ATE360689T1 - Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung - Google Patents

Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung

Info

Publication number
ATE360689T1
ATE360689T1 AT97940941T AT97940941T ATE360689T1 AT E360689 T1 ATE360689 T1 AT E360689T1 AT 97940941 T AT97940941 T AT 97940941T AT 97940941 T AT97940941 T AT 97940941T AT E360689 T1 ATE360689 T1 AT E360689T1
Authority
AT
Austria
Prior art keywords
chemokine receptor
antibodies
nucleic acid
mig
receptor
Prior art date
Application number
AT97940941T
Other languages
English (en)
Inventor
Marcel Loetscher
Bernhard Moser
Shixin Qin
Charles R Mackay
Original Assignee
Kocher Theodor Inst
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27108320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE360689(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/709,838 external-priority patent/US6140064A/en
Application filed by Kocher Theodor Inst, Millennium Pharm Inc filed Critical Kocher Theodor Inst
Application granted granted Critical
Publication of ATE360689T1 publication Critical patent/ATE360689T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97940941T 1996-09-10 1997-09-10 Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung ATE360689T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/709,838 US6140064A (en) 1996-09-10 1996-09-10 Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3
US08/829,839 US6184358B1 (en) 1996-09-10 1997-03-31 IP-10/Mig receptor designated CXCR3, antibodies, nucleic acids, and methods of use therefor

Publications (1)

Publication Number Publication Date
ATE360689T1 true ATE360689T1 (de) 2007-05-15

Family

ID=27108320

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97940941T ATE360689T1 (de) 1996-09-10 1997-09-10 Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung

Country Status (8)

