ATE360072T1 - Expression eukarotischer peptide in pflanzenplastiden - Google Patents
Expression eukarotischer peptide in pflanzenplastidenInfo
- Publication number
- ATE360072T1 ATE360072T1 AT99933798T AT99933798T ATE360072T1 AT E360072 T1 ATE360072 T1 AT E360072T1 AT 99933798 T AT99933798 T AT 99933798T AT 99933798 T AT99933798 T AT 99933798T AT E360072 T1 ATE360072 T1 AT E360072T1
- Authority
- AT
- Austria
- Prior art keywords
- plastid
- plant
- eukaryotic
- peptides
- constructs
- Prior art date
Links
- 210000002706 plastid Anatomy 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 2
- 239000003550 marker Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000005030 transcription termination Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8214—Plastid transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
- C12N15/8275—Glyphosate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Cultivation Of Plants (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/113,244 US6512162B2 (en) | 1998-07-10 | 1998-07-10 | Expression of eukaryotic peptides in plant plastids |
| US31684799A | 1999-05-21 | 1999-05-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360072T1 true ATE360072T1 (de) | 2007-05-15 |
Family
ID=26810845
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99933798T ATE360072T1 (de) | 1998-07-10 | 1999-07-10 | Expression eukarotischer peptide in pflanzenplastiden |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6812379B2 (de) |
| EP (1) | EP1097211B1 (de) |
| JP (1) | JP2002520019A (de) |
| AT (1) | ATE360072T1 (de) |
| BR (1) | BR9912019A (de) |
| CA (1) | CA2333148A1 (de) |
| DE (1) | DE69935857T2 (de) |
| DK (1) | DK1097211T3 (de) |
| ES (1) | ES2286886T3 (de) |
| PT (1) | PT1097211E (de) |
| WO (1) | WO2000003012A2 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7741536B2 (en) | 1997-08-07 | 2010-06-22 | University Of Central Florida Research Foundation, Inc. | Expression of human serum albumin in plastids |
| US20100251425A9 (en) | 1998-05-15 | 2010-09-30 | University Of Central Florida | Expression of human interferon in transgenic chloroplasts |
| RU2001111881A (ru) * | 1998-10-07 | 2003-06-20 | Зингента Партисипейшнс Аг (Ch) | Терапевтически активные протеины в растениях |
| US6815580B1 (en) | 1999-05-13 | 2004-11-09 | Monsanto Technology Llc | Expression of the Chlorella sorokiniana sedoheptulose 1,7-bisphosphatase in transgenic plants |
| CA2372123C (en) * | 1999-05-13 | 2010-10-26 | Monsanto Technology Llc | Expression of sedoheptulose 1,7 bisphosphatase in transgenic plants |
| CA2401958A1 (en) * | 2000-02-29 | 2001-09-07 | Auburn University | Multiple gene expression for engineering novel pathways and hyperexpression of foreign proteins in plants |
| AU2001245358A1 (en) * | 2000-02-29 | 2001-09-12 | Auburn University | Production of antibodies in transgenic plastids |
| US20030041353A1 (en) | 2001-04-18 | 2003-02-27 | Henry Daniell | Mutiple gene expression for engineering novel pathways and hyperexpression of foreign proteins in plants |
| EP2080803B1 (de) * | 2000-03-01 | 2011-05-25 | Auburn University | Plastidtransformationsvektoren zur Expression von Proinsulin, das an die Cholera Toxin B-Untereinheit fusioniert ist, in Pflanzen |
| AU2001253107A1 (en) * | 2000-04-03 | 2001-10-15 | Monsanto Technology Llc | Expression and purification of bioactive, authentic polypeptides from plants |
| JP4552280B2 (ja) | 2000-06-14 | 2010-09-29 | ソニー株式会社 | テレビ受信システム、選局装置および表示装置 |
| GB2364705A (en) * | 2000-07-14 | 2002-02-06 | Icgeb | Fusion protein expression in plastids |
| JP4838434B2 (ja) * | 2001-03-22 | 2011-12-14 | 財団法人地球環境産業技術研究機構 | 植物体を用いたタンパク質発現系 |
| CN1886512B (zh) * | 2002-04-23 | 2015-11-25 | 斯克里普斯研究所 | 多肽在叶绿体中的表达以及用于表达多肽的组合物和方法 |
| ATE516295T1 (de) | 2004-01-20 | 2011-07-15 | Monsanto Technology Llc | Chimäre promotoren zur verwendung in pflanzen |
| US20100015713A1 (en) * | 2005-06-28 | 2010-01-21 | Scott Deeter | Components of cell culture media produced from plant cells |
| JP5086999B2 (ja) * | 2005-09-16 | 2012-11-28 | バイエル・クロップサイエンス・アーゲー | 内腔指向性タンパク質を発現する色素体形質転換植物 |
| EP2803728B1 (de) | 2006-05-16 | 2018-11-21 | Monsanto Technology LLC | Verwendung einer bakteriellen nichtagrobakteriellen Spezies zur Pflanzenumwandlung |
| US7838729B2 (en) | 2007-02-26 | 2010-11-23 | Monsanto Technology Llc | Chloroplast transit peptides for efficient targeting of DMO and uses thereof |
| AU2008226443B2 (en) | 2007-03-09 | 2013-07-11 | Monsanto Technology Llc | Preparation and use of plant embryo explants for transformation |
| WO2008118394A1 (en) | 2007-03-23 | 2008-10-02 | New York University | Methods of affecting nitrogen assimilation in plants |
| CA2692893C (en) * | 2007-06-01 | 2015-06-23 | The Scripps Research Institute | High throughput screening of genetically modified photosynthetic organisms |
| NZ583620A (en) * | 2007-09-11 | 2012-08-31 | Sapphire Energy Inc | Methods of producing organic fuel products with photosynthetic organisms |
| CA2698801A1 (en) * | 2007-09-11 | 2009-03-19 | Sapphire Energy, Inc. | Molecule production by photosynthetic organisms |
| US10689633B2 (en) | 2008-02-29 | 2020-06-23 | The Trustees Of The University Of Pennsylvania | Expression of β-mannanase in chloroplasts and its utilization in lignocellulosic woody biomass hydrolysis |
| PT2262896E (pt) | 2008-04-07 | 2014-04-28 | Monsanto Technology Llc | Elementos reguladores de plantas e suas utilizações |
| WO2010096588A2 (en) | 2009-02-20 | 2010-08-26 | Ventria Bioscience | Cell culture media containing combinations of proteins |
| US20120277117A1 (en) | 2009-02-27 | 2012-11-01 | Adel Zayed | Hydroponic apparatus and methods of use |
| BR112012019582B1 (pt) | 2010-01-14 | 2021-09-21 | Monsanto Technology Llc | Molécula de dna compreendendo elementos reguladores de plantas |
| KR20140016865A (ko) | 2010-08-30 | 2014-02-10 | 다우 아그로사이언시즈 엘엘씨 | 사탕수수 간균형 바이러스(scbv) 인핸서 및 식물 기능유전체학에서의 그의 용도 |
| EP4059342A1 (de) | 2010-12-17 | 2022-09-21 | Monsanto Technology LLC | Verfahren zur verbesserung der kompetenz von pflanzenzellen |
| PH12013501978A1 (en) | 2011-03-25 | 2013-11-25 | Monsanto Technology Llc | Plant regulatory elements and uses thereof |
| CA2997731C (en) | 2011-05-13 | 2020-05-26 | Monsanto Technology Llc | Plant regulatory elements and uses thereof |
| IN2014DN06986A (de) | 2012-02-29 | 2015-04-10 | Dow Agrosciences Llc | |
| US9663793B2 (en) | 2012-04-20 | 2017-05-30 | Monsanto Technology, Llc | Plant regulatory elements and uses thereof |
| AU2013362921B2 (en) | 2012-12-19 | 2018-03-01 | Monsanto Technology Llc | Plant regulatory elements and uses thereof |
| JP6580027B2 (ja) | 2013-03-14 | 2019-09-25 | モンサント テクノロジー エルエルシー | 植物調節エレメントおよびその使用 |
| CR20200120A (es) | 2013-03-14 | 2020-06-05 | Monsanto Technology Llc | Elementos regulatorios de planta y sus usos (divisional 2015-0554) |
| US11519011B2 (en) | 2015-03-26 | 2022-12-06 | The Texas A&M University System | Conversion of lignin into bioplastics and lipid fuels |
| EP3356537B1 (de) | 2015-10-02 | 2022-08-17 | Monsanto Technology LLC | Rekombinante mais-b-chromosomensequenz und verwendungen davon |
| BR112018001122B1 (pt) | 2016-03-11 | 2021-06-01 | Monsanto Technology Llc | Molécula de dna recombinante compreendendo elementos reguladores de planta e método de expressão de uma molécula de dna passível de transcrição |
| EP3462844B1 (de) | 2016-05-24 | 2024-11-27 | Monsanto Technology LLC | Pflanzenregulierungselemente und verwendungen davon |
