ATE358491T1 - Neue derivate von morphin-6-glucuronid, diese derivate enthaltende pharmazeutische zusammensetzungen, herstellungs- und verwendungsverfahren dafür - Google Patents
Neue derivate von morphin-6-glucuronid, diese derivate enthaltende pharmazeutische zusammensetzungen, herstellungs- und verwendungsverfahren dafürInfo
- Publication number
- ATE358491T1 ATE358491T1 AT04816470T AT04816470T ATE358491T1 AT E358491 T1 ATE358491 T1 AT E358491T1 AT 04816470 T AT04816470 T AT 04816470T AT 04816470 T AT04816470 T AT 04816470T AT E358491 T1 ATE358491 T1 AT E358491T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- glucuronide
- new
- morphin
- production
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- GNJCUHZOSOYIEC-GAROZEBRSA-N Morphine-6-glucuronide Chemical class O([C@H]1C=C[C@H]2[C@H]3CC=4C5=C(C(=CC=4)O)O[C@@H]1[C@]52CCN3C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O GNJCUHZOSOYIEC-GAROZEBRSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 102000003840 Opioid Receptors Human genes 0.000 abstract 1
- 108090000137 Opioid Receptors Proteins 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000002460 anti-migrenic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- -1 linear or branched Chemical group 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0315160A FR2864082B1 (fr) | 2003-12-22 | 2003-12-22 | Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE358491T1 true ATE358491T1 (de) | 2007-04-15 |
Family
ID=34630441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04816470T ATE358491T1 (de) | 2003-12-22 | 2004-12-22 | Neue derivate von morphin-6-glucuronid, diese derivate enthaltende pharmazeutische zusammensetzungen, herstellungs- und verwendungsverfahren dafür |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7365055B2 (de) |
| EP (1) | EP1696935B8 (de) |
| AT (1) | ATE358491T1 (de) |
| AU (1) | AU2004308720A1 (de) |
| CA (1) | CA2548921A1 (de) |
| DE (1) | DE602004005752T2 (de) |
| DK (1) | DK1696935T3 (de) |
| ES (1) | ES2285568T3 (de) |
| FR (1) | FR2864082B1 (de) |
| PL (1) | PL1696935T3 (de) |
| PT (1) | PT1696935E (de) |
| WO (1) | WO2005063263A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2907121B1 (fr) * | 2006-10-12 | 2012-05-04 | Neorphys | Nouveaux derives morphiniques |
| FR2939436B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Synthese de morphine-6-glucuronide ou de l'un de ses derives |
| FR2939437B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| FR2939796B1 (fr) * | 2008-12-11 | 2010-12-17 | Sanofi Aventis | Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| US8450089B2 (en) * | 2009-11-23 | 2013-05-28 | New York University | Compounds as L-cystine crystallization inhibitors and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0816375A1 (de) * | 1995-11-29 | 1998-01-07 | Rolabo Sl | Glycokonjugate von opiaten |
| FR2821272B1 (fr) * | 2001-02-23 | 2004-12-17 | Synt Em | Composes constitues d'une molecule analgesique liee a un vecteur capable de vectoriser ladite molecule a travers la barriere hematoencephalique et compositions pharmaceutiques les contenant |
-
2003
- 2003-12-22 FR FR0315160A patent/FR2864082B1/fr not_active Expired - Fee Related
-
2004
- 2004-12-22 PT PT04816470T patent/PT1696935E/pt unknown
- 2004-12-22 AT AT04816470T patent/ATE358491T1/de not_active IP Right Cessation
- 2004-12-22 DK DK04816470T patent/DK1696935T3/da active
- 2004-12-22 DE DE602004005752T patent/DE602004005752T2/de not_active Expired - Lifetime
- 2004-12-22 CA CA002548921A patent/CA2548921A1/fr not_active Abandoned
- 2004-12-22 AU AU2004308720A patent/AU2004308720A1/en not_active Abandoned
- 2004-12-22 WO PCT/FR2004/003342 patent/WO2005063263A1/fr not_active Ceased
- 2004-12-22 ES ES04816470T patent/ES2285568T3/es not_active Expired - Lifetime
- 2004-12-22 EP EP04816470A patent/EP1696935B8/de not_active Expired - Lifetime
- 2004-12-22 US US10/583,992 patent/US7365055B2/en not_active Expired - Fee Related
- 2004-12-22 PL PL04816470T patent/PL1696935T3/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005063263A1 (fr) | 2005-07-14 |
| PT1696935E (pt) | 2007-06-28 |
| EP1696935A1 (de) | 2006-09-06 |
| CA2548921A1 (fr) | 2005-07-14 |
| US7365055B2 (en) | 2008-04-29 |
| DE602004005752T2 (de) | 2008-01-10 |
| US20070116665A1 (en) | 2007-05-24 |
| DE602004005752D1 (de) | 2007-05-16 |
| PL1696935T3 (pl) | 2007-10-31 |
| ES2285568T3 (es) | 2007-11-16 |
| AU2004308720A1 (en) | 2005-07-14 |
| FR2864082A1 (fr) | 2005-06-24 |
| DK1696935T3 (da) | 2007-08-06 |
| FR2864082B1 (fr) | 2006-03-10 |
| EP1696935B8 (de) | 2007-06-20 |
| EP1696935B1 (de) | 2007-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1696935 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |