ATE357231T1 - Funktionelle beschichtung von linezolidmikrokapseln zur geschmacksmaskierung und damit verbundene oral anzuwendende arzneizubereitung - Google Patents

Funktionelle beschichtung von linezolidmikrokapseln zur geschmacksmaskierung und damit verbundene oral anzuwendende arzneizubereitung

Info

Publication number
ATE357231T1
ATE357231T1 AT01902073T AT01902073T ATE357231T1 AT E357231 T1 ATE357231 T1 AT E357231T1 AT 01902073 T AT01902073 T AT 01902073T AT 01902073 T AT01902073 T AT 01902073T AT E357231 T1 ATE357231 T1 AT E357231T1
Authority
AT
Austria
Prior art keywords
taste
masked
linezolid
fast
disintegrating
Prior art date
Application number
AT01902073T
Other languages
English (en)
Inventor
Phillip J Percel
Gopi M Venkatesh
Krishna S Vishnupad
Original Assignee
Eurand Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eurand Inc filed Critical Eurand Inc
Application granted granted Critical
Publication of ATE357231T1 publication Critical patent/ATE357231T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01902073T 2000-01-20 2001-01-16 Funktionelle beschichtung von linezolidmikrokapseln zur geschmacksmaskierung und damit verbundene oral anzuwendende arzneizubereitung ATE357231T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17723300P 2000-01-20 2000-01-20
US09/506,051 US6451345B1 (en) 2000-01-20 2000-02-17 Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration

Publications (1)

Publication Number Publication Date
ATE357231T1 true ATE357231T1 (de) 2007-04-15

Family

ID=26873062

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01902073T ATE357231T1 (de) 2000-01-20 2001-01-16 Funktionelle beschichtung von linezolidmikrokapseln zur geschmacksmaskierung und damit verbundene oral anzuwendende arzneizubereitung

Country Status (6)

Country Link
US (1) US6451345B1 (de)
EP (1) EP1248616B1 (de)
AT (1) ATE357231T1 (de)
AU (1) AU2001227915A1 (de)
DE (1) DE60127379D1 (de)
WO (1) WO2001052848A2 (de)

