IT1196500B - Derivati dell'acido malonico e metodi per la loro sintesi - Google Patents

Derivati dell'acido malonico e metodi per la loro sintesi

Info

Publication number: IT1196500B
Authority: IT; Italy
Prior art keywords: acid derivatives; malonic acid; ornithine; cysteine; tyrosine
Prior art date: 1986-07-16

Application number

IT21143/86A

Other languages

English (en)

Other versions

IT8621143A0 (it

Inventor

Trapani Romano Di

Antonio Silvio Verdini

Original Assignee

Eniricerche Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-16

Filing date

1986-07-16

Publication date

1988-11-16

1986-07-16 Application filed by Eniricerche Spa filed Critical Eniricerche Spa

1986-07-16 Publication of IT8621143A0 publication Critical patent/IT8621143A0/it

1986-07-16 Priority to IT21143/86A priority Critical patent/IT1196500B/it

1987-06-29 Priority to AT87109318T priority patent/ATE84044T1/de

1987-06-29 Priority to EP87109317A priority patent/EP0254080B1/en

1987-06-29 Priority to ES87109318T priority patent/ES2052517T3/es

1987-06-29 Priority to DE8787109318T priority patent/DE3783280T2/de

1987-06-29 Priority to AT87109317T priority patent/ATE86964T1/de

1987-06-29 Priority to ES87109317T priority patent/ES2044874T3/es

1987-06-29 Priority to EP87109318A priority patent/EP0253190B1/en

1987-06-29 Priority to DE8787109317T priority patent/DE3784799T2/de

1987-07-08 Priority to CA000541628A priority patent/CA1318457C/en

1987-07-08 Priority to CA000541630A priority patent/CA1304539C/en

1987-07-16 Priority to JP62176064A priority patent/JPH0832720B2/ja

1987-07-16 Priority to JP62176063A priority patent/JPS6323834A/ja

1987-07-16 Priority to US07/074,053 priority patent/US4914226A/en

1987-07-16 Priority to US07/074,054 priority patent/US4816560A/en

1988-11-16 Application granted granted Critical

1988-11-16 Publication of IT1196500B publication Critical patent/IT1196500B/it

1993-03-30 Priority to GR920403197T priority patent/GR3007494T3/el

Links

150000002690 malonic acid derivatives Chemical class 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 2
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 2
AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 abstract 2
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 2
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
239000004472 Lysine Substances 0.000 abstract 2
AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 abstract 2
UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 abstract 2
235000001014 amino acid Nutrition 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 2
235000003704 aspartic acid Nutrition 0.000 abstract 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 2
235000018417 cysteine Nutrition 0.000 abstract 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
235000013922 glutamic acid Nutrition 0.000 abstract 2
239000004220 glutamic acid Substances 0.000 abstract 2
229960003104 ornithine Drugs 0.000 abstract 2
235000002374 tyrosine Nutrition 0.000 abstract 2
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Peptides Or Proteins (AREA)

IT21143/86A 1986-07-16 1986-07-16 Derivati dell'acido malonico e metodi per la loro sintesi IT1196500B (it)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
IT21143/86A IT1196500B (it)	1986-07-16	1986-07-16	Derivati dell'acido malonico e metodi per la loro sintesi
DE8787109317T DE3784799T2 (de)	1986-07-16	1987-06-29	Malonsaeurederivate und ihre synthesemethoden.
EP87109317A EP0254080B1 (en)	1986-07-16	1987-06-29	Malonic acid derivatives and methods for their synthesis
ES87109318T ES2052517T3 (es)	1986-07-16	1987-06-29	Analogos de tuftsina parcialmente retroinversos, metodo de preparacion de los mismos y composiciones farmaceuticas que los contienen.
DE8787109318T DE3783280T2 (de)	1986-07-16	1987-06-29	Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
AT87109317T ATE86964T1 (de)	1986-07-16	1987-06-29	Malonsaeurederivate und ihre synthesemethoden.
ES87109317T ES2044874T3 (es)	1986-07-16	1987-06-29	Derivados del acido malonico y metodos para su sintesis.
EP87109318A EP0253190B1 (en)	1986-07-16	1987-06-29	Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
AT87109318T ATE84044T1 (de)	1986-07-16	1987-06-29	Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
CA000541630A CA1304539C (en)	1986-07-16	1987-07-08	Malonic acid derivatives and methods for their synthesis
CA000541628A CA1318457C (en)	1986-07-16	1987-07-08	Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
JP62176064A JPH0832720B2 (ja)	1986-07-16	1987-07-16	タフトシン類似体、その製法及び医薬組成物
JP62176063A JPS6323834A (ja)	1986-07-16	1987-07-16	マロン酸誘導体
US07/074,053 US4914226A (en)	1986-07-16	1987-07-16	Malonic acid derivatives and methods for their synthesis
US07/074,054 US4816560A (en)	1986-07-16	1987-07-16	Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
GR920403197T GR3007494T3 (it)	1986-07-16	1993-03-30

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT21143/86A IT1196500B (it)	1986-07-16	1986-07-16	Derivati dell'acido malonico e metodi per la loro sintesi

Publications (2)

Publication Number	Publication Date
IT8621143A0 IT8621143A0 (it)	1986-07-16
IT1196500B true IT1196500B (it)	1988-11-16

Family

ID=11177375

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT21143/86A IT1196500B (it)	1986-07-16	1986-07-16	Derivati dell'acido malonico e metodi per la loro sintesi

Country Status (8)

Country	Link
US (1)	US4914226A (it)
EP (1)	EP0254080B1 (it)
JP (1)	JPS6323834A (it)
AT (1)	ATE86964T1 (it)
CA (1)	CA1304539C (it)
DE (1)	DE3784799T2 (it)
ES (1)	ES2044874T3 (it)
IT (1)	IT1196500B (it)

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JPH02245277A (ja) *	1989-03-20	1990-10-01	Ntn Corp	圧電素子を用いた加振装置
US5569745A (en) *	1994-02-25	1996-10-29	Resolution Pharmaceuticals Inc.	Peptide-Chelator conjugates
US7683071B2 (en) *	2000-07-26	2010-03-23	Taro Pharmaceuticals Industries Ltd.	Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
US6756379B2 (en)	2001-07-26	2004-06-29	Taro Pharmaceutical Industries Ltd.	Non-sedating barbiturate compounds as neuroprotective agents
US6939873B2 (en) *	2000-07-26	2005-09-06	Taro Pharmaceuticals Industries Limited	Non-sedating barbituric acid derivatives
CL2003002588A1 (es) *	2002-12-11	2005-01-07	Taro Pharmaceuticals Ireland L	Uso de una composicion farmaceutica que comprende acido n,n-dimetoximetildifenil barbiturico, acido n-metoximetildifenil barbiturico o acido difenil barbiturico o una sal farmaceuticamente aceptable del mismo para preparar un medicamento util en el t
EP1781624A4 (en) *	2004-07-02	2010-06-23	Taro Pharma Ind	PROCESS FOR THE PREPARATION OF 1-METHOXYMETHYL-5,5-DIPHENYLBARBITURIC ACID
WO2008066704A2 (en) *	2006-11-14	2008-06-05	Taro Pharmaceuticals North America, Inc.	Method of improving bioavailability for non-sedating barbiturates
US9279022B1 (en)	2014-09-08	2016-03-08	Sirrus, Inc.	Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US9828324B2 (en)	2010-10-20	2017-11-28	Sirrus, Inc.	Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
JP2014503474A (ja)	2010-10-20	2014-02-13	バイオフオーミツクス・インコーポレイテツド	エネルギー移動手段の存在下での急速回収を用いたメチレンマロナートの合成
US10414839B2 (en)	2010-10-20	2019-09-17	Sirrus, Inc.	Polymers including a methylene beta-ketoester and products formed therefrom
US9249265B1 (en)	2014-09-08	2016-02-02	Sirrus, Inc.	Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
EP2768917B1 (en)	2011-10-19	2018-12-05	Sirrus, Inc.	Multifunctional monomers and methods for making them
US10913875B2 (en)	2012-03-30	2021-02-09	Sirrus, Inc.	Composite and laminate articles and polymerizable systems for producing the same
JP6345644B2 (ja)	2012-03-30	2018-06-20	シラス・インコーポレイテッド	インク配合物およびコーティング配合物ならびにこれらを作製するための重合性の系
CA2869108A1 (en)	2012-03-30	2013-10-03	Bioformix Inc.	Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
WO2013181600A2 (en)	2012-06-01	2013-12-05	Bioformix Inc.	Optical material and articles formed therefrom
CN105008438B (zh)	2012-11-16	2019-10-22	拜奥福米克斯公司	塑料粘结体系及方法
WO2014085570A1 (en)	2012-11-30	2014-06-05	Bioformix, Inc.	Composite compositions for electronics applications
WO2014110388A1 (en)	2013-01-11	2014-07-17	Bioformix Inc.	Method to obtain methylene malonate via bis(hydroxymethyl) malonate pathway
US9416091B1 (en)	2015-02-04	2016-08-16	Sirrus, Inc.	Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9315597B2 (en)	2014-09-08	2016-04-19	Sirrus, Inc.	Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US10501400B2 (en)	2015-02-04	2019-12-10	Sirrus, Inc.	Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en)	2015-05-29	2016-05-10	Sirrus, Inc.	Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en)	2015-06-01	2015-12-22	Sirrus, Inc.	Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en)	2016-05-13	2016-12-13	Sirrus, Inc.	High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9617377B1 (en)	2016-06-03	2017-04-11	Sirrus, Inc.	Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US9567475B1 (en)	2016-06-03	2017-02-14	Sirrus, Inc.	Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10196481B2 (en)	2016-06-03	2019-02-05	Sirrus, Inc.	Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US10428177B2 (en)	2016-06-03	2019-10-01	Sirrus, Inc.	Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
KR102943550B1 (ko) *	2019-09-26	2026-03-26	아지노모토 가부시키가이샤	유기 물질의 유도체의 제조방법 및 유기 물질을 포함하는 시료의 분석 방법

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US3013069A (en) *	1958-07-15	1961-12-12	American Cyanamid Co	2-(substituted-benzyl)-1, 3-propane-dicarboxylic acids
AR194578A1 (es) *	1970-11-09	1973-07-31	Kendall & Co	Un procedimiento para preparar acidos 5-sustituidos-5-fenilalquil barbituricos y un compuesto intermedio obtenido durante dicho procedimiento
FR2211007A5 (it) *	1972-12-15	1974-07-12	Ugine Kuhlmann
IT1212508B (it) *	1981-12-22	1989-11-22	Anic Spa	Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1190891B (it) *	1982-06-24	1988-02-24	Anic Spa	Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
US4499079A (en) *	1982-11-18	1985-02-12	E. R. Squibb & Sons, Inc.	Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
EP0253190B1 (en) *	1986-07-16	1992-12-30	ENIRICERCHE S.p.A.	Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them

1986
- 1986-07-16 IT IT21143/86A patent/IT1196500B/it active
1987
- 1987-06-29 DE DE8787109317T patent/DE3784799T2/de not_active Expired - Fee Related
- 1987-06-29 AT AT87109317T patent/ATE86964T1/de not_active IP Right Cessation
- 1987-06-29 ES ES87109317T patent/ES2044874T3/es not_active Expired - Lifetime
- 1987-06-29 EP EP87109317A patent/EP0254080B1/en not_active Expired - Lifetime
- 1987-07-08 CA CA000541630A patent/CA1304539C/en not_active Expired - Lifetime
- 1987-07-16 JP JP62176063A patent/JPS6323834A/ja active Pending
- 1987-07-16 US US07/074,053 patent/US4914226A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0254080A3 (en)	1989-05-31
JPS6323834A (ja)	1988-02-01
DE3784799D1 (de)	1993-04-22
ES2044874T3 (es)	1994-01-16
ATE86964T1 (de)	1993-04-15
EP0254080A2 (en)	1988-01-27
IT8621143A0 (it)	1986-07-16
DE3784799T2 (de)	1993-06-24
CA1304539C (en)	1992-06-30
EP0254080B1 (en)	1993-03-17
US4914226A (en)	1990-04-03

Publication	Publication Date	Title
DE3784799D1 (de)	1993-04-22	Malonsaeurederivate und ihre synthesemethoden.
NO911787D0 (no)	1991-05-07	Peptidaminer samt fremgangsmaate for fremstilling derav.
RU95112539A (ru)	1997-06-27	Новый полипептид и фармацевтическая композиция против вич-инфекции
NO901571L (no)	1990-10-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazoler.
ATE176483T1 (de)	1999-02-15	Derivate des parathormons
DK1086124T3 (da)	2004-03-29	Nye cyclosporiner
ES2164218T3 (es)	2002-02-16	Derivados de camptotecina.
DK1109831T3 (da)	2011-04-18	Cytotoksiske peptider modificeret ved store eller lipofile dele
HUP0100669A2 (hu)	2001-08-28	Szerin proteázokat gátló peptidszármazékok és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
ES514240A0 (es)	1984-04-16	Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados.
NO20020725L (no)	2002-04-08	Celleadhesjonsinhibitorer
DE3672529D1 (de)	1990-08-16	Oligopeptid-derivate, deren herstellung und deren verwendung als hautfreundliche tenside.
ATE3283T1 (de)	1983-05-15	Somatostatin-analoge peptide, ihre herstellung und verwendung, sie enthaltende pharmazeutische praeparate und deren herstellung.
EE02950B1 (et)	1996-12-16	Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon
ES506284A0 (es)	1983-01-01	Un procedimiento para la preparacion de acidos 1, carbadestiapen-2-em-3-carboxililos 2- y 6- sustituidos.
KR900009692A (ko)	1990-07-05	레트로바이러스 프로테아제 억제제
KR950032165A (ko)	1995-12-20	토코페롤 유도체
HUT55034A (en)	1991-04-29	Process for producing peptides with hemoregulating effect and pharmaceutical compositions comprising such compounds as active ingredient
ITRM910189A1 (it)	1992-09-22	Derivati amminoacilici e oligopeptidici dell'allopurinolo dotati di attivita' immunostimolante e composizioni farmaceutiche che li contengono
PT87537A (pt)	1989-05-31	Process for the preparation of cyclic anticoagulant peptides
PT87536A (pt)	1989-05-31	Process for the preparation of cyclic anticoagulant peptides
ES2057116T3 (es)	1994-10-16	Derivados de acido n-(5,6,7,8-tetrahidropirido-(2,3-d)pirimidin-6-ilalcanoil) glutamico.
ATE92315T1 (de)	1993-08-15	Aminosaeurederivate enthaltende antikonvulsive zusammensetzungen und verwendung dieser aminosaeurederivate.
KR890013061A (ko)	1989-09-21	폴리펩티드 유도체
EP0264802A3 (en)	1989-07-26	Synthesis of peptide-aminoalkyl amides and peptide hydrazides by the solid phase method