ATE360647T1 - Verfahren zur aufreinigung von il-18-bindendem protein - Google Patents

Verfahren zur aufreinigung von il-18-bindendem protein

Info

Publication number
ATE360647T1
ATE360647T1 AT04798163T AT04798163T ATE360647T1 AT E360647 T1 ATE360647 T1 AT E360647T1 AT 04798163 T AT04798163 T AT 04798163T AT 04798163 T AT04798163 T AT 04798163T AT E360647 T1 ATE360647 T1 AT E360647T1
Authority
AT
Austria
Prior art keywords
binding protein
purifying
purification
fluid
relates
Prior art date
Application number
AT04798163T
Other languages
English (en)
Inventor
Mara Rossi
Thierry Ziegler
Laure Valognes
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Application granted granted Critical
Publication of ATE360647T1 publication Critical patent/ATE360647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04798163T 2003-11-05 2004-11-04 Verfahren zur aufreinigung von il-18-bindendem protein ATE360647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51744703P 2003-11-05 2003-11-05
EP03104092 2003-11-05

Publications (1)

Publication Number Publication Date
ATE360647T1 true ATE360647T1 (de) 2007-05-15

Family

ID=34924126

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04798163T ATE360647T1 (de) 2003-11-05 2004-11-04 Verfahren zur aufreinigung von il-18-bindendem protein

Country Status (19)

