DK1572661T5 - Krystallinsk form af quinaprilhydrochlorid og fremgangsmåde til fremstilling af samme - Google Patents

Krystallinsk form af quinaprilhydrochlorid og fremgangsmåde til fremstilling af samme

Info

Publication number: DK1572661T5
Authority: DK; Denmark
Prior art keywords: quinapril hydrochloride; formula; nitroalkane; quinapril; solvate
Prior art date: 2002-12-16

Application number

DK02796958T

Other languages

English (en)

Other versions

DK1572661T3 (da

Inventor

Girij P Singh

Vilas N Dhake

Sagar P Nehate

Govind S Rawat

Original Assignee

Lupin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-16

Filing date

2002-12-16

Publication date

2007-11-05

2002-12-16 Application filed by Lupin Ltd filed Critical Lupin Ltd

2007-09-03 Publication of DK1572661T3 publication Critical patent/DK1572661T3/da

2007-11-05 Application granted granted Critical

2007-11-05 Publication of DK1572661T5 publication Critical patent/DK1572661T5/da

Links

229960003042 quinapril hydrochloride Drugs 0.000 title abstract 10
IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 title abstract 9
238000000034 method Methods 0.000 title abstract 3
125000004971 nitroalkyl group Chemical group 0.000 abstract 5
239000002904 solvent Substances 0.000 abstract 5
239000012453 solvate Substances 0.000 abstract 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
230000001476 alcoholic effect Effects 0.000 abstract 3
-1 diketopiperazine compound Chemical class 0.000 abstract 3
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000012535 impurity Substances 0.000 abstract 2
238000002441 X-ray diffraction Methods 0.000 abstract 1
230000003197 catalytic effect Effects 0.000 abstract 1
238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 abstract 1
LYGJENNIWJXYER-BJUDXGSMSA-N nitromethane Chemical group [11CH3][N+]([O-])=O LYGJENNIWJXYER-BJUDXGSMSA-N 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
229960001455 quinapril Drugs 0.000 abstract 1
JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK02796958T 2002-12-16 2002-12-16 Krystallinsk form af quinaprilhydrochlorid og fremgangsmåde til fremstilling af samme DK1572661T5 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2002/000235 WO2004054980A1 (en)	2002-12-16	2002-12-16	Crystalline form of quinapril hydrochloride and process for preparing the same

Publications (2)

Publication Number	Publication Date
DK1572661T3 DK1572661T3 (da)	2007-09-03
DK1572661T5 true DK1572661T5 (da)	2007-11-05

Family

ID=32587693

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02796958T DK1572661T5 (da)	2002-12-16	2002-12-16	Krystallinsk form af quinaprilhydrochlorid og fremgangsmåde til fremstilling af samme

Country Status (12)

Country	Link
US (1)	US7482361B2 (da)
EP (1)	EP1572661B1 (da)
AT (1)	ATE360616T1 (da)
AU (1)	AU2002361494A1 (da)
CA (1)	CA2510773C (da)
CY (1)	CY1106742T1 (da)
DE (1)	DE60219837T2 (da)
DK (1)	DK1572661T5 (da)
ES (1)	ES2286325T3 (da)
PT (1)	PT1572661E (da)
SI (1)	SI1572661T1 (da)
WO (1)	WO2004054980A1 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CL2004000541A1 (es)	2003-03-31	2005-02-04	Warner Lambert Co	Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva
WO2009113081A1 (en) *	2008-03-10	2009-09-17	Lupin Limited	Tris (hydroxymethyl ) amino methane salt of quinapril and ramipril

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4344949A (en) *	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (da)	1981-03-19	1985-05-11	Usv Pharma Corp
EP0065301A1 (en)	1981-05-18	1982-11-24	Merck & Co. Inc.	Isoquinoline carboxylic acid derivates, process for preparing and pharmaceutical composition containing the same
US4761479A (en) *	1987-03-30	1988-08-02	Warner-Lambert Company	Crystalline quinapril and a process for producing the same
ES2122941B1 (es)	1997-05-29	1999-07-01	Esteve Quimica Sa	Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

2002
- 2002-12-16 EP EP02796958A patent/EP1572661B1/en not_active Expired - Lifetime
- 2002-12-16 ES ES02796958T patent/ES2286325T3/es not_active Expired - Lifetime
- 2002-12-16 SI SI200230575T patent/SI1572661T1/sl unknown
- 2002-12-16 US US10/538,858 patent/US7482361B2/en not_active Expired - Fee Related
- 2002-12-16 WO PCT/IN2002/000235 patent/WO2004054980A1/en not_active Ceased
- 2002-12-16 AU AU2002361494A patent/AU2002361494A1/en not_active Abandoned
- 2002-12-16 PT PT02796958T patent/PT1572661E/pt unknown
- 2002-12-16 DE DE60219837T patent/DE60219837T2/de not_active Expired - Fee Related
- 2002-12-16 CA CA2510773A patent/CA2510773C/en not_active Expired - Fee Related
- 2002-12-16 AT AT02796958T patent/ATE360616T1/de not_active IP Right Cessation
- 2002-12-16 DK DK02796958T patent/DK1572661T5/da active
2007
- 2007-07-19 CY CY20071100960T patent/CY1106742T1/el unknown

Also Published As

Publication number	Publication date
CY1106742T1 (el)	2012-05-23
WO2004054980A1 (en)	2004-07-01
CA2510773C (en)	2010-04-13
ES2286325T3 (es)	2007-12-01
DK1572661T3 (da)	2007-09-03
ATE360616T1 (de)	2007-05-15
EP1572661A1 (en)	2005-09-14
US20060058347A1 (en)	2006-03-16
EP1572661B1 (en)	2007-04-25
DE60219837D1 (de)	2007-06-06
PT1572661E (pt)	2007-07-24
CA2510773A1 (en)	2004-07-01
DE60219837T2 (de)	2008-01-17
US7482361B2 (en)	2009-01-27
AU2002361494A1 (en)	2004-07-09
SI1572661T1 (sl)	2007-10-31

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