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* Cited by examiner, † Cited by third party
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FR2795962B1 (fr) * 1999-07-08 2003-05-09 Prographarm Laboratoires Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
US20030091634A1 (en) * 2001-09-14 2003-05-15 Pawan Seth Delayed release tablet of venlafaxin
US7488496B2 (en) 2002-03-06 2009-02-10 Christer Rosen Effervescent compositions comprising bisphosphonates and methods related thereto
US20050269722A1 (en) * 2002-07-17 2005-12-08 Stefano De Luigi Brushci Process for the preparation of pharmaceutical microcapsules with enhanced taste-masking and high dissolution rate
US20040013737A1 (en) * 2002-07-19 2004-01-22 Philippe Becourt Taste masked oral composition of telithromycin
MXPA05000322A (es) * 2002-07-19 2005-03-31 Aventis Pharma Sa Composicion oral de telitromicina con sabor enmascarado.
US20040208936A1 (en) * 2002-07-22 2004-10-21 Roland Chorin Novel compositions
US6875784B2 (en) * 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
US20040191326A1 (en) * 2003-03-31 2004-09-30 Reo Joseph P. Taste-masking vehicle for coated oxazolidinone particles
US20040265373A1 (en) * 2003-06-27 2004-12-30 David Wynn Soft tablet containing high molecular weight cellulosics
US20040265372A1 (en) * 2003-06-27 2004-12-30 David Wynn Soft tablet containing high molecular weight cellulosics
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
US8168228B2 (en) * 2003-10-17 2012-05-01 Sandoz Ag Antibiotic clarithromycin micropellet compositions
US7387793B2 (en) 2003-11-14 2008-06-17 Eurand, Inc. Modified release dosage forms of skeletal muscle relaxants
US8545881B2 (en) * 2004-04-19 2013-10-01 Eurand Pharmaceuticals, Ltd. Orally disintegrating tablets and methods of manufacture
IS7724A (is) * 2005-03-02 2006-09-03 Actavis Group Samsetning á töflum með hraða sundrun sem innihalda þungt magnesíum karbónat
US20070098746A1 (en) * 2005-11-02 2007-05-03 Nichols William M Multi-layered coating technology for taste masking
US20080014257A1 (en) * 2006-07-14 2008-01-17 Par Pharmaceutical, Inc. Oral dosage forms
JP5228359B2 (ja) * 2007-04-12 2013-07-03 ニプロ株式会社 主薬粒子及びその製造方法ならびに口腔内崩壊錠
FR2918296B1 (fr) 2007-07-05 2009-09-18 Oreal Capsules de type noyau/ecorce et procede de preparation
TW200938186A (en) * 2008-02-13 2009-09-16 Eurand Inc Orally disintegrating tablet compositions of ranitidine and methods of manufacture
WO2010046933A2 (en) 2008-10-22 2010-04-29 Rubicon Research Private Limited Pharmaceutical compositions of taste-masked linezolid
EP3632417A1 (de) * 2009-01-30 2020-04-08 Sunovion Pharmaceuticals Inc. Dragees mit 6-(5-chloro-2-pyridyl) -5-[ (4-methyl-1-piperazinyl) carbonyloxy]-7-oxo-6, 7-dihydro-5h-pyrrolo [3,4-b] pyrazin
WO2011080570A2 (en) * 2009-12-29 2011-07-07 Micro Labs Limited Extended release pharmaceutical composition comprising linezolid and process for preparing the same
CA2802994A1 (en) 2010-06-17 2011-12-22 The United States Of America As Represented By The Secretary, National I Nstitutes Of Health Compositions and methods for treating inflammatory conditions
CA2818249C (en) * 2010-11-24 2021-04-13 Rib-X Pharmaceuticals, Inc. Pharmaceutical compositions comprising radezolid, hydroxypropylmethyl cellulose polymer, and a physical mixture
US20120308662A1 (en) * 2011-06-01 2012-12-06 Nitto Denko Corporation Particulate preparation and method for producing the same
JP6003890B2 (ja) 2011-06-10 2016-10-05 ニプロ株式会社 口腔内崩壊錠の製造方法
WO2013088389A1 (en) * 2011-12-14 2013-06-20 Alembic Pharmaceuticals Limited Linezolid premix
GR1008143B (el) 2013-03-11 2014-03-14 "Φαρματεν Α.Β.Ε.Ε.", Φαρμακευτικο σκευασμα περιεχον ενα οξαζολιδινονικο αντιβακτηριακο παραγοντα και μεθοδος για την παρασκευη αυτου
CN104739788B (zh) * 2013-12-27 2018-02-16 桂林南药股份有限公司 一种小儿利奈唑胺组合物冻干口腔崩解片及其制备方法
WO2015130760A1 (en) 2014-02-25 2015-09-03 Orbis Biosciences, Inc. Taste masking drug formulations
CN105055354B (zh) * 2015-09-08 2017-11-21 深圳万乐药业有限公司 一种利奈唑胺片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4800087A (en) 1986-11-24 1989-01-24 Mehta Atul M Taste-masked pharmaceutical compositions
US4948801A (en) 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
US5082669A (en) 1989-07-20 1992-01-21 Dainippon Pharmaceutical Co., Ltd. Rapid-releasing oral particle pharmaceutical preparation with unpleasant taste masked
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5075114A (en) 1990-05-23 1991-12-24 Mcneil-Ppc, Inc. Taste masking and sustained release coatings for pharmaceuticals
ATE181672T1 (de) * 1993-04-28 1999-07-15 Takeda Chemical Industries Ltd Geschmacksmaskierte feste zubereitung und verfahren zur herstellung
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
DE69811717T2 (de) 1997-11-18 2003-10-16 Pharmacia & Upjohn Co., Kalamazoo Verwendung von oxazolidinonderivate zur behandlung von arthritis
WO1999037630A1 (en) 1998-01-23 1999-07-29 Versicor, Inc. Oxazolidinone combinatorial libraries, compositions and methods of preparation

Also Published As

Publication number Publication date
US6451345B1 (en) 2002-09-17
DE60127379D1 (de) 2007-05-03
EP1248616B1 (de) 2007-03-21
WO2001052848A3 (en) 2001-12-13
WO2001052848A2 (en) 2001-07-26
EP1248616A2 (de) 2002-10-16
AU2001227915A1 (en) 2001-07-31

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