ATE357537T1 - Zielgerichtete verfahren des wirkstoff screenings unter verwendung von co-kultivierungs verfahren - Google Patents

Zielgerichtete verfahren des wirkstoff screenings unter verwendung von co-kultivierungs verfahren

Info

Publication number
ATE357537T1
ATE357537T1 AT00982313T AT00982313T ATE357537T1 AT E357537 T1 ATE357537 T1 AT E357537T1 AT 00982313 T AT00982313 T AT 00982313T AT 00982313 T AT00982313 T AT 00982313T AT E357537 T1 ATE357537 T1 AT E357537T1
Authority
AT
Austria
Prior art keywords
methods
gene
cell
target gene
molecule
Prior art date
Application number
AT00982313T
Other languages
English (en)
Inventor
Matthew Ashby
Daniel D Shoemaker
Original Assignee
Rosetta Inpharmatics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Inpharmatics Llc filed Critical Rosetta Inpharmatics Llc
Application granted granted Critical
Publication of ATE357537T1 publication Critical patent/ATE357537T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00982313T 1999-12-03 2000-11-30 Zielgerichtete verfahren des wirkstoff screenings unter verwendung von co-kultivierungs verfahren ATE357537T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/454,889 US6518035B1 (en) 1998-06-02 1999-12-03 Targeted methods of drug screening using co-culture methods

Publications (1)

Publication Number Publication Date
ATE357537T1 true ATE357537T1 (de) 2007-04-15

Family

ID=23806481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00982313T ATE357537T1 (de) 1999-12-03 2000-11-30 Zielgerichtete verfahren des wirkstoff screenings unter verwendung von co-kultivierungs verfahren

Country Status (9)

Country Link
US (1) US6518035B1 (de)
EP (1) EP1235935B1 (de)
JP (1) JP4718082B2 (de)
AT (1) ATE357537T1 (de)
AU (1) AU1936301A (de)
CA (1) CA2393360C (de)
DE (1) DE60034059T2 (de)
ES (1) ES2283334T3 (de)
WO (1) WO2001040518A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001067103A1 (en) * 2000-03-06 2001-09-13 Bioseek, Inc. Function homology screening
WO2002000940A2 (en) * 2000-06-23 2002-01-03 Cytokinetics, Inc Image analysis for phenotyping sets of mutant cells
AU2002303645A1 (en) * 2001-05-04 2002-11-18 Axiom Biotechnologies, Inc. Matrix assays in genomically indexed cells
US6894205B2 (en) * 2001-06-22 2005-05-17 Vanderbilt University Assay for toxin induced neuronal degeneration and viability in C. elegans
US6977152B2 (en) * 2001-09-07 2005-12-20 Virtual Arrays, Inc. Biological assays using coded RNA reporters
US20030069256A1 (en) * 2001-09-25 2003-04-10 Torrance Christopher J. Use of isogenic human cancer cells for high-throughput screening and drug discovery
EP1448797B1 (de) 2001-11-21 2009-03-18 Bioimics AB Verfahren und kit zum nachweis neuer hemmstoffe gegen krankheitserreger
DE10261834A1 (de) * 2002-12-20 2004-07-08 Phenion Gmbh & Co. Kg Hochdurchsatz-geeignetes Screening-Verfahren zur Identifikation von Wirkstoffen
WO2005020886A2 (en) * 2003-06-27 2005-03-10 New England Biolabs, Inc. Identification and use of cofactor independent phosphoglycerate mutase as a drug target
EP1646926A2 (de) * 2003-07-18 2006-04-19 Cytokinetics, Inc. Charakterisierung biologischer stimuli durch ansprechkurven
US7150969B2 (en) * 2004-06-04 2006-12-19 Rosetta Inpharmatics Llc Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2)
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
WO2007008609A2 (en) 2005-07-07 2007-01-18 The Regents Of The University Of California Methods and apparatus for cell culture array
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
US7745210B2 (en) * 2006-06-30 2010-06-29 Corning Incorporated Fluid flow diverter for cell culture vessel
WO2008073900A1 (en) * 2006-12-08 2008-06-19 Worcester Polytechnic Institute (Wpi) Targets, including yap1, for antifungal drug discovery and therapy
US7897379B2 (en) * 2007-02-26 2011-03-01 Corning Incorporated Device and method for reducing bubble formation in cell culture
US9309491B2 (en) * 2007-05-29 2016-04-12 Corning Incorporated Cell culture apparatus for co-culture of cells
GB2451287A (en) * 2007-07-26 2009-01-28 Envirogene Ltd Identification of hydrocarbon deposits through detection of a microbial polynucleotide
ES2882661T3 (es) 2008-01-03 2021-12-02 Emd Millipore Corp Sistema de matriz de cultivo celular para ensayos automatizados y métodos de funcionamiento y de fabricación del mismo
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
EP2785825B1 (de) 2011-12-03 2021-04-21 EMD Millipore Corporation Mikrofluidische zellkultursysteme
US20180327806A1 (en) * 2015-11-04 2018-11-15 The Broad Institute, Inc. Multiplex high-resolution detection of micro-organism strains, related kits, diagnostics methods and screening assays
KR102127949B1 (ko) * 2018-11-16 2020-06-29 충북대학교 산학협력단 Erg11 단백질에 특이적으로 결합하는 dna 앱타머 및 이의 용도
EP4022307A1 (de) * 2019-09-24 2022-07-06 Université de Genève Verfahren zur unabhängigen analyse mehrerer biologischer prozesse in eingekapselten 3d-zell-co-kulturen
CN113130000B (zh) * 2021-03-22 2022-09-16 同济大学 一种青蒿素抗疟作用靶基因的筛选方法
US20250003953A1 (en) * 2021-07-23 2025-01-02 The Regents Of The University Of California Methods and Model Systems for Assessing Therapeutic Properties of Candidate Agents and Related Computer Readable Media and Systems

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980281A (en) 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators
WO1995006132A2 (en) 1993-08-27 1995-03-02 Myco Pharmaceuticals, Incorporated Identifying biologically active agents through culture color change
AU8116494A (en) 1993-11-12 1995-06-13 Kenichi Matsubara Gene signature
AU730811B2 (en) 1996-08-07 2001-03-15 Regents Of The University Of California, The AFC1 and RCE1:isoprenylated CAAX processing enzymes
WO1998054333A2 (en) 1997-06-02 1998-12-03 Acacia Biosciences Inc. Mammalian caax processing enzymes
CA2234418A1 (en) 1997-06-24 1998-12-24 Smithkline Beecham Corporation Human afc1
CA2234402A1 (en) 1997-06-24 1998-12-24 Smithkline Beecham Corporation Human rce1
US6046002A (en) 1998-01-05 2000-04-04 The Board Of Trustees Of The Leland Stanford Junior University Highly parallel and sensitive method for identifying drugs and drug targets

Also Published As

Publication number Publication date
CA2393360C (en) 2013-01-08
AU1936301A (en) 2001-06-12
WO2001040518A1 (en) 2001-06-07
EP1235935B1 (de) 2007-03-21
JP2003517308A (ja) 2003-05-27
DE60034059T2 (de) 2007-12-13
EP1235935A1 (de) 2002-09-04
ES2283334T3 (es) 2007-11-01
JP4718082B2 (ja) 2011-07-06
US6518035B1 (en) 2003-02-11
DE60034059D1 (de) 2007-05-03
EP1235935A4 (de) 2004-10-20
CA2393360A1 (en) 2001-06-07

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