| US11732268B2 (en) | 2016-06-28 | 2023-08-22 | Monsanto Technology Llc | Methods and compositions for use in genome modification in plants |
| WO2018005589A1 (en) | 2016-06-28 | 2018-01-04 | Cellectis | Altering expression of gene products in plants through targeted insertion of nucleic acid sequences |
| CR20240086A (es) | 2017-01-19 | 2024-09-30 | Monsanto Technology Llc | ELEMENTOS REGULATORIOS DE PLANTAS Y SUS USOS (Divisional 2019-0377) |
| US20200332311A1 (en) | 2018-01-12 | 2020-10-22 | The Texas A&M University System | Increasing plant bioproduct yield |
| MX2021002743A (es) | 2019-01-10 | 2021-05-12 | Monsanto Technology Llc | Elementos reguladores de planta y usos de los mismos. |
| CN110065267B (zh) | 2019-04-26 | 2021-03-26 | 京东方科技集团股份有限公司 | 可形变材料、形变结构、Micro-LED显示装置、应变传感器 |
| MX2021014528A (es) | 2019-05-29 | 2022-01-06 | Monsanto Technology Llc | Metodos y composiciones para generar alelos dominantes usando edicion del genoma. |
| EP3872088A1 (de) * | 2020-02-28 | 2021-09-01 | Alganelle | Verwendung von aprotinin als träger zum herstellen eines rekombinanten proteins, polypeptides oder peptids in algen |
| TW202305130A (zh) | 2021-03-26 | 2023-02-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 原核系統中環狀多核糖核苷酸之產生 |
| EP4314281A1 (de) | 2021-03-26 | 2024-02-07 | Flagship Pioneering Innovations VII, LLC | Herstellung von zirkulären polyribonukleotiden in einem eukaryotischen system |
| US20240263206A1 (en) | 2021-03-26 | 2024-08-08 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for producing circular polyribonucleotides |
| UY39997A (es) | 2021-11-01 | 2023-05-15 | Flagship Pioneering Innovations Vii Llc | Polinucleótidos para modificar organismos |
| AU2023209447A1 (en) | 2022-01-20 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Polynucleotides for modifying organisms |
| AU2023337091A1 (en) | 2022-09-09 | 2025-03-06 | Eidgenössische Technische Hochschule Zürich | Plant regulatory elements and uses thereof |
| CN121712897A (zh) | 2023-05-03 | 2026-03-20 | 旗舰创业创新第七有限责任公司 | 用于植物的分体病毒卫星rna扩增系统 |
| WO2024229385A1 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial ghabrivirales satellite rnas |
| WO2024229356A2 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial solemoviridae satellite rnas |
| CN121816422A (zh) | 2023-05-03 | 2026-04-07 | 旗舰创业创新第七有限责任公司 | 人工混合病毒属卫星rna |
| EP4705474A2 (de) | 2023-05-03 | 2026-03-11 | Flagship Pioneering Innovations VII, LLC | Künstliche tymovirale satelliten rnas |
| WO2024229347A1 (en) | 2023-05-03 | 2024-11-07 | Flagship Pioneering Innovations Vii, Llc | Artificial tombusviridae satellite rnas |
| EP4705478A1 (de) | 2023-05-03 | 2026-03-11 | Flagship Pioneering Innovations VII, LLC | Künstliche morellivirale satelliten-rnas |
| AR132591A1 (es) | 2023-05-03 | 2025-07-16 | Flagship Pioneering Innovations Vii Llc | Arn satélite de secoviridae artificiales |
| CN121712898A (zh) | 2023-05-03 | 2026-03-20 | 旗舰创业创新第七有限责任公司 | 用于植物的内源核糖核酸病毒卫星rna扩增系统 |
| US20250075226A1 (en) | 2023-08-29 | 2025-03-06 | University Of Freiburg | Proteins for regulation of symbiotic infection and associated regulatory elements |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5132213A (en) * | 1986-10-02 | 1992-07-21 | Massachusetts Institute Of Technology | Method for producing proteins and polypeptides using ubiquitin fusions |
| ATE247708T1 (de) * | 1986-10-02 | 2003-09-15 | Massachusetts Inst Technology | Verfahren zur regulierung der metabolischen stabilität von proteinen |
| JP2753274B2 (ja) * | 1988-08-24 | 1998-05-18 | 株式会社三和化学研究所 | モチリン様ポリペプチドの製法並びにそのための組換えｄｎａ及び発現用プラスミド |
| US5693507A (en) * | 1988-09-26 | 1997-12-02 | Auburn University | Genetic engineering of plant chloroplasts |
| GB8918496D0 (en) * | 1989-08-14 | 1989-09-20 | Cambridge Advanced Tech | Thylakoid targeting sequence |
| US5959177A (en) * | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
| KR910014790A (ko) * | 1990-01-10 | 1991-08-31 | 한태희 | 랩탑 컴퓨터의 기능선택방법 및 인터페이스회로 |
| AU7583691A (en) * | 1990-03-05 | 1991-10-10 | Upjohn Company, The | Protein expression via seed specific regulatory sequences |
| US5877402A (en) * | 1990-05-01 | 1999-03-02 | Rutgers, The State University Of New Jersey | DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein |
| US5773705A (en) * | 1992-12-31 | 1998-06-30 | Wisconsin Alumni Research Foundation | Ubiquitin fusion protein system for protein production in plants |
| US5576198A (en) * | 1993-12-14 | 1996-11-19 | Calgene, Inc. | Controlled expression of transgenic constructs in plant plastids |
| US5545818A (en) * | 1994-03-11 | 1996-08-13 | Calgene Inc. | Expression of Bacillus thuringiensis cry proteins in plant plastids |
| US5723755A (en) * | 1995-05-16 | 1998-03-03 | Francis E. Lefaivre | Large scale production of human or animal proteins using plant bioreactors |
| US5824870A (en) * | 1995-11-06 | 1998-10-20 | Baszczynski; Chris | Commercial production of aprotinin in plants |
| TR199900312T2 (xx) * | 1996-08-14 | 1999-04-21 | Novartis Ag | Bitki patojenik mantar�na kar�� menedici tesirli peptid. |
| WO1998011235A2 (en) * | 1996-09-12 | 1998-03-19 | Novartis Ag | Transgenic plants expressing cellulolytic enzymes |
| CA2188220A1 (en) * | 1996-10-18 | 1998-04-18 | Kimberley Kenward | Non-food crop plant bioreactor |
| US6121436A (en) * | 1996-12-13 | 2000-09-19 | Monsanto Company | Antifungal polypeptide and methods for controlling plant pathogenic fungi |
| AU733792B2 (en) * | 1997-01-17 | 2001-05-24 | Scripps Research Institute, The | RNA binding protein and binding site useful for expression of recombinant molecules |
| HUP0004228A3 (en) * | 1997-06-17 | 2002-11-28 | Monsanto Technology Llc | Expression of fructose 1,6 bisphosphate aldolase in transgenic plants |
| ES2244073T5 (es) * | 1997-08-07 | 2009-02-01 | Auburn University | Vectores universales de integracion y de expresion de cloroplastos, y plantas transformadas. |
-
1999
- 1999-07-10 DE DE69935857T patent/DE69935857T2/de not_active Expired - Lifetime
- 1999-07-10 CA CA002333148A patent/CA2333148A1/en not_active Abandoned
- 1999-07-10 PT PT99933798T patent/PT1097211E/pt unknown
- 1999-07-10 BR BR9912019-4A patent/BR9912019A/pt not_active Application Discontinuation
- 1999-07-10 WO PCT/US1999/015473 patent/WO2000003012A2/en not_active Ceased
- 1999-07-10 EP EP99933798A patent/EP1097211B1/de not_active Expired - Lifetime
- 1999-07-10 JP JP2000559233A patent/JP2002520019A/ja not_active Withdrawn
- 1999-07-10 ES ES99933798T patent/ES2286886T3/es not_active Expired - Lifetime
- 1999-07-10 DK DK99933798T patent/DK1097211T3/da active
- 1999-07-10 AT AT99933798T patent/ATE360072T1/de not_active IP Right Cessation
-
2002
- 2002-03-20 US US10/103,516 patent/US6812379B2/en not_active Expired - Fee Related
-
2004
- 2004-08-13 US US10/917,774 patent/US7259293B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20030033636A1 (en) | 2003-02-13 |
| WO2000003012A2 (en) | 2000-01-20 |
| US20050283848A1 (en) | 2005-12-22 |
| PT1097211E (pt) | 2007-07-12 |
| DK1097211T3 (da) | 2007-06-04 |
| ES2286886T3 (es) | 2007-12-01 |
| EP1097211A2 (de) | 2001-05-09 |
| DE69935857D1 (de) | 2007-05-31 |
| WO2000003012A3 (en) | 2000-06-08 |
| BR9912019A (pt) | 2002-02-19 |
| DE69935857T2 (de) | 2008-01-10 |
| WO2000003012A9 (en) | 2000-07-20 |
| JP2002520019A (ja) | 2002-07-09 |
| US7259293B2 (en) | 2007-08-21 |
| US6812379B2 (en) | 2004-11-02 |
| CA2333148A1 (en) | 2000-01-20 |
| EP1097211B1 (de) | 2007-04-18 |
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