ATE360017T1 - L-ascorbinsäure-2-o-maleinsäure-a- tocopheroldiester-1-propanol addukt und verfahren zu dessen herstellung - Google Patents

L-ascorbinsäure-2-o-maleinsäure-a- tocopheroldiester-1-propanol addukt und verfahren zu dessen herstellung

Info

Publication number: ATE360017T1
Authority: AT; Austria
Prior art keywords: production; acid; maleic acid; ascorbic acid; propanol adduct
Prior art date: 2001-06-06

Application number

AT02733329T

Other languages

English (en)

Inventor

Kazumi Ogata

Noriko Saito

Kazuhiko Yamada

-Chome Tsurugaoka

Genta Maruyama

Original Assignee

Senju Pharma Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-06

Filing date

2002-06-05

Publication date

2007-05-15

2002-06-05 Application filed by Senju Pharma Co filed Critical Senju Pharma Co

2007-05-15 Application granted granted Critical

2007-05-15 Publication of ATE360017T1 publication Critical patent/ATE360017T1/de

Links

BDERNNFJNOPAEC-UHFFFAOYSA-N 1-propanol Substances CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 title 1
229960001295 tocopherol Drugs 0.000 title 1
239000011732 tocopherol Substances 0.000 title 1
239000003638 chemical reducing agent Substances 0.000 abstract 2
RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 abstract 2
YOZNUFWCRFCGIH-BYFNXCQMSA-L hydroxocobalamin Chemical compound O[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O YOZNUFWCRFCGIH-BYFNXCQMSA-L 0.000 abstract 2
235000007672 methylcobalamin Nutrition 0.000 abstract 2
239000011585 methylcobalamin Substances 0.000 abstract 2
JEWJRMKHSMTXPP-BYFNXCQMSA-M methylcobalamin Chemical compound C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O JEWJRMKHSMTXPP-BYFNXCQMSA-M 0.000 abstract 2
235000000639 cyanocobalamin Nutrition 0.000 abstract 1
239000011666 cyanocobalamin Substances 0.000 abstract 1
229960002104 cyanocobalamin Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
235000004867 hydroxocobalamin Nutrition 0.000 abstract 1
239000011704 hydroxocobalamin Substances 0.000 abstract 1
229960001103 hydroxocobalamin Drugs 0.000 abstract 1
239000012022 methylating agents‎ Substances 0.000 abstract 1
230000001035 methylating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Otolaryngology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

AT02733329T 2001-06-06 2002-06-05 L-ascorbinsäure-2-o-maleinsäure-a- tocopheroldiester-1-propanol addukt und verfahren zu dessen herstellung ATE360017T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001171559		2001-06-06

Publications (1)

Publication Number	Publication Date
ATE360017T1 true ATE360017T1 (de)	2007-05-15

Family

ID=19013310

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02733329T ATE360017T1 (de)	2001-06-06	2002-06-05	L-ascorbinsäure-2-o-maleinsäure-a- tocopheroldiester-1-propanol addukt und verfahren zu dessen herstellung

Country Status (8)

Country	Link
US (1)	US6828348B2 (de)
EP (1)	EP1394161B1 (de)
JP (1)	JP4179809B2 (de)
KR (1)	KR100876371B1 (de)
AT (1)	ATE360017T1 (de)
DE (1)	DE60219620T2 (de)
ES (1)	ES2281518T3 (de)
WO (1)	WO2003006460A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2642726C (en)	2006-02-21	2015-11-03	Mary Kay, Inc.	Stable vitamin c compositions
US20150024152A1 (en)	2013-07-19	2015-01-22	Agilent Technologies, Inc.	Metal components with inert vapor phase coating on internal surfaces
US10767259B2 (en)	2013-07-19	2020-09-08	Agilent Technologies, Inc.	Components with an atomic layer deposition coating and methods of producing the same
JP2019081726A (ja) *	2017-10-30	2019-05-30	日光ケミカルズ株式会社	エラスターゼ活性阻害剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4816901B1 (de) *	1969-05-21	1973-05-25
JPS59219295A (ja) *	1983-05-30	1984-12-10	Senjiyu Seiyaku Kk	リン酸ジエステルまたはその塩およびそれらの製造法
JPS62205091A (ja) *	1986-03-04	1987-09-09	Senjiyu Seiyaku Kk	新規なリン酸ジエステルならびにその塩、その製造法およびそれを含有する製剤
JPH0499772A (ja)	1990-08-17	1992-03-31	Kanebo Ltd	トコフェロール―５，６―０―イソプロピリデン―ｌ―アスコルビン酸―２―ジカルボン酸ジエステル，及びその製造方法，並びにそれより成るビタミンｃ・ビタミンｅ補給剤
JPH04149113A (ja)	1990-10-08	1992-05-22	Kanebo Ltd	美白化粧料
WO1999033818A1 (en)	1997-12-24	1999-07-08	Senju Pharmaceutical Co., Ltd.	Vitamin e derivatives
WO2001004114A1 (en) *	1999-07-08	2001-01-18	Senju Pharmaceutical Co., Ltd.	Diesters of maleic or fumaric acid

2002
- 2002-06-05 AT AT02733329T patent/ATE360017T1/de not_active IP Right Cessation
- 2002-06-05 EP EP02733329A patent/EP1394161B1/de not_active Expired - Lifetime
- 2002-06-05 ES ES02733329T patent/ES2281518T3/es not_active Expired - Lifetime
- 2002-06-05 JP JP2002164600A patent/JP4179809B2/ja not_active Expired - Lifetime
- 2002-06-05 US US10/479,145 patent/US6828348B2/en not_active Expired - Lifetime
- 2002-06-05 WO PCT/JP2002/005573 patent/WO2003006460A1/ja not_active Ceased
- 2002-06-05 KR KR1020037015786A patent/KR100876371B1/ko not_active Expired - Lifetime
- 2002-06-05 DE DE60219620T patent/DE60219620T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2003006460A1 (fr)	2003-01-23
DE60219620T2 (de)	2008-01-31
US6828348B2 (en)	2004-12-07
JP4179809B2 (ja)	2008-11-12
US20040171676A1 (en)	2004-09-02
KR20040003046A (ko)	2004-01-07
EP1394161A4 (de)	2004-06-30
KR100876371B1 (ko)	2008-12-29
ES2281518T3 (es)	2007-10-01
EP1394161A9 (de)	2004-07-07
DE60219620D1 (de)	2007-05-31
EP1394161A1 (de)	2004-03-03
JP2003055374A (ja)	2003-02-26
EP1394161B1 (de)	2007-04-18

Legal Events

Date	Code	Title	Description
2007-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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DE60026354D1 (de)	2006-04-27	Verfahren zur herstellung von methylcobalamin
TW200617009A (en)	2006-06-01	Organic compounds
WO2006028958A3 (en)	2006-04-13	Pyridyl inhibitors of hedgehog signalling
MXPA02011458A (es)	2003-04-25	Derivados de acilfenilurea, metodos para su produccion y uso de los mismos como farmacos.
WO2005063734A3 (de)	2007-08-30	Substituierte thiophene
MX2009013565A (es)	2010-06-02	Derivados de azapeptidos.
BR0017043A (pt)	2003-01-07	Imidazo[1,3,5]triazinonas e sua aplicação
UA88645C2 (ru)	2009-11-10	Гетероарильные соединения как бета-миметики для лечения заболеваний дыхательных путей
NO20062644L (no)	2006-09-07	DPP-IV inhibitorer
DE60310759D1 (de)	2007-02-08	Pulver auf silber-basis, verfahren zu dessen herstellung, und härtbare siloxanzusammensetzung
TW200509948A (en)	2005-03-16	Prevention of urogenital infections
CA2449480A1 (en)	2002-12-12	Process for producing methylcobalamin
WO2004033423A3 (en)	2004-07-29	Anticancer compounds
IL172015A (en)	2016-07-31	Phosphonate grouping shaft compounds, method of preparation and use thereof for the preparation of drugs for the treatment of viral infection
DE60219620D1 (de)	2007-05-31	L-ascorbinsäure-2-o-maleinsäure-a-tocopheroldiester-1-propanol addukt und verfahren zu dessen herstellung
NL1027790A1 (nl)	2005-06-20	Werkwijze voor vervaardigen van een fosfaat van de lanthaniden en daaruit vervaardigd fosfaat.
DE60201984D1 (de)	2004-12-23	Werkzeugstahl von hoher zähigkeit, verfahren zum herstellen von teilen aus diesem stahl und so hergestellte teile
ATE506346T1 (de)	2011-05-15	Verfahren zur herstellung von (z)-1-phenyl-1-(n,n-diethylaminocarbonyl)idomet ylcyclopropan
DE60211303D1 (de)	2006-06-14	Verfahren zur herstellung und zwischenprodukte von pyridin-2-yl-amin
BRPI0307897A2 (pt)	2016-06-21	processo para a descarbonização profunda de massas fundidas de aço.
DE602006013596D1 (de)	2010-05-27	Mutageneseverfahren
PL375483A1 (en)	2005-11-28	Machine and process for shaping, annealing and quenching glass sheets, or similar materials
DE10195718D2 (de)	2004-04-15	Verfahren zum Herstellen von Objektion, Volumina, Möbelmodulen und Möbel sowie nach diesem Verfahren erzeugte Gegenstände