ES2155134T3 - Derivados de imidazolidina y su utilizacion. - Google Patents

Derivados de imidazolidina y su utilizacion.

Info

Publication number
ES2155134T3
ES2155134T3 ES95926500T ES95926500T ES2155134T3 ES 2155134 T3 ES2155134 T3 ES 2155134T3 ES 95926500 T ES95926500 T ES 95926500T ES 95926500 T ES95926500 T ES 95926500T ES 2155134 T3 ES2155134 T3 ES 2155134T3
Authority
ES
Spain
Prior art keywords
rent
alquilpiperazinil
sterified
ceno
oalquenilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95926500T
Other languages
English (en)
Inventor
Harukazu Fukami
Motoo Sumida
Shinjiro Niwata
Saki Kakutani
Masayuki Saitoh
Hiroshi Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2155134T3 publication Critical patent/ES2155134T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

DERIVADO DE IMIDAZOLIDINA REPRESENTADO POR LA FORMULA GENERAL (I) Y MEDICINAS QUE LO CONTIENEN COMO EL INGREDIENTE ACTIVO, EJEMPLOS REPRESENTATIVOS QUE INCLUYEN UN INHIBIDOR DE QUIMASA Y UN PREVENTIVO O REMEDIO PARA ENFERMEDADES CIRCULATORIAS O CARDIACAS CAUSADAS POR PALPITACIONES ANORMALES INDUCIDAS POR LA ANGIOTENSINA II, DONDE A Y B REPRESENTAN CADA UNO UN GRUPO DE HIDROCARBURO AROMATICO QUE PUEDE SER SUSTITUIDO POR UNO O MAS SUSTITUYENTES SELECCIONADOS DE ENTRE HALOGENO, C ALQUILO, ALCOXI, ALQUILENODIOXI, FENOXI, NITRO,CIANO, FENILO, ALCANOILAMINO, CARBOXILO QUE PUEDE SER ESTERIFICADO CON ALQUILO O ALQUENILO, CARBOXIALQUILO QUE PUEDE SER ESTERIFICADO CON ALQUILO O ALQUENILO, CARBOXIALQUILOXI QUE SER ESTERIFICADO CON ALQUILO OALQUENILO, N-ALQUILPIPERAZINIL CARBONILO, N-ALQUILPIPERAZINIL-CARBONIALQUILO, N-ALQUILOPIPERAZINIL-CARBONILALQUILOXI Y MORFOLINOCARBONILO; X REPRESENTA OXIGENO O SULFURO.
ES95926500T 1994-07-29 1995-07-26 Derivados de imidazolidina y su utilizacion. Expired - Lifetime ES2155134T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20786794 1994-07-29
JP33370694 1994-12-07

Publications (1)

Publication Number Publication Date
ES2155134T3 true ES2155134T3 (es) 2001-05-01

Family

ID=26516513

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95926500T Expired - Lifetime ES2155134T3 (es) 1994-07-29 1995-07-26 Derivados de imidazolidina y su utilizacion.

Country Status (7)

Country Link
US (1) US5691335A (es)
EP (1) EP0721944B1 (es)
AT (1) ATE198743T1 (es)
AU (1) AU3086095A (es)
DE (1) DE69519921T2 (es)
ES (1) ES2155134T3 (es)
WO (1) WO1996004248A1 (es)

Families Citing this family (42)

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US5912261A (en) * 1994-12-20 1999-06-15 Nippon Zoki Pharmaceutical Co., Ltd. Carboxyalkyl heterocyclic derivatives
US6197806B1 (en) 1995-12-20 2001-03-06 Nippon Zoki Pharmaceutical Co., Ltd. Eliminating agent for activated oxygen and free radicals
JPH10182460A (ja) * 1996-12-27 1998-07-07 Nippon Zoki Pharmaceut Co Ltd ３−デオキシグルコソン生成阻害剤
US20050267148A1 (en) * 1998-07-15 2005-12-01 Teijin Limited Benzimidazole derivative
HUP0103256A3 (en) 1998-07-15 2002-05-28 Teijin Ltd Thiobenzimidazole derivatives and pharmaceutical compositions containing the compounds
KR100381214B1 (ko) * 1998-08-10 2003-09-22 주식회사 엘지생명과학 항암제로유용한이미다졸리딘-2,4-디온유도체및그의제조방법
WO2000010605A2 (en) * 1998-08-20 2000-03-02 Senju Pharmaceutical Co., Ltd. Preventives or remedies for eye circulatory failure
ES2259476T3 (es) * 1998-08-21 2006-10-01 Daiichi Asubio Pharma Co., Ltd. Derivados de quinazolina y sus aplicaciones farmaceuticas.
AU754989B2 (en) 1998-11-16 2002-11-28 Nippon Zoki Pharmaceutical Co., Ltd. A therapeutic agent for intractable vasculitis
AU1414000A (en) * 1998-12-01 2000-06-19 Meiji Seika Kaisha Ltd. Sf2809-i, ii, iii, iv, v and vi substances exhibiting chymase-inhibiting activities
AU7954900A (en) * 1999-10-25 2001-05-08 Senju Pharmaceutical Co., Ltd. Tension-relieving agents for ciliary muscle
ATE360423T1 (de) 1999-11-01 2007-05-15 Daiichi Asubio Pharma Co Ltd Verwendung von chymase hemmern gegen vaskuläre lipidablagerung
US6300503B1 (en) * 1999-12-17 2001-10-09 Dixie Chemical Company Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same
CN1366461A (zh) 2000-02-22 2002-08-28 三得利株式会社 含有胃促胰酶抑制剂作为有效成分的预防或治疗纤维变性的药物
EP1174151B1 (en) 2000-02-22 2007-01-24 Daiichi Asubio Pharma Co., Ltd. Therapeutic treatment of eosinophilia using chymase inhibitors as the active ingredient
CN1245979C (zh) * 2000-02-22 2006-03-22 第一阿斯比奥制药株式会社 含有胃促胰酶抑制剂作为有效成分的预防和治疗皮炎的药物
JP4711523B2 (ja) 2001-02-13 2011-06-29 日本臓器製薬株式会社 低アルブミン血症改善剤
WO2002083649A1 (en) * 2001-04-11 2002-10-24 Senju Pharmaceutical Co., Ltd. Novel imidazolidinedione derivatives and use thereof as drugs
US20060148833A1 (en) * 2002-07-30 2006-07-06 Schroff Robert W Use of chymase inhibitors for the prevention and/or treatment of arterio-venous graft failure
FR2845383B1 (fr) * 2002-10-04 2004-12-31 Fournier Lab Sa Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique
FR2845384B1 (fr) * 2002-10-04 2004-12-31 Fournier Lab Sa Composes derives de la 2-thiohydantoine et leur utilisation en therapeutique
AU2003279442A1 (en) * 2002-10-04 2004-04-23 Laboratoires Fournier S.A. 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes
CN101439039B (zh) 2003-05-09 2012-06-13 东丽株式会社 增强剂
US7423155B2 (en) 2003-11-14 2008-09-09 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US7361767B2 (en) * 2003-11-14 2008-04-22 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
ATE502298T1 (de) 2003-12-19 2011-04-15 Univ California Verfahren und materialien zur beurteilung von prostatakrebstherapien
NZ550102A (en) 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
US7544756B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
SI2656842T1 (sl) 2006-03-27 2016-10-28 The Regents Of The University Of California Modulator androgenih receptorjev za zdravljenje raka prostate in bolezni, povezanih z androgenimi receptorji
WO2007127010A2 (en) 2006-03-29 2007-11-08 The Regents Of The University Of California Diarylthiohydantoin compounds
EP2620432A3 (en) 2007-10-26 2013-12-18 The Regents Of the University of California Diarylhydantoin compounds
US8501749B2 (en) 2009-01-30 2013-08-06 Boehringer Ingelheim International Gmbh Azaquinazolinediones chymase inhibitors
AU2011218173C1 (en) 2010-02-16 2015-04-16 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
NZ744456A (en) 2012-09-26 2019-09-27 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
PL2945628T3 (pl) 2013-01-15 2020-09-21 Aragon Pharmaceuticals, Inc. Modulator receptorów androgenowych w skojarzeniu z octanem abirateronu i prednizonem do leczenia nowotworu stercza
EP3066096A1 (de) * 2013-11-08 2016-09-14 Bayer Pharma Aktiengesellschaft Substituierte uracile als chymase inhibitoren
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
ES2844184T3 (es) * 2016-06-14 2021-07-21 Bristol Myers Squibb Co 4-hidroxi-3-sulfonilpiridin-2(1H)-onas como agonistas del receptor de APJ
US10508104B2 (en) * 2016-06-14 2019-12-17 Bristol-Myers Squibb Company 6-hydroxy-5-(phenyl/heteroarylsulfonyl)pyrimidin-4(1H)-one as APJ agonists
WO2019023448A1 (en) * 2017-07-26 2019-01-31 Emory University INHIBITORS OF NADPH OXIDASE AND THEIR USE
US10702508B2 (en) 2017-10-16 2020-07-07 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
DE1207391B (de) * 1962-05-30 1965-12-23 Degussa Verfahren zur Herstellung von 3-Benzoyl-5, 5-dimethylhydantoinen
US4166124A (en) * 1970-05-15 1979-08-28 U.S. Philips Corporation Insecticidal 2,6-dihalobenzoyl urea derivatives
JPS5371073A (en) * 1976-12-03 1978-06-24 Sumitomo Chem Co Ltd 1-cyclic alkyl carbonyl-3(3,5-dihalogenophenyl)hydantoin derivs., process fo r their preparation and fungicides for agriculture and horti culture contg. the same as active constituents
JPS5855468A (ja) * 1981-09-25 1983-04-01 Sumitomo Chem Co Ltd ５−クロロヒダントイン誘導体、その製造法およびそれを有効成分として含有する殺虫剤
US4474796A (en) * 1983-02-04 1984-10-02 Sumitomo Chemical Company, Limited Insecticidal substituted hydantoins
JPH068281B2 (ja) * 1985-09-19 1994-02-02 持田製薬株式会社 ヒダントイン誘導体及びそれを有効成分とするアルド−スレダクタ−ゼ阻害剤

Also Published As

Publication number Publication date
WO1996004248A1 (en) 1996-02-15
EP0721944B1 (en) 2001-01-17
DE69519921D1 (de) 2001-02-22
DE69519921T2 (de) 2001-06-13
EP0721944A4 (en) 1997-01-02
EP0721944A1 (en) 1996-07-17
ATE198743T1 (de) 2001-02-15
AU3086095A (en) 1996-03-04
US5691335A (en) 1997-11-25

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