ATE360423T1 - Verwendung von chymase hemmern gegen vaskuläre lipidablagerung - Google Patents
Verwendung von chymase hemmern gegen vaskuläre lipidablagerungInfo
- Publication number
- ATE360423T1 ATE360423T1 AT00971729T AT00971729T ATE360423T1 AT E360423 T1 ATE360423 T1 AT E360423T1 AT 00971729 T AT00971729 T AT 00971729T AT 00971729 T AT00971729 T AT 00971729T AT E360423 T1 ATE360423 T1 AT E360423T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors against
- against vascular
- chymase inhibitors
- lipid deposit
- vascular lipid
- Prior art date
Links
- 239000003601 chymase inhibitor Substances 0.000 title abstract 3
- 150000002632 lipids Chemical class 0.000 title abstract 2
- 230000002792 vascular Effects 0.000 title 1
- 229940119334 Chymase inhibitor Drugs 0.000 abstract 2
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000004218 vascular function Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31125799 | 1999-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360423T1 true ATE360423T1 (de) | 2007-05-15 |
Family
ID=18014979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00971729T ATE360423T1 (de) | 1999-11-01 | 2000-11-01 | Verwendung von chymase hemmern gegen vaskuläre lipidablagerung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6921766B1 (de) |
| EP (1) | EP1142586B1 (de) |
| KR (1) | KR20010100004A (de) |
| CN (1) | CN1335778A (de) |
| AT (1) | ATE360423T1 (de) |
| AU (1) | AU784467B2 (de) |
| CA (1) | CA2358314A1 (de) |
| DE (1) | DE60034545T2 (de) |
| ES (1) | ES2281358T3 (de) |
| HU (1) | HUP0104952A3 (de) |
| WO (1) | WO2001032214A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU3413601A (en) | 2000-02-22 | 2001-09-03 | Daiichi Asubio Pharma Co., Ltd. | Preventive or therapeutic drugs for dermatitises containing chymase inhibitors as the active ingredient |
| CN1245978C (zh) | 2000-02-22 | 2006-03-22 | 第一阿斯比奥制药株式会社 | 含有胃促胰酶抑制剂作为活性成分的预防和治疗各种与嗜酸性粒细胞增多有关的疾病的药物 |
| AU3413401A (en) | 2000-02-22 | 2001-09-03 | Daiichi Asubio Pharma Co., Ltd. | Preventive or therapeutic drugs for fibrosis containing chymase inhibitors as the active ingredient |
| WO2003007964A1 (en) * | 2001-07-18 | 2003-01-30 | Nippon Kayaku Kabushiki Kaisha | Remedial or preventive agent for cardiopathy or aneurysm containing chymase inhibitory compound |
| WO2004071531A1 (en) * | 2003-02-13 | 2004-08-26 | Licentia Oy | Use of a mast cell activation or degranulation blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia |
| AU2005310490B2 (en) | 2004-12-02 | 2012-01-19 | Daiichi Sankyo Company, Limited | 7-membered ring compound, process for producing the same, and medicinal use thereof |
| JP5117382B2 (ja) | 2006-05-31 | 2013-01-16 | 第一三共株式会社 | ７員環化合物の製造方法 |
| CN101925585B (zh) * | 2008-01-30 | 2013-04-17 | 新丰制药株式会社 | 喹唑啉-2,4-二酮衍生物及含有所述衍生物的用于预防和治疗脑神经疾病的药物组合物 |
| JP6364362B2 (ja) * | 2015-02-17 | 2018-07-25 | 学校法人福岡大学 | ヒトキマーゼ阻害剤および機能性食品、並びにヒトキマーゼの活性を阻害する方法 |
| US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5199279A (en) | 1991-08-13 | 1993-04-06 | Reynolds Martin M | Drum contact freezer system and method |
| JP2982454B2 (ja) | 1991-12-20 | 1999-11-22 | 王子製紙株式会社 | 感熱記録体 |
| CA2137832C (en) | 1992-06-12 | 2000-09-26 | Dennis J. Hoover | Inhibitors of angiotensin i chymase(s) including human heart chymase |
| WO1996004248A1 (en) | 1994-07-29 | 1996-02-15 | Suntory Limited | Imidazolidine derivative and use thereof |
| US5948785A (en) * | 1995-04-27 | 1999-09-07 | The Green Cross Corporation | Heterocyclic amide compounds and pharmaceutical use of the same |
| US5596111A (en) | 1995-06-05 | 1997-01-21 | North Dakota State University | Method for preparation of carboxylic acids |
| WO1997011941A1 (fr) | 1995-09-28 | 1997-04-03 | Suntory Limited | Derives de la quinazoline et leurs emplois |
| JP4073489B2 (ja) | 1996-05-24 | 2008-04-09 | ニューロサーチ・アクティーゼルスカブ | 酸性基を有するフエニル誘導体、その製造方法及びそれをクロライドチャンネル遮断剤として使用する方法 |
| AUPO062696A0 (en) * | 1996-06-24 | 1996-07-18 | Fujisawa Pharmaceutical Co., Ltd. | Novel compounds |
| KR20000052775A (ko) | 1996-10-25 | 2000-08-25 | 가마쿠라 아키오 | 신규한 헤테로사이클릭 아미드 화합물 및 의약으로서의 그의 용도 |
| EP1055683A4 (de) | 1998-02-17 | 2007-07-25 | Nippon Kayaku Kk | Neuartiges acetamid-derivat und verwendung desselben |
| HUP0103387A3 (en) * | 1998-08-21 | 2002-07-29 | Daiichi Asubio Pharma Co Ltd | Quinazoline derivatives preparation thereof, medicament containing them and their intermediates |
| WO2000032587A1 (en) * | 1998-12-01 | 2000-06-08 | Meiji Seika Kaisha, Ltd. | Sf2809-i, ii, iii, iv, v and vi substances exhibiting chymase-inhibiting activities |
-
2000
- 2000-11-01 US US09/869,360 patent/US6921766B1/en not_active Expired - Fee Related
- 2000-11-01 DE DE60034545T patent/DE60034545T2/de not_active Expired - Lifetime
- 2000-11-01 WO PCT/JP2000/007706 patent/WO2001032214A1/ja not_active Ceased
- 2000-11-01 HU HU0104952A patent/HUP0104952A3/hu unknown
- 2000-11-01 ES ES00971729T patent/ES2281358T3/es not_active Expired - Lifetime
- 2000-11-01 CA CA002358314A patent/CA2358314A1/en not_active Abandoned
- 2000-11-01 AT AT00971729T patent/ATE360423T1/de not_active IP Right Cessation
- 2000-11-01 AU AU10536/01A patent/AU784467B2/en not_active Ceased
- 2000-11-01 CN CN00802476A patent/CN1335778A/zh active Pending
- 2000-11-01 KR KR1020017008302A patent/KR20010100004A/ko not_active Ceased
- 2000-11-01 EP EP00971729A patent/EP1142586B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010100004A (ko) | 2001-11-09 |
| EP1142586B1 (de) | 2007-04-25 |
| EP1142586A1 (de) | 2001-10-10 |
| HUP0104952A3 (en) | 2006-02-28 |
| CN1335778A (zh) | 2002-02-13 |
| AU1053601A (en) | 2001-05-14 |
| ES2281358T3 (es) | 2007-10-01 |
| US6921766B1 (en) | 2005-07-26 |
| AU784467B2 (en) | 2006-04-06 |
| WO2001032214A1 (en) | 2001-05-10 |
| CA2358314A1 (en) | 2001-05-10 |
| DE60034545T2 (de) | 2007-10-25 |
| DE60034545D1 (de) | 2007-06-06 |
| EP1142586A4 (de) | 2003-03-19 |
| HUP0104952A2 (en) | 2002-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |