ATE363482T1 - Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten - Google Patents

Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten

Info

Publication number
ATE363482T1
ATE363482T1 AT03779416T AT03779416T ATE363482T1 AT E363482 T1 ATE363482 T1 AT E363482T1 AT 03779416 T AT03779416 T AT 03779416T AT 03779416 T AT03779416 T AT 03779416T AT E363482 T1 ATE363482 T1 AT E363482T1
Authority
AT
Austria
Prior art keywords
muscarino
pyridylmethyl
piperidine
amino
substituted
Prior art date
Application number
AT03779416T
Other languages
English (en)
Inventor
Mathai Mammen
Richard Wilson
Yan Chen
Sarah Dunham
Adam Hughes
Craig Husfeld
Yu-Hua Ji
Li Li
Trevor Mischki
Ioanna Stergiades
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Application granted granted Critical
Publication of ATE363482T1 publication Critical patent/ATE363482T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT03779416T 2002-10-30 2003-10-29 Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten ATE363482T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42222902P 2002-10-30 2002-10-30
US48648303P 2003-07-11 2003-07-11

Publications (1)

Publication Number Publication Date
ATE363482T1 true ATE363482T1 (de) 2007-06-15

Family

ID=32314442

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03779416T ATE363482T1 (de) 2002-10-30 2003-10-29 Substituierte 4-amino-1-(pyridylmethyl)piperidine zur verwendung als muscarinrezeptor-antagonisten

Country Status (20)

Country Link
US (2) US7285564B2 (de)
EP (1) EP1556372B1 (de)
JP (2) JP4448492B2 (de)
KR (1) KR20050061504A (de)
AR (1) AR041855A1 (de)
AT (1) ATE363482T1 (de)
AU (1) AU2003285100A1 (de)
BR (1) BR0315778A (de)
CA (1) CA2500800A1 (de)
DE (1) DE60314170T2 (de)
EC (1) ECSP055762A (de)
ES (1) ES2287543T3 (de)
IS (1) IS7780A (de)
MX (1) MXPA05004507A (de)
NO (1) NO20052521L (de)
PE (1) PE20040606A1 (de)
PL (1) PL376716A1 (de)
RU (1) RU2005116239A (de)
TW (2) TW200800953A (de)
WO (1) WO2004041806A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
EP1644356A1 (de) 2003-07-11 2006-04-12 Theravance, Inc. Substituierte 4-amino-1-benzylpiperidinverbindungen
PE20050973A1 (es) * 2003-10-29 2005-11-19 Theravance Inc Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos
JP2007528418A (ja) * 2004-03-11 2007-10-11 セラヴァンス， インコーポレーテッド ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
US7071224B2 (en) * 2004-03-11 2006-07-04 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
TW200628465A (en) * 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
JP2008521821A (ja) * 2004-11-29 2008-06-26 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
WO2006105035A2 (en) 2005-03-28 2006-10-05 Vertex Pharmaceuticals Incorporated Muscarinic modulators
WO2008103426A1 (en) * 2007-02-23 2008-08-28 Theravance, Inc. Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2009153649A1 (en) * 2008-06-19 2009-12-23 Medichem, S.A. Process for preparing 3-substituted pyrrolidine compounds
CA2774992A1 (en) * 2009-10-07 2011-04-14 Merck Sharp & Dohme Corp. Combination therapy using a beta 3 adrenergic receptor agonist and an antimuscarinic agent
US20110281853A1 (en) 2010-05-12 2011-11-17 Rishi Arora Compositions and methods for treating or preventing atrial fibrillation
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
SG187689A1 (en) * 2010-08-03 2013-03-28 Altherx Inc Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
WO2013119910A1 (en) * 2012-02-09 2013-08-15 Altherx, Inc. Combination of muscarinic receptor antagonists and beta- 3 adrenoceptor agonists for treating overactive bladder
EP3226849A4 (de) 2014-12-03 2018-05-09 Velicept Therapeutics, Inc. Zusammensetzungen und verfahren zur verwendung von solabegron mit modifizierter freisetzung für symptome der unteren harnwege
US10065922B2 (en) 2015-10-23 2018-09-04 Velicept Therapeutics, Inc. Solabegron zwitterion and uses thereof

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EP1644356A1 (de) * 2003-07-11 2006-04-12 Theravance, Inc. Substituierte 4-amino-1-benzylpiperidinverbindungen
PE20050973A1 (es) 2003-10-29 2005-11-19 Theravance Inc Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos
JP2007528418A (ja) 2004-03-11 2007-10-11 セラヴァンス， インコーポレーテッド ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
US7071224B2 (en) 2004-03-11 2006-07-04 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
TW200540154A (en) 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
TW200628465A (en) 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds

Also Published As

Publication number Publication date
BR0315778A (pt) 2005-09-06
US8030502B2 (en) 2011-10-04
ES2287543T3 (es) 2007-12-16
PE20040606A1 (es) 2004-09-08
ECSP055762A (es) 2005-07-06
US20080091034A1 (en) 2008-04-17
JP4448492B2 (ja) 2010-04-07
EP1556372A2 (de) 2005-07-27
US7285564B2 (en) 2007-10-23
MXPA05004507A (es) 2005-10-18
IS7780A (is) 2005-03-31
JP2006512408A (ja) 2006-04-13
TWI295669B (en) 2008-04-11
JP2010059214A (ja) 2010-03-18
CA2500800A1 (en) 2004-05-21
AU2003285100A1 (en) 2004-06-07
DE60314170T2 (de) 2008-01-24
AR041855A1 (es) 2005-06-01
KR20050061504A (ko) 2005-06-22
TW200418833A (en) 2004-10-01
US20040122014A1 (en) 2004-06-24
WO2004041806A2 (en) 2004-05-21
WO2004041806A3 (en) 2004-08-05
DE60314170D1 (de) 2007-07-12
PL376716A1 (pl) 2006-01-09
EP1556372B1 (de) 2007-05-30
RU2005116239A (ru) 2006-01-27
NO20052521L (no) 2005-05-25
TW200800953A (en) 2008-01-01

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