ATE357457T1 - Verfahren zum screenen eines plättchenhemmers - Google Patents

Verfahren zum screenen eines plättchenhemmers

Info

Publication number
ATE357457T1
ATE357457T1 AT01978964T AT01978964T ATE357457T1 AT E357457 T1 ATE357457 T1 AT E357457T1 AT 01978964 T AT01978964 T AT 01978964T AT 01978964 T AT01978964 T AT 01978964T AT E357457 T1 ATE357457 T1 AT E357457T1
Authority
AT
Austria
Prior art keywords
screening
sub
tool
antiplatelet agent
protein
Prior art date
Application number
AT01978964T
Other languages
English (en)
Inventor
Jun Takasaki
Mitsuyuki Matsumoto
Masazumi Kamohara
Tetsu Saito
Takahide Ohishi
Takatoshi Soga
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE357457T1 publication Critical patent/ATE357457T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT01978964T 2000-11-01 2001-10-31 Verfahren zum screenen eines plättchenhemmers ATE357457T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000334721 2000-11-01
JP2001003577 2001-01-11

Publications (1)

Publication Number Publication Date
ATE357457T1 true ATE357457T1 (de) 2007-04-15

Family

ID=26603288

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01978964T ATE357457T1 (de) 2000-11-01 2001-10-31 Verfahren zum screenen eines plättchenhemmers

Country Status (8)

Country Link
US (1) US7405051B2 (de)
EP (1) EP1331228B1 (de)
JP (1) JP3519078B2 (de)
AT (1) ATE357457T1 (de)
AU (1) AU2002210982A1 (de)
DE (1) DE60127435T2 (de)
ES (1) ES2282304T3 (de)
WO (1) WO2002036631A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2395416A1 (en) 1999-12-23 2001-06-28 Millennium Pharmaceuticals, Inc. P2y12 receptor
EP1411134A1 (de) * 2002-10-15 2004-04-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Zusammenhang zwischen dem H2 Haplotyp des P2Y12 Rezeptors und einem erhöten Risiko auf Thrombose und peripheren arteriellen Erkrankungen
EP1411130A1 (de) * 2002-10-15 2004-04-21 Institut National De La Sante Et De La Recherche Medicale (Inserm) Zusammenhang zwischen dem H2 Haplotyp des P2Y12 Rezeptors und einem erhöten Risiko auf Thrombose und peripheren arteriellen Erkrankungen
US20070243632A1 (en) 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
US7790362B2 (en) 2003-07-08 2010-09-07 Accumetrics, Inc. Controlled platelet activation to monitor therapy of ADP antagonists
WO2005076007A2 (en) * 2004-02-03 2005-08-18 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor p2y12 (p2y12)
EP1812429A4 (de) * 2004-09-29 2010-07-21 Portola Pharm Inc Substituierte 2h-1,3-benzoxazin-4(3h)-one
TWI391378B (zh) 2006-03-16 2013-04-01 Astellas Pharma Inc 喹啉酮衍生物或其製藥學上可被容許之鹽
DE102006020385A1 (de) * 2006-04-28 2007-10-31 Dade Behring Marburg Gmbh Verfahren und Vorrichtung zur Bestimmung der Thrombozytenfunktion unter Flussbedingungen
DE102006020386A1 (de) * 2006-04-28 2007-10-31 Dade Behring Marburg Gmbh Verfahren zur Bestimmung der Thrombozytenfunktion unter Flussbedingungen
US20100113391A1 (en) 2007-04-19 2010-05-06 Astellas Pharma Inc. Bicyclic heterocyclic compound
CN101675342A (zh) * 2007-05-03 2010-03-17 阿库米特里克斯股份有限公司 测量凝血酶受体拮抗剂对血小板聚集的抑制的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060272A (en) 1997-05-07 2000-05-09 Human Genome Sciences, Inc. Human G-protein coupled receptors
EP1123391A2 (de) * 1998-09-01 2001-08-16 BASF Aktiengesellschaft Verfahren zur verbesserung der funktion von heterologen g-protein-gekoppelten rezeptoren
KR20010080882A (ko) 1998-10-13 2001-08-25 리처드 피. 버군 쥬니어 구성적으로 활성화된 비내생성 인간 g 단백질 결합형수용체
WO2000028028A1 (en) * 1998-11-06 2000-05-18 Millennium Pharmaceuticals, Inc. G-protein coupled receptors, homologous to ebv-induced gpcr 2 (ebi-2). methods to seek for ligands thereof
DK1584683T3 (da) * 1998-11-20 2007-10-29 Arena Pharm Inc Human G-protein-koblet orphan receptor RUP3
SE9804274D0 (sv) * 1998-12-10 1998-12-10 Astra Pharma Inc Novel receptor
US6689866B1 (en) * 1999-03-09 2004-02-10 Curagen Corporation Polynucleotides and proteins encoded thereby
CA2395416A1 (en) * 1999-12-23 2001-06-28 Millennium Pharmaceuticals, Inc. P2y12 receptor
US20010046497A1 (en) * 2000-04-21 2001-11-29 Zhang Fang Liang G-protein coupled receptor and methods
AU2001261476A1 (en) 2000-05-11 2001-11-20 Lifespan Biosciences, Inc. Nucleic acid sequences for novel gpcrs

Also Published As

Publication number Publication date
US7405051B2 (en) 2008-07-29
DE60127435T2 (de) 2007-11-29
JPWO2002036631A1 (ja) 2004-03-11
EP1331228A4 (de) 2005-01-19
AU2002210982A1 (en) 2002-05-15
DE60127435D1 (de) 2007-05-03
JP3519078B2 (ja) 2004-04-12
WO2002036631A1 (en) 2002-05-10
US20030124626A1 (en) 2003-07-03
EP1331228B1 (de) 2007-03-21
ES2282304T3 (es) 2007-10-16
EP1331228A1 (de) 2003-07-30

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