BRPI0616630B8 - compostos de pirazol substituídos - Google Patents

compostos de pirazol substituídos

Info

Publication number
BRPI0616630B8
BRPI0616630B8 BRPI0616630A BRPI0616630A BRPI0616630B8 BR PI0616630 B8 BRPI0616630 B8 BR PI0616630B8 BR PI0616630 A BRPI0616630 A BR PI0616630A BR PI0616630 A BRPI0616630 A BR PI0616630A BR PI0616630 B8 BRPI0616630 B8 BR PI0616630B8
Authority
BR
Brazil
Prior art keywords
pyrazole compounds
substituted pyrazole
aurora
disclosed
methods
Prior art date
Application number
BRPI0616630A
Other languages
English (en)
Inventor
m treston Anthony
V Patel Dinish
E Agoston Gregory
S Ward John
R Bray Mark
Xiao Xiao-Yi
Original Assignee
Miikana Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miikana Therapeutics Inc filed Critical Miikana Therapeutics Inc
Publication of BRPI0616630A2 publication Critical patent/BRPI0616630A2/pt
Publication of BRPI0616630B1 publication Critical patent/BRPI0616630B1/pt
Publication of BRPI0616630B8 publication Critical patent/BRPI0616630B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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Abstract

compostos de pirazol substituídos. são revelados inibidores de proteína quinase, composições compreendendo tais inibidores e métodos de uso dos mesmos. mais particularmente, são revelados inibidores de proteína quinase aurora a (aurora-2). também são revelados métodos de tratamento de doenças associadas à proteínas quinases, especialmente doenças associadas à aurora-2, tal como câncer.
BRPI0616630A 2005-09-30 2006-09-29 compostos de pirazol substituídos BRPI0616630B8 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US72221705P 2005-09-30 2005-09-30
US60/722,217 2005-09-30
US73234005P 2005-10-31 2005-10-31
US60/732,340 2005-10-31
US73386805P 2005-11-04 2005-11-04
US60/733,868 2005-11-04
PCT/US2006/038174 WO2007041358A2 (en) 2005-09-30 2006-09-29 Substituted pyrazole compounds

Publications (3)

Publication Number Publication Date
BRPI0616630A2 BRPI0616630A2 (pt) 2011-06-28
BRPI0616630B1 BRPI0616630B1 (pt) 2020-08-18
BRPI0616630B8 true BRPI0616630B8 (pt) 2021-05-25

Family

ID=37906747

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0616630A BRPI0616630B8 (pt) 2005-09-30 2006-09-29 compostos de pirazol substituídos

Country Status (12)

Country Link
US (2) US7563787B2 (pt)
EP (1) EP1928456B1 (pt)
JP (1) JP5597353B2 (pt)
KR (2) KR101487027B1 (pt)
AU (1) AU2006297120B2 (pt)
BR (1) BRPI0616630B8 (pt)
CA (1) CA2622352C (pt)
ES (1) ES2535854T3 (pt)
IL (1) IL190450A0 (pt)
NO (1) NO20081952L (pt)
NZ (1) NZ567241A (pt)
WO (1) WO2007041358A2 (pt)

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US20090264422A1 (en) 2009-10-22
KR20140025610A (ko) 2014-03-04
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US20070142368A1 (en) 2007-06-21
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BRPI0616630A2 (pt) 2011-06-28
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US8114870B2 (en) 2012-02-14
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