-05 | 2010-03-29 | Biotica Tech Ltd | Hybrid polyketidsyntase I-gen |
| IL132590A0 (en) | 1997-04-30 | 2001-03-19 | Kosan Biosciences Inc | Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold |
| NZ510819A (en) | 1998-10-02 | 2004-03-26 | Kosan Biosciences Inc | Polyketide synthase enzymes and recombinant DNA constructs therefor |
| ATE356880T1 (de) * | 1999-10-29 | 2007-04-15 | Kosan Biosciences Inc | Rapamycin analoge |
-
2000
- 2000-10-30 AT AT00990461T patent/ATE356880T1/de not_active IP Right Cessation
- 2000-10-30 AU AU27487/01A patent/AU2748701A/en not_active Abandoned
- 2000-10-30 DE DE60033965T patent/DE60033965T2/de not_active Expired - Lifetime
- 2000-10-30 ES ES00990461T patent/ES2283344T3/es not_active Expired - Lifetime
- 2000-10-30 WO PCT/US2000/041701 patent/WO2001034816A1/en not_active Ceased
- 2000-10-30 EP EP00990461A patent/EP1244800B1/de not_active Expired - Lifetime
- 2000-10-30 US US09/702,029 patent/US6670168B1/en not_active Expired - Lifetime
-
2003
- 2003-10-21 US US10/690,949 patent/US20040224394A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6670168B1 (en) | 2003-12-30 |
| DE60033965D1 (de) | 2007-04-26 |
| US20040224394A1 (en) | 2004-11-11 |
| EP1244800B1 (de) | 2007-03-14 |
| AU2748701A (en) | 2001-06-06 |
| WO2001034816A1 (en) | 2001-05-17 |
| EP1244800A1 (de) | 2002-10-02 |
| ES2283344T3 (es) | 2007-11-01 |
| DE60033965T2 (de) | 2008-01-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60033965D1 (de) | Rapamycin analoge | |
| EP2339017A3 (de) | Erhöhte Proteinexpression in Bacillus | |
| DE60329277D1 (de) | Oligonukleotidzusammensetzungen mit verbesserter effizienz | |
| BRPI0616630B8 (pt) | compostos de pirazol substituídos | |
| GEAP202315908A (en) | Polyheterocyclic modulators of sting (stimulator of interferon genes) | |
| DK1476562T3 (da) | Overekspression af extremozymgener i pseudomonas og nært beslægtede bakterier | |
| ATE536415T1 (de) | Klonierung des cytochrome p450 gens von nicotiana | |
| DK1546174T3 (da) | Fremgangsmåder og sammensætninger til RNA-interferens | |
| DK0698105T3 (da) | Nukleotidsekvenser til styring af ekspressionen af DNAsekvenser i en værtscelle | |
| NO20066002L (no) | Rekombinant kimært adenovirus, replikasjonsmanglende variant derav, fremgangsmåte for isolering av adenoviruset, anvendelse derav i terapi, samt fremgangsmåte for å inhibere vekst av en kreftcelle. | |
| BR9901538A (pt) | Processo, e, sistema de moagem de farinha. | |
| WO2001080896A3 (en) | Flavopiridol drug combinations and methods with reduced side effects | |
| ATE494381T1 (de) | Verbesserte expressionselemente | |
| FI962268A0 (fi) | Homologinen, rekombinanttinen vasta-aineilmentämisjärjestelmä rottien tai hiirien soluille | |
| AU2002230691A1 (en) | Putrescine-n-methyltransferase promoter | |
| HUP0103618A2 (hu) | A keményítő búzából származó II-es elágaztató enzimének izoformái (SBE-IIA és SBE-IIB) | |
| HK1048650A1 (zh) | 在细胞培养物中增强细胞激动素(cytokines)的方法 | |
| ATE309353T1 (de) | Verfahren zur herstellung von rekombinanten peptiden | |
| WO2023081883A3 (en) | Methylation sequencing methods and compositions | |
| EA202192806A1 (ru) | Системы редактирования генов для модифицирования гена scn9a или scn10a и способы их применения | |
| MX2021015613A (es) | Enzimas variantes acetato cinasa dise?adas. | |
| AU3159501A (en) | Isolated polynucleotides having a reduced or an increased content of epigenetic control motifs and uses thereof | |
| WO2005077048A3 (en) | Immune modulation by regulating expression of the “minor” gene in immune dendritic cells | |
| ATE493176T1 (de) | Verwendung von 3-positions-cyclosporin-derivaten für haarwachstum | |
| ATE362535T1 (de) | Mutiertes cyclin g1 protein |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |