ATE360616T1 - Kristalline form von quinapril hydrochlorid und verfahren zu dessen herstellung - Google Patents

Kristalline form von quinapril hydrochlorid und verfahren zu dessen herstellung

Info

Publication number: ATE360616T1
Authority: AT; Austria
Prior art keywords: quinapril hydrochloride; formula; nitroalkane; quinapril; solvate
Prior art date: 2002-12-16

Application number

AT02796958T

Other languages

English (en)

Inventor

Girij P Singh

Taluka Mulshi Village

Govind S Jubilant Organo Rawat

Vilas N Dhake

Sagar P Nehate

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-16

Filing date

2002-12-16

Publication date

2007-05-15

2002-12-16 Application filed by Lupin Ltd filed Critical Lupin Ltd

2007-05-15 Application granted granted Critical

2007-05-15 Publication of ATE360616T1 publication Critical patent/ATE360616T1/de

Links

229960003042 quinapril hydrochloride Drugs 0.000 title abstract 10
IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 title abstract 9
238000000034 method Methods 0.000 title abstract 3
125000004971 nitroalkyl group Chemical group 0.000 abstract 5
239000002904 solvent Substances 0.000 abstract 5
239000012453 solvate Substances 0.000 abstract 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
230000001476 alcoholic effect Effects 0.000 abstract 3
-1 diketopiperazine compound Chemical class 0.000 abstract 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000012535 impurity Substances 0.000 abstract 2
238000002441 X-ray diffraction Methods 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 abstract 1
LYGJENNIWJXYER-BJUDXGSMSA-N nitromethane Chemical group [11CH3][N+]([O-])=O LYGJENNIWJXYER-BJUDXGSMSA-N 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
229960001455 quinapril Drugs 0.000 abstract 1
JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT02796958T 2002-12-16 2002-12-16 Kristalline form von quinapril hydrochlorid und verfahren zu dessen herstellung ATE360616T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2002/000235 WO2004054980A1 (en)	2002-12-16	2002-12-16	Crystalline form of quinapril hydrochloride and process for preparing the same

Publications (1)

Publication Number	Publication Date
ATE360616T1 true ATE360616T1 (de)	2007-05-15

Family

ID=32587693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02796958T ATE360616T1 (de)	2002-12-16	2002-12-16	Kristalline form von quinapril hydrochlorid und verfahren zu dessen herstellung

Country Status (12)

Country	Link
US (1)	US7482361B2 (de)
EP (1)	EP1572661B1 (de)
AT (1)	ATE360616T1 (de)
AU (1)	AU2002361494A1 (de)
CA (1)	CA2510773C (de)
CY (1)	CY1106742T1 (de)
DE (1)	DE60219837T2 (de)
DK (1)	DK1572661T5 (de)
ES (1)	ES2286325T3 (de)
PT (1)	PT1572661E (de)
SI (1)	SI1572661T1 (de)
WO (1)	WO2004054980A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CL2004000541A1 (es) *	2003-03-31	2005-02-04	Warner Lambert Co	Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva
WO2009113081A1 (en) *	2008-03-10	2009-09-17	Lupin Limited	Tris (hydroxymethyl ) amino methane salt of quinapril and ramipril

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4344949A (en)	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (de)	1981-03-19	1985-05-11	Usv Pharma Corp
EP0065301A1 (de)	1981-05-18	1982-11-24	Merck & Co. Inc.	Derivate der Isochinolin-Carbonsäuren, Verfahren zu ihrer Herstellung und diese enthaltendes Arzneimittel
US4761479A (en)	1987-03-30	1988-08-02	Warner-Lambert Company	Crystalline quinapril and a process for producing the same
ES2122941B1 (es)	1997-05-29	1999-07-01	Esteve Quimica Sa	Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

2002
- 2002-12-16 AU AU2002361494A patent/AU2002361494A1/en not_active Abandoned
- 2002-12-16 US US10/538,858 patent/US7482361B2/en not_active Expired - Fee Related
- 2002-12-16 EP EP02796958A patent/EP1572661B1/de not_active Expired - Lifetime
- 2002-12-16 WO PCT/IN2002/000235 patent/WO2004054980A1/en not_active Ceased
- 2002-12-16 AT AT02796958T patent/ATE360616T1/de not_active IP Right Cessation
- 2002-12-16 PT PT02796958T patent/PT1572661E/pt unknown
- 2002-12-16 ES ES02796958T patent/ES2286325T3/es not_active Expired - Lifetime
- 2002-12-16 DK DK02796958T patent/DK1572661T5/da active
- 2002-12-16 CA CA2510773A patent/CA2510773C/en not_active Expired - Fee Related
- 2002-12-16 DE DE60219837T patent/DE60219837T2/de not_active Expired - Fee Related
- 2002-12-16 SI SI200230575T patent/SI1572661T1/sl unknown
2007
- 2007-07-19 CY CY20071100960T patent/CY1106742T1/el unknown

Also Published As

Publication number	Publication date
DE60219837T2 (de)	2008-01-17
WO2004054980A1 (en)	2004-07-01
CA2510773A1 (en)	2004-07-01
US7482361B2 (en)	2009-01-27
DK1572661T3 (da)	2007-09-03
AU2002361494A1 (en)	2004-07-09
EP1572661A1 (de)	2005-09-14
CY1106742T1 (el)	2012-05-23
CA2510773C (en)	2010-04-13
SI1572661T1 (sl)	2007-10-31
US20060058347A1 (en)	2006-03-16
DE60219837D1 (de)	2007-06-06
DK1572661T5 (da)	2007-11-05
ES2286325T3 (es)	2007-12-01
PT1572661E (pt)	2007-07-24
EP1572661B1 (de)	2007-04-25

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Legal Events

Date

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Title

Description

2007-10-15

UEP

Publication of translation of european patent specification

Ref document number: 1572661

Country of ref document: EP

2010-09-15

REN

Ceased due to non-payment of the annual fee