ATE357215T1 - Verabreichungssyteme für proteinarzneistoffe unter verwendung von membranmimetika - Google Patents

Verabreichungssyteme für proteinarzneistoffe unter verwendung von membranmimetika

Info

Publication number
ATE357215T1
ATE357215T1 AT99945793T AT99945793T ATE357215T1 AT E357215 T1 ATE357215 T1 AT E357215T1 AT 99945793 T AT99945793 T AT 99945793T AT 99945793 T AT99945793 T AT 99945793T AT E357215 T1 ATE357215 T1 AT E357215T1
Authority
AT
Austria
Prior art keywords
drug administration
protein drug
administration systems
membrane mimetics
mimetics
Prior art date
Application number
AT99945793T
Other languages
English (en)
Inventor
Pankaj Modi
Original Assignee
Generex Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generex Pharm Inc filed Critical Generex Pharm Inc
Application granted granted Critical
Publication of ATE357215T1 publication Critical patent/ATE357215T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99945793T 1998-09-27 1999-09-23 Verabreichungssyteme für proteinarzneistoffe unter verwendung von membranmimetika ATE357215T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/161,447 US6193997B1 (en) 1998-09-27 1998-09-27 Proteinic drug delivery system using membrane mimetics

Publications (1)

Publication Number Publication Date
ATE357215T1 true ATE357215T1 (de) 2007-04-15

Family

ID=22581206

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99945793T ATE357215T1 (de) 1998-09-27 1999-09-23 Verabreichungssyteme für proteinarzneistoffe unter verwendung von membranmimetika

Country Status (14)

Country Link
US (1) US6193997B1 (de)
EP (1) EP1115381B1 (de)
JP (1) JP2002525309A (de)
AR (1) AR023055A1 (de)
AT (1) ATE357215T1 (de)
AU (1) AU749892B2 (de)
BR (1) BR9915761B1 (de)
CA (1) CA2345075A1 (de)
DE (1) DE69935602T2 (de)
DK (1) DK1115381T3 (de)
ES (1) ES2285860T3 (de)
MX (1) MXPA01003156A (de)
NZ (1) NZ510191A (de)
WO (1) WO2000018371A1 (de)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2686899B1 (fr) * 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US6290987B1 (en) * 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
AU2006200276B2 (en) * 1998-12-21 2007-11-29 Generex Pharmaceuticals Inc. Micellar pharmaceutical compositions for buccal and pulmonary application
US6451286B1 (en) * 1998-12-21 2002-09-17 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary administration comprising an alkali metal alkyl sulfate and at least three micelle-forming compounds
US7087215B2 (en) * 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6375975B1 (en) * 1998-12-21 2002-04-23 Generex Pharmaceuticals Incorporated Pharmaceutical compositions for buccal and pulmonary application
US6849263B2 (en) * 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US6350432B1 (en) * 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
GB0007150D0 (en) * 2000-03-24 2000-05-17 Lamellar Therapeutics Limited Immunotherapeutic methods and compositions
US6432383B1 (en) * 2000-03-30 2002-08-13 Generex Pharmaceuticals Incorporated Method for administering insulin
US6926898B2 (en) * 2000-04-12 2005-08-09 Human Genome Sciences, Inc. Albumin fusion proteins
US7371721B2 (en) 2000-09-18 2008-05-13 Sanos Bioscience A/S Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes
PT1326630E (pt) 2000-09-18 2008-09-02 Sanos Bioscience As Utilização de péptidos glp-2
SG126676A1 (en) * 2001-05-09 2007-01-30 Nanomaterials Tech Pte Ltd Process for the controlled production of organic particles
DE10291905D2 (de) * 2001-05-10 2004-05-27 Kuhs Kosmetik Gmbh & Co Kg Pharmazeutische Zusammensetzung
WO2002097038A2 (en) * 2001-05-25 2002-12-05 Human Genome Sciences, Inc. Chemokine beta-1 fusion proteins
CN1335182A (zh) * 2001-08-08 2002-02-13 华中科技大学 胰岛素口腔喷剂及其制备工艺
DE10148065A1 (de) * 2001-09-28 2003-04-17 Max Planck Gesellschaft (Ester)-Lysolecithine in Liposomen
EP1460992B1 (de) * 2001-12-03 2009-03-11 Dor Biopharma, Inc. Stabilisierte umkehr-mizellen-zusammensetzungen und ihre verwendung
WO2005003296A2 (en) 2003-01-22 2005-01-13 Human Genome Sciences, Inc. Albumin fusion proteins
WO2003059934A2 (en) * 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin fusion proteins
CA2841097A1 (en) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Albumin and g-csf fusion proteins
GB0207653D0 (en) 2002-04-03 2002-05-15 Lamellar Therapeutics Ltd Methods of using lamellar bodies for therapeutic purposes
DE10214983A1 (de) * 2002-04-04 2004-04-08 TransMIT Gesellschaft für Technologietransfer mbH Vernebelbare Liposomen und ihre Verwendung zur pulmonalen Applikation von Wirkstoffen
US20040018237A1 (en) * 2002-05-31 2004-01-29 Perricone Nicholas V. Topical drug delivery using phosphatidylcholine
US8435942B2 (en) * 2002-05-31 2013-05-07 Transdermal Biotechnology, Inc. Methods for formulating stabilized insulin compositions
NZ537186A (en) * 2002-06-20 2006-10-27 Novartis Consumer Health S Nasal compositions comprising a mucopolysaccharide and propylene glycol
GB0322448D0 (en) * 2003-09-25 2003-10-29 Lamellar Therapeutics Ltd Using lamellar bodies to modify linear biological macro molecules
US20070248541A1 (en) * 2003-12-01 2007-10-25 Mitsubishi Pharma Corporation Liposome
CN1557479A (zh) * 2004-01-16 2004-12-29 深圳市海王英特龙生物技术股份有限公 干扰素脂质体乳膏
EP1706095B1 (de) * 2004-01-20 2008-12-24 Allergan, Inc. Zusammensetzungen für die lokalisierte therapie des auges, vorzugsweise enthaltend triamcinolon-acetonid und hyaluronsäure
US20050238632A1 (en) * 2004-04-23 2005-10-27 Alburty David S Propellant formulations
ES2747978T3 (es) * 2005-10-03 2020-03-12 Mark A Pinsky Liposomas no fosfolipídicos que comprenden ácido hialurónico
ES2798257T3 (es) 2008-09-08 2020-12-10 Childrens Medical Center Administración mucosa de moléculas, proteínas o partículas terapéuticas acopladas a lípidos de ceramida
DE102009031274A1 (de) 2009-06-30 2011-01-13 Justus-Liebig-Universität Giessen Liposomen zur pulmonalen Applikation
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
JP2014508166A (ja) 2011-03-17 2014-04-03 トランスダーマル バイオテクノロジ インコーポレーテッド 局所的一酸化窒素システム及びその使用方法
HK1201547A1 (en) 2011-12-20 2015-09-04 Adhesys Medical Gmbh Isocyanate-functional prepolymer for a biologically degradable fabric adhesive
US8871256B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and systems for treatment of inflammatory diseases with nitric oxide
US8871255B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment of skin and soft tissue infection with nitric oxide
US8871257B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery
US8871260B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Methods and compositions for muscular and neuromuscular diseases
US8871262B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Compositions and methods for treatment of osteoporosis and other indications
US8871261B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Cancer treatments and compositions for use thereof
US8871258B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Treatment and prevention of learning and memory disorders
US8871259B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Techniques and systems for treatment of neuropathic pain and other indications
US8871254B2 (en) 2012-09-19 2014-10-28 Transdermal Biotechnology, Inc. Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system
US20140271937A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US20140271938A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9241899B2 (en) 2013-03-13 2016-01-26 Transdermal Biotechnology, Inc. Topical systems and methods for treating sexual dysfunction
US9320706B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9314422B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US9295647B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Systems and methods for delivery of peptides
US9295636B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9687520B2 (en) 2013-03-13 2017-06-27 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US9314423B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Hair treatment systems and methods using peptides and other compositions
US9387159B2 (en) 2013-03-13 2016-07-12 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9295637B2 (en) 2013-03-13 2016-03-29 Transdermal Biotechnology, Inc. Compositions and methods for affecting mood states
US9750787B2 (en) 2013-03-13 2017-09-05 Transdermal Biotechnology, Inc. Memory or learning improvement using peptide and other compositions
US20140271731A1 (en) 2013-03-13 2014-09-18 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9393264B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Immune modulation using peptides and other compositions
US9320758B2 (en) 2013-03-13 2016-04-26 Transdermal Biotechnology, Inc. Brain and neural treatments comprising peptides and other compositions
US9314433B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9339457B2 (en) 2013-03-13 2016-05-17 Transdermal Biotechnology, Inc. Cardiovascular disease treatment and prevention
US9393265B2 (en) 2013-03-13 2016-07-19 Transdermal Biotechnology, Inc. Wound healing using topical systems and methods
US9849160B2 (en) 2013-03-13 2017-12-26 Transdermal Biotechnology, Inc. Methods and systems for treating or preventing cancer
US9314417B2 (en) 2013-03-13 2016-04-19 Transdermal Biotechnology, Inc. Treatment of skin, including aging skin, to improve appearance
US9724419B2 (en) 2013-03-13 2017-08-08 Transdermal Biotechnology, Inc. Peptide systems and methods for metabolic conditions
US20160151283A1 (en) * 2014-11-27 2016-06-02 Icnoderm S.R.L. Hyalurosomes, their use in topical cosmetic or pharmaceutical compositions and their preparation process
CA3080521A1 (en) 2017-10-27 2019-05-02 Children's Medical Center Corporation Short chain ceramide-based lipids and uses thereof
EP3773564A4 (de) 2018-04-12 2022-04-20 Children's Medical Center Corporation Ceramid-ähnliche lipdbasierte freisetzungsvehikel und deren verwendung
US11198831B2 (en) 2019-01-31 2021-12-14 Kvi Llc Lubricant for a device