Country Link
EP (1) EP0925358B1 (de)
JP (1) JP4502408B2 (de)
AT (1) ATE360689T1 (de)
AU (1) AU734090B2 (de)
CA (1) CA2265915C (de)
DE (1) DE69737656T2 (de)
ES (1) ES2288305T3 (de)
WO (1) WO1998011218A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
EP0962467A4 (de) 1996-09-26 2002-10-30 Chugai Pharmaceutical Co Ltd Antikörper gegen menschliches parathormon verwandten peptide
SE9801098D0 (sv) * 1998-03-30 1998-03-30 Astra Pharma Prod Receptors
AU3962099A (en) * 1998-05-07 1999-11-23 William Douglas Mckee Valve assembly
US6171590B1 (en) 1998-09-30 2001-01-09 Corixa Corporation Chemokine receptor peptide for inducing an immune response
WO2000028028A1 (en) * 1998-11-06 2000-05-18 Millennium Pharmaceuticals, Inc. G-protein coupled receptors, homologous to ebv-induced gpcr 2 (ebi-2). methods to seek for ligands thereof
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6358697B2 (en) 1999-04-21 2002-03-19 Children's Hospital Medical Center Intracellular pharmaceutical targeting
JP2003506042A (ja) 1999-08-03 2003-02-18 ミレニアム ファーマシューティカルズ インク． セクレチン様ファミリーの新規ｇｐｃｒ様分子１５５７１及びその使用
EP2261256A3 (de) * 1999-11-24 2011-03-02 Schering Corporation Verfahren zur inhibierung von krebs metastasen
US6949243B1 (en) 1999-11-24 2005-09-27 Schering Corporation Methods of inhibiting metastasis
AU2001249546A1 (en) * 2000-03-27 2001-10-08 Corixa Corporation Methods for treating disease with antibodies to cxcr3
US8029793B2 (en) 2000-04-28 2011-10-04 Chugai Seiyaku Kabushiki Kaisha Methods for inhibiting cell proliferation
US7052676B2 (en) 2000-09-26 2006-05-30 The Regents Of The University Of Michigan Methods for inhibition of HIV replication using a small molecule inhibitor
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
AU2002316674B2 (en) * 2001-07-12 2007-09-13 The Regents Of The University Of California CXCL10 treatment of secondary tissue degeneration
US7442512B2 (en) 2001-11-30 2008-10-28 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7871619B2 (en) 2001-11-30 2011-01-18 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7253007B2 (en) 2001-11-30 2007-08-07 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7413866B2 (en) 2001-11-30 2008-08-19 Chemocentryx, Inc. Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
EP1491209A4 (de) * 2002-02-28 2006-05-17 Kyowa Hakko Kogyo Kk Mittel für die diagnose und behandlung der interstitiellen pneumonie
JPWO2003082335A1 (ja) * 2002-04-03 2005-07-28 住友製薬株式会社 新規血糖調節薬及びそのスクリーニング方法
NZ566263A (en) 2002-05-24 2009-09-25 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
KR100874292B1 (ko) 2002-11-18 2008-12-18 케모센트릭스 아릴 술폰아마이드
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
KR101061352B1 (ko) 2002-12-20 2011-08-31 케모센트릭스 인간 종양-발현된 ｃｃｘｃｋｒ2의 저해물질
US7834155B2 (en) 2003-07-21 2010-11-16 Immunogen Inc. CA6 antigen-specific cytotoxic conjugate and methods of using the same
WO2005030793A2 (en) 2003-09-24 2005-04-07 Millennium Pharmaceuticals, Inc. Antibodies which bind human cxcr3
EP1723970A4 (de) * 2004-03-09 2009-08-12 Univ Kyoto Medizinische zusammensetzung mit cxcr3-hemmer
EP1723178A4 (de) 2004-03-12 2007-12-12 Human Genome Sciences Inc Humaner g-protein-chemokinrezeptor (ccr5) hdgnr10
US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
ES2434852T3 (es) 2005-04-21 2013-12-17 Chemocentryx, Inc. Anticuerpos que se unen a CCX-CKR2
EP2004675A1 (de) 2006-03-16 2008-12-24 Protagonists Ltd. Kombination von cytokin und cytokinrezeptor zur modulation der funktion des immunsystems
US8519135B2 (en) 2006-07-14 2013-08-27 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2/CCR9
JP5371780B2 (ja) * 2007-02-01 2013-12-18 テバ バイオファーマシューティカルズ ユーエスエー インコーポレーティッド Ｃｘｃｒ３に対するヒト化抗体
US7776877B2 (en) 2007-06-22 2010-08-17 Chemocentryx, Inc. N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides
JP5306344B2 (ja) 2007-07-12 2013-10-02 ケモセントリックス， インコーポレイテッド 炎症の治療のためのｃｃｒ２モジュレーターとしての縮合ヘテロアリールピリジルおよびフェニルベンゼンスルホンアミド
WO2013109974A2 (en) * 2012-01-20 2013-07-25 Genzyme Corporation Anti-cxcr3 antibodies
HK1212628A1 (zh) * 2012-06-27 2016-06-17 吉安特科技公司 用於抑制炎症的抗-cxcl9、抗-cxcl10、抗-cxcl11、抗-cxcl13、抗-cxcr3和抗-cxcr5试剂
US9681647B2 (en) 2012-07-05 2017-06-20 Cornell University Mammal with an orthotopic tumor capable of metastasis, a method of making and a method of using
WO2014186842A1 (en) * 2013-05-22 2014-11-27 Monash University Antibodies and uses thereof
RU2765737C2 (ru) 2016-11-23 2022-02-02 Хемоцентрикс, Инк. Способ лечения фокально-сегментарного гломерулосклероза
WO2018106945A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (de) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Behandlung einer erkrankung des gastrointestinaltraktes mit einem chemokin/chemokin-rezeptor-inhibitor
RU2020113612A (ru) 2017-10-11 2021-11-12 Хемоцентрикс, Инк. Лечение фокально-сегментарного гломерулосклероза антагонистами ccr2
EP3883635A1 (de) 2018-11-19 2021-09-29 Progenity, Inc. Verfahren und vorrichtungen zur behandlung einer krankheit mit biotherapeutika
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
EP4277924A2 (de) * 2021-01-12 2023-11-22 Charité - Universitätsmedizin Berlin Cxcr3+-zelle oder zellpräparat zur verwendung in der krebsbehandlung
WO2025185738A1 (zh) * 2024-03-08 2025-09-12 演生潮(北京)生物科技有限公司 靶向cxcr3的抗原结合蛋白及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0486572B1 (de) * 1989-08-11 1998-01-07 Amrad Corporation Limited Rezeptor für granulozyten-macrophagen-koloniestimulierungsfaktor und seine derivate
ES2250964T3 (es) * 1992-11-10 2006-04-16 Genentech, Inc. Receptor de la quimioquina c-c(c-c ckr-1).
US6806061B1 (en) * 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor

Also Published As

Publication number Publication date
DE69737656T2 (de) 2008-01-03
JP2002513388A (ja) 2002-05-08
ES2288305T3 (es) 2008-01-01
JP4502408B2 (ja) 2010-07-14
AU4260897A (en) 1998-04-02
CA2265915C (en) 2012-11-20
WO1998011218A1 (en) 1998-03-19
EP0925358A1 (de) 1999-06-30
DE69737656D1 (de) 2007-06-06
AU734090B2 (en) 2001-06-07
CA2265915A1 (en) 1998-03-19
EP0925358B1 (de) 2007-04-25

Similar Documents

Publication Publication Date Title
ATE360689T1 (de) Cxcr3 chemokine rezeptor, antikoerper, nukleinsaeure und deren verfahren zur anwendung
DK0673420T3 (da) Mammale receptorer for interleukin 10 (IL-10)
ATE449109T1 (de) Sekretierte und transmembran-polypeptide sowie nukleinsäuren zu deren kodierung
CH0229046H1 (de) Method for obtaining dna, rna, peptides, polypeptinique. des or proteins by means of a dna recombinant tech
DK672788D0 (da) Rekombinant-dna-vektorer til direkte udtrykkelse af aktiveret humant protein c
DE68929043D1 (de) Für androgen-rezeptor-protein kodierende dna
ATE140963T1 (de) Verfahren zur herstellung von sekretierten rezeptoranalogen
ES2090007T3 (es) Receptores hibridos, acidos nucleicos que los codifican, su preparacion y su utilizacion en la determinacion de ligandos y sus antagonistas y agonistas.
NO961115D0 (no) Humane metabotrope glutamatreseptorsubtyper (HMR4, HMR6, HMR7) og relaterte DNA forbindelser
WO2001077332A3 (en) Compositions and methods related to canine igg and canine il-13 receptors
EP1464706A3 (de) HEK5, HEK7, HEK8, HEK11, EPH-ähnliche Protein-Tyrosinkinase-Rezeptoren
ATE378407T1 (de) Morphogene protein-spezifische zelloberflächenrezeptoren und ihre verwendungen
IL134968A0 (en) Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1672070A3 (de) Sekretierte und transmembrane Polypeptide, sowie dafür codierende Nukleinsäuren
NZ502391A (en) Mammalian cytokine: interleukin-B30 and related reagents
EP1609863A3 (de) Ausgeschiedene und Transmembranpolypeptide und dafür kodierende Nukleinsäure
WO1998001557A3 (en) Mammalian chemokine reagents
WO1998011226A3 (en) Mammalian chemokines, related reagents
DE69637217D1 (de) Meltrine
DE69115917D1 (de) Humane gammainterferonantagonisten
DE69426076D1 (de) Gereinigte flt3 liganden von saeugentieren, agonisten und antagonisten davon
DE69728897D1 (de) Saeugetierchemokine
DK198188D0 (da) Rekombinant-dna-kloningsvektorer, der fremkalder spiramycin-resistens
DE69017996D1 (de) Verfahren zur Ammoxidation von Paraffinen.
DK1241179T3 (da) Humant protein med in vitro antiproliferativ aktivitet.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties