ATE357456T1 - Mittel zur förderung von knochenbildung - Google Patents

Mittel zur förderung von knochenbildung

Info

Publication number: ATE357456T1
Authority: AT; Austria
Prior art keywords: bone formation; alkyl group; hydrogen atom; promoting agent; agents
Prior art date: 1995-12-08

Application number

AT96942315T

Other languages

English (en)

Inventor

Kazuyuki Kitamura

Osamu Komiyama

Mizuho Inazu

Roland Baron

Thomas Gadek

Jochen Knolle

Han-Ulrich Stilz

Volkmar Wehner

Robert S Mcdowell

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-08

Filing date

1996-12-06

Publication date

2007-04-15

1996-12-06 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2007-04-15 Application granted granted Critical

2007-04-15 Publication of ATE357456T1 publication Critical patent/ATE357456T1/de

Links

230000011164 ossification Effects 0.000 title abstract 5
230000001737 promoting effect Effects 0.000 title abstract 4
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
239000003795 chemical substances by application Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
RGNVSYKVCGAEHK-GUBZILKMSA-N (3s)-3-[[2-[[(2s)-2-[(2-aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-oxobutanoic acid Chemical compound NC(N)=NCCC[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O RGNVSYKVCGAEHK-GUBZILKMSA-N 0.000 abstract 1
IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 abstract 1
150000001413 amino acids Chemical group 0.000 abstract 1
108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
108010034892 glycyl-arginyl-glycyl-aspartyl-serine Proteins 0.000 abstract 1
108010059557 kistrin Proteins 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
ZTYNVDHJNRIRLL-FWZKYCSMSA-N rhodostomin Chemical compound C([C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H]2C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CSSC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CC=2NC=NC=2)C(O)=O)[C@@H](C)O)=O)CSSC[C@H]2C(=O)N[C@H]3CSSC[C@@H](C(NCC(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H]2NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)CN)CSSC2)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N2CCC[C@H]2C(=O)N[C@H](C(N4)=O)CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC3=O)C(=O)N[C@@H](CCCCN)C(=O)N1)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=CC=C1 ZTYNVDHJNRIRLL-FWZKYCSMSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Epidemiology (AREA)
Zoology (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Crystallography & Structural Chemistry (AREA)
Hematology (AREA)
Marine Sciences & Fisheries (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Rehabilitation Tools (AREA)

AT96942315T 1995-12-08 1996-12-06 Mittel zur förderung von knochenbildung ATE357456T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP34505795A JP3895792B2 (ja)	1995-12-08	1995-12-08	骨形成促進剤

Publications (1)

Publication Number	Publication Date
ATE357456T1 true ATE357456T1 (de)	2007-04-15

Family

ID=18374002

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96942315T ATE357456T1 (de)	1995-12-08	1996-12-06	Mittel zur förderung von knochenbildung

Country Status (8)

Country	Link
US (2)	US6194380B1 (de)
EP (1)	EP0865446B1 (de)
JP (2)	JP3895792B2 (de)
AT (1)	ATE357456T1 (de)
CA (1)	CA2236335A1 (de)
DE (1)	DE69636987T2 (de)
IL (1)	IL124623A0 (de)
WO (1)	WO1997021726A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3895792B2 (ja) *	1995-12-08	2007-03-22	プロスケリア・エス・ア・エス	骨形成促進剤
ATE212990T1 (de) *	1996-03-20	2002-02-15	Hoechst Ag	Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten
US6376476B1 (en) *	1996-12-13	2002-04-23	Zymogenetics Corporation	Isoprenoid pathway inhibitors for stimulating bone growth
EP0933367A1 (de) *	1997-12-19	1999-08-04	Hoechst Marion Roussel Deutschland GmbH	Acylguanidin Derivate als Inhibitoren von Knochenaufsauge und als Vitronectin Rezeptor Antagonisten
US6313119B1 (en)	1998-01-23	2001-11-06	Adventis Pharma Deutschland Gmbh	Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion
BR9907735A (pt) *	1998-01-23	2000-10-17	Aventis Pharma Gmbh	Derivados de sulfonamida como inibidores da reabsorção óssea e como inibidores da aderência celular
US6410521B1 (en)	1998-06-12	2002-06-25	Osteoscreen, Inc.	Nutritional supplements for stimulating bone growth
AU748621B2 (en) *	1998-08-13	2002-06-06	Merck & Co., Inc.	Integrin receptor antagonists
FR2786182B1 (fr) *	1998-11-24	2001-01-12	Hoechst Marion Roussel Inc	Nouveaux derives d'acylguanidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP1108721A1 (de)	1999-12-15	2001-06-20	Aventis Pharma Deutschland GmbH	Thienylalaninderivate als Inhibitoren der Zelladhäsion
AU2003221582A1 (en) *	2002-05-03	2003-11-17	Millenium Biologix Inc.	Connective tissue stimulating peptides
AU2003272814A1 (en)	2003-10-02	2005-05-19	Ibrahim Al-Habdan	Peptide for promoting healing of fractures
KR101013999B1 (ko) *	2004-03-19	2011-02-14	재단법인서울대학교산학협력재단	표면에 골조직 형성 증진 펩타이드가 고정된 차폐막 및임플란트
KR100676945B1 (ko) *	2005-03-18	2007-02-01	재단법인서울대학교산학협력재단	표면에 골조직 형성 증진 펩타이드가 고정된 골이식재 및 조직공학용 지지체
KR100757241B1 (ko) *	2006-09-13	2007-09-10	재단법인서울대학교산학협력재단	골조직 형성 증진 펩타이드가 함유된 골이식재
KR100909867B1 (ko) *	2007-04-16	2009-07-29	주식회사바이오러넥스	골대사성 질환의 예방 및 치료를 위한 조성물
KR100879704B1 (ko) *	2008-06-11	2009-01-22	오스템임플란트 주식회사	골유착 및 골형성을 증진시키는 올리고펩타이드
WO2016204545A1 (ko) *	2015-06-18	2016-12-22	서울대학교 산학협력단	골 형성 촉진 또는 골 흡수 억제용 펩타이드 및 이의 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5384309A (en) *	1989-07-17	1995-01-24	Genentech, Inc.	Cyclized peptides and their use as platelet aggregation inhibitors
DE4126277A1 (de)	1991-08-08	1993-02-11	Cassella Ag	Hydantoinderivate
US5217994A (en)	1991-08-09	1993-06-08	Merck & Co., Inc.	Method of inhibiting osteoclast-mediated bone resorption by administration of aminoalkyl-substituted phenyl derivatives
DE4427979A1 (de) *	1993-11-15	1996-02-15	Cassella Ag	Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
US6046033A (en) *	1994-06-27	2000-04-04	Snow Brand Milk Products Co., Ltd.	Basic osteoblast growth factor II (bOGF-II)
JP3895792B2 (ja) *	1995-12-08	2007-03-22	プロスケリア・エス・ア・エス	骨形成促進剤

1995
- 1995-12-08 JP JP34505795A patent/JP3895792B2/ja not_active Expired - Lifetime
1996
- 1996-12-06 CA CA002236335A patent/CA2236335A1/en not_active Abandoned
- 1996-12-06 DE DE69636987T patent/DE69636987T2/de not_active Expired - Lifetime
- 1996-12-06 JP JP9521692A patent/JP2000502996A/ja active Pending
- 1996-12-06 IL IL12462396A patent/IL124623A0/xx unknown
- 1996-12-06 AT AT96942315T patent/ATE357456T1/de not_active IP Right Cessation
- 1996-12-06 WO PCT/EP1996/005380 patent/WO1997021726A1/en not_active Ceased
- 1996-12-06 EP EP96942315A patent/EP0865446B1/de not_active Expired - Lifetime
- 1996-12-06 US US09/077,714 patent/US6194380B1/en not_active Expired - Lifetime
2000
- 2000-07-26 US US09/626,302 patent/US6344439B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IL124623A0 (en)	1998-12-06
DE69636987D1 (de)	2007-05-03
JP2000502996A (ja)	2000-03-14
WO1997021726A1 (en)	1997-06-19
DE69636987T2 (de)	2007-12-06
US6194380B1 (en)	2001-02-27
EP0865446B1 (de)	2007-03-21
CA2236335A1 (en)	1997-06-19
US6344439B1 (en)	2002-02-05
JPH09157181A (ja)	1997-06-17
JP3895792B2 (ja)	2007-03-22
EP0865446A1 (de)	1998-09-23

Legal Events

Date	Code	Title	Description
2007-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69636987D1 (de)	2007-05-03	Mittel zur förderung von knochenbildung
CA2200192C (en)	2001-01-16	Amidino and guanidino substituted inhibitors of trypsin-like enzymes
NO911787D0 (no)	1991-05-07	Peptidaminer samt fremgangsmaate for fremstilling derav.
SE9604341D0 (sv)	1996-11-26	Hepta-peptide oxytocin analogue
FI941987A0 (fi)	1994-04-29	Uudet aminohappojohdannaiset, menetelmät niiden valmistamiseksi ja näitä yhdisteitä sisältävät farmaseuttiset koostumukset
IL99527A (en)	1997-08-14	Tripeptide antithrombotic agents
IT1196500B (it)	1988-11-16	Derivati dell'acido malonico e metodi per la loro sintesi
NO924929L (no)	1992-12-18	Farmasoeytisk aktive benzoquinazolinforbindelser
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