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2408387A2 (fr) 1975-06-30 1979-06-08 Oreal Compositions a base de dispersions aqueuses de spherules lipidiques
FR2571963B1 (fr) 1984-10-24 1987-07-10 Oreal Composition a usage cosmetique ou pharmaceutique contenant des niosomes et au moins un polyamide hydrosoluble et procede de preparation de cette composition.
US5234767A (en) 1987-03-13 1993-08-10 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
US5147723A (en) 1987-07-28 1992-09-15 Micro-Pak, Inc. Paucilamellar lipid vesicles
US4895452A (en) * 1988-03-03 1990-01-23 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
JP3765579B2 (ja) * 1990-08-24 2006-04-12 イーデーエーアー アーゲー 作用物質投与用超微小滴状調剤
US5643600A (en) 1991-09-17 1997-07-01 Micro-Pak, Inc. Lipid vesicles containing avocado oil unsaponifiables
US5260065A (en) 1991-09-17 1993-11-09 Micro Vesicular Systems, Inc. Blended lipid vesicles
US5653987A (en) 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
DE69732308T2 (de) * 1996-09-27 2005-06-02 Jagotec Ag Arzneistoffverabreichungssystem mit hyaluronsäure
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation

Also Published As

Publication number Publication date
WO2000018371A1 (en) 2000-04-06
ES2285860T3 (es) 2007-11-16
BR9915761B1 (pt) 2010-12-14
CA2345075A1 (en) 2000-04-06
DE69935602D1 (de) 2007-05-03
MXPA01003156A (es) 2003-05-15
EP1115381A1 (de) 2001-07-18
EP1115381B1 (de) 2007-03-21
BR9915761A (pt) 2001-07-24
AU5843599A (en) 2000-04-17
DK1115381T3 (da) 2007-07-23
AR023055A1 (es) 2002-09-04
US6193997B1 (en) 2001-02-27
DE69935602T2 (de) 2007-12-06
NZ510191A (en) 2002-09-27
AU749892B2 (en) 2002-07-04
JP2002525309A (ja) 2002-08-13

Similar Documents

Publication Publication Date Title
DE69935602D1 (de) Verabreichungssyteme für proteinarzneistoffe unter verwendung von membranmimetika
NO994837D0 (no) Intravesikal medikamentavleveringssystem
FI963217A7 (fi) Nestemäinen oftalminen, hidastetusti vapauttava antosysteemi
DE69729835D1 (de) Verabreichungssystem für Narkosemittel
DE69633340D1 (de) Kühlschrank zur sicheren annahme von lieferungen
DE19882536T1 (de) Doppelpumpenanlage
NL1007544A1 (nl) Membraan.
NO20000160L (no) Borekaksinjeksjonsystem
DE69913553D1 (de) Konfigurierung von systemeinheiten
ID22187A (id) Produksi gas sintesa dengan membran penghantar campuran
BR9801027B1 (pt) sistema de distribuiÇço de medicamentos.
DE69810445D1 (de) Sitzbelegung-feststellungssystem
DE69604249D1 (de) Fehlertolerantes verteiltes Steuerungssystem
DE69926644D1 (de) Medikamentenzufuhrsysteme
DE69830932D1 (de) Teilentladungsmesssystem unter verwendung von spitzendetektion
IT1284337B1 (it) Struttura di membrana sopportata
DE69801983D1 (de) Verbindungssystem
EE04685B1 (et) Ravimi l„bimiskiirust kontrolliv membraan v?i maatriks
DE69534294D1 (de) Mess-system unter verwendung von vollblut
ATE241338T1 (de) Arzneistoffabgabesystem, insbesondere zur verabreichung von androgenen
NO973223L (no) Enrofloxacin-injekson eller infusjonslösninger
DE69704269D1 (de) Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung
DE69705017D1 (de) Medikamente bindendes Protein
DE69806110D1 (de) Integriertes System zur Abgabe mehrerer Toner
DE69800089D1 (de) Abgabesysteme

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties