ATE360647T1 - Verfahren zur aufreinigung von il-18-bindendem protein - Google Patents

Verfahren zur aufreinigung von il-18-bindendem protein

Info

Publication number
ATE360647T1
ATE360647T1 AT04798163T AT04798163T ATE360647T1 AT E360647 T1 ATE360647 T1 AT E360647T1 AT 04798163 T AT04798163 T AT 04798163T AT 04798163 T AT04798163 T AT 04798163T AT E360647 T1 ATE360647 T1 AT E360647T1
Authority
AT
Austria
Prior art keywords
binding protein
purifying
purification
fluid
relates
Prior art date
Application number
AT04798163T
Other languages
English (en)
Inventor
Mara Rossi
Thierry Ziegler
Laure Valognes
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Application granted granted Critical
Publication of ATE360647T1 publication Critical patent/ATE360647T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04798163T 2003-11-05 2004-11-04 Verfahren zur aufreinigung von il-18-bindendem protein ATE360647T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51744703P 2003-11-05 2003-11-05
EP03104092 2003-11-05

Publications (1)

Publication Number Publication Date
ATE360647T1 true ATE360647T1 (de) 2007-05-15

Family

ID=34924126

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04798163T ATE360647T1 (de) 2003-11-05 2004-11-04 Verfahren zur aufreinigung von il-18-bindendem protein

Country Status (19)

Country Link
US (1) US7820800B2 (de)
EP (1) EP1689777B1 (de)
JP (1) JP4741504B2 (de)
AT (1) ATE360647T1 (de)
AU (1) AU2004291341B2 (de)
CA (1) CA2544146C (de)
CY (1) CY1106683T1 (de)
DE (1) DE602004006157T2 (de)
DK (1) DK1689777T3 (de)
ES (1) ES2285543T3 (de)
HR (1) HRP20070196T3 (de)
IL (1) IL175431A (de)
ME (1) ME01198B (de)
NO (1) NO330538B1 (de)
PL (1) PL1689777T3 (de)
PT (1) PT1689777E (de)
RS (1) RS50516B (de)
SI (1) SI1689777T1 (de)
WO (1) WO2005049649A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1601776E (pt) 2003-03-11 2008-09-17 Serono Lab Vectores de expressão que compreendem o promotor ie2 do mcmv
DK1622939T3 (da) * 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
JP4745972B2 (ja) * 2003-10-21 2011-08-10 メルク セローノ ソシエテ アノニム クロマチンインスレーターとして作用する極小ｄｎａ配列、及びタンパク質発現におけるその使用
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
PL1720979T3 (pl) * 2004-03-01 2008-03-31 Ares Trading Sa Zastosowanie podłoża pozbawionego surowicy do hodowli komórkowej do wytwarzania IL-18BP w komórkach ssaków
DE602005009827D1 (de) 2004-06-29 2008-10-30 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
EP1869067A1 (de) * 2005-04-11 2007-12-26 Medarex, Inc. Proteinreinigung mittels hcic und ionenaustauschchromatographie
EP2267024B1 (de) * 2005-06-03 2012-05-09 Ares Trading S.A. Herstellung von rekombinantem Il-18 bindendem Protein
SI1891088T1 (sl) * 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
MX336725B (es) 2007-09-26 2016-01-28 Chugai Pharmaceutical Co Ltd Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr).
EP2245044A2 (de) 2008-01-18 2010-11-03 F. Hoffmann-La Roche AG Reinigung nicht-glycosylierter proteine
TWI700293B (zh) 2008-04-11 2020-08-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗體
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
WO2011156369A2 (en) * 2010-06-07 2011-12-15 Dr. Reddy's Laboratories Ltd. Purification of modified cytokines
KR102568454B1 (ko) 2010-11-30 2023-08-18 추가이 세이야쿠 가부시키가이샤 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자
EP3604330A1 (de) 2011-02-25 2020-02-05 Chugai Seiyaku Kabushiki Kaisha Fcgammariib-spezifischer fc-antikörper
DK2691411T3 (da) 2011-03-29 2020-05-11 Glaxosmithkline Llc Buffersystem til proteinoprensning
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TW201817745A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
BR112014013081A2 (pt) 2011-11-30 2020-10-20 Chugai Seiyaku Kabushiki Kaisha veículo contendo fármaco em célula para formação de um complexo imune
AU2014250434B2 (en) 2013-04-02 2019-08-08 Chugai Seiyaku Kabushiki Kaisha Fc region variant
JP6293907B2 (ja) * 2014-03-10 2018-03-14 リヒター ゲデオン エヌワイアールティー． プレクリーニング工程を用いた免疫グロブリンの精製
US10617975B2 (en) 2014-12-15 2020-04-14 Merck Patent Gmbh Target molecule capture from crude solutions
TWI656133B (zh) 2014-12-19 2019-04-11 日商中外製藥股份有限公司 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法
KR101838645B1 (ko) 2014-12-19 2018-03-14 추가이 세이야쿠 가부시키가이샤 항-c5 항체 및 그의 사용 방법
WO2016125495A1 (en) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
EP3263132B1 (de) 2015-02-27 2023-12-06 Chugai Seiyaku Kabushiki Kaisha Zusammensetzung zur behandlung von il-6-assoziierten erkrankungen
WO2017110981A1 (en) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
CN109689099B (zh) 2016-08-05 2023-02-28 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
WO2018139623A1 (en) 2017-01-30 2018-08-02 Chugai Seiyaku Kabushiki Kaisha Anti-sclerostin antibodies and methods of use
EP3620531A4 (de) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry Verfahren zur vorhersage und beurteilung der therapeutischen wirkung bei erkrankungen im zusammenhang mit il-6 und neutrophilen

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
KR100537558B1 (ko) 1998-09-01 2005-12-19 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 인터류킨-18 결합 단백질
JP4216950B2 (ja) * 1998-09-01 2009-01-28 株式会社林原生物化学研究所 インターロイキン−１８結合蛋白質
US20020052475A1 (en) * 2000-07-20 2002-05-02 Schering Ag High affinity soluble interleukin-18 receptor
DK1392830T3 (da) * 2001-03-08 2006-05-08 Ares Trading Sa Interleukin-18 mutanter, deres fremstilling og anvendelse
MY143582A (en) * 2001-06-26 2011-05-31 Amgent Fremont Inc Antibodies to opgl
WO2003089614A2 (en) * 2002-04-18 2003-10-30 Genencor International, Inc. Production of functional antibodies in filamentous fungi
PT1601776E (pt) 2003-03-11 2008-09-17 Serono Lab Vectores de expressão que compreendem o promotor ie2 do mcmv
DK1622939T3 (da) 2003-05-13 2012-04-10 Merck Serono Sa Aktive varianter af det IL-18-bindende protein og medicinske anvendelser deraf
JP4745972B2 (ja) 2003-10-21 2011-08-10 メルク セローノ ソシエテ アノニム クロマチンインスレーターとして作用する極小ｄｎａ配列、及びタンパク質発現におけるその使用
PL1720979T3 (pl) 2004-03-01 2008-03-31 Ares Trading Sa Zastosowanie podłoża pozbawionego surowicy do hodowli komórkowej do wytwarzania IL-18BP w komórkach ssaków
DE602005009827D1 (de) * 2004-06-29 2008-10-30 Ares Trading Sa Verfahren zur aufreinigung von il-18-bindendem protein
EP2267024B1 (de) 2005-06-03 2012-05-09 Ares Trading S.A. Herstellung von rekombinantem Il-18 bindendem Protein
SI1891088T1 (sl) 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina

Also Published As

Publication number Publication date
AU2004291341A1 (en) 2005-06-02
JP2007533651A (ja) 2007-11-22
JP4741504B2 (ja) 2011-08-03
US20070037734A1 (en) 2007-02-15
NO20062545L (no) 2006-08-03
RS50516B (sr) 2010-05-07
ME01198B (me) 2013-03-20
NO330538B1 (no) 2011-05-09
WO2005049649A1 (en) 2005-06-02
IL175431A0 (en) 2006-09-05
DE602004006157D1 (de) 2007-06-06
PT1689777E (pt) 2007-05-31
CY1106683T1 (el) 2012-05-23
IL175431A (en) 2011-02-28
SI1689777T1 (sl) 2007-08-31
EP1689777A1 (de) 2006-08-16
DE602004006157T2 (de) 2008-01-03
DK1689777T3 (da) 2007-06-11
CA2544146A1 (en) 2005-06-02
US7820800B2 (en) 2010-10-26
AU2004291341B2 (en) 2010-08-05
ES2285543T3 (es) 2007-11-16
EP1689777B1 (de) 2007-04-25
HRP20070196T3 (hr) 2007-06-30
PL1689777T3 (pl) 2007-09-28
CA2544146C (en) 2012-10-02

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