Country Link
US (1) US7820800B2 (de)
EP (1) EP1689777B1 (de)
JP (1) JP4741504B2 (de)
AT (1) ATE360647T1 (de)
AU (1) AU2004291341B2 (de)
CA (1) CA2544146C (de)
CY (1) CY1106683T1 (de)
DE (1) DE602004006157T2 (de)
DK (1) DK1689777T3 (de)
ES (1) ES2285543T3 (de)
HR (1) HRP20070196T3 (de)
IL (1) IL175431A (de)
ME (1) ME01198B (de)
NO (1) NO330538B1 (de)
PL (1) PL1689777T3 (de)
PT (1) PT1689777E (de)
RS (1) RS50516B (de)
SI (1) SI1689777T1 (de)
WO (1) WO2005049649A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE399872T1 (de) 2003-03-11 2008-07-15 Serono Lab Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
DK1622939T3 (da) * 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
ATE484591T1 (de) * 2003-10-21 2010-10-15 Merck Serono Sa Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein- expression
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
DE602005002829T2 (de) * 2004-03-01 2008-07-10 Ares Trading S.A. Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
AU2005259269B2 (en) 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
US8129508B2 (en) 2005-04-11 2012-03-06 Medarex, Inc. Protein purification using HCIC and ion exchange chromatography
ES2385639T3 (es) 2005-06-03 2012-07-27 Ares Trading S.A. Producción de una proteína de unión a IL-18 recombinante
AU2006256763B2 (en) * 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein
CN101874042B9 (zh) 2007-09-26 2019-01-01 中外制药株式会社 利用cdr的氨基酸取代来改变抗体等电点的方法
AU2009204998B2 (en) 2008-01-18 2014-03-27 F. Hoffmann-La Roche Ag Purification of non-glycosylated proteins
EP2275443B1 (de) 2008-04-11 2015-12-02 Chugai Seiyaku Kabushiki Kaisha Antigen bindendes molekül, das dazu in der lage ist, wiederholt zwei oder mehr antigenmoleküle zu binden
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
WO2011156369A2 (en) * 2010-06-07 2011-12-15 Dr. Reddy's Laboratories Ltd. Purification of modified cytokines
TWI654204B (zh) 2010-11-30 2019-03-21 Chugai Seiyaku Kabushiki Kaisha 具有鈣依存性的抗原結合能力之抗體
CA2827923C (en) 2011-02-25 2021-11-23 Chugai Seiyaku Kabushiki Kaisha Fc.gamma.riib-specific fc antibody
JP6147726B2 (ja) 2011-03-29 2017-06-14 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ タンパク質精製のためのバッファー系
TW201817744A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
US20150050269A1 (en) 2011-09-30 2015-02-19 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
CA3233142A1 (en) 2011-11-30 2013-06-06 Chugai Seiyaku Kabushiki Kaisha Drug containing carrier into cell for forming immune complex
WO2013125667A1 (ja) 2012-02-24 2013-08-29 中外製薬株式会社 FcγRIIBを介して抗原の消失を促進する抗原結合分子
TWI636062B (zh) 2013-04-02 2018-09-21 中外製藥股份有限公司 Fc region variant
SI3116891T1 (sl) * 2014-03-10 2020-07-31 Richter Gedeon Nyrt. Čiščenje imunoglobulina z uporabo predčistilnih stopenj
CN107001411B (zh) * 2014-12-15 2021-07-23 默克专利股份公司 从粗溶液捕获靶分子
NZ730607A (en) 2014-12-19 2022-07-01 Chugai Pharmaceutical Co Ltd Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
SG10201710322VA (en) 2014-12-19 2018-02-27 Chugai Pharmaceutical Co Ltd Anti-c5 antibodies and methods of use
WO2016125495A1 (en) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
TWI873632B (zh) 2015-02-27 2025-02-21 日商中外製藥股份有限公司 Il-6受體抗體用於製備醫藥組成物的用途
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
BR112019001902A2 (pt) 2016-08-05 2019-07-09 Chugai Seiyaku Kabushiki Kaisha composição para profilaxia ou tratamento de doenças relacionadas à il-8
JP7191833B2 (ja) 2017-01-30 2022-12-19 中外製薬株式会社 抗スクレロスチン抗体およびその使用
US11851486B2 (en) 2017-05-02 2023-12-26 National Center Of Neurology And Psychiatry Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2340579A1 (en) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin 18-binding protein
JP4216950B2 (ja) * 1998-09-01 2009-01-28 株式会社林原生物化学研究所 インターロイキン−１８結合蛋白質
US20020052475A1 (en) * 2000-07-20 2002-05-02 Schering Ag High affinity soluble interleukin-18 receptor
DK1392830T3 (da) * 2001-03-08 2006-05-08 Ares Trading Sa Interleukin-18 mutanter, deres fremstilling og anvendelse
CA2451955C (en) * 2001-06-26 2015-09-29 Abgenix, Inc. Antibodies to opgl
EP1495055B1 (de) * 2002-04-18 2013-08-14 Genencor International, Inc. Herstellung von funktionellen antikörpern in filamentösen pilzen
ATE399872T1 (de) 2003-03-11 2008-07-15 Serono Lab Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
DK1622939T3 (da) 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
ATE484591T1 (de) 2003-10-21 2010-10-15 Merck Serono Sa Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein- expression
DE602005002829T2 (de) 2004-03-01 2008-07-10 Ares Trading S.A. Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen
AU2005259269B2 (en) 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
ES2385639T3 (es) * 2005-06-03 2012-07-27 Ares Trading S.A. Producción de una proteína de unión a IL-18 recombinante
AU2006256763B2 (en) 2005-06-10 2012-08-02 Ares Trading S.A. Process for the purification of IL-18 binding protein

Also Published As

Publication number Publication date
EP1689777A1 (de) 2006-08-16
AU2004291341A1 (en) 2005-06-02
US20070037734A1 (en) 2007-02-15
DK1689777T3 (da) 2007-06-11
IL175431A (en) 2011-02-28
CA2544146C (en) 2012-10-02
PT1689777E (pt) 2007-05-31
DE602004006157D1 (de) 2007-06-06
NO330538B1 (no) 2011-05-09
ES2285543T3 (es) 2007-11-16
CY1106683T1 (el) 2012-05-23
US7820800B2 (en) 2010-10-26
IL175431A0 (en) 2006-09-05
PL1689777T3 (pl) 2007-09-28
ME01198B (me) 2013-03-20
AU2004291341B2 (en) 2010-08-05
RS50516B (sr) 2010-05-07
SI1689777T1 (sl) 2007-08-31
CA2544146A1 (en) 2005-06-02
NO20062545L (no) 2006-08-03
WO2005049649A1 (en) 2005-06-02
JP4741504B2 (ja) 2011-08-03
HRP20070196T3 (hr) 2007-06-30
JP2007533651A (ja) 2007-11-22
EP1689777B1 (de) 2007-04-25
DE602004006157T2 (de) 2008-01-03

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